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Topic: Baclofen

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	Baclofen Pump Therapy for Muscle Spasms
		Intrathecal baclofen withdrawal syndrome is a very rare, potentially life-threatening complication of baclofen pump caused by an abrupt cessation of intrathecal baclofen.
		The dose of intrathecal baclofen was decreased to 300 micrograms/day.
		Baclofen, an agonist of -amino butyric acid, is one of the most effective drugs in the treatment of spastic movement disorders.
	www.apparelyzed.com /support/baclofen-pump/baclofen-pump.html (1222 words)

	Lioresal (Baclofen) drug description - prescription drugs and medications at RxList
		Abrupt discontinuation of intrathecal baclofen, regardless of the cause, has resulted in sequelae that include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, that in rare cases has advanced to rhabdomyolysis, multiple organ-system failure and death.
		Baclofen is a white to off-white, odorless or practically odorless crystalline powder, with a molecular weight of 213.66.
		Baclofen injection: is a sterile, pyrogen-free, isotonic solution free of antioxidants, preservatives or other potentially neurotoxic additives indicated only for intrathecal administration.
	www.rxlist.com /cgi/generic/baclofen.htm (365 words)

	Baclofen - Wikipedia, the free encyclopedia
		Baclofen (brand names Kemstro® and Lioresal®) is a derivative of gamma-aminobutyric acid, and is an agonist specific to GABA
		Baclofen is a white to off-white, odorless or practically odorless crystalline powder, with a molecular weight of 213.66.
		Symptoms of a baclofen overdose include vomiting, weakness, drowsiness, slow breathing, seizures, unusual pupil size, and coma.
	en.wikipedia.org /wiki/Baclofen (199 words)

	National MS Society \| Baclofen (Site not responding. Last check: 2007-10-25)
		Baclofen acts on the central nervous system to relieve spasms, cramping, and tightness of muscles caused by spasticity in multiple sclerosis.
		Studies in animals have shown that baclofen, when given in doses several times higher than the amount given to humans, increases the chance of hernias, incomplete or slow development of bones in the fetus, and lower birth weight.
		Baclofen passes into the breast milk of nursing mothers but has not been reported to cause problems in nursing infants.
	www.nationalmssociety.org /Meds-Baclofen.asp (466 words)

	Data Sheet
		Baclofen is beneficial in neurological diseases associated with spasm of the skeletal muscles by providing relief from painful spasms, clonus and automatism as well as reflex muscle contractions.
		Baclofen should be used with caution in patients with or with a history of peptic ulcers, cerebrovascular diseases, or hepatic, renal or respiratory failure.
		Because baclofen is primarily excreted unchanged through the kidneys it should be given with caution to patients with impaired renal function and it may be necessary to reduce the dosage.
	www.medsafe.govt.nz /Profs/datasheet/a/alphabaclofentab.htm (1834 words)

	Baclofen -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-25)
		Baclofen is a white to off-white, odorless or practically odorless (additional info and facts about crystalline) crystalline powder, with a ((chemistry) the sum of the relative atomic masses of the constituent atoms of a molecule) molecular weight of 213.66.
		It is slightly (additional info and facts about soluble) soluble in water, very slightly soluble in (A light volatile flammable poisonous liquid alcohol; used as an antifreeze and solvent and fuel and as a denaturant for ethyl alcohol) methanol, and insoluble in (A volatile liquid haloform (CHCl3); formerly used as an anesthetic) chloroform.
		Symptoms of a baclofen (additional info and facts about overdose) overdose include vomiting, weakness, drowsiness, slow breathing, seizures, unusual pupil size, and (A state of deep and often prolonged unconsciousness; usually the result of disease or injury) coma.
	www.absoluteastronomy.com /encyclopedia/b/ba/baclofen.htm (171 words)

	Intrathecal Baclofen Therapy (for MS)
		Baclofen is a muscle relaxant medicine commonly used to decrease spasticity related to multiple sclerosis, spinal cord injuries, or other neurological diseases.
		Of the oral baclofen delivered throughout the body, only a small portion goes to the spinal fluid where it is needed to work.
		During the medicine trial, baclofen is injected into the spinal canal (using a small needle) and you are assessed by the treatment team over two to four hours to determine how well the medicine treats the spasticity.
	www.clevelandclinic.org /health/health-info/docs/2200/2210.asp?index=8997 (852 words)

	baclofen and other drugs
		Baclofen (ITB) is a medication with almost the same chemical makeup as GABA and functions in the same way as GABA, relaxing muscles.
		The introduction of the baclofen pump greatly improves the benefits of the medicine because it inserts the medicine into the spinal cord where it is needed.
		A baclofen pump is inserted under the skin of the abdomen, a small tube is tunneled under the skin around to the back.
	cerebralboy.com /cp/baclofen.shtml (307 words)

	Addiction Medicine - Baclofen
		Baclofen, known as Lioresal ®, is a GABAB receptor agonist (GABA is the predominant inhibitory neurotransmitter in the brain) that is used to alleviate the signs and symptoms of muscle spasticity from Multiple Sclerosis.
		Baclofen is available in tablets with the initial dose of 5 mg three times a day to a maximum of 80 mg per day for treatment of muscle spasticity.
		Hallucinations and seizures have occurred on abrupt withdrawal of Baclofen.
	www.oasas.state.ny.us /AdMed/meds/fyibaclofen.htm (442 words)

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