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Topic: Basal cell of olfactory epithelium


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In the News (Mon 28 May 12)

  
  List of distinct cell types in the adult human body - Wikipedia, the free encyclopedia
Surface epithelial cell of stratified squamous epithelium of cornea, tongue, oral cavity, esophagus, anal canal, distal urethra and vagina
basal cell (stem cell) of epithelia of cornea, tongue, oral cavity, esophagus, anal canal, distal urethra and vagina
Basal cell of olfactory epithelium (stem cell for olfactory neurons)
en.wikipedia.org /wiki/List_of_distinct_cell_types_in_the_adult_human_body   (527 words)

  
 Olfactory epithelium - Wikipedia, the free encyclopedia
The olfactory epithelium is a specialized epithelial tissue inside the nasal cavity that is involved in smell.
The tissue is made of three types of cells: the olfactory receptor neurons which transduce the odor to electrical signals, the supporting cells which protect the neurons and secrete mucus, and the basal cells which are a type of stem cell that differentiate into olfactory receptor neurons to replace dead receptor neurons.
The olfactory epithelium can be damaged by inhalation of toxic fumes, physical injury to the interior of the nose, and possibly by the use of some nasal sprays.
en.wikipedia.org /wiki/Olfactory_epithelium   (226 words)

  
 4. The Adult Stem Cell [Stem Cell Information]
The bone marrow-derived cells are sometimes sorted—using a panel of surface markers—into populations of hematopoietic stem cells or bone marrow stromal cells [46, 54, 71].
Adjacent to the ependymal cell layer, in a region sometimes designated as the subependymal or subventricular zone, is a mixed cell population that consists of neuroblasts (immature neurons) that migrate to the olfactory bulb, precursor cells, and astrocytes.
Neural stem cells in the mammalian fetal brain are concentrated in seven major areas: olfactory bulb, ependymal (ventricular) zone of the lateral ventricles (which lie in the forebrain), subventricular zone (next to the ependymal zone), hippocampus, spinal cord, cerebellum (part of the hindbrain), and the cerebral cortex.
stemcells.nih.gov /info/scireport/chapter4.asp   (11899 words)

  
 Gazi Tıp Fakültesi - Gazi Medical Journal   (Site not responding. Last check: 2007-10-24)
Olfactory epithelium (OE) consists of sensory neurons projecting to the olfactory bulb, sustentacular cells, cytokeratin containing horizontal basal cells (HBCs) and cytokeratin lacking globose basal cells (GBCs) (9,10).
Despite the systematic immunoreaction on the olfactory epithelium, a weak immunostaining was detected in the fibers and fibroblast cytoplasm of Lp.
Olfactory receptor neurons are continuously replaced postnatally through the initiation of division and terminal differentiation of progenitor cells located in the basal layer of OE.
www.med.gazi.edu.tr /gmj/immuno.html   (1988 words)

  
 cell
's in the olfactory lobe of the brain whose dendrites synapse (in glomeruli) with axons of the olfactory receptor c.
in the basal ganglia and thalamus in hepatocerebral degeneration and Wilson's disease.
's occur in neoplastic epithelium in the ducts and in the epidermis of the nipple, areola, and adjacent skin.
www.painhealth.com /word.asp?q=7196   (5906 words)

  
 research/malicki
At the onset of neurogenesis, it consists of a morphologically uniform population of neuroepithelial cells.
Cell polarity is a multifaceted phenomenon that involves, among other processes, the subdivision of the cell membrane into biochemically distinct subdomains, intracellular transport, and cell-cell interactions.
Although the ciliary compartments of other sensory neurons, auditory hair cells, and olfactory sensory neurons, are less prominent, in the absence of ovl function these cells too suffer from a loss of cilia and subsequently cell death.
www.howelaboratory.harvard.edu /malicki.htm   (680 words)

  
 Roskams Lab - ORN Apoctosis
The olfactory epithelium (OE) is the oldest recognized source of potential neural stem cells in the adult vertebrate, yet we know so little about the nature of the basal cells that are the founders of all embryonic and adult ORNs and other OE-derived cells.
As olfactory neurons die, they direct local progenitors (globose or horizontal basal cells) to guide their own replacement using mechanisms we have only just begun to elucidate.
We are using techniques found throughout the epidermal and haematopoietic stem cell world to recognize, clonally isolate and expand olfactory progenitors from the olfactory epithelium.
www.zoology.ubc.ca /~roskams/Progen.html   (200 words)

  
 A Transient Population of Neurons Pioneers the Olfactory Pathway in the Zebrafish -- Whitlock and Westerfield 18 (21): ...
axonal scaffold for the later-arriving olfactory sensory neurons.
olfactory placode is an apparently homogeneous population of cells.
The growth cones of the sensory neurons in the differentiating olfactory bulb colocalize (arrowhead) with the axons of the pioneer neurons.
www.jneurosci.org /cgi/content/full/18/21/8919   (6420 words)

  
 ORGANS OF SENSE
The structure represents a "mucus membrane", consisting of a pseudostratified epithelium underlaid by connective tissue, the lamina propria (Olfactory membrane 1).
The olfactory epithelium or mucosae is a tall columnar pseudostratified epithelium, containing three different cell types: (1) basal cells (stem cells), (2) sustentacular cells (supporting); and (3) olfactory receptor cells (bipolar nerve cells).
It is composed of a pigmented and a sensory or neural layer (Retina 1).
lifesci.rutgers.edu /~babiarz/sensory.htm   (781 words)

  
 Olfactory Epithelium
The olfactory region covers most of the roof of the nasal cavity from the anterior end of the superior concha and extending posteriorly for a short distance.
The mucous membrane of the olfactory area consists of pseudostratified ciliated columnar epithelium interspersed with goblet cells and a thick lamina propria.
The final cell type are the Basal Cells, (green arrow) which are simple the cells that will give rise to new olfactory cells.
www3.umdnj.edu /histsweb/lab10/lab10olfactory.html   (624 words)

  
 ummc research   (Site not responding. Last check: 2007-10-24)
The neurons located in the olfactory epithelium are unique in the nervous system in that they are constantly generated and replaced throughout life, derived from a resident population of persistently mitotic stem cells called basal cells.
In order to monitor the generation and turnover of olfactory receptor neurons, the basal cells are labeled with bromo-deoxyuridine (BrdU), which is incorporated into their DNA prior to mitosis, during S phase, then is passed to the daughter cells during mitosis, and ultimately labels the olfactory receptor neurons into which they differentiate.
We sought to better understand the mechanisms that regulate basal cell proliferation and olfactory neurogenesis, as well as the long-term consequences that persistent turnover of receptor neurons may have on the functioning of the olfactory system.
www.mit.edu /people/jocelyns/olfnsf99/abstract1.html   (616 words)

  
 List of distinct cell types in the adult human body - Gurupedia
5 Epithelial absorptive cells (Gut, Exocrine Glands and Urogenital Tract)
Surface epithelial cell of stratified squamous epithelium of
Epithelial absorptive cells (Gut, Exocrine Glands and Urogenital Tract)
www.gurupedia.com /l/li/list_of_distinct_cell_types_in_the_adult_human_body.htm   (489 words)

  
 Laboratory Ten: Respiratory System
The majority of the nuclei in the olfactory epithelium belong to olfactory cells, which are receptor bipolar neurons.
The pseudostratified columnar epithelium is comprised of three types of epithelial cells: basal cells, ciliated columnar cells, and goblet cells.
The epithelium is anchored to the basement membrane, a thick, pink-stained region adjacent to the epithelium.
medinfo.ufl.edu /year1/histo/review/lab10.html   (1494 words)

  
 Epithelium
The cell has it's half of the desmosome and since there is no adjacent cell there is not a complimentary half desmosome.
Basal lamina of the EM can only be visualized when two basal lamina combine or when there is an extra thick connective layer associated with the Recticular lamina of EM.
Two of the thickest Basal membranes are present in the trachea and the lens capsule of eye.
histo.ipfw.edu /histo-embryo/epithelia.html   (2324 words)

  
 Schwob Laboratory
Goldstein, B.J., and J.E. Schwob 1996 Analysis of the globose basal cell compartment in rat olfactory epithelium using GBC-1, a new monoclonal antibody against globose basal cells.
Goldstein, B.J., H. Fang, S.L. Youngentob and J.E. Schwob 1998 Transplantation of multipotent progenitor cells from adult olfactory epithelium.
J.E., S. Saha, S.L. Youngentob and B. Jubelt 2001 Intranasal inoculation with the olfactory bulb line variant of mouse hepatitis virus causes extensive destruction of the olfactory bulb and accelerated turnover of neurons in the olfactory epithelium of mice.
www.tufts.edu /sackler/cmdb/schwob-pub.htm   (613 words)

  
 The Dictionary of Cell and Molecular Biology - Online!   (Site not responding. Last check: 2007-10-24)
General term for relatively undifferentiated cells in an epithelial sheet that give rise to more specialized cells (act as stem cells).
In the stratified squamous epithelium] of mammalian skin the basal cells of the epidermis (stratum basale) give rise by an unequal division to another basal cell and to cells that progress through the spinous, granular and horny layers, becoming progressively more keratinised, the outermost being shed as squames.
In the epithelium of epididymis their function is unclear, but they probably serve as stem cells.
www.mblab.gla.ac.uk /~julian/dict2.cgi?735   (116 words)

  
 Defining the role of olfactory ensheathing cells in facilitating axon remyelination following damage to the spinal cord ...
Olfactory receptor neurons in the olfactory epithelium project axons that are accompanied by OECs from the olfactory lamina propria through the cribiform plate of the ethmoid bone and into the nerve fiber layer of the olfactory bulb.
Doucette, J. (1984) The glial cells in the nerve fiber layer of the rat olfactory bulb.
Au, E., Roskams, A. (2003) Olfactory ensheathing cells of the lamina propria in vivo and in vitro.
www.fasebj.org /cgi/content/full/19/7/694   (6325 words)

  
 Evidence that thyroid hormone induces olfactory cellular proliferation in salmon during a sensitive period for ...
Evidence that thyroid hormone induces olfactory cellular proliferation in salmon during a sensitive period for imprinting -- Lema and Nevitt 207 (19): 3317 -- Journal of Experimental Biology
was restricted to the basal region of the olfactory epithelium,
proliferation of neural progenitor cells in the salmon epithelium.
jeb.biologists.org /cgi/content/abstract/207/19/3317   (292 words)

  
 Gerald Schwarting - Cell Biology - Faculty - Research - UMass Medical School
Project #1: The soluble chemoattractant/repellent netrin-1 is expressed in the ventricular zone of the developing olfactory bulb and by neurons in the olfactory epithelium in the early mouse embryo at a time when the olfactory system is being patterned.
A mouse line that expresses GFP specifically in LHRH cells is now on hand in my lab and will allow us to follow the migration of identified LHRH cells in vivo and in vitro as they move along olfactory and brain pathways.
Immunofluorescence, confocal and light microscopic techniques allow us to follow live migrating LHRH cells into the forebrain and will allow us to test molecules that are important for regulating cell migration.
www.umassmed.edu /cellbio/faculty/schwarting.cfm?start=Rotations&   (333 words)

  
 NTP: ChemIDPlus/HSDB 74-83-9 Toxicity
We used the inhalation of methyl bromide gas to produce a near-complete destruction of the rat olfactory epithelium and analyzed the reinnervation of the bulb during reconstitution of the epithelium.
The degeneration of olfactory axons elicits a transient up-regulation of glial cell proliferation and glial fibrillary acidic protein expression in the olfactory nerve and olfactory nerve layer of the bulb.
However, in rats that are lesioned while food restricted, a significant fraction of olfactory epithelium becomes respiratory during its reconstitution, and the population of reinnervating fibers is less.
ntp.niehs.nih.gov /index.cfm?objectid=E88271F4-BDB5-82F8-F150ED059040694F   (13056 words)

  
 ANNALS Nov2000: PROLIFERATION MARKERS, PROLIFERATING CELL NUCLEAR ANTIGEN, KI67, . . .   (Site not responding. Last check: 2007-10-24)
Authors: YASUSHI OHTA, MD, KEIICHI ICHIMURA, MD We immunohistochemically identified proliferating cells in the olfactory epithelium of mice, using an anti#proliferating cell nuclear antigen (PCNA) antibody, an anti-Ki67 antibody, an anti#5-bromo-2'-deoxyuridine (BrdU) antibody, and an anti#cyclin D1 antibody.
Positive cells stained by the 4 antibodies were identified mainly in the basal layer.
The mean numbers of positive cells stained by the 4 antibodies in 500 olfactory epithelium cells from each animal were as follows: PCNA-positive cells 42, Ki67-positive cells 23, BrdU-positive cells 13.7, and cyclin D1#positive cells 9.2.
www.annals.com /abs/annals613.htm   (186 words)

  
 AppendixC
Urinary epithelium cell (lining bladder and urinary ducts)
Adrenal gland cell secreting steroid hormones (mineralcorticoids and gluco corticoids)
Neuron cell (large variety of types, still poorly classified)
www.nanomedicine.com /NMI/AppendixC.htm   (460 words)

  
 Cell Cycle Regulation during Mouse Olfactory Neurogenesis -- Legrier et al. 12 (12): 591 -- Cell Growth & ...
Cell Cycle Regulation during Mouse Olfactory Neurogenesis -- Legrier et al.
birth, olfactory neural progenitors, the basal cells, exhibited
basal cells in a quiescent state, whereas p27Kip1 expression
cgd.aacrjournals.org /cgi/content/abstract/12/12/591   (371 words)

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