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Topic: Basement membrane

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	ARUP: Epithelial Basement Membrane Zone IgG Antibodies (Site not responding. Last check: 2007-10-07)
		Antibodies to two basement membrane zone-containing substrates, human epidermis split at the basement membrane zone and monkey esophagus epithelium, are detected by indirect immunofluorescence (IFA).
		IgG and complement are found at the basement membrane zone in perilesional tissue, and IgG basement membrane zone antibodies are present in sera in up to 80 percent of patients with localization on the epidermal side of split skin.
		Basement membrane zone antibody testing by IFA is a well established test and can be used to distinguish pemphigoid from linear IgA disease (linear IgA bullous disease and childhood immunobullous disease) and epidermolysis bullosa acquisita, as well as other immunobullous diseases such as pemphigus and dermatitis herpetiformis.
	www.aruplab.com /guides/clt/tests/clt_a236.jsp (667 words)

	Human Amniotic Membrane, Like Corneal Epithelial Basement Membrane, Manifests the {alpha}5 Chain of Type IV Collagen -- ...
		5(IV) is absent in the basement membrane of amniotic membrane
		Consequently, the basement membrane of the amniotic membrane
		denuded amniotic membrane as a substrate for cultivating corneal
	www.iovs.org /cgi/content/full/45/6/1771 (1789 words)

	MedlinePlus Medical Encyclopedia: Anti-glomerular basement membrane
		This is a blood test that detects the presence of antibodies to glomerular (kidney) basement membrane proteins.
		This test is used when the presence of antibodies against the glomerular basement membrane (part of the kidney filtering system) is suspected as the cause of kidney disease.
		In the first case, formation of antibodies against the basement membrane of the filtering system results in damage to the basement membrane and kidney failure.
	www.nlm.nih.gov /medlineplus/ency/article/003524.htm (667 words)

	Basement membrane chondroitin sulfate proteoglycan alterations in a rat model of polycystic kidney disease. (Site not responding. Last check: 2007-10-07)
		Alterations in basement membrane components, notably proteoglycans, in a rat model of polycystic kidney disease have been investigated.
		Staining of tissue sections with two mouse monoclonal antibodies to a recently described basement membrane chondroitin sulfate proteoglycan (BM-CSPG) core protein was markedly diminished in the basement membranes of dilated cystic tubules.
		Staining with antibody to a basement membrane heparan sulfate proteoglycan core protein related to perlecan did not diminish but rather stained affected tubules intensely, whereas laminin, on the other hand, was apparently diminished in the basement membranes of the cystic tubules.
	www.arclab.org /medlineupdates/abstract_7510458.html (310 words)

	LaserMyEye :: Encyclopedia :: Basement membrane
		The basement membrane is a membrane of tissue beneath the epithelium which helps the epithelium adhere to the Bowman's layer or stromal tissue.
		For patients getting LASIK, it is very important that the basement membrane be in good condition.
		A poor basement membrane resulting in loosely adhering epithelium will put LASIK patients at far higher risk of serious epithelial defects, extremely slow healing and severe chronic dry eye after surgery.
	www.lasermyeye.org /encyclopedia/basementmembrane.html (147 words)

	► Anti-glomerular basement membrane (Site not responding. Last check: 2007-10-07)
		A blood test that detects the presence of antibodies to glomerular (renal) basement membrane proteins.
		This test is used when the presence of antibodies against the glomerular basement membrane (part of the kidney filtering system) is suspected as the cause of renal (kidney) disease.
		Immunologically-mediated renal diseases may involve autoantibodies (antibodies against the body's own tissue) directed against renal antigens; or it may involve immune complexes of autoantibodies (an antibody and antigen combine to form a complex) that become deposited in the filtering system of the kidneys.
	www.umm.edu /ency/article/003524.htm (498 words)

	Isoform Switching of Type IV Collagen Is Developmentally Arrested In X-Linked Alport Syndrome Leading to Increased ...
		Timoneda, A.M. Chonko, S.J. Edwards, M.E. Noelken, and B.G. Hudson (1991) Glomerular basement membrane: identification of dimeric subunits of the noncollagenous domain (hexamer) of collagen IV and the Goodpasture antigen.
		Risteli, and K.I. Kivirikko (1978) Glomerular basement membrane collagen and activities of the intracellular enzymes of collagen biosynthesis in congenital nephrotic syndrome of the Finnish type.
		Sanders, and G.A. Coles (1978) The degradation of human glomerular basement membrane with purified lysosomal proteinases: evidence for the pathogenic role of the polymorphonuclear leucocyte in glomerulonephritis.
	www.jci.org /cgi/content/full/99/10/2470 (4938 words)

	THE MERCK MANUAL, Sec. 6, Ch. 77, Goodpasture's Syndrome
		148) of unknown cause, characterized by circulating anti-glomerular basement membrane antibodies in the blood and linear deposition of immunoglobulin and complement in the glomerular basement membrane and causing pulmonary hemorrhage with severe and progressive glomerulonephritis.
		In the lungs and kidneys, the primary target of the anti-glomerular basement membrane antibodies is the noncollagenous (NC-1) domain of the
		Circulating anti-glomerular basement membrane antibodies are present in the blood.
	www.merck.com /pubs/mmanual/section6/chapter77/77a.htm (439 words)

	ARUP: Glomerular Basement Membrane Antibodies (Site not responding. Last check: 2007-10-07)
		FAQE-->): Biochemical studies have shown that the antigen involved in Goodpasture's syndrome is a part of the globular domain of the collagen IV chains in the glomerular basement membrane.
		Goodpasture's syndrome is a rapidly progressive autoimmune disease associated with glomerular and tubular basement membrane antibodies, pulmonary hemorrhages, and acute glomerulonephritis, commonly of the rapidly progressive type.
		A rapid assay for circulating anti-glomerular basement membrane antibodies in Goodpasture syndrome.
	www.aruplab.com /guides/clt/tests/clt_a282.jsp (984 words)

	Decreased Glomerular Basement Membrane Heparan Sulfate Proteoglycan in Essential Hypertension -- Heintz et al. 25 (3): ...
		and, to a lesser extent, in the basement membrane of tubuli.
		in the glomerular basement membranes of the kidney in hypertension.
		The small heparan sulfate proteoglycan is located predominantly in the glomerular basement membrane and, to a lesser extent, in the basement membrane of tubuli but also in the mesangium.
	hyper.ahajournals.org /cgi/content/full/25/3/399 (3697 words)

	Thesis (Site not responding. Last check: 2007-10-07)
		This is in sharp contrast to benign mucous membrane pemphigoid histological characteristics.
		There is a separation of the basement membrane from the epithelium, with some portions of the basement membrane attached to the epithelium occasionally found.
		Cross-reactivity between the basement membrane components (BMCs) tested and the bacterial antigens, and between the monoclonal antibodies to the BMCs was observed.
	www.dent.ucla.edu /pic/visitors/honigman.thesis.html (7346 words)

	Basement Membrane Pores in Human Bronchial Epithelium : A Conduit for Infiltrating Cells? -- Howat et al. 158 (2): 673 ...
		A: The pore (arrowheads) traverses the full thickness of the basement membrane with epithelium (E) intact and connects with what appears to be a cell-filled channel at the lamina reticularis/lamina propria boundary (star).
		at the boundary of the lamina reticularis and basement membrane
		In summary, pores are present in the basement membrane of bronchial epithelium.
	ajp.amjpathol.org /cgi/content/full/158/2/673 (3957 words)

	cDNA Cloning of the Basement Membrane Chondroitin Sulfate Proteoglycan Core Protein, Bamacan: A Five Domain Structure ...
		e.g., renal glomerular basement membrane and neuromuscular junction
		The biology of perlecan: the multifaceted heparan sulfate proteoglycan of basement membranes and pericellular matrices.
		Basement membrane specific chondroitin sulfate proteoglycan is abnormally associated with the glomerular capillary basement membrane in diabetic rats.
	www.jcb.org /cgi/content/full/136/2/433 (6221 words)

	Distribution of the collagen IV isoforms in human Bruch's membrane -- Chen et al. 87 (2): 212 -- British Journal of ...
		The RPE basement membrane is also identified adjacent to the RPE cell overlying the basal deposit (red arrowhead).
		Organization and expression of basement membrane collagen IV genes and their roles in human disorders.
		Human corneal basement membrane heterogeneity: topographical differences in the expression of type IV collagen and laminin isoforms.
	bjo.bmjjournals.com /cgi/content/full/87/2/212 (2140 words)

	Basement membrane definition - Medical Dictionary definitions of popular medical terms
		Basement membrane: A thin membrane upon which is posed a single layer of cells.
		The basement membrane is made up of proteins held together by type IV collagen.
		The epithelial cells are anchored with hemidesmosome to the basement membrane.
	www.medterms.com /script/main/art.asp?articlekey=39157 (198 words)

	Agarose-Dextran Gels as Synthetic Analogs of Glomerular Basement Membrane: Water Permeability -- White and Deen 82 (4): ...
		Assessment of the charge-selectivity of glomerular basement membrane using Ficoll sulfate.
		Glomerular basement membrane: in vitro studies of water and protein permeability.
		Characterization of the glycosaminoglycan component of the renal glomerular basement membrane and its relationship to the peptide portion.
	www.biophysj.org /cgi/content/full/82/4/2081 (4303 words)

	Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early ...
		Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development -- Pöschl et al.
		Ultrastructural abnormalities in basement membranes of collagen IV-deficient embryos.
		Thomas, T. and Dziadek, M. Genes coding for basement membrane glycoproteins laminin, nidogen, and collagen IV are differentially expressed in the nervous system and by epithelial, endothelial, and mesenchymal cells of the mouse embryo.
	dev.biologists.org /cgi/content/full/131/7/1619 (5812 words)

	Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement ...
		Basement membrane proteoglycans in glomerular morphogenesis: chondroitin sulfate proteoglycan is temporally and spatially restricted during development.
		Widespread expression of perlecan proteoglycan in basement membranes and extracellular matrices of human tissues as detected by a novel monoclonal antibody against domain III and by in situ hybridization.
		Basement membrane-specific chondroitin sulfate proteoglycan is abnormally associated with the glomerular capillary basement membrane of diabetic rats.
	ndt.oupjournals.org /cgi/content/full/14/9/2119 (6154 words)

	D'Eyealogues - Fixing Epithelial Basement Membrane Dystrophy
		In patients who present with mild and asymptomatic epithelial basement membrane dystrophy, laser in situ keratomileusis should be performed with caution, or photorefractive keratectomy may be the preferred refractive procedure.
		Transmission electron microscopy of all epithelial debridement specimens disclosed consistent abnormality of the basement membrane adhesion complex, as thickened and multilaminated basement membrane remained adherent to the intact epithelial sheet.
		Corneal epithelial dysadhesion and defects occurring in the course of LASIK surgery may be associated with an intrinsic compromise of the basement membrane adhesion complex, as evidenced clinically by the adhesion test and demonstrated pathologically by duplicated basement membrane
	www.lasermyeye.org /forums/showthread.php?t=219 (1301 words)

	fig001jbs: The basement membrane of the intestine (Site not responding. Last check: 2007-10-07)
		At the interface between the two tissues is the basement membrane, which is a thin sheet of specialised extracellular matrix.
		The basement membrane (in red) is located at the interface between the two tissues.
		Both epithelial and mesenchymal cells are responsible for the production (arrows) of specific basement membrane molecules (see Refs 13 and 26 for more details).
	www.expertreviews.org /01003635h.htm (263 words)

	Coordinated Reassembly of the Basement Membrane and Junctional Proteins during Corneal Epithelial Wound Healing -- ...
		Coordinated Reassembly of the Basement Membrane and Junctional Proteins during Corneal Epithelial Wound Healing -- Suzuki et al.
		for laminin-1 was detected in the basement membrane region beneath
		This observation that the re-establishment of the basement membrane
	www.iovs.org /cgi/content/full/41/9/2495 (2996 words)

	Antibody Response Against the Glomerular Basement Membrane Protein Agrin in Patients with Transplant Glomerulopathy (Site not responding. Last check: 2007-10-07)
		Continue to Antibody Response Against the Glomerular Basement Membrane Protein Agrin in Patients with Transplant Glomerulopathy on Medscape Headlines.
		SARS neutralizing antibody level is positively correlated with clinical severity, and in a portion of the patients with mild infection, a detectable neutralizing antibody response may not develop.
		The structure of the membrane protein NhaA has been revealed by researchers at the Hebrew University of Jerusalem and the Max Planck Institute of Germany.
	www.medical-buzz.com /antibody-response-against-the-glomerular-basement-membrane-protein-agrin-in-patients-with-transplant-glomerulopathy,46770.html (184 words)

	Leung, Mol Vis 2000; 6:15-23.
		The presence of RCFM posterior to the preexisting Descemet's membrane (DM) is thought to represent an end-stage disease process of the corneal endothelium that results in functional alterations of the corneal endothelium, leading to corneal opacity and blindness.
		This membrane is called the basement membrane of the corneal endothelium because of its location and ultrastructral appearance.
		This pathological membrane consists of fibrous ECM and elongated cells that are responsible for the fibrillar phenotypes.
	www.molvis.org /molvis/v6/a4 (4367 words)

	Laminin assembles into separate basement membrane and fibrillar matrices in Schwann cells -- Tsiper and Yurchenco 115 ...
		We postulate that laminin induces the assembly of a basement
		Laminin-1 induction of an ultrastructural basement membrane morphology
		Basement membranes during development of human nerve: Schwann cells and perineurial cells display marked changes in their expression profiles for laminin subunits and beta 1 and beta 4 integrins.
	jcs.biologists.org /cgi/content/full/115/5/1005 (6337 words)

	Antigen Retrieval of Basement Membrane Proteins from Archival Eye Tissues -- Hann et al. 49 (4): 475 -- Journal of ...
		predominantly in the basement membrane adjacent to the canal,
		Note labeling of basement membrane (bm) with clumping of the label.
		Darker gray homogeneous tissue beneath basement membrane is sheath material surrounding an elastic tendon (see Fig 2C and Fig 2D).
	www.jhc.org /cgi/content/full/49/4/475 (3471 words)

	Basement membrane components -- Li and Thompson 56 (12): 885 -- Journal of Clinical Pathology
		The gut epithelial basement membrane is a specialised structure
		to laminin in the basement membrane accompanied by an increase
		Deficiency of epithelial basement membrane laminin in ulcerative colitis affected human colonic mucosa.
	jcp.bmjjournals.com /cgi/content/full/56/12/885 (1713 words)

	[Frontiers in Bioscience 2, d343-352, July 15, 1997] (Site not responding. Last check: 2007-10-07)
		Skin basement membrane zone (BMZ) is an ultrastructurally defined area situated between the outer layer of skin, the epidermis, and the inner layer of skin, the dermis.
		J.J. Zone, T.B. Taylor, D.P. Kadunce and L.J. Meyer: Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis.
		L.S. Chan and D.T. Woodley: The 105-kDa basement membrane autoantigen p105 is N-terminally homologous to a tumor-associated antigen.
	bioscience.org /1997/v2/d/chan/343-352.htm (5510 words)

	Handbook of Ocular Disease Management - Epithelial Basement Membrane Dystrophy
		EBMDs are bilateral, often asymmetrical corneal basement membrane disorders usually occurring in individuals over 30.
		In EBMD disorders, the basal epithelial cells manufacture abnormal finger-like projections that protrude from the abnormally thickened basement membrane.
		Anterior stromal puncture (ASP) under topical anesthesia involves the use of a 25g needle to place 0.1mm deep perforations, breaching Bowmans's membrane, at 0.25mm intervals in a chronic RCE zone in an attempt to initiate scar formation and healing.
	www.revoptom.com /handbook/sect3i.htm (608 words)

	Airway Inflammation in Childhood Asthma -- Barbato et al. 168 (7): 798 -- American Journal of Respiratory and Critical ...
		Individual values for reticular basement membrane thickness in bronchial biopsies of children with asthma, children with atopy, and children who were control subjects.
		Microphotograph showing bronchial biopsies from a child with asthma (A) and a control child (B), demonstrating an increased basement membrane thickness in the child with asthma.
		Early thickening of the reticular basement membrane in children with difficult asthma.
	ajrccm.atsjournals.org /cgi/content/full/168/7/798 (3813 words)

	Tumor Necrosis Factor-{alpha}-Induced Matrix Proteolytic Enzyme Production and Basement Membrane Remodeling by Human ...
		surface epithelial basement membrane in ovulation and neoplastic
		Stenbeck F., Wasenius V-M. Basement membrane structures in tumors of the ovary.
		Evidence for a role as a potent basement membrane degrading enzyme.
	cancerres.aacrjournals.org /cgi/content/full/64/4/1534 (4539 words)

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