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Topic: Basophils

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	Untitled Document (Site not responding. Last check: 2007-10-20)
		Basophils are similar in appearance to eosinophils except that their cytoplasm contains blue or purple staining granules.
		Basophils have relatively large, sparse, cytoplasmic granules which stain dark purple with basic (alkaline) dyes, and tend to disappear in films stained with new methylene blue.
		The characteristic metachromasia of basophils and mast cells is ascribed to their granule content of sulfated glycosaminoglycans (mucopolysaccharides), particularly heparin or chondroitin sulfate and dermatan sulfate, depending on the species.
	www.vet.purdue.edu /bms/nour/bms520/content/blood/basophil2.htm (256 words)

	HON Allergy Glossary Basophil
		Basophils are responsible for the symptoms of allergy.
		Basophils are derived from bone marrow progenitors (psc) and contain granules that bind basic dyes.
		Basophils, like other inflammatory granulocytes, enter tissues only when they are recruited into inflammatory sites.
	www.hon.ch /Library/Theme/Allergy/Glossary/basophil.html (158 words)

	Detection of tryptase in cytoplasmic granules of basophils in patients with chronic myeloid leukemia and other myeloid ...
		Basophils and mast cells (MCs) are effector cells of allergic reactions.
		Basophils from 2 patients with CML, 1 with IMF, and 1 with MDS were examined by electron microscopy.
		Basophil and mast cell degranulation: ultrastructural analysis of mechanisms of mediator release.
	www.bloodjournal.org /cgi/content/full/98/8/2580 (1755 words)

	Photochemistry and Photobiology: Influence of UVB, UVA and UVA1 irradiation on histamine release from human basophils ... (Site not responding. Last check: 2007-10-20)
		In additional experiments, basophils were preincubated with superoxide dismutase, ascorbate or trolox to study the role of antioxidants in the modulation of histamine release after UV irradiation.
		Basophils were enriched (29% purity, with lymphocytes as contaminants) by Percoll density gradient centrifugation.
		Basophils from six donors were additionally preincubated for 10 min with antioxidants (superoxide dismutase 1000 U, trolox 10 mM and ascorbate 1 [mu]g/mL) before the UVA1 irradiation.
	www.findarticles.com /p/articles/mi_qa3931/is_200305/ai_n9299377 (1258 words)

	Basophils Infiltrate Human Gastric Mucosa at Sites of Helicobacter pylori Infection, and Exhibit Chemotaxis in Response ...
		A, BB1-immunoreactive basophils are closely associated with surface epithelium; B, an isolated basophil beneath the foveolar epithelium; C and D, clusters of basophils around the foveolar and gland epithelia; E, intramucosal small blood vessel containing a single basophil (immunoperoxidase with light hematoxylin counterstain).
		Basophils were incubated with the indicated concentrations of stimuli for 45 min at 37°C. Values are the mean ± SEM obtained from six experiments with different basophil preparations.
		Basophils were allowed to migrate for 1 h at 37°C in a humidified incubator with 5% CO Values are the mean ± SEM from five experiments.
	www.jimmunol.org /cgi/content/full/172/12/7734 (6366 words)

	Blue Histology - Blood
		Eosinophils and basophils are the only cell types present in normal blood which initially may be difficult to distinguish - in particular in darker smears.
		The 2-3 nuclear lobes of basophils are not as well defined as those of eosinophils, granules are not as numerous as in eosinophils, and pretty much all of them can be identified "as individuals" rather than the dense mass they form in eosinophils.
		Basophilic granulocytes have a 2 or 3 lobed nucleus.
	www.lab.anhb.uwa.edu.au /mb140/CorePages/Blood/Blood.htm (3645 words)

	AADMC: Selected Articles 2000: Increased basophils and mast cells in airways after allergen inhalation challenge in ...
		Basophils were also more frequent in the sputum of dual responders than in ER- only subjects.
		Basophil frequency correlated with the degree of airway hyper-reactivity suggesting that the basophil accumulation may contribute to this airway hyper-reactivity.
		Also the increased number of basophils and mast cells exuding from the bronchial wall represent a cell population readily exposed to subsequently inhaled allergens with potential for perpetration of the allergic reaction.
	www.aaaai.org /aadmc/currentliterature/selectedarticles/2000archive/increased_basophils.html (272 words)

	1.3.1 Mast cells and basophils
		Basophils are the smallest circulating granulocytes with relatively the least known function.
		The increase in the number of mast cells and basophils, and the enhanced secretion at sites of inflammation, can accelerate the elimination of the cause of tissue injury or, paradoxically, may lead to a chronic inflammatory response.
		Thus, manipulating mast-cell and basophil adhesion may be an important strategy for controlling the outcome of allergic and inflammatory responses.
	nic.sav.sk /logos/books/scientific/node13.html (1159 words)

	Immunohistochemical Detection of Human Basophils in Postmortem Cases of Fatal Asthma -- KEPLEY et al. 164 (6): 1053 -- ...
		The numbers of basophils were counted around AW and in AL in lung sections of FA (A and B), NFA (C and D), and control subjects (E and F).
		Identification of basophilic cells that express mast cell granule proteases in the peripheral blood of asthma, allergy, and drug-reactive patients.
		Basophils, eosinophils, and mast cells in atopic and nonatopic asthma and in late-phase allergic reactions in the lung and skin.
	ajrccm.atsjournals.org /cgi/content/full/164/6/1053 (3147 words)

	Development and Characterization of a Monoclonal Antibody Specific for Human Basophils and the Identification of a ...
		Despite increasing evidence that basophils can infiltrate into inflamed tissues during allergic reactions, determination of the extent of infiltration and elucidation of their role in allergic disease has been frustrated by the lack of reliable means for detecting this cell type in tissues.
		Basophils were isolated from peripheral blood by Percoll density gradient centrifugation and a positive-selection immunomagnetic procedure and injected into mice to produce monoclonal antibodies.
		Staining of basophils with BB1 gave a granular appearance, although flow cytometry indicated that some antigen was also present on the surface of the cell.
	info.med.yale.edu /labinvest/abstracts/99months/9901jan/9901_027.html (377 words)

	Characteristics of Arachidonic Acid Generation in Human Basophils: Relationship Between the Effects of Inhibitors of ...
		Human basophils were isolated from leukocyte enriched preparations from residual blood after plateletpheresis.
		basophils in the absence of triacsin C and by 92 pmol/10
		of 5-lipoxygenase to the nucleus of unstimulated rat basophilic
	jpet.aspetjournals.org /cgi/content/full/284/3/847 (7555 words)

	Faculty Page (Site not responding. Last check: 2007-10-20)
		While mast cells and basophils importantly contribute to the pathogenesis of acute allergic reactions, these cell types also participate in many other biological responses in which their role is less clear.
		We are evaluating whether certain of the important biological functions of basophils and mast cells are expressed via "piecemeal degranulation" of these cells, in which histamine and other mediators are transported between the cytoplasmic granules and the plasma membrane within small, membrane-bound cytoplasmic vesicles.
		Accordingly, piecemeal degranulation of basophils and mast cells may contribute to the persistence of the inflammation that is associated with certain IgE-independent reactions.
	www.hms.harvard.edu /dms/bbs/fac/dvorak.html (357 words)

	Increased Numbers of Both Airway Basophils and Mast Cells in Sputum after Allergen Inhalation Challenge of Atopic ...
		Mast cells and basophils are metachromatic cells that participate in allergic inflammation.
		Appearance of basophils in sputum of patients with bronchial asthma.
		Airway basophil and mast cell density in patients with bronchial asthma: relationship to bronchial hyperresponsiveness.
	ajrccm.atsjournals.org /cgi/content/full/161/5/1473 (4816 words)

	[No title] (Site not responding. Last check: 2007-10-20)
		The invention is particularly useful for differentiating and enumerating the basophil sub-population of leukocytes in a blood sample.
		Of the five sub- populations of leukocytes, the basophils present a particularly difficult challenge to differentiate owing to (1) their relatively low number (compared to the number of other leukocytes in a normal human blood sample), and (2) their similarity to monocytes and lymphocytes in responding to
		as basophils indeed appear in the cluster defined for the basophils by DC and opacity measurements.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=01/11339.010215&ELEMENT_SET=DECL (3992 words)

	Cellular and Molecular Medicine - Donald MacGlashan, Jr., M.D., Ph.D. (Site not responding. Last check: 2007-10-20)
		Basophils from this non-releasing class of donor possess cell surface IgE but don't respond to IgE-mediated stimulation.
		Biphasic Ca++ responses in human basophils: Evidence that the initial transient elevation associated with mobilization of intracellular calcium is an insufficient signal for degranulation.
		Releasability of human basophils: Cellular sensitivity and maximal histamine release are independent variables.
	www.hopkinsmedicine.org /graduateprograms/cmm/macglashan.html (262 words)

	Parasite Antigen-Driven Basophils Are a Major Source of IL-4 in Human Filarial Infections -- Mitre et al. 172 (4): 2439 ...
		A, Representative dot plots of basophil cytokine release from an uninfected subject and a filaria-infected patient after 2-h incubation with medium, BmAg at 0.1 µg/ml, BmAg at 10 µg/ml, or ionomycin.
		Basophil populations were analyzed by gating on PBMC that stained positively for surface IgE and negatively for CD2, CD14, CD16, and CD19 (leftmost plots) and then analyzing frequencies of IL-4 and IL-13 positivity.
		Frequency and characterization of antigen-specific IL-4- and IL-13-producing basophils and T cells in peripheral blood of healthy and asthmatic subjects.
	www.jimmunol.org /cgi/content/full/172/4/2439 (4903 words)

	Merck Vet. Edition - Granulocytes
		Granulocytes consist of neutrophils, eosinophils, and basophils, which are produced in the bone marrow from a common progenitor cell, the myeloblast.
		During the myelocyte stage, granulocytes form specific granules that have characteristic staining affinity, eg, basophilic for basophils, eosinophilic for eosinophils, and neutral for neutrophils.
		Although basophils and mast cells have similar functions and enzymatic contents, basophils do not become mast cells and there is no proof of a common precursor cell.
	www.merckvetmanual.com /mvm/htm/bc/10702.htm (1079 words)

	High Expression of the Chemokine Receptor CCR3 in Human Blood Basophils . Role in Activation by Eotaxin, MCP-4, and ...
		Basophils from venous blood of healthy volunteers (29) were enriched (10-45%) by fractionation in a discontinuous Percoll
		Basophils were incubated with different chemokines (100 nM) for 5 min, exposed to IL-3 (10 ng/ml), and subsequently stimulated
		the predominant receptor for basophil migration in response to
	www.jci.org /cgi/content/full/100/5/1137 (5199 words)

	Schroeder, John T. Ph.D.
		As a result, this laboratory has played a significant role in characterizing the basophil as a major source of these "Th2-like" cytokines, so named for their initial description in a subclass of T helper lymphocytes.
		As a result, this laboratory has established protocols for rapidly isolating large numbers of basophils at high purity from human blood, and for growing culture-derived mast cells from human progenitor cells.
		These studies also focus on the use of basophils and mast cells, and have additionally incorporated investigations probing the biology of specific dendritic cells that express IgE receptors.
	www.hopkinsmedicine.org /allergy/faculty/schroeder.html (473 words)

	Characterization of LDL and VLDL Binding Sites on Human Basophils and Mast Cells -- Virgolini et al. 15 (1): 17 -- ... (Site not responding. Last check: 2007-10-20)
		primary basophils (ie, 4320 sites/cell); the corresponding dissociation constant was 10 mg protein/mL (ie, 10 nmol/L).
		the capacity of the basophils to release histamine and stem
		Basophils were obtained from a nonallergic donor and exposed to various concentrations of lipoproteins as indicated.
	atvb.ahajournals.org /cgi/content/full/15/1/17 (4491 words)

	Basophils Produce IL-4 and Accumulate in Tissues after Infection with a Th2-inducing Parasite -- Min et al. 200 (4): ...
		in basophil IL-4 responses in response to Nb infection.
		Basophils express a type 2 cytokine profile on exposure to protease from helminthes and house dust mites.
		Ablation of immunity to Amblyomma americanum by anti-basophil serum: cooperation between basophils and eosinophils in expression of immunity to ectoparasites (ticks) in guinea pigs.
	www.jem.org /cgi/content/full/200/4/507 (6446 words)

	AADMC: Selected Articles 2002: Basophils in the airways in fatal asthma
		The frequency of basophils was significantly higher in the tissue from FA patients than from the NAF and control groups.
		This increased frequency of basophils in the lungs of the FA patients was not simply a reflection of an overall greater inflammatory cell accumulation in the airways of FA patients; the frequency of cells expressing the pan-leukocyte marker CD45 was not significantly different in the lung tissue from the FA and NAF groups.
		Therefore, it would not be surprising if such basophil accumulation played a role in mediator release in the lower airways as well, contributing to the pathogenesis of asthma.
	www.aaaai.org /AADMC/CURRENTLITERATURE/SELECTEDARTICLES/2002archive/basophils.html (271 words)

	Basophils are a specific type - Washington DC
		Basophils are a specific type - Washington DC and
		Basophils are a specific type of white blood cell.
		Basophils make up only a small portion of the number of white blood cells but are important parts of the body's immune response.
	www.whcenter.org /13293.cfm (191 words)

	LACK OF BASOPHILIA IN HUMAN PARASITIC INFECTIONS -- MITRE and NUTMAN 69 (1): 87 -- American Journal of Tropical ...
		Studies of the responses of basophil and eosinophil leucocytes and mast cells to the nematode Trichostrongylus colubriformis.
		Nippostrongylus brasiliensis: peripheral leukocyte responses and correlation of basophils with blood histamine concentration during infection in rats.
		Basophils and eosinophils in three strains of rats and in athymic (nude) rats following infection with the nematodes Nippostrongylus brasiliensis or Trichinella spiralis.
	www.ajtmh.org /cgi/content/full/69/1/87 (2974 words)

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