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	Bcl 2 -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-22)
		Bcl 2 -- Facts, Info, and Encyclopedia article
		The titular protein of the family was first discovered as a reciprocal gene translocation in (A threadlike body in the cell nucleus that carries the genes in a linear order) chromosomes 14 and 18 in follicar (A neoplasm of lymph tissue that is usually malignant; one of the four major types of cancer) lymphomas.
		The protein also conforms to the general structure of Bcl-2 proteins, with a transmembrane domain in its C-terminus.
	www.absoluteastronomy.com /encyclopedia/b/bc/bcl_2.htm (341 words)

	Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells -- Wang ...
		DNA ladders were visualized on 2% of agarose gel after the cells were treated with 50 µM HA14-1 compound at the designated time.
		Lanes: 1, control; 2, 1 h of HA14-1 treatment; 3, 2 h of HA14-1 treatment; 4, 3 h of HA14-1 treatment; 5, 4 h of HA14-1 treatment; 6, preincubation with zVAD-fmk for 2 h before the treatment with HA14-1 for 4 h.
		Cells were treated with Fas antibody or HA14-1 for 24 h and were analyzed for DNA ladders on 2% agarose gel.
	www.pnas.org /cgi/content/full/97/13/7124 (5062 words)

	CS0520 Bcl 2 ELISA
		2 ELISA is a sensitive and specific alternative to immunoblotting and RIA.
		2 protein from lysates of cells, independent of its phosphorylation state.
		2 ELISA is a fast (total time 4 hours), sensitive, and specific alternative to immunoblotting and RIA.
	www.sigmaaldrich.com /catalog/search/ProductDetail?ProdNo=CS0520&Brand=SIGMA (266 words)

	Attenuation of Both Apoptotic and Necrotic Actions of Cadmium by Bcl-2 (Site not responding. Last check: 2007-10-22)
		The c-myc cDNA probe corresponding to human exon 2 was from Takara (Kyoto, Japan).
		The bad expression vector (2 µg) was co-transfected with pcDNA3.1/Zeo (1 µg) into the clone TI 14 as above.
		The RNA was denatured with 1 M glyoxal and 50% dimethyl sulfoxide, electrophoresed on an agarose gel, and transferred to a Hybond-N nylon membrane (Amersham Pharmacia Biotech).
	ehp.niehs.nih.gov /members/2002/110p37-42ishido/ishido-full.html (4596 words)

	APOPCR Apoptosis PCR Bax Bcl 2 Multiplex Primer Sets
		2 is a member of a large gene family encoding proteins that can either inhibit (e.g.
		2 inhibits apoptosis by preventing the release of Apoptosis Inducing Factor (AIF) and cytochrome c from mitochondria.
		2 to Bax in the cell can determine whether or not the cell initiates apoptosis or survives.
	www.sigmaaldrich.com /catalog/search/ProductDetail?ProdNo=APOPCR&Brand=SIGMA (360 words)

	Welcome to Genta Incorporated (Site not responding. Last check: 2007-10-22)
		High levels of Bcl-2 are associated with most types of human cancer (graphic 1).
		In preclinical studies Bcl-2 has been shown to block the release of cytochrome C which would ordinarily be triggered by cancer therapy (graphic 2).
		Graphic 2: The up-regulation (or high levels) of Bcl-2 blocks the release of cytochrome C from the mitochondria thereby preventing apoptosis (cell death).
	www.genta.com /genta/Products/bcl2.html (253 words)

	Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and ...
		Strong K14/Bcl-2 immunoreactivity (IR) is shown on keratinocytes of the basal epidermal layer (e) and hair germs (g) (stage 2); there is strong expression on hair matrix (arrowhead) and outer root sheath keratinocytes (arrow) of hair pegs (stages 3 and 4).
		Stronger K14 IR is found on keratinocytes of the basal epidermal layer (e) and slightly weaker K14 IR on hair germs (stages 3 and 4) (arrows); strong K14 IR is found on the developing outer root sheath keratinocytes (arrowheads) but not on the developing inner root sheath (I).
		Strong K14 IR is found on basal epidermal layer (e) keratinocytes and hair germs (stage 2) (arrow); strong K14 IR is found on the developing outer root sheath keratinocytes (arrowheads) but not on the developing inner root sheath (I) of stage 3 hair follicles.
	ajp.amjpathol.org /cgi/content/full/156/4/1395 (5919 words)

	Genasense (Bcl-2 antisense)
		The trial is investigating whether the addition of Genasense to oral high-dose dexamethasone is superior to high-dose dexamethasone alone.
		Genasense was administered as a continuous intravenous infusion over a 1-week period, followed by 2 weeks off.
		Phase II In September 2002, Genta announced the initiation of a Phase II study of Genasense in combination with thalidomide and dexamethasone for the treatment of relapsed and refractory myeloma (University of Maryland).
	www.multiplemyeloma.org /treatments/3.08.01.asp (1202 words)

	APPARENT ABSENCE OF BCL-2 REARRANGEMENT IN TEN SAUDI FOLLICULAR LYMPHOMAS: A PRELIMINARY REPORT: 14(3) (Site not responding. Last check: 2007-10-22)
		Tumor tissues from a total of 10 B-cell follicular NHLs (2 snap frozen and 8 paraffin embedded) were obtained from the Department of Pathology and Laboratory Medicine, KFSHandRC.
		In all cases, a prominent and follicular staining for L-26 was noted (Figure 2).
		protocol described by Wright and Monos.18 Briefly, 2 µg of extracted DNA were added to 100 µl of 1xPCR buffer (10 mM TRIS pH 8.3, 50 mM KCl, 2.5 mM MgCl2, 200 µM concentration of each deoxynucleotide, 0.02% gelatin), 2.5 units of amplitaq and approximately 100 pmols of each primer.
	www.kfshrc.edu.sa /annals/143/93124.html (3124 words)

	Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane -- Kaufmann et ...
		2 C. The mitochondrial colocalization marker is cytochrome c.
		2 B) was specifically targeted to mitochondria (Fig.
		2 A), the role of these positive charges was investigated.
	www.jcb.org /cgi/content/full/160/1/53 (6725 words)

	BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M -- ...
		(50 mM NaF, 2 mM sodium orthovanadate, 5 mM EDTA, 5 mM EGTA) at
		Of note, the intensity of band 2 was stronger than that of band 1 by autoradiography, while their intensities were comparable
		Tryptic peptides derived from bands 1, 2, and 3 were also eluted from the radioactive spots on TLC plates (A, C, and E) and subjected to phosphoamino acid analysis, confirming their composition.
	mcb.asm.org /cgi/content/full/19/12/8469 (7713 words)

	Expression of bcl-2 From a Defective Herpes Simplex Virus—1 Vector Limits Neuronal Death in Focal Cerebral Ischemia -- ... (Site not responding. Last check: 2007-10-22)
		Lane 1, cells transduced with HSVlac virus; lanes 2 and 3, cells transduced with HSVbcl2 virus from two different viral stocks.
		Left, The distance from the midline of the brain to the medial edge of the infarct was determined at each injection site (sites 1 and 2) and at a site equidistant between the two injection sites (midpoint).
		Right, The extent of viable tissue from the longitudinal fissure to the medial edge of the infarction along a line perpendicular to the midsagittal plane was measured with a digital micrometer in animals that received HSVlac (open bars) and HSVbcl2 (shaded bars).
	stroke.ahajournals.org /cgi/content/full/26/9/1670 (4478 words)

	Btf, a Novel Death-Promoting Transcriptional Repressor That Interacts with Bcl-2-Related Proteins -- Kasof et al. 19 ...
		with 2% paraformaldehyde in phosphate-buffered saline (PBS) and
		Bcl-2 homologous regions 1, 2, 3, and 4 (BH1, BH2, BH3, and BH4)
		Immunoprecipitated proteins (lanes 1 and 2) were analyzed to confirm the presence of the in vitro-translated products.
	mcb.asm.org /cgi/content/full/19/6/4390 (6759 words)

	Bcl-2, Sandwich ELISA : APT230
		B-cell leukemia/lymphoma 2 (Bcl-2) was one of the first oncogenic proteins discovered to inhibit apoptosis.
		Bcl-2 is localized within the outer mitochondrial membrane, endoplasmic reticulum, and the nuclear envelope, where it exerts cell survival functions within many cell types1.
		Bcl-2 Sample Buffer: (Part No. 61621) One 2 mL (10X) bottle of buffer used to dilute standards and samples.
	www.chemicon.com /Product/ProductDatasheet.asp?ProductItem=APT230 (654 words)

	Triplex forming oligonucleotide targeted to 3'UTR downregulates the expression of the bcl-2 proto-oncogene in HeLa ...
		and incubated at room temperature for 2 h.
		Plasmid pTRE-bcl2-tri was incubated with specific TFOs (TFO1 and 2) and controls (PUR2, INV, SCR, N) and transfected into HeLa cells that have been stably transfected with plasmid pTet-On.
		2 Frank-Kamenetskii,M.D. and Mirkin,S.M. (1995) Triplex DNA structures.
	nar.oxfordjournals.org /cgi/content/full/29/3/622 (3738 words)

	Kupffer cell-derived cyclooxygenase-2 regulates hepatocyte Bcl-2 expression in choledocho-venous fistula rats -- Souto ...
		and hepatocytes and 2) immunohistochemistry in fixed liver specimens.
		2 days before surgery to ensure that they would tolerate the diet
		Callejas, NA, Bosca L, Williams CS, Du BR, and Martin-Sanz P. Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins.
	ajpgi.physiology.org /cgi/content/full/280/5/G805 (3533 words)

	Bcl-2 and Bax Are Differentially Expressed in Hyperplastic, Premalignant, and Malignant Lesions of Mammary ...
		of their histology, scores of 2+ and 3+ predominated.
		The mRNA expression of Bcl-2 and Bax is given for control (Lanes 1 and 2) and Vz-treated (Lanes 3–8) tumors.
		Lanes 1 and 2 contain RNA from control tumors, Lanes 3 and 4 contain RNA from tumors treated with 0.32 mg Vz/kg b.w.
	cgd.aacrjournals.org /cgi/content/full/11/8/437 (6222 words)

	Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein -- Liang et al. 72 ... (Site not responding. Last check: 2007-10-22)
		[2 µg of poly(A) RNA] was confirmed by hybridization to a
		experimental group were sacrificed at days 1, 2, and 4 after inoculation.
		apoptotic nuclei were present at day 2 after infection in the
	jvi.asm.org /cgi/content/full/72/11/8586 (7247 words)

	Involvement of Bik, a Proapoptotic Member of the Bcl-2 Family, in Surface IgM-Mediated B Cell Apoptosis -- Jiang and ...
		µg/ml aprotinin, and 2 µg/ml leupeptin) and phosphatase inhibitors
		None of the caspases (1, 2, 3, 6, 7, 8,
		catalytic subunit with a peak of 3-fold induction at 2 min (Fig.
	www.jimmunol.org /cgi/content/full/166/10/6025 (6470 words)

	Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection -- Cuconati and White 16 (19): 2465 -- ...
		Note that low homology, particularly in BH4, BH3, and BH2, suggests the absence of these regions in some vBCL-2s, which could nonetheless be conserved at the level of protein structure.
		2, which are poorly conserved in HHV8, correspond to
		The system in which inhibition of death receptor-mediated apoptosis by vBCL-2s has been explored most thoroughly is with adenoviruses.
	www.genesdev.org /cgi/content/full/16/19/2465 (6698 words)

	Involvement of Bcl-2 and Bax in Photodynamic Therapy-mediated Apoptosis. ANTISENSE Bcl-2 OLIGONUCLEOTIDE SENSITIZES RIF ...
		Transfection of A431 Cells-- The A431 cells were transfected with a eukaryotic expression vector (pSFFV/neo) containing an EcoRI fragment of human Bcl-2
		The cells were seeded at 2 × 10
		(1:1) and then precipitated with 95% ethanol for 2 h at
	www.jbc.org /cgi/content/full/276/18/15481 (5609 words)

	Apoptosis and Expression of Apoptosis Regulating Proteins bcl-2, mcl-1, bcl-X, and bax in Malignant Mesothelioma -- ...
		from the lungs, 3 from breast, 2 from kidneys, 1 from bile duct,
		incubating the slides in 2% hydrogen peroxide in PBS (pH 7.2).
		The gel was electrophoresed for 2 h (80V) at room
	clincancerres.aacrjournals.org /cgi/content/full/5/11/3508 (4355 words)

	Expression and Function of a Proapoptotic Bcl-2 Family Member Bcl-XL/Bcl-2-Associated Death Promoter (BAD) in Rat Ovary ...
		rescue follicles from apoptotic demise (1, 2, 3, 4).
		hybridization, the membranes were washed twice in 2
		Interactions of BAD with WT and mutated forms of Bcl-2 or with unrelated proteins in yeast two-hybrid system.
	endo.endojournals.org /cgi/content/full/138/12/5497 (5199 words)

	Bcl-2 Expression Inhibits Liver Carcinogenesis and Delays the Development of Proliferating Foci -- Pierce et al. 160 ...
		2 µg/ml pepstatin A, 2 µg/ml leupeptin, and 10 µg/ml
		, respectively by Western blot at 0, 1, 2, and 7 days after the start of zinc water treatment.
		WT littermates were analyzed either before zinc water treatment (WT, 0) or 7 days after the start of the treatment (WT, 7).
	ajp.amjpathol.org /cgi/content/full/160/5/1555 (2993 words)

	Effect of Bcl-2 on the Primordial Follicle Endowment in the Mouse Ovary -- Flaws et al. 64 (4): 1153 -- Biology of ...
		The numbers in parentheses designate whether the tissues were collected from line 1, 2, or 3.
		In transgenic lines 1 and 2, an excess number of primordial
		In lines 1 and 2, primordial follicles returned to normal by
	www.biolreprod.com /cgi/content/full/64/4/1153 (5034 words)

	Methamphetamine causes differential regulation of pro-death and anti-death Bcl-2 genes in the mouse neocortex -- ...
		mice killed at 2, 4, and 16 h after the single dose of saline
		patterns of gene expression in mice killed at 2, 4, or 16 h
		(>1.9-fold) of 149, 116, 219 genes at 2, 4, and 16 h, respectively
	www.fasebj.org /cgi/content/full/15/10/1745 (4772 words)

	Survivin, bcl-2, bax, and bcl-X Gene Expression in Sentinel Lymph Nodes From Melanoma Patients -- Gradilone et al. 21 ...
		on 2% agarose gel and transferred to Hybond N membrane (Amersham,
		number of positively stained cells and (2) the intensity of
		Lanes 1 to 6, sentinel lymph nodes; lane 7, positive control (RNA from M14 cell line); M, molecular weight marker; lane 9, negative control (sample without RNA).
	www.jco.org /cgi/content/full/21/2/306 (3599 words)

	BCL-2 and BCL-XL Restrict Lineage Choice during Hematopoietic Differentiation -- Haughn et al. 278 (27): 25158 -- ...
		clones examined, fewer than 2% of cells with erythroid morphology
		after IL-3 deprivation for 24 h in the presence of 2 µ
		We demonstrated expression of the epitope-tagged 36-kDa CAT-Raf
	www.jbc.org /cgi/content/full/278/27/25158 (4057 words)

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	academic.bowdoin.edu /courses/f04/chem360/images/CaitlinCancerApoptosis.ppt (1037 words)

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