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Topic: BCL2

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	Transcription factor GATA4 regulates cardiac BCL2 gene expression in vitro and in vivo -- Kobayashi et al., ... (Site not responding. Last check: 2007-10-19)
		Bcl2 transcript and protein levels were reduced by doxorubicin in neonatal rat ventricular cardiomyocytes (NRVC) and in mouse heart as determined by RT-PCR and Western blot analysis.
		The reduction in Bcl2 was prevented by overexpression of GATA4 in NRVC and in transgenic mouse heart.
		Also, expression of GATA4 increased baseline Bcl2 levels by 30% in NRVC and 2.7-fold in transgenic heart, indicating the sufficiency of GATA4 to up-regulate Bcl2 gene expression.
	www.fasebj.org /cgi/content/abstract/05-5426fjev1?etoc (290 words)

	Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent ...
		In vitro and in vivo phosphorylation of Bcl2.
		In vitro and in vivo hyperphosphorylation of Bcl2.
		(A) PKA (0.01, 0.1, and 1 IU) induces Bcl2 hyperphosphorylation in vitro.
	mcb.asm.org /cgi/content/full/18/6/3509 (7271 words)

	A Functional Role for Nicotine in Bcl2 Phosphorylation and Suppression of Apoptosis -- Mai et al. 278 (3): 1886 -- ...
		Nicotine Induces Bcl2 Phosphorylation in Human SCLC Cells and Is Associated With Suppression of Apoptosis-- Nicotine is a survival agonist that inhibits apoptosis after various stresses (6).
		Phosphorylation of Bcl2 was analyzed as in Fig.
		Bcl2 phosphorylation was assessed as described in the legend for Fig.
	www.jbc.org /cgi/content/full/278/3/1886 (4091 words)

	Cancer Spectrum: Deng et al., pp. 30-37.
		Bcl2 phosphorylation at serine 70 occurs within the flexible loop (aa 29–80) that is between the BH4 domain and the BH3 domain.
		Bcl2 phosphorylation at ser70 is necessary for maximal and stable association with Bax.
		Bcl2 : Bax ratio is calculated with the use of densitometry analysis and is expressed as a percentage of the bound Bcl2 : Bax in the absence (100%) and following addition of C2-ceramide at concentrations of 1, 10, and 50 µ M.
	jncicancerspectrum.oupjournals.org /cgi/content/full/jncimono%3B2000/28/30 (5875 words)

	Regulation of Bcl2 Phosphorylation and Potential Significance for Leukemic Cell Chemoresistance -- Deng et al. 2000 ...
		Bcl2 phosphorylation at serine 70 occurs within the flexible loop (aa 29–80) that is between the BH4 domain and the BH3 domain.
		Bcl2 : Bax is reduced in a dose-dependent manner, following addition of C2-ceramide to cells before detergent lysis and processing as described in the legend to Fig.
		Bcl2 : Bax ratio is calculated with the use of densitometry analysis and is expressed as a percentage of the bound Bcl2 : Bax in the absence (100%) and following addition of C2-ceramide at concentrations of 1, 10, and 50 µM.
	jncimono.oxfordjournals.org /cgi/content/full/2000/28/30 (5692 words)

	A Functional Role for Mitochondrial Protein Kinase Calpha in Bcl2 Phosphorylation and Suppression of Apoptosis -- ...
		Recent studies have shown that phosphorylation of Bcl2 is required for the antiapoptotic function of Bc12 (7, 8).
		Bcl2 in vitro by a pan PKC mixture was found to be Ca -dependent, a role for a classic PKC isoform was suggested (7).
		Localization in Association with Increased Resistance to Chemotherapy-- Bcl2 is localized in outer mitochondrial and nuclear membranes and in the endoplasmic reticulum (16, 17).
	www.jbc.org /cgi/content/full/273/39/25436 (4824 words)

	BioMed Central \| Full text \| Collecting duct carcinoma of the kidney: an immunohistochemical study of 11 cases
		Bcl2 expression with 100% of the tumor cells positive was observed in 4 of 11 (36%) cases.
		Bcl2 protein expression in 100% of the CDC tumor cells was observed in four of eleven cases (36%) (Figure 1F), while the remaining seven (64%) were negative.
		The proto-oncogene BCL2, implicated in the regulation of cell death by inhibiting apoptosis, seems to be vital in normal kidney morphogenesis.
	www.biomedcentral.com /1471-2490/4/11 (4814 words)

	BCL2 - B-cell CLL/lymphoma 2 - Cancer GeneticsWeb
		BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma.
		The prognostic impact of BCL2 protein expression in acute myelogenous leukemia varies with cytogenetics.
		Bcl2 and p53 regulate vascular endothelial growth factor (VEGF)-mediated angiogenesis in non-small cell lung carcinoma.
	www.cancerindex.org /geneweb/BCL2.htm (718 words)

	IngentaConnect Proteasomal Degradation of Human Peptidyl Prolyl Isomerase Pin1-p... (Site not responding. Last check: 2007-10-19)
		Microtubule inhibitor–induced Bcl2 phosphorylation is detrimental to its antiapoptotic function.
		Phosphorylation of Bcl2 predominantly occurs on two serine residues (70 and 87) in cells arrested at G2-M phase by microtubule disarraying agents.
		Pin1 and its homologues are known to target the proline residue carboxyl terminal to the phosphorylated threonine or serine residue of mitotic phosphoproteins, such as Bcl2.
	www.ingentaconnect.com /content/neo/neo/2002/00000004/00000003/art00005 (264 words)

	BCL2-IGH Gene Rearrangements
		There are two common breakpoint regions involving BCL2 with approximately 65% of the breakpoints occurring at the major breakpoint region (MBR) and approximately 10% occurring at the minor cluster region (mcr).
		When the BCL2 gene is overexpressed, it will act to prevent apoptosis and possibly may render cells resistant to cell death by irradiation and certain chemotherapeutic agents.
		A translocation between immunoglobulin genes (heavy chain or light chain genes) and BCL2 results in the overexpression of BCL2 protein and thus the expansion of B cells due to halting cell death.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/mo000300.htm (598 words)

	Rapid Detection of IgH/BCL2 Rearrangement in Follicular Lymphoma by Interphase Fluorescence in Situ Hybridization with ...
		On the BCL2 gene, 60% to 70% of breakpoints
		The total length of the BCL2 probe is 300 kb, spanning the entire 225 kb of BCL2 and its 5' and 3' flanking genomic regions.
		Matolcsy A, Casali P, Warnke RA, Knowles DM: Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene.
	jmd.amjpathol.org /cgi/content/full/4/3/144 (4066 words)

	Web Reprint: A Partial Critique of BCL3 (Site not responding. Last check: 2007-10-19)
		Other literary figures are present in BCL3 as the subjects of critical studies or in translation, but not in the form of their original texts.
		BCL3, like BCL2, suggests concordances for major English language authors and works, but not for their foreign counterparts.
		The Classiques Garnier edition of Mme de La Fayette is dropped from BCL2, with the reader having access to only La Princesse de Clèves in the unanalysed Romanciers du XVIIe siècle, edited by Adam in the Pléiade, and no access at all to her other fiction.
	www.lib.virginia.edu /wess/nl/reprint.html (2445 words)

	tab007rbg: BAX and BCL2 family of proteins and drug resistance
		BCL2 : BCL2 (also known as B-cell CLL/lymphoma 2; bcl-2 and BCL-2) is a proto-oncogene that encodes BCL2 (transforming protein bcl2), a 25-kDa protein that inhibits apoptosis (Refs 11, 12, 41).
		It has been proposed that BCL2 and BAX (BCL2-associated X protein) form heterodimers, and that the activity of the apoptosis system is determined by the balance between the two components.
		Clinical data: There are contradictory results with BCL2 protein expression and its association with improved outcome; this contradiction might be due to an association with an increased rate of cell proliferation (Ref. 15).
	www-ermm.cbcu.cam.ac.uk /99001064h.htm (314 words)

	KoreaMed - Basic Search (Site not responding. Last check: 2007-10-19)
		Topographic expression of p21WAF1/SDI1/CIP1, bcl2, and p53 is altered at theearly stage of colorectal carcinogenesis.
		We analyzed the expression of p21, bcl2, and p53 in normal and differentpathologic mucosa of the human colorectum using immunohistochemistry and coldpolymerase chain reaction-single strand conformation polymorphism.
		In adenomas, whereas bcl2 expression increasedand extended to parabasal and superficial dysplastic epithelium, the increase ofp21 expression was limited to surface dysplastic epithelium.
	www.koreamed.org /SearchBasic.php?RID=16609&DT=1&QY=%22J+Korean+Med++Sci%22+%5BJTI%5D+AND+2000+%5BDPY%5D+AND+Dec+%5BDPM%5D (217 words)

	Natural resistance of pigment cells to sunlight may make deadly skin cancer tough to treat
		The MITF gene, dubbed by scientists as “the master melanocyte regulator,” is found in melanocytes and is critical for their proper development and their long-term survival.
		BCL2 is a cell-death suppressor, many of whose actions were discovered by Dana-Farber researcher Stanley J. Korsmeyer, MD.
		When either the MITF or BCL2 gene is mutated or missing, the whiskers and fur of mice turn from fl to gray or white because melanocytes have died.
	www.eurekalert.org /pub_releases/2002-06/dci-nro061202.php (879 words)

	Regression of the Decidualized Mesometrium and Decidual Cell Apoptosis Are Associated with a Shift in Expression of ...
		Expression of Bax and Bcl2 and the incidence
		The upper panel is a representative immunoblot of Bcl2 expression in DB at various stages during pregnancy.
		Bcl2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
	www.biolreprod.org /cgi/content/full/63/1/188 (4234 words)

	Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases -- Deng et al. 97 (4): 1578 -- ...
		Bcl2 and other related proteins of the Bcl2 family regulate the effector stage of apoptosis (1, 2).
		Bcl2 was immunoprecipitated by using a Bcl2 antibody (lanes 1-6) or preimmune serum (Pre).
		The cells were harvested, washed, and lysed in detergent buffer at the indicated times, and the lysates were immunoprecipitated by using Bcl2 antibodies or a Bax-specific antisera as described (8).
	www.pnas.org /cgi/content/full/97/4/1578 (5731 words)

	Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737 ...
		of BIM and BCL2 in the absence of detergents.
		BIM is sequestered by BCL2 and displaced by antagonism of BCL2.
		BCL2 that is relatively unoccupied by activators, due to the
	www.jci.org /cgi/content/full/117/1/112 (6099 words)

	UniProtKB/Swiss-Prot entry P10415 [BCL2_HUMAN] Apoptosis regulator Bcl-2
		Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle.
		In the absence of growth factors, Bcl2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases.
		BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
	www.expasy.org /uniprot/P10415 (1242 words)

	Viewing Product: BCL2/JH Tube C - Unlabeled
		Three are used to identify translocations in the major breakpoint region (Mbr) and minor cluster region (mcr) of BCL2.
		The Specimen Control Size Ladder master mix targets multiple genes and generates a series of amplicons of 100, 200, 300, 400, and 600 basepairs to ensure that the quality and quantity of input DNA is adequate to yield a valid result.
		The BCL2 t(14;18) (q32;q21) translocation is found in 80-90% of follicular lymphomas and 30% of diffuse large cell lymphomas.
	www.invivoscribe.com /viewproduct.cfm?catId=54&prodId=23090070 (1057 words)

	Anti-BCL2 Agent Sensitizes Refractory Leukemia to Chemotherapy (Site not responding. Last check: 2007-10-19)
		BCL2 is a protein which exists in delicate balance with other related proteins whose function is to block cells from apoptosis (death).
		Through several mechanisms not entirely understood, BCL2 proteins assist cancer cells in defying the killing effects of chemotherapy.
		It does this by binding to specific molecules at a genetic level that are responsible for the initial development of BCL2.
	patient.cancerconsultants.com /leukemia_cancer_news.aspx?id=17806 (574 words)

	Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. (Site not responding. Last check: 2007-10-19)
		Bcl2 also regulates cell cycle progression but the molecular mechanism is unclear.
		Bcl2 is functionally expressed in mitochondria where it can act as an antioxidant that may regulate intracellular reactive oxygen species (ROS).
		In addition to expression of the phosphomimetic Bcl2 mutants, either IL3 withdrawal or treatment of cells with the antioxidant pyrrolidine dithiocarbamate (PDTC) also reduces intracellular ROS levels in association with up-regulation of p27 and accumulation of cells in G0/G1.
	grape-seed-extract-5.viagenbio.com /antioxidant-research-abs.4529.html (508 words)

	Detection of a Clonal BCL2 Gene Rearrangement in Tissues from a Patient with Whipple Disease -- Fest et al. 124 (8): ...
		Detection of a Clonal BCL2 Gene Rearrangement in Tissues from a Patient with Whipple Disease -- Fest et al.
		Detection of a Clonal BCL2 Gene Rearrangement in Tissues from a Patient with Whipple Disease
		Structural alterations in the 5 prime region of the BCL2 gene in follicular lymphomas with BCL2-MBR or BCL2-MCR rearrangements.
	www.annals.org /cgi/content/full/124/8/738 (1428 words)

	BCL2 Translocation Defines a Unique Tumor Subset within the Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma ...
		Thus, of the 141 cases, 34 cases were BCL2 translocation-positive and 107 were negative.
		B: BCL2 gene expression in cases with and without the t(14;18) in the GCB subgroup.
		BCL2 gene expression was calculated as detailed in the text to more accurately reflect the true expression levels.
	ajp.amjpathol.org /cgi/content/full/165/1/159 (5025 words)

	Open Biosystems: - Technical Resources - (Site not responding. Last check: 2007-10-19)
		On the BCL2 gene, 60% to 70% of breakpoints are clustered in the major breakpoint region (MBR), 20% to 30% occur in the minor cluster region (mcr), and the rest are widely scattered over the BCL2 genomic region.
		Two positive BAC clones were identified for the BCL2 gene: 253F8 was positive for the primer of exon II, and 260D23 was positive for the MBR and the mcr.
		The total length of the BCL2 probe was estimated to be >300 kb\, spanning the entire 225 kb of BCL2 and its 5' and 3' flanking genomic regions.
	www.openbiosystems.com /cell_article_summary.php (2380 words)

	Detection of BCL2 Rearrangements in Follicular Lymphoma -- Aster and Longtine 160 (3): 759 -- American Journal of ...
		Gribben JG, Neuberg D, Freedman AS, Gimmi CD, Pesek KW, Barber M, Saporito L, Woo SD, Coral F, Spector N, Rabinowe SN, Grossbard ML, Ritz J, Nadler LM: Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma.
		Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ: BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
		Skinnider BF, Horsman DE, Dupuis B, Gascoyne RD: Bcl-6 and Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: correlation with 3q27 and 18q21 chromosomal abnormalities.
	ajp.amjpathol.org /cgi/content/full/160/3/759 (3220 words)

	Tramadol, buy tramadol, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, weight loss, ... (Site not responding. Last check: 2007-10-19)
		Both cell lines were treated with different classes of compounds that were anticipated to be exclusively apoptosis inducers, or compounds known to be clastogens or aneugens, some of which were anticipated to be both genotoxic and apoptotic.
		Finally, higher responses were induced in CTLL-2 cells compared to CTLL-2 bcl2 cells that were treated with aneugens or clastogens that were also apoptosis inducers, suggesting that the greater response in CTLL-2 cells is a consequence of both genotoxicity and apoptosis.
		The results indicate that coupling the in vitro micronucleus test in both CTLL-2 and CTLL-2 bcl2 cells with the measurement of apoptosis is able to distinguish the genotoxic effects of a test compound from its apoptotic potential and is able to avoid interference from apoptosis in the in vitro micronucleus test.
	www.wellstreetpharmacy.com /ref-condylox/condylox-research-abs3.1110.html (844 words)

	(BW) Genta Reports Biological Activity Of G3139 Antisense Compound In Various Types Of Cancer
		The target of G3139 -- the BCL2 gene -- is a proto-oncogene involved in the inhibition of apoptosis (programmed cell death) of cancerous cells and is believed to be important in a number of solid tumor and hematological malignancies including non-Hodgkin's lymphoma, malignant melanoma, breast, colorectal, ovarian and prostate cancers.
		The protein produced by the BCL2 gene has two known critical functions in the progression of cancer -- it makes cancer cells immortal, creating a survival advantage of malignant over normal cells and it confers resistance to radiation and chemotherapy, rendering these treatments ineffective in late-stage cancers.
		High levels of the BCL2 protein are associated with a poor clinical prognosis for certain cancer patents.
	www.aegis.com /news/bw/1996/BW960917.html (862 words)

	Result Content View
		There was a significant association of BCL2 status and prediction of PET scan status on interim scanning (p<0.001, Fisher exact test).
		A significant association of BCL2 status and ability to stay in remission was demonstrated (p<0.05, Fisher exact test).
		The combination of a negative PET scan and negative BCL2 status is strongly predictive for remission status (p<0.001, Fisher exact test).
	www.abstracts2view.com /hem/view.php?nu=HEM3L1_3846 (603 words)

	MEN 2A: DNA ANALYSIS (Site not responding. Last check: 2007-10-19)
		AIM : To detect the molecular evidence of t(14;18) (q32;q21) chromosomal abnormality characteristic of ~ 90 % of cases of follicular lymphoma.
		The translocation juxtaposes the BCL2 gene on 18q21 and the enhancer region of the IGH gene from chromosome 14q32.
		Negative control for BCL2 rearrangement is DNA from a normal individual that produces a positive signal for ß-globin gene amplification.
	www.surgery.wustl.edu /bjcmdl/bcl2.htm (337 words)

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