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Topic: Benzofuran


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  Benzofuran (IARC Summary & Evaluation, Volume 63, 1995)   (Site not responding. Last check: 2007-11-04)
Benzofuran is produced by isolation from coal-tar oils, which are obtained as by-products of coking coal.
Benzofuran was tested for carcinogenicity by oral administration in one study in mice and in one study in rats.
In mice, benzofuran increased the incidence of hepatocellular adenomas in animals of each sex and of hepatoblastomas and forestomach papillomas and carcinomas in males; the incidence of alveolar-bronchiolar adenomas was increased in both males and females.
www.inchem.org /documents/iarc/vol63/benzofuran.html   (236 words)

  
 doc 50   (Site not responding. Last check: 2007-11-04)
Brasseur R, Ruysschaert JM and Chatelain P. The conformations of 3-benzoyl-2-ethyl benzofuran, (3-(3,5-dibromo-4-hydroxy-benzoyl)-2-ethyl benzofuran, benzbromarone), 3-benzoyl-2-methyl benzofuran and 3-benzoyl benzofuran were calculated by a serni-empirical conformational analysis.
In 3-benzoyl benzofuran, the two cyclic systems and the carbonyl are in the same plane.
Introduction of an alkyl substituent in position 2 on the benzofuran ring introduces a kink in the molecule and hinders the conjugation.
www.fsagx.ac.be /bp/abstracts/a50.htm   (131 words)

  
 Alkoxy benzofuran carboxylic acids and salts and esters thereof as hypolipidemic agents - Patent 4229467
This invention relates to alkoxy substituted benzofuran carboxylic acids, their esters and their pharmaceutically acceptable salts which are useful as hypolipidemic agents.
Saturated lower alkoxy substituted benzofuran carboxylic acids and esters are known.
The pills are prepared by blending the active ingredient (a) and the corn starch then adding the liquid glucose with thorough kneading to form a plastic mass from which the pills are cut and formed.
www.freepatentsonline.com /4229467.html   (3352 words)

  
 Benzofuran compounds and their use - Patent 5723479   (Site not responding. Last check: 2007-11-04)
Benzofuran compound represented by the formula: ##STR1## wherein ##STR2## represents a group capable of releasing a cation in which.......
With respect to the formula (I), Y and R.sup.2 are attached to 2-, or 3-position on the benzofuran ring, R.sup.1 -0 is attached to 4-, 5-, 6- or 7-position on the benzofuran ring.
R.sup.1 -0 is preferably attached to 6-position on the benzofuran ring and Y is preferably attached to 2-position on the benzofuran ring.
www.freepatentsonline.com /5723479.html   (10552 words)

  
 endo-exo
Although we were unable to isolate benzofurans 16 and 17 due to their facile conversion to benzopyrans 11 and 13, their structures were confirmed by ozonolysis of the crude reaction mixture to phthalide and the corresponding aryl aldehydes.
Benzofuran 17 undergoes a related sequence ultimately affording lactol 28 which is converted to lactone 18 and spiro ketal 19 via an acid-catalyzed Cannizzaro reaction [20].
Benzofuran 16 was treated with a solution of saturated ammonium chloride and immediately extracted with CH2Cl2.
www.ch.ic.ac.uk /ectoc/papers/08   (1549 words)

  
 Synthesis of Some 3-Amino-2-Benzoylbenzofurans, 3-Amino-2-Benzoylindoles, and Benzofuran[3,2-B]Quinolin-10(5h,10h)-Ones   (Site not responding. Last check: 2007-11-04)
Cyclization of these compounds to the corresponding 3-amino-2-benzoylbenzofurans was achieved under various conditions.
Alkylation of 2 with iodomethane gave a mixture of major N-alkylation product 6 and minor O-alkylation product 7 suggesting that compound 2 is present mainly in its quinolone keto form (Scheme 4).
The compound is insoluble in water and therefore its potential therapeutic use is limited.
www.ch.ic.ac.uk /ectoc/echet98/pub/078/index.htm   (1717 words)

  
 benzofuran - OneLook Dictionary Search
Tip: Click on the first link on a line below to go directly to a page where "benzofuran" is defined.
benzofuran : Merriam-Webster's Online Dictionary, 10th Edition [home, info]
benzofuran : The American Heritage® Dictionary of the English Language [home, info]
www.onelook.com /?w=benzofuran   (104 words)

  
 Research
If you are a UW Oshkosh student and are curious about research opportunities in my lab, please stop by or email me.
The benzofuran heterocycle is a commonly occurring substructure in organic chemistry, and appears in a variety of structurally and biologically interesting natural products.
A powerful yet relatively unexplored strategy for creating benzofuran natural products involves the reaction of a quinone with an enol ether.
www.uwosh.edu /faculty_staff/kedrowsk/research.htm   (282 words)

  
 Electrophysiological Effects of Dronedarone (SR33589), a Noniodinated Benzofuran Derivative, in the Rabbit Heart : ...   (Site not responding. Last check: 2007-11-04)
Electrophysiological Effects of Dronedarone (SR33589), a Noniodinated Benzofuran Derivative, in the Rabbit Heart : Comparison With Amiodarone -- Sun et al.
of the noniodinated benzofuran derivative SR33589 (SR), or dronedarone
Compared with AM, in the SR molecule, ethyl groups on the terminal nitrogen are replaced by butyls, and a methanesulfonyl group has been added to the benzofuran moiety.
circ.ahajournals.org /cgi/content/full/100/22/2276   (3494 words)

  
 Japanese Patent 3732554 B2 - novel 2,3-di hydro benzofuran derivative , manufacturing method and application   (Site not responding. Last check: 2007-11-04)
Japanese Patent 3732554 B2 - novel 2,3-di hydro benzofuran derivative, manufacturing method and application
novel 2,3-di hydro benzofuran derivative, manufacturing method and application
) And, 2, 3-di hydro benzofuran derivative or its salt.
cxp.paterra.com /jppatent3732554.html   (292 words)

  
 Aromaticity studies of benzofused thieno[3,2-b] furans
as a dienophile with various substituted buta-1,3-dienes to create the corresponding cycloadducts 4 (some representative examples are shown in Scheme 1) that could be easily oxidized to a new dibenzo fused system 3 possessing a substituent in the benzofuran part of the molecule.
Heterocycle 2 did not enter such cycloaddition reactions and starting compound was always recovered.
Diels-Alder reactions of 5 can be practically used for synthesis of tetracyclic derivatives of 3 possessing substituents in the "benzofuran" part of the molecule.
www.mdpi.net /ecsoc-5/a0013/a0013.htm   (1723 words)

  
 An intercalation inhibitor altering the target selectivity of DNA damaging agents: Synthesis of site-specific aflatoxin ...   (Site not responding. Last check: 2007-11-04)
adducts seemed to exhibit neighbor-exclusion properties, the benzofuran moiety was tested to see if it possessed
presence of the intercalated benzofuran moiety and not merely
is unclear whether the benzofuran moiety possesses neighbor-excluding
www.pnas.org /cgi/content/full/94/18/9579   (3568 words)

  
 Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans -- Bouras et ...   (Site not responding. Last check: 2007-11-04)
Selective stimulation of colonic transit by the benzofuran 5HT
agonist, the first of a new chemical class of benzofurans,
Prucalopride (R093877) is a benzofuran derivative and a specific 5HT
gut.bmjjournals.com /cgi/content/full/44/5/682   (2750 words)

  
 Effects of metabolites and analogs of amiodarone on alveolar macrophages: structure-activity relationship -- Quaglino ...   (Site not responding. Last check: 2007-11-04)
Structure of amiodarone: benzofuran moiety with butyl lateral group (A), diiodobenzoyl moiety (B), and diethylamino-
which lacks the benzofuran moiety but retains a complete diethylaminoethoxy
and the benzofuran moiety with its associated butyl group (Figs.
ajplung.physiology.org /cgi/content/full/287/2/L438   (4034 words)

  
 Enzymology-Diabetes, obesity or neoplasia therapy may be derived from benzof...
Your subject, your numbers, you control the cost.
Diabetes, obesity or neoplasia therapy may be derived from benzofuran inhibitors of MKP-1
2006 OCT 2 -- Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1 may offer diabetes, obesity or neoplasia treatments.
www.newsrx.com /health-articles/361507.html   (284 words)

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