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Topic: Benzopyran

	Patent 5169957: Benzopyran derivatives
		Benzopyran derivatives of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof possess the inhibitory activity on Maillard reaction and an antioxidizing effect, and therefore, are useful for the prevention and treatment of several diabetic complications, diseases induced by aging and several diseases caused by formation of peroxidized fat.
		The benzopyran derivative (109.9 g) prepared in reference example 22 was dissolved in dimethylformamide (500 ml).
		The compounds, of the present invention, shown in the following table 12 were obtained with using the benzopyran derivative prepared in reference example 18 by the same procedure as example 27 (with the proviso that the corresponding appropriate compounds were used instead of p-(2-hydroxyethyl)phenol and p-mercaptonitrophenol).
	www.freepatentsonline.com /5169957.html (8836 words)

	Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase ... (Site not responding. Last check: 2007-11-04)
		Initially, a novel solid-phase synthesis of the benzopyran motif is developed employing a unique cycloloading strategy that relies on the use of a new, polystyrene-based selenenyl bromide resin.
		The relatively high incidence of this benzopyran unit (and its derivatives, vide infra) in natural products is partially attributable to the numerous prenylation and cyclization reactions in many polyketide biosynthesis pathways.
		When considering a solid-phase method to load, derivatize, and cleave the benzopyran motif, we were particularly interested in developing a strategy whereby the loading and/or cleavage step(s) would contribute to the complexity of the target structure.
	pubs.acs.org /cgi-bin/jcen?jacsat/122/i41/html/ja002033k.html (6937 words)

	Pharmacological Actions of a Novel, Potent, Tissue-Selective Benzopyran Estrogen -- Galbiati et al. 303 (1): 196 -- ... (Site not responding. Last check: 2007-11-04)
		We have identified a new benzopyran derivative, 3-(4-methoxy) phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]-2 H -1-benzopyran-7-ol
		CHF 4227 is a new benzopyran derivative that is classified as a selective estrogen receptor modulator based on its in vivo pharmacological profile.
		In conclusion, the new benzopyran derivative CHF 4227 is a selective estrogen receptor modulator that compares favorably in
	jpet.aspetjournals.org /cgi/content/full/303/1/196 (5600 words)

	Natural Product-like Combinatorial Libraries Based on Privileged Structures. 3. The "Libraries from Libraries" ... (Site not responding. Last check: 2007-11-04)
		A benzopyran library is initially constructed using solid-phase split-and-pool synthesis, and it is formatted into 96-well microtiter plates upon cleavage with one compound per well.
		Hence, we proceeded to test this reagent with a variety of benzopyran substrates from the libraries generated by the previous solid-phase studies.
		During the search for benzopyran ring system 6 (Figure 1) care was taken to exclude compounds which possessed the Pmc (2,2,5,7,8-pentamethylchroman-6-sulfonyl) peptide protecting group since such structures do not represent true derivatives of the benzopyran template.
	pubs.acs.org /cgi-bin/jcen?jacsat/122/i41/html/ja0020355.html (5105 words)

	Natural Product-like Combinatorial Libraries Based on Privileged Structures. 2. Construction of a 10 000-Membered ... (Site not responding. Last check: 2007-11-04)
		Having developed a reliable and versatile solid-phase strategy for the split-and-pool synthesis of naturally occurring and designed derivatives of the benzopyran template (see preceding paper), we now report the construction of a 10 000-membered natural product-like compound library for chemical biology studies.
		H NMR spectra of benzopyran 74 cleaved manually (top spectrum) and cleaved automatically (bottom spectrum) were identical except for small differences in the amounts of residual solvents (i.e.
		Integration of this chemistry with the new IRORI NanoKan optical encoding platform has resulted in the rapid construction of a 10 000-membered natural product-like library, whose members are obtained in quantities of 1-2 mg each, to be used in chemical biology studies.
	pubs.acs.org /cgi-bin/jcen?jacsat/122/i41/html/ja002034c.html (6603 words)

	美国专利申请公开说明书 20040157764 - Solid phase benzopyran composition, process for preparing same and ... (Site not responding. Last check: 2007-11-04)
		Described is a solid phase benzopyran composition comprising predominately 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[G]-2-benzopyran and at least one other benzopyran compound.
		The novel compositions are used in augmenting, enhancing and/or imparting aromas in to consumable materials such as perfume compositions, perfumed articles including soaps, detergents, fabric softener compositions, fabric softener articles, fragranced candles, cosmetics, hair preparations, perfumed polymers and colognes.
		Also described is a process for producing the solid phase benzopyran compositions.
	cxp.paterra.com /uspregrant20040157764cn.html (103 words)

	endo-exo
		Much to our surprise, the mode of cyclization seemed to be greatly influenced by the nature of the substituent in the ortho -position of the aromatic ring.
		Although we were unable to isolate benzofurans 16 and 17 due to their facile conversion to benzopyrans 11 and 13, their structures were confirmed by ozonolysis of the crude reaction mixture to phthalide and the corresponding aryl aldehydes.
		Benzopyran 11 was further treated with a saturated ammonium chloride solution and stirred at rt for 10 min.
	www.ch.ic.ac.uk /ectoc/papers/08 (1583 words)

	Antifertility potential of 2-[piperdinoethoxyphenyl]-3-[4- methoxyphenyl]-2H benzopyran: a potent anti-oestrogenic ...
		Antifertility potential of 2-[piperdinoethoxyphenyl]-3-[4- methoxyphenyl]-2H benzopyran: a potent anti-oestrogenic compound in rats -- Singh 106 (1): 49 -- Reproduction
		Antifertility potential of 2-[piperdinoethoxyphenyl]-3-[4- methoxyphenyl]-2H benzopyran: a potent anti-oestrogenic compound in rats
		The present study was carried out to investigate the artifertility potential of 2-[piperdinoethoxyphenyl]-3-[4-methoxyphenyl]-2H benzopyran (K-7) in rats.
	www.reproduction-online.org /cgi/content/abstract/106/1/49 (235 words)

	Academic and Research Archive (Site not responding. Last check: 2007-11-04)
		Theoretical analysis of meosgenic properties of benzalazine and benzopyran derivatives.
		In this study we observed that chloro group irrespective of its position show mesogenic behavior.
		Theoretical analysis of mesogenic properties of benzalazine and benzopyran derivatives (Work done at Japan).
	orca.st.usm.edu /~snshah/ARARCIVE.html (2146 words)

	Disposition and Metabolism of 2-(2"(1",3"-Dioxolan-2-Yl)-2-Methyl-4-(2'-Oxopyrrolidin-1-Yl)-6-Nitro-2h-1-Benzopyran ...
		Keiji K, Yumiko A, Takahito K, Shuji F, Shouhei H, Zen-ichi T, Mitsuru S and Toshifumi W (1994) Antihypertensive and cardiovascular effects of a new potassium channel opener, TCV-295, in rats and dogs.
		Lawson K, Barras M, Zazzi-Sudriez E, Martin DJ, Armstrong JM and Hicks PE (1992) Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers.
		Lee BH, Yoo SE and Shin HS (1998a) Hemodynamic profile of SKP-450, a new potassium-channel activator.
	dmd.aspetjournals.org /cgi/content/full/27/4/510 (3496 words)

	美国专利申请公开说明书 20030096860 - Benzopyran derivative and antiallergic agent (Site not responding. Last check: 2007-11-04)
		美国专利申请公开说明书 20030096860 - Benzopyran derivative and antiallergic agent
		The present invention provides a compound which is highly safe in terms of toxicity and has a stronger antiallergic action, and particularly has an action of inhibiting both immediate and delayed type allergic reactions.
		Bicyclo ring system having the hetero ring as one of the cyclos (e.g., chromones, etc.)
	cxp.paterra.com /uspregrant20030096860cn.html (104 words)

	Lib #: WA00157 - Enhanced cytotoxicity in a z-photoisomer of a benzopyran derivative of propolis (Site not responding. Last check: 2007-11-04)
		Lib #: WA00157 - Enhanced cytotoxicity in a z-photoisomer of a benzopyran derivative of propolis
		If you are having problems opening the PDF, press and hold the Control Key while you click on the PDF.
		Enhanced cytotoxicity in a z-photoisomer of a benzopyran derivative of propolis
	www2.waters.com /Watprod.nsf/Newdocs/WA00157 (83 words)

	United States Patent Application: 0040204471 (Site not responding. Last check: 2007-11-04)
		[0077] Benzopyrans that can serve as a Cox-2 selective inhibitor of the present invention include substituted benzopyran derivatives that are described in U.S. Pat.
		[0088] Another class of benzopyran derivatives that can serve as the Cox-2 selective inhibitor of the present invention includes compounds having the structure of formula II: 5
		[0100] Other benzopyran Cox-2 selective inhibitors useful in the practice of the present invention are described in U.S. Pat.
	appft1.uspto.gov /netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1="20040204471".PGNR.&OS=DN/20040204471&RS=DN/20040204471 (11594 words)

	Prevention of Lipopolysaccharide-Induced Apoptosis by ...
		Prevention of Lipopolysaccharide-Induced Apoptosis by (2S,3S,4R)-N"-Cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine, a Benzopyran Analog, in Endothelial Cells -- Kim et al.
		Prevention of Lipopolysaccharide-Induced Apoptosis by (2 S,3 S,4 R)- N "-Cyano- N -(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2 H -benzopyran-4-yl)- N '-benzylguanidine, a Benzopyran Analog, in Endothelial Cells
		Neuroprotective Effect of (2S,3S,4R)-N""-cyano-N-(6-amino-3, 4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine (KR-31378), a Benzopyran Analog, against Focal Ischemic Brain Damage in Rats
	jpet.aspetjournals.org /cgi/content/full/300/2/535 (4379 words)

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