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Topic: Berberine

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	New Uses of Berberine: A Valuable Alkaloid from Herbs for "Damp-Heat" Syndromes
		Berberine is an isoquinoline alkaloid with a bright yellow color that is easily seen in most of the herb materials that contain any significant amount of this compound.
		Berberine has long been used as a dye; it is currently known as "natural yellow 18," being one of about 35 yellow dyes from natural sources.
		Berberine was isolated and used as an herbal drug in China 50 years ago (the drug forms are usually the hydrochloride or sulfate; the chloride, as used in the dye, may have the strongest antiseptic action).
	www.itmonline.org /arts/berberine.htm (1121 words)

	Berberine : by Ray Sahelian, M.D., health benefits
		Moreover, berberine was processed through hepatobiliary excretion against a concentration gradient based on the bile-to-blood distribution ratio (AUC(bile)/AUC(blood)); the active berberine efflux might be affected by P-gp and OCT since coadministration of berberine and CsA or quinidine at the same dosage of 10 mg kg(-1) significantly decreased the berberine amount in bile.
		In addition, berberine was metabolized in the liver with phase I demethylation and phase II glucuronidation, as identified by liquid chromatography/tandem mass spectrometry.
		Berberine produced a voltage-dependent block on IK that increased with stronger depolarization, and once all channels were activated, there was no further block at positive potentials.
	www.raysahelian.com /berberine.html (2451 words)

	Goldenseal (Hydrastis Canadensis L.), Berberine
		Due to the small amount of berberine actually present in most goldenseal preparations (0.5-6%), it is difficult to extend the research of berberine salts to the use of goldenseal.
		A small amount of research reports that berberine, a chemical found in goldenseal, may be beneficial in the treatment of chloroquine-resistant malaria when used in combination with pyrimethamine.
		Berberine sulfate is often used as well, and the hydrochloride and sulfate forms are generally thought to be equivalent.
	allnutritionals.com /natural-products/goldenseal-hydrastis-canadensis-l-berberine.shtml (1819 words)

	Hydrastis canadensis
		Berberine is a plant alkaloid present in Hydrastis canadensis with demonstrated antimicrobial activity against bacteria, viruses, fungi, protozoans, helminths, and chlamydia., is used clinically for bacterial diarrhea, intestinal parasite infections, and ocular trachoma infections.
		Berberine inhibited apoptosis induced by dexamethasone, etoposide or camptothecin Miura 1997
		Berberine and sanguinarine intercalate DNA and inhibit DNA synthesis and reverse transcriptase Schmeller 1997
	www.herbmed.org /Herbs/Herb83.htm (2080 words)

	Berberine: a candidate for the treatment of diarrhea in AIDS patients.
		Berberine is a quaternary plant alkaloid which has been used to treat a variety of medical conditions, including diarrhea from protozoal, fungal and bacterial infections.
		Berberine inhibited growth of Entamoeba histolytica by 25% at a concentration of 1 mg/ml.
		Although berberine may not be as potent in vitro as therapeutics like metronidazole or albendazole, it has few side effects and thus may be used to not only to treat the primary infection but also in a maintenance or prophylactic regimen.
	www.aegis.com /aidsline/1998/apr/m9841177.html (466 words)

	Berberine (Site not responding. Last check: 2007-10-25)
		Berberine inhibited platelet aggregation in both in vitro and in vivo assays, and inhibited the decline of renal blood flow.
		Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins.
		Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organisms.
	www.thorne.com /altmedrev/fulltext/berb.html (4130 words)

	NTP: Goldenseal
		for berberine sulfate in mice is 24.3 mg/kg (0.056 mmol/kg).
		Berberine inhibited the growth of cultured mouse sarcoma-180 tumor cells, an effect that was ameliorated by cotreatment with glucose.
		Berberine chloride inhibited the growth of cultured HeLa cells, and was toxic to T2/D1 human teratocarcinoma cells and F9 murine teratocarcinoma cells.
	ntp-server.niehs.nih.gov /index.cfm?objectid=03DB2444-D3BD-D85F-5DF8227531330659 (2050 words)

	MedlinePlus Herbs and Supplements: Goldenseal (Hydrastis Canadensis L.), Berberine (Site not responding. Last check: 2007-10-25)
		Berberine dosing: For infectious diarrhea, 100 to 200 milligrams of berberine hydrochloride taken by mouth four times daily, or a single dose of 400 milligrams taken by mouth has been studied.
		Based on laboratory and animal research, the use of goldenseal or its component berberine could increase the risk of bleeding when taken with herbs or supplements that are believed to increase the risk of bleeding.
		Based on laboratory research, the goldenseal component berberine may reduce the effectiveness of yohimbine, which is found in small amounts in yohimbe bark extract.
	www.nlm.nih.gov /medlineplus/druginfo/natural/patient-goldenseal.html (2550 words)

	Goldenseal
		Berberine is a substance widely used in Traditional Chinese Medicine to treat dysentery and infectious diarrhea.
		Berberine has been shown to dilate blood vessels and, therefore, may prove useful in the treatment of irregular heartbeat and heart failure.
		Berberine has also been shown to kill a wide range of other types of germs, such as those that cause candida (yeast) infections, as well as various parasites such as tapeworms and giardia.
	www.umm.edu /altmed/ConsHerbs/Goldensealch.html (1221 words)

	Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein -- Sakai et al. ...
		Berberine uptake was determined by the amount of berberine absorbed from the medium into the cells after 10 h of incubation.
		Berberine was added 14 d after inoculation at an initial concentration of 250 µM. The value 100% means the complete uptake of the berberine added to the medium.
		Berberine was added on the 14th day of culture at an initial concentration of 250 µM. The viability of the cells was checked by the staining with neutral red, and the recovery of cell growth was also confirmed after washing the cells.
	jxb.oxfordjournals.org /cgi/content/full/53/376/1879 (4098 words)

	Sundance Elixir - Hoxsey Tonic - Berberine - Cancer Salves
		These plants are used for their berberine content and are quite comparable.In vitro studies indicate that berberine fights cancer by increasing macrophage activity.
		Berberine is so skilled in this action that when scientifically compared to chemotherapy, the kill rate was 91% for berberine as compared to 43% for chemotherapeutic drugs.
		In China, berberine is given after chemotherapy to aid restoration of white blood cell counts.Berberine is a superb natural antibiotic that can cross the blood-brain barrier.
	www.cancersalves.com /botanical_approaches/sms_formulas/sundance_elixir.html (1098 words)

	Combined effectiveness of berberine and albendazole against microsporidia.
		Berberine is a quaternary plant alkaloid in development for the treatment of chronic diarrhea in AIDS patients.
		Berberine has both antisecretory and antimicrobial properties and has been used to successfully treat a variety of gastrointestinal conditions caused by bacteria or protozoa.
		We are now investigating the antimicrobial profile of berberine in combination with albendazole, another drug which has been examined as an antimicrosporidial agent.
	www.aegis.com /aidsline/2000/may/a0050494.html (482 words)

	Garlic, Berberine & Spleen Extracts Broad-Spectrum Support Against Antibiotic-Resistant Superbugs
		In laboratory studies, berberine, the most important of the berberis alkaloids, has been shown to have antibiotic, immunostimulatory, anticonvulsant, sedative, and hypotensive (blood pressure-lowering) activity, among other effects.
		Berberine also inhibits the growth of yeasts, such as Candida, which often overgrow and cause a secondary infection after ordinary antibiotic treatment.
		Berberine is used clinically to treat acute diarrhea caused by a variety of pathogenic bacteria, including E. coli, Klebsiella, Giardia lamblia, and Vibrio cholerae.
	intelegen.com /ImmuneSystem/garlic_berberine.htm (2394 words)

	Berberine May Support Healthy Levels of LDL Cholesterol, New Study Says Breaking News 11/15/04 Article
		The herb berberine may lower levels of total and LDL bad cholesterol, researchers report in a recent issue of the journal Nature Medicine.
		The patients treated with berberine experienced an 18 percent drop in total cholesterol and a 20 percent drop in LDL cholesterol.
		In these subjects, those using berberine for three months experienced a 29 percent reduction in total cholesterol, a 25 percent reduction in LDL cholesterol, and a 35 percent decline in triglycerides.
	www.vrp.com /art/1532.asp (585 words)

	Anti-Diarrhea Potential of Goldenseal
		Berberine (concentration range 0-500 microM) reduced both basal and stimulated ion transport responses in human colonic mucosae in a manner which was non-specific for Ca2+ -or cAMP-mediated signals.
		Berberine did not alter the rate of generation of cAMP by adenylyl cyclase or the activity of protein kinase A, the effector enzyme of the cAMP pathway.
		Addition of berberine hydrochloride (3.2 X 10(-5) M) to the perfusate reduced the jejunal secretory response of water, sodium, potassium, and chloride to ST and enhanced water and electrolyte absorption in control segments.
	www.sleepyhollowherbfarm.com /MedData/AntiDiarrhea.htm (1932 words)

	Berberine
		Berberine is an alkaloid found in various plants, including goldenseal, barberry, Oregon grape, and goldthread.
		Berberine exhibits a broad spectrum of antibiotic activity in test-tube, animal, and human studies.
		In addition, berberine's actions include: antagonism of the effects of cholera and E. coli toxin, inhibition of intestinal ion secretion, inhibition of smooth muscle contraction (spasms), and reduction of inflammation.
	www.fungusfocus.com /html/berberine.htm (581 words)

	The Effect of Berberine Chloride on Experimental Colitis in Rats In Vivo and In Vitro -- Zhou and Mineshita 294 (3): ...
		Berberine chloride (15 mg/kg) decreased the wet weight of colon and intestinal wall thickening on day 7 compared with TNB (30 mg) group.
		Berberine is an isoquinoline alkaloid present in numerous plants of the genera Berberis and Coptis.
		Lahiri SC and Dutta NK (1967) Berberine and chloramphenicol in the treatment of cholera and severe diarrhoea.
	jpet.aspetjournals.org /cgi/content/full/294/3/822 (4469 words)

	Golden Seal
		Its most active ingredients are called alkaloids, the most important of these being berberine, and most of our scientific understanding is due to research into berberine.
		Berberine is able to activate a type of cell called the macrophage, which is responsible for ridding the body of foreign matter.
		Berberine also supports the immune system by increasing the blood flow to the spleen, the organ responsible for filtering the blood, and thus giving goldenseal the nickname of "blood purifier".
	members.tripod.com /vitaminman/nutrition/golden.htm (352 words)

	[No title]
		Berberis vulgaris Historical or traditional use (may or may not be supported by scientific studies): Traditionally, in European and American herbalism, barberry was used to treat a large number of conditions, particularly infections and stomach problems.1 It has also been used internally to treat skin conditions.
		Berberine, which ranges from 0.5-6.0% of the alkaloids present in goldenseal root and rhizome, has been the most extensively researched.
		We found that berberine, an isoquinoline alkaloid present in plants of the genera Berberis and Coptis, effectively inhibits COX-2 transcriptional activity in colon cancer cells in a dose- and time-dependent manner at concentrations higher than 0.3 microM.
	ourworld.compuserve.com /homepages/suthercon/Berber.htm (744 words)

	[No title]
		Berberine was found in vitro, as to its displacing effect on a molar basis, to be about tenfold superior to phenylbutazone, a known potent displacer of bilirubin, and about hundredfold to papaverine, a berberine-type alkaloid.
		The objective of the present study was to examine the effect of berberine on the expression of GR and its relation to cell cycle progression of HepG2 cells.
		Direct potentiometry determination of berberine in various samples showed an average recovery of 99.5- 103.5% and a relative standard deviation of 1.3-3.5% at a sampling rate of 120/h.
	www.swsbm.com /Abstracts/Coptis-AB.txt (4298 words)

	Healthnotes Newswire: Herbal Help for Heart Disease
		Known for its antibacterial and immune-enhancing properties, berberine is a component from several medicinal plants including goldenseal (Hydrastis canadensis), Oregon grape (Berberis aquifolium), and Huanlian (Coptis sinensis, an herb from traditional Chinese medicine).
		The effect of berberine was even more pronounced in people who were not doing any other cholesterol-lowering treatment: a 29% drop in total-cholesterol levels, a 25% drop in LDL-cholesterol levels, and a 35% drop in triglycerides.
		The results of this study suggest that berberine might be a useful therapy for lowering heart disease risk.
	www.pccnaturalmarkets.com /health/Newswire/Back_issues/newswire_2005_01_06_1.htm (556 words)

	Goldenseal
		Berberine is an active ingredient in goldenseal and is responsible for some of the activity of goldenseal in the body.
		The berberine contained in goldenseal can effect the heart and blood vessels in numerous ways.(11) If you have a cardiovascular condition including congestive heart failure, arrhythmias (irregular heartbeats) or high blood pressure do not use berberine containing products unless closely monitored by a health care professional.
		Due to berberine's ability to displace bilirubin,(20, 21) a pigment found in bile from the breakdown of waste products in the liver, berberine and berberine containing products should not be used in newborns, especially jaundiced newborns.
	content.nhiondemand.com /psv/monoAll-style.asp?objID=100117&ctype=ds&mtyp=1 (852 words)

	goldenseal-hp
		All of the clinical studies of goldenseal have focused on the constituent berberine.
		At least 3 studies have examined the efficacy of berberine sulfate as adjunctive therapy in the treatment of cholera and E.coli diarrhea, as compared to treatment with tetracycline alone.
		In one study, they compared 0.2% berberine chloride drops to sulfacetamide eye drops over 8 weeks of treatment or a combination of the two.
	www.med.unc.edu /phyrehab/ncmedicinalherbs/goldenseal/Goldenseal-hp.html (514 words)

	Oregon Grape: Herb Library
		Berberine is a constituent common to Berberis and Mahonia species as well as to goldenseal, Hydrastis canadensis.
		The principal constituents of Oregon grape responsible for its activity are the isoquinoline alkaloids, especially berberine, berbamine, isocorydin, and oxyacanthine.
		In one study, berberine proved effective in treating diarrhea due to toxic pathogens such as cholera.
	www.peoplespharmacy.org /archives/herb_library/oregon_grape.asp (560 words)

	Metagenics CandiBactin-BR
		features 400 mg per serving of berberine sulfate purified from berberis root, along with premium extracts of coptis root and barberry root standardized to 20% and 10% berberine, respectively.
		Berberine is a natural compound that supports immune function and encourages the body to purge unwanted compounds.
		Traditional practitioners familiar with the application of bitter plant principles such as berberine suggest that these plants be tempered with additional herbs that promote healthy digestion and liver function and normalize bowel transit time, which encourages the efficient elimination of metabolic waste.
	www.allyourhealthneeds.com /product823.html (155 words)

	Photochemistry and Photocytotoxicity of Alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine
		The topical application of Goldenseal or berberine to the skin or eyes raises the possibility that an adverse phototoxic reaction may result from an interaction between the alkaloid and light.
		In the latter solvent and in the absence of oxygen, the neutral berberine radical formed by one electron reduction was observed.
		M berberine resulted in an 80% decrease in cell viability and a 3-fold increase in DNA damage as measured by the Comet assay.
	pubs.acs.org /cgi-bin/abstract.cgi/crtoec/2001/14/i11/abs/tx0155247.html (329 words)

	Barberry - Swedish MC, Seattle, Washington, WA
		Berberine inhibits the growth of many microorganisms, including fungi, protozoa, and bacteria.
		Berberine has also shown potential as a treatment for various heart-related conditions, including reducing high cholesterol and high blood pressure and preventing heart arrythmias.
		Kaneda Y. In vitro effects of berberine sulphate on the growth and structure of Entamoeba histolytica, Giardialamblia and Trichomonas vaginalis.
	www.swedish.org /114514.cfm (939 words)

	[No title]
		Berberine inhibited Lysophosphatidyl choline-induced DNA synthesis and cell proliferation in vascular smooth muscle cell as well as migration of the lysoPC-stimulated vascular smooth muscle cell, suggesting its potential in the prevention of atherosclerosis and restenosis.
		Berberine display a dose-dependent inhibition to cytosolic N-acetyltransferases (NAT) activity and intact mice leukemia cells; time-course experiments indicate that N-acetylation of AF measured from intact mice leukemia cells were inhibited by berberine for up to 24 h.
		Berberine an antidiarrheal medication inhibited by approximately 70% the secretory responses of the heat-labile enterotoxins of Vibrio cholerae and Escherichia coli in the rabbit ligated intestinal loop model and was effective when given either before or after enterotoxin binding.
	www.herbmed.org /viewherb.asp?varHerb_ID=93 (2510 words)

	VascularWeb: Chinese Medicine Berberine is Unique Cholesterol Lowering Agent
		In a series of in vitro studies, the researchers found that berberine increased LDL receptor activity independently of sterol-regulatory element binding proteins, with an action depending on ERK activity.
		Jiang and colleagues then analyzed berberine's effect in a subset of patients who were not taking any other medications or herbs before or during the study.
		While the effect of berberine was small compared with that seen with statins, he and his colleagues note, the dose used in the current study was "moderate." Larger effects may be seen with larger doses, they add, as the medication showed a dose-dependent effect in the hamster studies.
	www.vascularweb.org /_CONTRIBUTION_PAGES/Medical_News_Reuters/Chinese_Medicine_Berberine.html (464 words)

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