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Topic: Betacarboline

In the News (Mon 28 May 12)

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	LILA -> Ayahuasca, Religion, and Nature
		Such plants - many of which have emetic, purgative, cathartic, dream-inducing and/or visionary effects — are used to facilitate states of consciousness that are believed to open into the worlds of spirit.
		In the typical ayahuasca preparation, the molecular basis for this lies in the betacarboline complex (harmine, tetrahydroharmine, etc.) and the indole dimethyltryptamine (DMT).
		These are part of a structural group that includes neurotransmitters, molecules used to effect internal communication in the human body.
	www.lila.info /document_view.phtml?document_id=12 (2104 words)

	Interactions between Betacarboline and Benzenoid Bases: FTIR Evidence for the Formation of NH- Hydrogen Bonds (Site not responding. Last check: 2007-10-08)
		In the presence of benzene, naphthalene, or phenanthrene, the NH stretching band of betacarboline in tetrachloroethane diminishes in intensity while a new red-shifted band grows.
		These changes are attributed to the formation of molecular association complexes between betacarboline and the benzenoid compounds.
		On the other hand, experiments using harmane, the 1-methylated betacarboline, proved steric hindrance for naphthalene and phenanthrene, which should be a consequence of the geometry of the complexes.
	pubs.acs.org /cgi-bin/abstract.cgi/jpcbfk/1999/103/i41/abs/jp991615p.html (202 words)

	MindVox : Ibogaine : Voices of Truth
		Two of these classes of molecules that have gotten some interest lately are tryptamines and the betacarbolines.
		Ibogaine has a betacarboline "backbone," the back of the molecule is betacarbonline-like.
		Well, it turns out that there are endogenous betacarbolines in our brain.
	ibogaine.mindvox.com /Media/Voices.html (1614 words)

	/beer and health/ (Site not responding. Last check: 2007-10-08)
		Polyphenols (tanins), for example, are present in beer and wine and play a role in preventing heart and circulatory disease by acting on the fat metabolism.
		Another interesting component in beer is harman, a betacarboline.
		Nonharman, a substance belonging to the same class, is also found in tobacco.
	www.bierengezondheid.be /index_eng.jsp?Page=Dos127&Doc=metabolisme (1212 words)

	Volume III, Number 3, Methadone Today
		The invention was for a new patent I had filed for the use of betacarbolines in combination with noribogaine.
		An example of a betacarboline would be harmaline, a substance that is one of the ingredients in Yage or Ayahuasca used in the Sainte Daime Church.
		The reality was that Deborah, either out of ignorance or purpose, never overcame the Patent Office objections to the noribogaine patent and further, she had never supplied me with any information indicating the combined used of betacarbolines and noribogaine to treat addiction.
	www.druglibrary.org /schaffer/heroin/methadone/dont/V3_n03.htm (4224 words)

	Walking Between the Worlds:
		I have discussed elsewhere that the pineal betacarbolines are linked with psychic states of consciousness and with the shamanic out-of-body state through the similarity of the harmala alkaloids and pinoline (Roney-Dougal, 1986,1988,1990,1991,1993, 1999).
		Callaway suggests that psychoactive tryptamine derivatives in the CNS of mammals play a role in the manifestations of visual and emotive phenomena during normal dream sleep.
		The hypothesis is extended to include psychoses by suggesting that hallucinatory psychotic episodes may result from a desychronised dream mechanism, where the individual essentially dreams while awake (Callaway, 1994).
	www.psi-researchcentre.co.uk /article_1.html (13716 words)

	Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands - Patent 5212310
		This compound is a high affinity competitive inhibitor of benzodiazepine and betacarboline binding and is capable of blocking the pharmacological actions of both these classes of compounds.
		When a radiolabeled form of this compound was studied (Mohler & Richards, 1981, Nature 294: 763-65), it was demonstrated that this compound would interact with the same number of sites as the benzodiazepines and betacarbolines, and that the interactions of these compounds were purely competitive.
		This compound is the ligand of choice for binding to GABAa receptors because it does not possess receptor subtype specificity and measures each state of the receptor.
	www.freepatentsonline.com /5212310.html (7753 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		Energy Citations Database (ECD) Document #6415753 - High-affinity benzodiazepine receptor ligands among benzodiazepines and betacarbolines with different intrinsic activity
		Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link.
		High-affinity benzodiazepine receptor ligands among benzodiazepines and betacarbolines with different intrinsic activity
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=6415753 (134 words)

	Bruce Sterling, William Gibson. Red star, winter orbit (Site not responding. Last check: 2007-10-08)
		His nostrils were festooned with white streamers of surgical cotton.
		He was convinced that Yefremov would try to break the strike with betacarboline aerosols.
		The cotton plugs were just one symptom of the general level of strain and paranoia.
	lib.sarbc.ru /lat/STERLINGB/r_star.txt (5951 words)

	Catalogo Articoli (Site not responding. Last check: 2007-10-08)
		Hydrogen bonding NH/pi interactions between betacarboline and methyl benzene derivatives
		Ground and singlet excited state hydrogen bonding interactions of betacarbolines
		Interactions between betacarboline and benzenoid pi bases: FTIR evidence for the formation of NH-pi hydrogen bonds
	serials.cib.unibo.it /cgi-ser/start/it/spogli/ds-s.tcl?authors=%22+MUNOZ+MA%22&language=ITALIANO (1992 words)

	Ayahuasca&PinealGland
		In adults REM sleep occurs about every one to one and half hours throughout the night so that dreams occur three to four times a night
		Furthermore J.C. Callaway in an interesting medical hypothesis on a proposed mechanism for visions in sleep has indicated that the periodic REM sleep is due to the interaction between Pinoline (the betacarboline similar to ayahuasca) and serotonin.
		Moreover this Beta carboline is functional in inducing REM sleep, lucid dreaming, and other naturally occurring states such as deep meditation.
	www.biolumanetics.net /tantalus/Provings/AyahuascaPinealgland.htm (10762 words)

	Cures not Wars.org
		Therefore, unless the vinegar/gall mixture contained harmala, you would either A) have to have a mushroom containing beta carbolines in addition to tryptamines (like ayahuasca); or B) what is more interesting, have to have a tryptamine incorporating a sidechain that funtions as third ring.
		As for A), it's possible; and I don't know, which is why I am publishing this on mayday@onelist and ibogaine@ibogaine.org, hoping the stores of erudition thereon can tell us whether such a mushroom, which would be the functional equibalent of ayahuasca, containing its own betacarbolines in addition to tryptamines, exists.
		Which leaves B) the anokhi mushroom represents an unknown indole ring alkaloid capable-- because it contains a sidechain acting as a third ring--of NMDA activity.
	www.cures-not-wars.org /dana1.html (6997 words)

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	mymoonlight.tripod.com /278333.html (1186 words)

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