
	Where results make sense

Topic: Betalactamase

	European Society of Clinical Microbiology and Infectious Diseases
		All isolates were resistant to ampicillin and susceptible to cefotaxime regardless of the betalactamase present.
		The prevalence of ROB-1 betalactamase in the H.
		The strains with ROB-1 betalactamase did not have higher MIC than the TEM-1 isolates for the betalactams studied.
	www.blackwellpublishing.com /eccmid14/abstract.asp?id=15593 (305 words)

	Datos recibidos (Site not responding. Last check: 2007-10-11)
		Presence of extended spectrum betalactamases (ESBL) was inferred by both double disk diffusion tests and minimum inhibitory concentration (MIC) of third and fourth generation cephalosporins alone and in the presence of clavulanic acid.
		CONCLUSION: The broad extended spectrum betalactamase within genus Proteus was TEM-1, while CTX-M-2 was the ESBL responsible for the third and fourth generation cephalosporins in P. mirabilis.
		In P. vulgaris and P. penneri this resistance was associated with the hyperproduction of the chromosomal encoded betalactamase.
	www.infodoctor.org /cgi-bin/abstracts.pl?uid=15757582 (318 words)

	Seminar Transcripts: MRSA In Canada - Progress, Priorities, and Plans
		I'm sure all of you are aware of betalactamases, enzymes that hydrolyze betalactam bonds, and penicillins and cephalosporins.
		It is a betalactamase that is responsible for penicillin resistance in Staph aureus.
		Betalactamase is responsible for penicillin resistance that is not the cause of methicillin-resistance to Staph aureus.
	www.maunco.com /seminars/transcripts/mrsa.htm (10691 words)

	Correlation between beta-lactamase production and MIC values against penicillin with coagulase negative staphylococci. ...
		Only 17.5% of betalactamase producers could be detected by one of the three methods used whereas 75.0% positivity was obtained by using all three methods.
		Totally, 18.4% of the strains were sensitive to penicillin by disc diffusion but were positive for betalactamases indicating insufficient amount of the enzymes to hydrolyse penicillin.
		In contrast, 22.6% were positive for betalactamase production even though they were sensitive to penicillin by disc diffusion technique.
	www.jpgmonline.com /article.asp?issn=0022-3859;year=1989;volume=35;issue=3;spage=147;epage=51;aulast=Narayani (1558 words)

	Amoxil Ampicillin Anti- (Site not responding. Last check: 2007-10-11)
		Betalactamase Ampicillin, generisches Ampicillin, Ampicillin wird benutzt, um viele unterschiedliche Arten Infektion, wie Tonsillitis, Pneumonie, Bronchitis, urinausscheidende FlÃ¤che Infektion, gonorrhea und Infektion der DÃ¤rme wie Salmonellen (Nahrungsmittelvergiftung) zu behandeln.
		Betalactamase Ampicillin, generisches Ampicillin, Ampicillin kann fÃ¼r Zwecke auch benutzt werden anders als die, die in diesem MedikationfÃ¼hrer verzeichnet werden.
		Betalactamase Ampicillin, generisches Ampicillin, Ampicillin kann die Wirksamkeit der Geburtenkontrollepillen verringern.
	ampicillin.ulovesex2.com /de/amoxil-ampicillin-anti.htm (562 words)

	Rhinology journals - Abstracts - (Site not responding. Last check: 2007-10-11)
		In the LEV group, the eradication rate for major pathogens of acute sinusitis was 100% for H. influenzae (both betalactamase +ve and -ve), 100% for S. pneumoniae and S. aureus, 100% for Neisseria species, and 66.7% for P. aeruginosa.
		The eradication rate in the COA group was 75% for H. influenzae (both betalactamase + ve and -ve), 100% for S. pnumoniae and S. aureus, 50% for Neisseria species, and 0% for P. aeruginosa.
		There were no significant changes in vital sign measurements or hemato-biochemical parameters at the end of treatment as compared to baseline values, in both groups.
	www.rhinologyjournal.com /article/view_abstract.php?mgzn_id=114&rtcl_id=484 (387 words)

	[No title]
		It is a betalactamase that \hich\af0\dbch\af4\loch\f0 \hich\af0\dbch\af4\loch\f0 is responsible for penicillin resistance in Staph aureus.
		\par \par \hich\af0\dbch\af4\loch\f0 Mechanisms Of Resistance \par \hich\af0\dbch\af4\loch\f0 Betalactamase is responsible for penicillin resistance that is not the cause of methicillin-resistance to Staph aureus.
		But this ultra penicill \hich\af0\dbch\af4\loch\f0 i\hich\af0\dbch\af4\loch\f0 n-binding protein has a low affinity not just for methicillin but also for all penicillins and cephalosporins so that MRSA are predictably cross-resistant to all betalactamase antibiotics.
	www.maunco.com /seminars/transcripts/MRSA-Transcript.rtf (11320 words)

	Contribution of beta -Lactamases to beta -Lactam Susceptibilities of Susceptible and Multidrug-Resistant Mycobacterium ...
		Distribution and characterization of betalactamases of mycobacteria and related organisms.
		The use of analytical isoelectric focusing for detection and identification of betalactamases.
		Betalactamase inhibitors and the inducibility of the betalactamase of Mycobacterium tuberculosis.
	aac.asm.org /cgi/content/full/42/6/1524 (1278 words)

	MRSA forum: MRSA superbug infection forum MRSA hospital bug
		All the broad spectrum penicillins are inactivated by betalactamase producing bacteria.
		Cloxacillin and flucloxacillin are not completely resistant to staphylococcal betalactamases, and, for 'SERIOUS INFECTION', they are used in combination with other antibiotics, such as gentamicin, fusidic acid or erythromycin." The combination I was given was Flucloxacillin, erythromycin, fusidic acid and gentamicin.
		On the next page 282 under the heading of 'betalactamase resistant penicillins'it lists Cloxacillin for 'Infections due to betalactamase-producing staphylococci.
	www.robprince.net /mrsa/forum.asp?action=replies&forumID=4237 (596 words)

	Brazilian Journal of Infectious Diseases - High frequency of colonization and absence of identifiable risk factors for ... (Site not responding. Last check: 2007-10-11)
		aureus were unaffected by penicillin by their production of penicillinase or betalactamase.
		Initially, they were recorded rarely but they soon became reported worldwide.
		In spite of the development of semi-synthetic penicillins, resistant to the betalactamase activity, other strains appeared that were resistant to methicillin.
	www.scielo.br /scielo.php?script=sci_arttext&pid=S1413-86702001000100001 (2796 words)

	Millipore - Technical Library - Development of a Culture Medium for Air Monitoring in an Antibiotic Production ...
		Results are expressed in diameter size, including the disc (5 mm); a value of zero indicates that bacterial culture cloth was in close contact with the disc, indicating no inhibitory effect at all of the antibiotic contained in the disc on bacterial growth.
		Our in-house testing shows new M Air T cassettes preloaded with betalactamase- enhanced TSA completely inhibit the antimicrobial effect of penicillin, oxacillin, ampicillin, azlocillin, piperacillin, mezlocillin, ticarcillin, mecillinam, cefsulodin and meropenem.
		Through a combination of hardware and disposables, the M Air T Air Monitoring System and prefilled betalactamase cassettes offer a convenient and versatile air monitoring solution for reliably sampling air and reducing false negatives in manufacturing environments that produce a wide range of beta-lactam antibiotics.
	www.millipore.com /publications.nsf/docs/qa25 (633 words)

	Dr. Schilling's Net Health Book - Acute Epiglottitis
		Close observation in an intensive care unit is important to monitor that no further deterioration occurs.
		Intravenous antibiotics with a betalactamase resistant antibiotic is given until the final culture report and sensitivity tests are back and the antibiotic can be adjusted.
		This outline is only a teaching aid to patients and should stimulate you to ask the right questions when seeing your doctor.
	www.nethealthbook.com /acuteepiglottitis.html (394 words)

	The Topics Archive » Blog Archive » Swapping linkers to change enzyme function (Site not responding. Last check: 2007-10-11)
		Using this approach, we were able to introduce beta-lactamase activity into the metallohydrolase scaffold of glyoxalase II.
		The resulting enzyme, evMBL8 (evolved metallo betalactamase 8), completely lost its original activity and, instead, catalyzed the hydrolysis of cefotaxime with a (kcat /Km)app of 1.8 x 102 (mole/liter)-1 second-1, thus increasing resistance to Escherichia coli growth on cefotaxime by a factor of about 100.
		This entry was posted on Monday, February 6th, 2006 at 9:20 pm and is filed under Articles, Foundations, Enzyme Mechanism.
	www.aviationplace.com /_wp/tech?p=97 (247 words)

	[No title]
		Occasional imports of multidrug-resistant typhoid have been identified in KwaZulu-Natal, where there is a large Indian community; these strains likely come from Southeast Asia.
		Nosocomial Infections Extended spectrum betalactamases are endemic particularly among Klebsiella species in intensive-care units throughout the country.
		Gram-negative bacteria producing chromosomally mediated Beta-lactamase are common in all of these settings and Acinetobacter-related problems abound in most intensive-care units.
	ftp.cdc.gov /pub/EID/vol4no4/ascii/klugman.txt (895 words)

	[No title]
		As shown in the following summary of the study, the general clinical effectiveness of Ceftin Tablets was comparable to an oral antimicrobial agent that contained a specific betalactamase inhibitor in treating acute maxillary sinusitis.
		Patients were randomized in a 1:1 ratio to cefuroxime axetil 250 mg twice daily or an oral antimicrobial agent that contained a specific betalactamase inhibitor.
		Safety: The incidence of drugrelated gastrointestinal adverse events was statistically significantly higher in the control arm (an oral antimicrobial agent that contained a specific betalactamase inhibitor) versus the cefuroxime axetil arm (12% versus 1%, respectively; P
	www.dphhs.mt.gov /medicaid/pdf/ceftinpi.doc (1463 words)

	[No title] (Site not responding. Last check: 2007-10-11)
		Effect of OmpF/OmpC expression in the activity of cephalosporins and carbapenems against Escherichia coli hyperproducing chromosomal betalactamase.
		Comparative activities of meropem and six other antimicrobial agents against clinical isolates of Klebsiella pneumoniae producing extended-spectrum betalactamase and deficient or not in porins.
		Comparative activities of meropenem, imipenem, ceftazidime, cefotaxime, and cefoxitin against extended-spectrum betalactamase producing isogenic strains of Klebsiella pneumoniae with defined porins alterations.
	www.uib.es /depart/dba/microbiologia/VJBgroupmeets98.html (640 words)

	John W. Mercer (Site not responding. Last check: 2007-10-11)
		Bootstrapped distance method tree for BETALACTAMASE sequence alignment
		Comment: Bootstrapped parsimony tree for PRION sequence alignment shows that the evolution of the prion gene seems to parallel that of speciation.
		The tree shows that the human PRION (PRIO HUMAN) has a greater sequence similarity to the macaque monkey PRION (PRIO MACFA), as compared to the mouse PRION (PRIO MOUSE), or the red deer PRION (PRIO CEREL).
	www.visualgenomics.ca /~mercerj/phylogenetic_analysis.htm (91 words)

	MEE Volume 2003-12
		TYPE: SECTION 3 LABEL AMENDMENT - TO ADD USE DIRECTIONS AND TO ADD A CLAIM AGAINST ESBL ESCHERICHIA COLI (EXTENDED SPECTRUM BETALACTAMASE PRODUCING E. SALMONELLA CHOLERAESUIS, TRICHOPHYTON MENTAGROPHYTES, HERPES SIMPLEX TYPE 1 and 2 AND HIV-1 ON HARD, NONPOROUS SURFACES
		TYPE: SECTION 3 LABEL AMENDMENT - TO ADD USE DIRECTIONS AND TO ADD A CLAIM AGAINST ESBL ESCHERICHIA COLI (EXTENDED SPECTRUM BETALACTAMASE PRODUCING E. SABER POUR-ON INSECTICIDE FOR BEEF CATTLE and CALVES
		USE: INSECTICIDE - FOR THE CONTROL OF VARIOUS INSECTS SUCH AS LICE AND HORN FLIES ON BEEF CATTLE AND CALVES
	www.cdpr.ca.gov /docs/mee/2003-12mee.htm (490 words)

	Stop Press (Site not responding. Last check: 2007-10-11)
		Note that certain important control of infection markers are now viewable on the PaWS system against Microbiology results and patients etc.
		A 'bug' icon indicates patients with MRSA, Extended Betalactamase Producers (ESBL) or Clostridium difficile and directs users to read guidelines for management.
		See the PaWS login page for more details.
	www.goodhope.org.uk /departments/pathweb/stoppress.htm (51 words)

	2003-20 Notice of Decisions
		TYPE: SECTION 3 LABEL AMENDMENT - TO ADD USE DIRECTIONS AND TO ADD A CLAIM AGAINST ESBL ESCHERICHIA COLI (EXTENDED SPECTRUM BETALACTAMASE PRODUCING E. Notice of Proposed Decisions to Register (Continued)
		USE: DISINFECTANT - FOR THE CONTROL OF VARIOUS ORGANISMS SUCH AS PSEUDOMONAS AERUGINOSA, STAPHYLOCOCCUS AUREUS, STREPTOCOCCUS PYOGENES, TRICHOPHYTON MENTAGROPHYTES, HERPES SIMPLEX TYPE 1 and 2 AND HIV-1 ON HARD, NONPOROUS SURFACES
		TYPE: SECTION 3 LABEL AMENDMENT - TO ADD USE DIRECTIONS AND TO ADD A CLAIM AGAINST ESBL ESCHERICHIA COLI (EXTENDED SPECTRUM BETALACTAMASE PRODUCING E. SALMONELLA CHOLERAESUIS, STREPTOCOCCUS PYOGENES, TRICHOPHYTON MENTAGROPHYTES, HERPES SIMPLEX TYPE 1 and 2 AND HIV-1 ON HARD, NONPOROUS SURFACES
	www.cdpr.ca.gov /docs/nod/2003-20.htm (1612 words)

	Pediazole - Resources from Educational and Academic Institutions (Site not responding. Last check: 2007-10-11)
		SAPHE: Alchohol: Drug Interactions: MACROLIDES Some examples are: azithromycin / ZITHROMAX clarithromycin / BIAXIN
		Grand Rounds Archives:...and M. catarrhalis organisms are betalactamase producing, so betalactamase resistant
		Pediazole has been found to clear 45% of cases
	mark.mongabay.com /medications/academic/Pediazole.html (548 words)

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