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036: CLONING AND CHARACTERIZATION OF A BETARETROVIRUS INFECTION IN PATIENTS WITH PRIMARY BILIARY CIRRHOSIS   (Site not responding. Last check: 2007-11-06) Serologic studies showed that 42 of 59 PBC patients had Western blot reactivity to betaretrovirus proteins as compared to 3 of 23 liver disease controls and 2 of 16 blood donors (p < 0.001). Immune purified anti-mitochondrial antibodies from PBC patients' sera were found to bind to pure virus Western blots, which was abrogated by pre-incubation of serum with the mitochondrial autoantigens. Serologic and tissue evidence for viral infection was found in ~75% of patients with PBC and was frequently observed in control subjects as well. www.cag-acg.org /cddw/cddw2003/abs/abs036.htm   (340 words)

Betaretrovirus - Encyclopedia, History, Geography and Biography A betaretrovirus is a genus of the retroviridae family. It has type B or type C morphology. This page was last modified 16:37, 12 January 2006. www.arikah.com /encyclopedia/Betaretrovirus   (87 words)

Biomedical terms Mason-Pfizer_monkey_virus A species of BETARETROVIRUS isolated from mammary carcinoma in rhesus monkeys. It appears to have evolved from a recombination between a murine B oncovirus and a primate C oncovirus related to the baboon endogenous virus. The core of the type D viruses is the intracytoplasmic type A particle and its mechanism of budding from the cell membrane is similar to the type B oncoviruses. www.lifezilla.com /ma/Mason-Pfizer_monkey_virus.html   (280 words)

Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, 5th edition, 2004 The retrovirus of OPA is distinct from the non-oncogenic ovine lentivirus, and classified as a betaretrovirus. Identification of the agent: The betaretrovirus of OPA cannot yet be propagated in vitro, therefore routine diagnostic methods, such as virus isolation, are not available for diagnosis. It has been demonstrated, recently, that OPA is caused by a betaretrovirus that cannot yet be cultured in vitro, but the virus has been cloned and sequenced. www.oie.int /fr/normes/mmanual/A_00075.htm   (2517 words)

Mason In my research, I have recently identified a human betaretrovirus associated with Primary Biliary Cirrhosis. Current areas of research include investigating the prevalence of this human betaretrovirus in patients with primary biliary cirrhosis and breast cancer by assessing reverse transcriptase activity, measuring viral levels by real time RT-PCR and standard serologic assays using ELISA and Western blot. Virus isolation studies are planned to determine Koch’s postulates in vitro using a cell culture model of primary biliary cirrhosis. www.departmentofmedicine.ualberta.ca /research/researcher_mason.htm   (320 words)

Identification of Novel Porcine Endogenous Betaretrovirus Sequences in Miniature Swine -- Ericsson et al. 75 (6): 2765 ... The tree is based on an alignment and calculations of N-terminal protein sequences from ERV pol sequences listed in Table 1. A few branches in the HML cluster had values as low as 22% but are not shown because of limited space. Four sequences in the betaretrovirus cluster are indicated to the right of the tree due to space limitation. jvi.asm.org /cgi/content/full/75/6/2765   (3306 words)

Mason A, Primary Sclerosing Cholangitis Literature Mason A, Xu L, Neuberger J 2004 Proof of principal studies to assess the role of the human betaretrovirus in patients with primary biliary cirrhosis. Mason A, Xu L, Shen Z, Fodera B, Joplin R, Neuberger J, O'donnell B 2004 Patients with primary biliary cirrhosis make anti-viral and anti-mitochondrial antibodies to mouse mammary tumor virus. Xu L, Sakalian M, Shen Z, Loss G, Neuberger J, Mason A 2004 Cloning the human betaretrovirus proviral genome from patients with primary biliary cirrhosis. home.insightbb.com /~rhodesdavid/MasonA.htm   (431 words)

Betaretroviruses: neonatal age, estrous cycle, pregnancy - Message Board - ezboard.com Identification of novel porcine endogenous betaretrovirus sequences in miniature swine. The identification of PERVs belonging to the Betaretrovirus genus shows that endogenous retroviruses of this family are more broadly represented in mammalian species than previously appreciated. The betaretrovirus sequences described in this report will allow such investigations to be actively pursued. p205.ezboard.com /fmsdiagnosedfrm70.showMessage?topicID=100.topic   (635 words)

NationMaster - Encyclopedia: Genetics   (Site not responding. Last check: 2007-11-06) The general structure of a section of DNA Deoxyribonucleic acid (DNA) is a nucleic acid — usually in the form of a double helix — that contains the genetic instructions monitoring the biological development of all cellular forms of life, and many viruses. Genera Alpharetrovirus Betaretrovirus Gammaretrovirus Deltaretrovirus Epsilonretrovirus Lentivirus Spumavirus A retrovirus is any virus belonging to the viral family Retroviridae. An oncovirus is a virus associated with cancer. www.nationmaster.com /encyclopedia/Genetics   (7301 words)

Does a betaretrovirus infection trigger primary biliary cirrhosis? -- Xu et al. 100 (14): 8454 -- Proceedings of the ... Induction of the PBC Phenotype in Vitro by Betaretrovirus. the human betaretrovirus was detected in 7 of 10 BEC derived Evidence for betaretrovirus infection was also observed in the www.pnas.org /cgi/content/full/100/14/8454   (4749 words)

HYAL2 - hyaluronoglucosaminidase 2 In addition, the ENTV Env protein mediates virus entry using the same receptor as does JSRV Env, the candidate tumor suppressor Hyal2. Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins. HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity. www.ihop-net.org /UniPub/iHOP/gi/94064.html   (272 words)

Human Endogenous Retrovirus Family HERV-K(HML-5): Status, Evolution, and Reconstruction of an Ancient Betaretrovirus in ... Human Endogenous Retrovirus Family HERV-K(HML-5): Status, Evolution, and Reconstruction of an Ancient Betaretrovirus in the Human Genome -- Lavie et al. Human Endogenous Retrovirus Family HERV-K(HML-5): Status, Evolution, and Reconstruction of an Ancient Betaretrovirus in the Human Genome of the oldest betaretrovirus in the primate genome known to jvi.asm.org /cgi/content/abstract/78/16/8788   (345 words)

retrovirus Information Center - retrovirus linked to autoimmunity research africa family Studies of retroviruses led to the first demonstrated synthesis of DNA from RNA templates, a fundamental endogenous retroviruses in health human hervs retrovirus life cycle gene mode for retrovirus transferring genetic material that occurs retrovirus linked to autoimmunity the news family practice in both eukaryotes and prokaryotes. Genus Betaretrovirus; type species: endogenous retroviruses + god Mouse mammary tumour virus Genus retrovirus linked to autoimmunity the research for news Gammaretrovirus; type species: Murine leukeamia virus; others include Feline leukemia virus www.scipeeps.com /Sci-Biochemistry_Topics_Q_-_Sm/retrovirus.html   (619 words)

Retrovirology | Full text | The pp24 phosphoprotein of Mason-Pfizer monkey virus contributes to viral genome packaging This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We have identified a lysine-arginine rich motif within Np24 that is conserved among many betaretrovirus and is essential for infectivity. Xu L, Sakalian M, Shen Z, Loss G, Neuberger J, Mason A: Cloning the human betaretrovirus proviral genome from patients with primary biliary cirrhosis. www.retrovirology.com /content/2/1/68   (7791 words)

Retrovirus - Biocrawler   (Site not responding. Last check: 2007-11-06) Certain groups speculate that the processes followed by retroviruses (that is, RNA>DNA>RNA>Protein) may be the key to the evolution of DNA; thus, that in the "primordial soup", retroviruses evolved to create DNA from the RNA templates, and it was subsequently adopted by cellular organisms due to the increased chemical stability of DNA. Genus Betaretrovirus; type species: Mouse mammary tumour virus Genus Gammaretrovirus; type species: Murine leukeamia virus; others include Feline leukemia virus www.biocrawler.com /encyclopedia/Retrovirus   (571 words)

Definition of betaretrovirus 302: **Genus ''[[Betaretrovirus]]''; type species: ''[[Mouse mammary tumour virus... 821: [[betaine compound]] -- [[betaretrovirus]] -- [[Betaseron]] -- The list of authors can be found here. www.wordiq.com /search/betaretrovirus.html   (104 words)

Betaretrovirus Cancer Related Definition Synonyms: Betaretrovirus, Retroviruses, Type B, Mammalian, Type B Mammalian Retrovirus, Type B Virus, Type D Retrovirus Click on a letter to find infomation NCI Cancer and related disease terms starting with that letter. I laughed, I cried and most of all, I found a connection to others I didn't realize I'd been longing for. www.thenutritionguide.com /nci/13700.html   (677 words)

Putative Phosphatidylinositol 3-Kinase (PI3K) Binding Motifs in Ovine Betaretrovirus Env Proteins Are Not Essential for ... Putative Phosphatidylinositol 3-Kinase (PI3K) Binding Motifs in Ovine Betaretrovirus Env Proteins Are Not Essential for Rodent Fibroblast Transformation and PI3K/Akt Activation -- Liu et al. Putative Phosphatidylinositol 3-Kinase (PI3K) Binding Motifs in Ovine Betaretrovirus Env Proteins Are Not Essential for Rodent Fibroblast Transformation and PI3K/Akt Activation that ovine betaretrovirus Env proteins transform the rodent jvi.asm.org /cgi/content/abstract/77/14/7924   (468 words)

FEBS Abstract Ribosomal frame-shifts during expression of retroviral proteins provide a unique possibility for covalent joining of nucleocapsid (NC) and dUTPase within Gag-Pro polyproteins. By developing an antibody against the prototype betaretrovirus Mason-Pfizer monkey virus dUTPase, we demonstrate that (i) the NC-dUTPase fusion protein exists both within the virions and infected cells providing the only form of dUTPase, and (ii) the retroviral protease does not cleave NC-dUTPase either in the virion or in vitro. We show that recombinant betaretroviral NC-dUTPase and dUTPase have low catalytic activity compared with all other dUTPase. www.blackwellpublishing.com /febsabstracts2004/abstract.asp?id=17439   (299 words)

Abstracts   (Site not responding. Last check: 2007-11-06) Ardon, O. HIV-1 Vpr interaction with cellular cyclophilin A is not required for Vpr mediated G2 cell cycle arrest Arnaud, F. The endogenous betaretrovirus enJS56A1 prevents targeting of exogenous JSRV Gag to the pericentriolar region Beyer, A.R. Characterization of betaretrovirus Gag intracellular trafficking meetings.cshl.edu /meetings/abstracts/2006retro_absstat.html   (4014 words)

Online Encyclopedia and Dictionary - Retrovirus Genus Alpharetrovirus ; type species: Avian leucosis virus Genus Betaretrovirus ; type species: Mouse mammary tumour virus Genus Gammaretrovirus ; type species: Murine leukeamia virus ; others include Feline leukemia virus www.fact-archive.com /encyclopedia/Retrovirus   (478 words)

Club Biotech Event with Massimo Palmarini He focuses on the study of the pathogenesis and oncogenesis of ovine pulmonary carcinoma (OPC). OPC is a naturally occurring contagious lung cancer of sheep associated with a betaretrovirus known as jaagsiekte sheep retrovirus (JSRV). OPC has striking similarities with human bronchioalveolar carcinoma (BAC). www.clubbiotech.at /massimo.htm   (454 words)

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