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Topic: Bezitramide

	Bezitramide - Wikipedia, the free encyclopedia
		Bezitramide itself is a prodrug which is readily hydrolyzed in the gastrointestinal tract to its main metabolite, despropionyl-bezitramide.
		Bezitramide was discovered at Janssen Pharmaceutica in 1961.
		Bezitramide is regulated much the same as morphine in all known jurisdictions and is, surprisingly, a Schedule II rather than Schedule I narcotic under the United States' Controlled Substances Act of 1970.
	en.wikipedia.org /wiki/Bezitramide (214 words)

	XXXV TIAFT Annual Meeting - Oral Abstracts (Site not responding. Last check: 2007-09-08)
		Bezitramide is a prodrug which is readily hydrolyzed in the gastrointestinal tract to its main metabolite, despropionyl-bezitramide.
		Results are given for the analysis of different biological samples from three fatalities that were due to the combined intake of several drugs, including bezitramide.
		Moreover, the data from the analysis of 17 urine samples, all from known drug abusers, are presented.
	www.tiaft.org /tiaft97/proceedings/abstract/051.html (264 words)

	HS Code 2933.33 Alfentanil (INN), anileridine (INN), bezitramide (INN), bromazepam (INN), difenoxin (INN), ... (Site not responding. Last check: 2007-09-08)
		HS Code 2933.33 Alfentanil (INN), anileridine (INN), bezitramide (INN), bromazepam (INN), difenoxin (INN), diphenoxylate (INN), dipipanone (INN), fentanyl (INN), ketobemidone (INN), methylphenidate (INN), pentazocine (INN), pethidine (INN), pethidine (INN) intermediate A, phencyclidine (INN) (PCP), phenoperidine (INN), pipradrol (INN), piritramide (INN), propiram (INN) and trimeperidine (INN); salts thereof - Lexikon
		HS Code 2933.33 Alfentanil (INN), anileridine (INN), bezitramide (INN), bromazepam (INN), difenoxin (INN), diphenoxylate (INN), dipipanone (INN), fentanyl (INN), ketobemidone (INN), methylphenidate (INN), pentazocine (INN), pethidine (INN), pethidine (INN) intermediate A, phencyclidine (INN) (PCP), phenoperidine (INN), pipradrol (INN), piritramide (INN), propiram (INN) and trimeperidine (INN); salts thereof
		Alfentanil (INN), anileridine (INN), bezitramide (INN), bromazepam (INN), difenoxin (INN), diphenoxylate (INN), dipipanone (INN), fentanyl (INN), ketobemidone (INN), methylphenidate (INN), pentazocine (INN), pethidine (INN), pethidine (INN) intermediate A, phencyclidine (INN) (PCP), phenoperidine (INN), pipradrol (INN), piritramide (INN), propiram (INN) and trimeperidine (INN); salts thereof
	www.top500.de /lexikon/hs_code_2933_33.php (327 words)

	22-1/S.M. De Baere/Quantitative GC Analysis of [1-(4-Piperidinyl)... (Site not responding. Last check: 2007-09-08)
		A gas chromatographic procedure with nitrogen-phosphorus detection was developed for the quantitative determination of 1-(4-piperidinyl)-l,3-dihydro-2H-benzimidazole-2-one, the basic metabolite of the narcotic analgesic bezitramide (Burgodin), in urine.
		Out of 150 urine samples, mainly from persons suspected of using bezitramide or from known drug abusers, 22 samples revealed basic metabolite concentrations that ranged from 17.0 to 1695.5 ng/mL.
		It can also be used to determine bezitramide abuse and to establish bezitramide overdoses.
	www.jatox.com /abstracts/1998/jan-feb/deljiab.htm (244 words)

	Quantitative Analysis of Despropionyl-Bezitramide, the Active Metabolite of Bezitramide (Burgodin), in Biological ... (Site not responding. Last check: 2007-09-08)
		A sensitive high-performance liquid chromatographic procedure with fluorescence detection was developed for the quantitative determination of despropionyl-bezitramide, the active metabolite of bezitramide (Burgodin), in biological samples.
		Samples (blood, urine, stomach contents, bile, liver, kidney) from five fatalities that were due to the combined intake of several drugs, including bezitramide, were analyzed and the results are reported.
		In addition, one blood sample and 14 urine samples from persons suspected of using bezitramide were analyzed, revealing despropionyl-bezitramide concentrations in urine ranging from 1.3 to 72.3 ng/mL.
	pubs.acs.org /cgi-bin/abstract.cgi/ancham/1997/69/i24/abs/ac9706180.html (311 words)

	Identification and Quantitation of Despropionyl-bezitramide in Postmortem Samples by Liquid Chromatography Coupled to ...
		A sensitive and specific method for the determination and quantitation of (despropionyl) bezitramide in postmortem samples using liquid chromatography combined with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) is presented.
		N-Methyldespropionyl bezitramide is used as the internal standard.
		Moreover, the isolates' identity and structure are confirmed by the CAD product ion spectra, thus allowing to make unequivocal conclusions about the prior intake of bezitramide by the three subjects.
	pubs.acs.org /cgi-bin/abstract.cgi/ancham/1999/71/i14/abs/ac981310r.html (361 words)

	4-Amino-3-p-halophenylbutyric acids and their derivatives used in the control of narcotic abuse - Patent 4126684
		The addicting agents most suitable for the compositions claimed herein are preferably narcotics, such as those commonly prescribed for pain and discomfort, e.g.
		alphaprodine, anileridine, bezitramide, codeine, dihydrocodeine, diphenoxylate, ethylmorphine, fentanyl, hydrocodone, hydromorphone, isomethadone, levomethorphan, levorphanol, metazocine, methadone, metopon, morphine, opium extracts, opium fluid extracts, powdered opium, granulated opium, raw opium, tincture of opium, oxycodone, oxymorphone, pethidine, phenazocine, piminodine, racemethorphan, racemorphan or thebaine, or their salts.
		Also for those narcotics, often illegally abused, a withdrawal-cure may be beneficial in conjunction with said 4-amino-3-p-halophenylbutyric acids or said derivatives thereof.
	www.freepatentsonline.com /4126684.html (1929 words)

	Quantitative Gas Chromatographic Analysis of ... (Site not responding. Last check: 2007-09-08)
		Quantitative Gas Chromatographic Analysis of 3-Cyano-3,3-Diphenylpropionic Acid, the Acidic Metabolite of Bezitramide (Burgodin®), in Urine
		A sensitive gas chromatographic procedure with nitrogen–phosphorus detection was developed for the quantitative determination of 3-cyano-3,3-diphenylpropionic acid, the acidic metabolite of the narcotic analgesic bezitramide (Burgodin®).
		Urine samples from 16 persons suspected of using bezitramide were analyzed, and they revealed metabolite concentrations that ranged from 10.5 to 88 ng/mL.
	www.jatox.com /abstracts/1996/may-june/159-deleenheer.htm (226 words)

	EXPERIENCE WITH BEZITRAMIDE AND DROPERIDOL EN THE TREATMENT OF SEVERE CHRONIC PAIN -- ADMIRAAL et al. 44 (11): 1191 -- ... (Site not responding. Last check: 2007-09-08)
		EXPERIENCE WITH BEZITRAMIDE AND DROPERIDOL EN THE TREATMENT OF SEVERE CHRONIC PAIN -- ADMIRAAL et al.
		EXPERIENCE WITH BEZITRAMIDE AND DROPERIDOL EN THE TREATMENT OF SEVERE CHRONIC PAIN
		bezitramide, and the neuroleptic, droperidol, it is concluded
	intl-bja.oxfordjournals.org /cgi/content/abstract/44/11/1191 (237 words)

	euthanasics
		There are no indications that an oral barbiturate could better be combined with another opiate.
		Bezitramide does not seem to be an appropriate choice, since vomiting may occur even at low doses.
		Cases of poisoning with orphenadrine often seem to take a lethal course.
	www.wweek.com /html/euthanasics.html (7036 words)

	A STUDY OF STRONG ORAL ANALGESICS: THE RELIEF OF POSTOPERATIVE PAIN USING DEXTROMORAMIDE, PENTAZOCINE AND BEZITRAMIDE ... (Site not responding. Last check: 2007-09-08)
		A STUDY OF STRONG ORAL ANALGESICS: THE RELIEF OF POSTOPERATIVE PAIN USING DEXTROMORAMIDE, PENTAZOCINE AND BEZITRAMIDE
		Pentazocine 50 mg and bezitramide 10 mg were compared with dextromoramide
		effects, bezitramide was given to only 47 patients.
	intl-bja.oxfordjournals.org /cgi/content/abstract/45/6/623 (285 words)

	UNDCP - E/NL. 1968/64: Announcement TAI-NEI-WAI No. 294374 of 21 November 1968
		PROVISIONAL INCLUSION OF THE NEW SYNTHETIC DRUG BEZITRAMIDE IN THE LIST OF NARCOTIC DRUGS UNDER CONTROL
		A note has been received from the Secretary-General of the United Nations stating that according to the World Health Organization, the new synthetic drug Bezitramide should be added to Schedule I of the Single Convention on Narcotic Drugs, 1961, and enclosing the relevant communications from the World Health Organization and the Government of Belgium.
		In view of the particularly dangerous properties of the above-mentioned drug, it should be included provisionally in Table IV of the Administrative Rules of the Regulations for the Control of Narcotic Drugs, [
	www.unodc.org /unodc/pt/legal_library/cn/legal_library_1969-09-22_1968-64.html (271 words)

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