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Bicuculline - Wikipedia, the free encyclopedia The action of bicuculline is primarily on the ionotropic GABA Sensitivity to bicuculline is defined by IUPHAR as a major criterion in the definition of GABA A water soluble form of bicuculline, bicuculline methiodide, is soluble in water to a concentration of 10 mg/mL. en.wikipedia.org /wiki/Bicuculline   (242 words)

Spinal GABAA receptors do not mediate the sympathetic baroreceptor reflex in the rat -- Goodchild et al. 279 (1): 320 ... The effects of intrathecal bicuculline or strychnine on arterial pressure and expired CO were evaluated in 18 rats. A: the effect of bicuculline is to increase the amplitude of the phrenic bursts as well as to alter burst duration and interval. Stimulus-triggered averages (75 sweeps) of rectified splanchnic nerve activity are shown before bicuculline application, at the peak level of arterial pressure attained (28 min), and during the recovery phase (56 min). ajpregu.physiology.org /cgi/content/full/279/1/R320   (6149 words)

University of Iowa Anesthesia Publications Subcutaneous injection of 0.25 to 5.0% formalin in the plantar surface of one hindpaw of the rat produced a concentration-dependent increase in plasma extravasation as measured by the Evans Blue method. This dose of bicuculline also did not affect plasma extravasation induced by injection of 3% kaolin/3% carrageenan in the knee of the rat. bicuculline is not secondary to enhanced peripheral inflammation, but more likely reflects enhancement of nociceptive transmission in the spinal cord. www.anesth.uiowa.edu /readabstract.asp?PMID=0009622664   (133 words)

Neuronal migration disorders: Heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the ... In the presence of bicuculline (10 µM), the same stimulation evoked a graded burst of action potentials in the CA1 cell and an all-or-none paroxysmal depolarizing shift in the heterotopic cell (upper traces). When bicuculline was bath-applied, the same stimulation evoked an epileptiform discharge in the CA3 region, followed by an epileptiform discharge in the heterotopia and neocortex. When bicuculline is ejected locally in the heterotopia, the same stimulation evoked a discharge in the heterotopia and neocortex whereas the field EPSP recorded in the CA1 region was not altered (lower traces). www.pnas.org /cgi/content/full/95/17/10263   (3365 words)

APStracts 8:0128J, 2001.   (Site not responding. Last check: 2007-10-09) A GABAA receptor antagonist (bicuculline methiodide), glutamate and GABA were administered iontophoretically to these neurons while determining their receptive fields and thresholds. Bicuculline administration resulted in expansion of the receptive field in 60% of the 93 neurons with cutaneous fields. Bicuculline also changed the split fields of seven neurons into continuous fields by exposing a responsive region between the split fields. www.uth.tmc.edu /apstracts/2001/jn/May/128j.html   (427 words)

[No title] Bicuculline increased the frequency and reduced the amplitude of the PSPs in 8 neurons and changed the pattern of PSPs from regular to bursting in 4 neurons. Unlike bicuculline, strychnine did not affect significantly the membrane potential of the neurons tested but progressively decreased the amplitude of the regular PSPs before they were abolished without altering their frequency or inducing a bursting pattern of PSPs. When bicuculline did not affect baseline PSPs, an increase in their frequency in its presence could still be induced by either NA (30 µM, n = 3) or PE (10 µM, n = 2). hayar.net /na.html   (7837 words)

Effects of Pulsatile Infusion of the GABAA Receptor Blocker Bicuculline on the Onset of Puberty in Female Rhesus ... Effects of Pulsatile Infusion of the GABAA Receptor Blocker Bicuculline on the Onset of Puberty in Female Rhesus Monkeys -- Keen et al. Effects of Bicuculline on the onset of puberty in the female rhesus monkey A representative case of the effects of pulsatile bicuculline infusion on circulating LH (A), FSH (B), and estrogen and progesterone (C) in weekly serum samples. endo.endojournals.org /cgi/content/full/140/11/5257   (5610 words)

[No title]   (Site not responding. Last check: 2007-10-09) Seizures were induced by local injections of bicuculline (30 mM) in cortex and thalamus of barbiturate-anesthetized cats. Seizures were recorded as field potentials by means of an array of 8 tungsten electrodes (interelectrode distance of 1 mm) placed over the suprasylvian gyrus or in the thalamus spanning from the rostral pole of the reticular nucleus to the lateral geniculate nucleus. (2) Injection of bicuculline in the thalamus decreased spindling frequency in a dose-dependent manner and increased the synchrony of spike bursts from thalamocortical and thalamic reticular cells. www.cnl.salk.edu /~alain/abstracts/neuroscience_abstract_96_2.html   (294 words)

Reduced endogenous GABA-mediated inhibition in the PVN on renal nerve discharge in rats with heart failure -- Zhang et ... At the end of the experiment, the rat was killed and the brain was removed and fixed in formalin for at least 24 h. Responses to microinjection of bicuculline (0.05, 0.1, and 0.2 nmol) to the area of hypothalamus outside the PVN of sham-operated and HF rats (n = 5). Cardiovascular responses to bicuculline in the paraventricular nucleus of the rat. ajpregu.physiology.org /cgi/content/full/282/4/R1006   (5625 words)

Spinal Effects of Bicuculline: Modulation of an Allodynia-Like State by an A1-Receptor Agonist, Morphine, and an ... To conclude, bicuculline caused an increase in the of bicuculline and strychnine (the glycine receptor antagonist) After bicuculline there was an increased initial and final response of the cells compared with controls. jn.physiology.org /cgi/content/full/79/3/1494   (5612 words)

The effect of GABA receptor ligands in experimental spina bifida occulta | BMC Pharmacology, Volume 1 - Mirror @ Uni ... To test this hypothesis pregnant rats were exposed to either the GABA a agonist muscimol (1, 2 or 4 mg/kg), the GABA a antagonist bicuculline (.5, 1, or 2 mg/kg), the GABA b agonist baclofen (15, 30, 60 mg/kg), or the GABA b antagonist hydroxysaclofen (1, 3, or 5 mg/kg) during neural tube formation. Bicuculline methiodide IP at 0.5, 1 or 2 mg/kg (1 mg/cc). Bicuculline is a well-documented specific and potent GABAa antagonist [33]. bmc.ub.uni-potsdam.de /1471-2210-1-2/text.htm   (3136 words)

Bicuculline and Gabazine Are Allosteric Inhibitors of Channel Opening of the GABAA Receptor -- Ueno et al. 17 (2): 625 ... Bicuculline and Gabazine Are Allosteric Inhibitors of Channel Opening of the GABAA Receptor -- Ueno et al. Bicuculline and gabazine block responses to GABA, pentobarbital, and alphaxalone. Bicuculline clearly does not act as a competitive antagonist for pentobarbital: the maximal block was not complete when 1 www.jneurosci.org /cgi/content/full/17/2/625   (6545 words)

Electrophysiological evidence that noradrenergic neurons of the rat locus coeruleus are tonically inhibited by GABA ... Iontophoretic ejections of bicuculline during W, SWS and PS (30-200 nA, 20-570 sec) induced a progressive and sustained increase in the discharge rate of LC neurons without inducing a change in vigilance state. In conclusion, the effects of strychnine and bicuculline seem to indicate the existence of tonic glycinergic and GABA-ergic inputs to LC cells during W, SWS and PS. In contrast, in the same situation but after bicuculline administration, the increase of discharge rate of a given neuron was not statistically different between W and SWS. sommeil.univ-lyon1.fr /articles/luppi/books/lydic1999/contents.html   (7013 words)

Behavioral Consequences of Bicuculline Injection in the Subthalamic Nucleus and the Zona Incerta in Rat -- ... Three saline injections alternated with the bicuculline injections to ascertain that the behaviors observed after bicuculline injection were specific to the injection and were not caused by a possible long-term residual effect of the injection or habituation to the test environment. Bicuculline (fl bars) was injected in separate groups of rats into the STN or ZI at three concentrations. (1) Bicuculline microinjection provoked an increase in the neuronal activity of subthalamic neurons, initially leading to an increase in neuronal activity in the output structures of the basal ganglia, which is known to cause behavior suppression. www.jneurosci.org /cgi/content/full/22/19/8711   (5525 words)

Central GABAergic mechanisms are involved in apnea induced by SLN stimulation in piglets -- Abu-Shaweesh et al. 90 (4): ... Bicuculline attenuated the decrease in phrenic nerve amplitude in response to SLN stimulation (P < 0.01 between the 2 curves). Bicuculline attenuated the decrease in phrenic nerve frequency in response to SLN stimulation (P < 0.05 between the 2 curves). Bicuculline did not affect the inspiratory time response to SLN stimulation, whereas it attenuated the prolongation in expiratory time in response to SLN stimulation (P < 0.01 between the 2 curves). jap.physiology.org /cgi/content/full/90/4/1570   (3647 words)

Action of Methylmercury on GABAA Receptor-Mediated Inhibitory Synaptic Transmission Is Primarily Responsible for Its ... spikes were similar to those of bicuculline on population spikes. amplitudes in the presence or absence of bicuculline. Effects of 20 µM bicuculline and 100 µM MeHg on muscimol-evoked responses in a hippocampal pyramidal cell. jpet.aspetjournals.org /cgi/content/full/282/1/64   (6001 words)

Propagation dynamics of epileptiform activity acutely induced by bicuculline in the hippocampal-parahippocampal region ... Propagation dynamics of epileptiform activity acutely induced by bicuculline in the hippocampal-parahippocampal region of the isolated Guinea pig brain. PURPOSE: Aim of the study is to investigate the involvement of parahippocampal subregions in the generation and in the propagation of focal epileptiform discharges in an acute model of seizure generation in the temporal lobe induced by arterial application of bicuculline in the in vitro isolated guinea pig brain preparation. METHODS: Electrophysiological recordings were simultaneously performed with single electrodes and multichannel silicon probes in the entorhinal, perirhinal, and piriform cortices and in the area CA1 of the hippocampus of the in vitro isolated guinea pig brain. epilepsy.researchtoday.net /archive/3/1/1659.htm   (554 words)

APStracts 8:0274J, 2001.   (Site not responding. Last check: 2007-10-09) Specifically, we wished to test the hypothesis that motoneurons are postsynaptically inhibited following the microinjection of bicuculline into the NPO and determine whether the inhibitory mechanisms are the same as those that are utilized during naturally-occurring active (REM) sleep. The microinjection of bicuculline into the NPO resulted in a sustained reduction in the amplitude of the spinal cord Ia- monosynaptic reflex. The preceding changes in the electrophysiological properties of motoneurons, as well as the development of active sleep-specific IPSPs, indicate that lumbar motoneurons are postsynaptically inhibited following the intrapontine administration of bicuculline in a manner that is comparable to that which occurs spontaneously during the atonia of active sleep. www.uth.tmc.edu /apstracts/2001/jn/August/274j.html   (413 words)

Role of Spinal gamma -Aminobutyric AcidA Receptors in Formalin-Induced Nociception in the Rat -- Kaneko and Hammond 282 ... The 0.3-µg dose of bicuculline was administered to four rats in the absence of formalin to determine whether this dose by formalin is nearly twice as noxious in the presence of bicuculline. Yamamoto, T. and Yaksh, T. Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat. jpet.aspetjournals.org /cgi/content/full/282/2/928   (6782 words)

Behavioural disorders induced by external globus pallidus dysfunction in primates: I. Behavioural study -- Grabli et ... by microinjections of bicuculline in the sensorimotor territory After a microinjection of bicuculline (site 46) into the limbic territory of the GPe (A, right panel), the monkey's behaviour was confined to two dominant behaviours: licking and biting the fingers (stereotypy). Matsumura M, Tremblay L, Richard H, Filion M. Activity of pallidal neurons in the monkey during dyskinesia induced by injection of bicuculline in the external pallidum. brain.oxfordjournals.org /cgi/content/full/127/9/2039   (7823 words)

Rat gastroduodenal motility in vivo: interaction of GABA and VIP in control of spontaneous relaxations -- Krantis et ... bicuculline and the nerve toxin TTX, indicative of the involvement A typical example of the effect of bicuculline on VIP (6 µg/kg iv)-evoked relaxation of rat duodenum. Bicuculline was administered 30 min before the second injection of VIP. ajpgi.physiology.org /cgi/content/full/275/5/G897   (3233 words)

IngentaConnect GABA-site antagonism and pentobarbital actions do not depend on t...   (Site not responding. Last check: 2007-10-09) Bicuculline blocked pentobarbital-activated currents in a reversible and non-competitive manner with the α1β2γ2L, α4β2γ2L, and α5β2γ2L receptors, indicating an allosteric inhibition of the GABA-site. No significant difference of bicuculline potencies in inhibiting GABA- and pentobarbital-activated currents was found between the α1β2γ2L, α4β2γ2L and α5β2γ2L receptors. The potencies of bicuculline to inhibit pentobarbital-activated currents are identical with receptors containing α1, α4 or α5-subunit. www.ingentaconnect.com /content/bsc/aps/2006/00000187/00000004/art00006   (342 words)

UNC-CH CEHS: Genetic Susceptibility to Prenatal Neurotoxicants   (Site not responding. Last check: 2007-10-09) This hypothesis is based on: 1) evidence for vulnerability of developing GABA, serotonin (5-HT) and catecholamine neurons following exposure to organochlorine pesticides (e.g., dieldrin) that act as potent GABAA receptor antagonists; and 2) evidence for aberrant development of 5-HT neurons in mice with a targeted mutation in Dhcr7. The Specific Aims test the hypothesis that Dhcr7 mice will be more vulnerable to prenatal exposure to dieldrin or the GABAA receptor antagonist, bicuculline (positive control) than their wildtype counterparts. In Specific Aim 1, dose-dependent treatment effects will be evaluated in adult offspring using a behavioral test battery to screen effective doses of prenatal treatments and determine long-term effects of prenatal exposure on social and perseverative behaviors. cehs.sph.unc.edu /research/project5-03.htm   (309 words)

Agonist Trapping by GABAA Receptor Channels -- Bianchi and Macdonald 21 (23): 9083 -- Journal of Neuroscience Deactivation currents were inhibited during bicuculline wash (hatched bar) before the cell was lifted, and this deactivation current overlapped with that observed in the same cell after it was lifted. The onset of block was time-dependent (the separation of deactivation currents during control wash and bicuculline wash increased with time). B, To illustrate the time course of bicuculline inhibition, the traces were subtracted (middle) for comparison with the direct effect of bicuculline (left) in the same cell. www.jneurosci.org /cgi/content/full/21/23/9083   (5406 words)

Self-inhibition of olfactory bulb neurons - Nature Neuroscience   (Site not responding. Last check: 2007-10-09) We estimated the rise times of the depolarizations using the bicuculline-subtracted responses (traces in the presence of bicuculline subtracted from control), because the rise of the depolarizations was sometimes masked by the action potential (Fig. In the presence of bicuculline and TTX, inward currents were elicited during depolarizing voltage jumps; these currents are likely to be carried by voltage-dependent calcium channels. We subtracted the bicuculline or gabazine average trace from the control average trace. www.nature.com /uidfinder/10.1038/nn882   (5007 words)

Effect of Bicuculline on Thalamic Activity: A Direct Blockade of IAHP in Reticularis Neurons -- Debarbieux et al. 79 ... Effect of Bicuculline on Thalamic Activity: A Direct Blockade of IAHP in Reticularis Neurons -- Debarbieux et al. bicuculline methobromide, and picrotoxin (Sigma or Tocris); GABA Bicuculline (free base) was dissolved in dimethyl sulfoxide, jn.physiology.org /cgi/content/full/79/6/2911   (3903 words)

Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral ... After superfusion of bicuculline, the response to AA is increased, and the hyperpolarization is eliminated. (C) (Upper) Bicuculline (100 µM) superfused over the olfactory bulb (10 min) reduces the amplitude of the AP-evoked hyperpolarization in a mitral cell in vivo. Data are two traces superimposed to illustrate the reliability of the odor-evoked responses. www.pnas.org /cgi/content/full/98/1/319   (4512 words)

Asymmetric Cross-inhibition between GABAA and Glycine Receptors in Rat Spinal Dorsal Horn Neurons -- Li et al. 278 ... in the absence or presence of bicuculline (Bic). bicuculline, the sequential application of GABA and Gly induced a current with amplitude and kinetics similar to the current induced by GABA or Gly alone. Strychnine or bicuculline was pretreated for 30 s before simultaneous application with GABA or Gly. www.jbc.org /cgi/content/full/278/40/38637   (4577 words)

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