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Topic: Bile biology


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  Gallbladder and Biliary Tract: Biology of the Digestive System: Merck Manual Home Edition
Bile flows out of the liver through the right and left hepatic ducts (see Biology of the Liver and Gallbladder: Blood Supply of the Liver), which come together to form the common hepatic duct.
Bile salts are reabsorbed by the last portion of the small intestine, extracted by the liver, and resecreted into bile.
This recirculation of bile salts is known as the enterohepatic circulation.
www.merck.com /mmhe/sec09/ch118/ch118g.html   (371 words)

  
  Bile - Wikipedia, the free encyclopedia
Bile salts are steroid compounds (deoxycholic and cholic acid), often conjugated with glycine and taurine, and act to some extent as a detergent, helping to emulsify fats (increasing surface area to help enzyme action), and thus aid in their absorption in the small intestine.
Since bile increases the absorption of fats, it is an important part of the absorption of the fat-soluble vitamins: A, D, E, and K.
Yellow bile and fl bile were two of the four vital fluids or humours of ancient and medieval medicine; for example, melancholia was believed to be caused by a bodily surplus of fl bile.
en.wikipedia.org /wiki/Bile_(biology)   (376 words)

  
 bile acid synthesis, Primary Sclerosing Cholangitis Literature
Redinger RN 2003 Nuclear receptors in cholesterol catabolism: molecular biology of the enterohepatic circulation of bile salts and its role in cholesterol homeostasis.
Redinger RN 2003 The role of the enterohepatic circulation of bile salts and nuclear hormone receptors in the regulation of cholesterol homeostasis: bile salts as ligands for nuclear hormone receptors.
Walters JR 2000 Bile acids are physiological ligands for a nuclear receptor.
home.insightbb.com /~rhodesdavid/bileas.htm   (10232 words)

  
 Gallbladder - Wikipedia, the free encyclopedia
The gallbladder (or cholecyst) is a pear-shaped organ that stores bile (or "gall") until the body needs it for digestion.
The gallbladder is connected to the main bile duct through the gallbladder duct (cystic duct or, in Latin, ductus cysticus).
The gallbladder stores bile, which is released when food containing fat enters the digestive tract, stimulating the secretion of cholecystokinin (CCK).
en.wikipedia.org /wiki/Gallbladder   (533 words)

  
 * Bile - (Biology): Definition
Bile emulsifies fats, facilitating their breakdown into progressively smaller fat globules until they can be acted upon by lipases.
The bile produced in the liver is collected in bile capillaries which merge to form bile ducts.
The disease is characterized by a buildup of bile in the liver due to a deficiency or absence of normal bile ducts inside the liver and a narrowing of bile ducts outside the liver.
en.mimi.hu /biology/bile.html   (325 words)

  
 Correlation between bile duct obstruction and ductal cancer found
When bile duct cancer cells were placed in the liver of animals with bile duct obstruction, they grew more rapidly than identical cells placed in animals without bile duct obstruction.
Bile duct obstruction has long been known to be present in both malignant and nonmalignant liver disease (jaundice, for example), but before the study by Dr. Sirica and his colleagues the direct effect of such obstruction on bile duct cancer cell growth and aggressiveness had not been previously investigated.
First, they establish an important correlation between bile duct obstruction and bile duct cancer, suggesting growth regulatory mechanisms that could be highly significant in the progression of the cancer and that could become good molecular targets for drug therapy.
www.eurekalert.org /pub_releases/2007-04/foas-cbb041907.php   (483 words)

  
 Liver function tests - Wikipedia, the free encyclopedia
ALP is also present in bone and placental tissue, so it is higher in growing children (as their bones are being remodelled).
The liver is responsible for clearing this, excreting it out through bile into the instestine.
Problems with the liver or blockage of the drainage of bile will cause increased levels of bilirubin, as will increased haemolysis of red cells.
en.wikipedia.org /wiki/Liver_enzyme   (643 words)

  
 Bile isn't Vile: Identifying the Scent that Lures Trout Home
Trout are so sensitive to the odor of these bile acids that they can detect them at concentrations of less than a thimble-full in a billion gallons of water.
Bile acids might eventually be used to restore trout and salmon to areas where populations have dwindled or to increase the rates at which stocked salmonids return to selected spawning streams.
Since a variety of stream fish species release unique sets of bile acids in feces and urine, biologists are realizing that the way some species respond to odors may lead to new management strategies.
www.oar.noaa.gov /spotlite/archive/spot_fishbile.html   (511 words)

  
 Bile acids, receptor key in regenerating livers
Yellow bile and fl bile are half of the four humors that they believed made up the body, along with blood and phlegm.
He and colleagues at BCM identified an imbalance of bile, specifically bile acids, as a major signal for this process.
Bile acids are made in the liver and are the "detergents" of fat metabolism, said Moore.
www.eurekalert.org /pub_releases/2006-04/bcom-bar041206.php   (546 words)

  
 bile metabolism, Primary Sclerosing Cholangitis Literature
Kamisako T, Ogawa H 2005 Alteration of the expression of adenosine triphosphate-binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis.
Koopen NR, Wolters H, Havinga R, Vonk RJ, Jansen PL, Muller M, Kuipers F 1998 Impaired activity of the bile canalicular organic anion transporter (Mrp2/cmoat) is not the main cause of ethinylestradiol-induced cholestasis in the rat.
Meng LJ, Reyes H, Palma J, Hernandez I, Ribalta J, Sjovall J 1997 Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy.
home.insightbb.com /~rhodesdavid/bilemet.htm   (10955 words)

  
 ABC transporter, Primary Sclerosing Cholangitis Literature
Hui DY, Howles PN 2005 Molecular mechanisms of cholesterol absorption and transport in the intestine.
Kamisako T, Ogawa H 2005 Alteration of the expression of adenosine triphosphate-binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis.
Takikawa H 2002 Hepatobiliary transport of bile acids and organic anions.
www.psc-literature.org /ABCt.htm   (11208 words)

  
 BIOLOGY OF THE EIMERIIDAE
Members of this large, heterogeneous assemblage are united, not necessarily by their biology and/or life histories, but by the presence of a unique "apical complex," composed of polar rings, rhoptries, micronemes, often a conoid, and other subcellular organelles, but visualized only by use of an electron microscope.
Both mechanical (muscular contractions) and enzymatic digestive (trypsin, bile salts) processes of the upper gastrointestinal tract of the host make the sporocyst and oocyst walls more permeable; eventually, certain parts of each may be digested, or they may collapse or are broken, releasing their sporozoites (Fig.
Eimeria steidai undergoes develpment in epithelial cells of the bile duct and parenchymal cells of the liver of rabbits.
biology.unm.edu /biology/coccidia/eimeriabiol.html   (1868 words)

  
 [No title]
Fecal bile acid excretion was measured as described under "Experimental Procedures." Fecal bile acid excretion was significantly increased in the wild type mice by cholesterol (*, p = 0.0152) and cholestyramine (*, p < 0.0001) feeding.
Finally, continued efforts to elucidate both the transcriptional control and trafficking of bile acid transporters will no doubt lead to fundamental insights into important aspects of the cellular biology of the hepatocyte.
To test whether up-regulation of CAR represents a means of protection against bile acid toxicity to compensate for the loss of FXR and PXR, animals were pretreated with CAR activators, phenobarbital or 1,4-bis[2-(3,5-dichlorpyridyloxy)]benzene (TCPOBOP), followed by the CA diet.
www.lycos.com /info/bile--mice.html   (375 words)

  
 BiologyMad A-Level Biology
Bile is a greenish fluid synthesised by hepatocytes; secreted into the bile duct; stored in the gallbladder before being emptied into the duodenum.
Bile is both excretory and secretory – in addition to bile salts, it contains cholesterol, phospholipids, and bilirubin (from the breakdown of haemoglobin).
Bile salts act as "detergents" that aid in the digestion and absorption of dietary fats.
www.biologymad.com /Kidneys/Kidneys.htm   (2560 words)

  
 Extrahepatic bile duct cancer
Cancer arising in the extrahepatic bile duct is an uncommon disease, curable by surgery in fewer than 10% of all cases.[1] Prognosis depends in part on the tumor's anatomic location, which affects its resectability.
They represent a very small minority of cases of bile duct cancer and usually are those with a lesion of the distal common bile duct where 5-year survival rate of 25% may be achieved.
Cures are not often achieved in these patients, in contrast to patients with tumors arising in the distal bile duct, for whom a 5-year survival may be achieved in as many as 25% of patients.
www.meds.com /pdq/bileduct_pro.html   (1418 words)

  
 Meningar.com om bile. Bile, acids, duct mm.
Secretion of Bile and the Role of Bile Acids In Digestion Digestion Index Glossary Secretion of Bile and the Role of Bile Acids In Digestion Bile is a complex fluid containing water, electrolytes and a battery of organic molecules including bile acids, c..
bile ducts Passages external to the liver for the conveyance of bile...
Their amphipathic nature enables bile acids to carry out two important functions: Emulsification of lipid aggregates: Bile acids have detergent action on particles of dietary fat which causes fat globules to break down or be emulsified into minute, micro..
www.meningar.com /bile.html   (1550 words)

  
 BioMed Central | Full text | Expression and subcellular localization of aquaporin water channels in the polarized ...
Bile secretion involves the movement of water across hepatocyte plasma membrane domains in response to transient osmotic gradients generated by active solute transport into the canalicular space of bile acids, glutathione and bicarbonate [1].
Hepatocyte bile secretion is formed by passive movement of water from plasma to the bile canaliculus in response to osmotic gradients established by the active secretion of solutes.
Rat liver Bsep is responsible for the biliary excretion of bile acids and therefore is key to the elaboration of canalicular bile [2].
www.biomedcentral.com /1472-6793/5/13   (4235 words)

  
 Bile Acid Regulation of Hepatic Physiology: III. Bile acids and nuclear receptors -- Chiang 284 (3): 349 -- AJP - ...
Bile acid and cholesterol synthesis and transport and nuclear receptor regulation of bile acid and cholesterol homeostasis in liver, intestine, and peripheral tissues.
In the liver, cholesterol is converted to bile acids by a pathway consisting of a cascade of 15 reactions (4).
Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7
ajpgi.physiology.org /cgi/content/full/284/3/G349   (4382 words)

  
 Bile Acid Biology and its Therapeutic Implications : Proceedings of the Falk Symposium 141 (XVIII Internationale Bile ...   (Site not responding. Last check: 2007-10-09)
Bile Acid Biology and its Therapeutic Implications : Proceedings of the Falk Symposium 141 (XVIII Internationale Bile Acid Meeting) held in Stockholm, Sweden, June 18 - 19, 2004 (Falk Symposium)
The 17 International Bile Acid Meetings in the past have been a great stimulus for new ideas and methods as well as the development of therapeutic applications of bile acids.
A new chapter of bile acid research was opened by the finding that bile acids are ligands of nuclear receptors which regulate synthesis, metabolism and transport of bile acids and steroids.
cadgate.com /book/un/1402028938   (339 words)

  
 NEOUCOM | Northeastern Ohio Universities College of Medicine
Bile acids are physiological detergents that facilitate absorption, transport, distribution and disposal of steroids, nutrients, vitamins, metabolites and xenobiotics.
Bile acids also are signaling molecules that activate a nuclear receptor FXR to regulate lipid and glucose homeostasis.
Bile acids, insulin, glucagon and inflammatory cytokine inhibit CYP7A1 and CYP8B1 in the liver.
www.neoucom.edu /audience/about/departments/MicroImmunoBiochem/MicroFaculty/JohnChiang   (1193 words)

  
 ScienceDaily: Feedback Loop Found That Could Forestall Liver Disease
Steven Kliewer (right), professor of molecular biology and pharmacology, Takeshi Inagaki, postdoctoral research fellow in molecular biology, and other UT Southwestern researchers have found that the small intestine communi-cates with the liver to control bile-acid production - a dis-covery with medical impli-cations in treating people at risk for certain types of liver disease.
The central elements in the research are the body's bile acids - powerful and essential detergents that help digest fatty foods and fat-soluble vitamins in the small intestine.
The liver makes bile acids out of cholesterol and sends them to the gallbladder, where they're stored until food is digested.
www.sciencedaily.com /releases/2005/11/051108084101.htm   (895 words)

  
 Bile salt biotransformations by human intestinal bacteria -- Ridlon et al. 47 (2): 241 -- Journal of Lipid Research
Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis.
Bile salt deconjugation by Lactobacillus plantarum 80 and its implication for bacterial toxicity.
Lactobacilli and bile salt hydrolysis in the murine intestinal tract.
www.jlr.org /cgi/content/full/47/2/241   (5944 words)

  
 Bile - definition from Biology-Online.org
bile salts aid in the digestion of fats.
bile passes out of the liver via the bile duct where it is stored in the gallbladder and released in response to a fat-containing meal.
bile is secreted from the liver, with this process being promoted by the hormone [[secretin.
www.biology-online.org /dictionary/Bile   (216 words)

  
 IBS Newsletter
Parasites are also one of the biggest threats to livestock in the UK and the rest of the world with drug resistance becoming a key problem, and unfortunately, only one vaccine is commercially available.
This is an area of biology known as proteomics, and Dr Jo Hamilton of the Parasitology group is currently developing this technology at Aberystwyth.
At Aberystwyth research interests in ecological parasitology focus on the ecological consequences of host behaviour change, the parasite fauna of introduced species, modelling transmission in natural populations and identifying the molecular mechanisms of behaviour change via proteomic approaches.
www.aber.ac.uk /biology/newsletter/bile.html   (950 words)

  
 Intestinal bile acid transport: biology, physiology, and pathophysiology.   (Site not responding. Last check: 2007-10-09)
Intestinal bile acid transport: biology, physiology, and pathophysiology.
Intestinal bile acid transport: biology, physiology, and pathophysiology.Intestinal reabsorption of bile salts plays a crucial role in human health and disease.
The bile acid responsiveness of the ASBT gene is not clear and may be dependent on both the experimental model used and the species being investigated.
www.pdg.cnb.uam.es /UniPub/iHOP/gp/8981628.html   (198 words)

  
 In Vitro Cell. Dev. Biol.--Animal 34:785–798, November-December 1998   (Site not responding. Last check: 2007-10-09)
STO feeder cell-dependent secondary cultures of adult pig bile duct cells were established from primary cultures of adult pig liver cells.
In contrast, adult pig bile duct cells replicated and were carried for 4-8 passages in secondary culture.
The bile duct cells spontaneously adopted a multicellular ductal morphology after 7-10 d in static culture which was similar to that found in in vivo pig liver.
www.sivb.org /animal_archives/abstracts/aa34-785.htm   (314 words)

  
 Stimulation of Bile Duct Epithelial Secretion by Glybenclamide in Normal and Cholestatic Rat Liver -- Nathanson et al. ...   (Site not responding. Last check: 2007-10-09)
Cholestatic disorders often are the result of dysfunction of bile duct cells, the epithelia that line the biliary tree (6).
Canalicular bile secretion by the couplets was determined by serial measurement of the cross-sectional area of this space over time (13, 14).
Cyclic AMP was measured by radioimmunoassay in freshly isolated bile duct cells that were unstimulated (controls) or stimulated with either 100 µM glybenclamide, 100 nM secretin, or 100 µM forskolin.
www.jci.org /cgi/content/full/101/12/2665   (5535 words)

  
 Does loss of bile acid homeostasis make mice melancholy? -- Moore 110 (8): 1067 -- Journal of Clinical Investigation   (Site not responding. Last check: 2007-10-09)
Bile is at the center of the traditional medicines of many cultures.
to be the bile acid–dependent induction of expression
Bile acids: natural ligands for an orphan nuclear receptor.
www.jci.org /cgi/content/full/110/8/1067   (1368 words)

  
 Bile (biology) Encyclopedia Article, Definition, History, Biography   (Site not responding. Last check: 2007-10-09)
Looking For bile biology - Find bile biology and more at Lycos Search.
Look for bile biology - Find bile biology at one of the best sites the Internet has to offer!
Search for bile biology - Find results for bile biology and anything else you are looking for instantly!
www.karr.net /search/encyclopedia/Bile_%28biology%29   (551 words)

  
 Kenneth D. Setchell, PhD, Cincinnati Children's Hospital Medical Center
His parallel research discoveries of the first mammalian lignans later led to the discovery of soy isoflavones in humans, their association with soy intake, and established his research in the area of bioactive plant constituents and human nutrition and disease.
Setchell and his group were the first to identify lignans and isoflavones in human urine and blood and his studies went on to show that flaxseed and soy protein are the richest dietary sources of these two classes of bioactive ingredients.
The discovery of six genetic defects in pathway for bile acid synthesis from cholesterol and which are manifest as progressive neonatal cholestasis.
www.cincinnatichildrens.org /svc/find-professional/s/kenneth-setchell.htm   (1342 words)

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