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Bile Acid Sequestrants, medications to lower cholesterol on MedicineNet.com Bile acid sequestrants such as cholestyramine (Questran), colestipol (Colestid), and colesevelam (Welchol) are medications for lowering LDL cholesterol. Bile acid sequestrants bind bile acids in the intestine and cause more of the bile acids to be excreted in the stool. Therefore, bile acid sequestrants used alone are not as effective as statins in lowering LDL cholesterol. www.medicinenet.com /bile_acid_sequestrants/article.htm   (524 words)

Bile - Wikipedia, the free encyclopedia salts are steroid compounds (deoxycholic and cholic acid), often conjugated with glycine and taurine, and act to some extent as a detergent, helping to emulsify fats (increasing surface area to help enzyme action), and thus aid in their absorption in the small intestine. Since bile increases the absorption of fats, it is an important part of the absorption of the fat-soluble vitamins: A, D, E, and K. Yellow bile and fl bile were two of the four vital fluids or humours of ancient and medieval medicine; for example, melancholia was believed to be caused by a bodily surplus of fl bile. en.wikipedia.org /wiki/Bile_salts   (375 words)

Reference.com/Encyclopedia/Bile acid sequestrant The bile acid sequestrants are a group of medications used for binding certain components of bile in the gastrointestinal tract. Thus, bile acid sequestrants, along with any bile acids bound to the drug, are excreted via the feces after passage through the gastrointestinal tract. Hence, bile acid sequenstrants may be used for the prevention of pruritus in patients with chronic liver disease. www.reference.com /browse/wiki/Bile_acid_sequestrant   (555 words)

Pharmaceutical composition containing bile acid sequestrant enclosed in a size-exclusion membrane - Patent 5091175 The bile acid sequestrant resins interrupt the bile acid cycle by binding to the bile acids and thereby increasing the amount of bile acids excreted in the feces. Although the efficacy of bile acid sequestrant resins, and particularly cholestyramine, is well known, administration of the resin is unpleasant because the resin is not palatable and must be taken in relatively high doses of 4 to 24 grams per day. Accordingly, one embodiment of the present invention is a composition which comprises a bile acid sequestrant resin maintained in a nondegradable membrane wherein the membrane enables bile acids from the digestive tract to bind to the sequestrant resin while it prevents substances having a higher molecular weight than bile acids from contacting the resin. www.freepatentsonline.com /5091175.html   (4291 words)

VI. Drug Therapy -- 106 (25): 3303 -- Circulation   (Site not responding. Last check: ) are a bile acid sequestrant or nicotinic acid. statins, bile acid sequestrants, fibrates, and nicotinic acid. to increase the lithogenicity of bile, increasing the likelihood circ.ahajournals.org /cgi/content/full/106/25/3303   (8190 words)

CIGNA - Bile acid sequestrants for high cholesterol Sequestrants bind to bile acids in the intestine and prevent them from being reabsorbed into the blood. Because the body needs cholesterol to make bile, the liver uses up the cholesterol in the blood, which reduces the amount of LDL cholesterol circulating in the blood. Bile acid sequestrants may interfere with the absorption of other drugs and vitamins. www.cigna.com /healthinfo/hw114997.html   (508 words)

Bile Acid Sequestrant Drugs - Swedish Medical Center, Seattle, Washington The bile acid sequestrant drugs are among the earliest class of medications used to lower cholesterol. Bile acid sequestrants have been reported to impair the absorption of numerous nutrients, including calcium, folate, iron, vitamin A, vitamin B Although the bile acid sequestrant used in the studies interfered with the absorption of the other nutrients, their levels remained in the normal range. www.swedish.org /111895.cfm   (287 words)

Method of reducing gastrointestinal side effects associated with orlistat treatment - Patent 6756364 Bile acids are synthesized in the liver and enter the bile as glycine and taurine conjugates. Bile acid sequestrants and methods for their preparation have been described for example in International Patent Applications WO 95/34585 (Geltex Pharmaceuticals, Inc.; relating to polyamine salt hydrophobic sequestrants), WO94/27620 (Geltex Pharmaceuticals, Inc.; relating to the preparation of polymeric sequestrants for bile acids), and WO94/04596 (DuPont; relating to crosslinked polymeric ammonium salts). The amount of bile acid sequestrant to be administered will depend on a number of factors including the age of the patient, the severity of the condition and the past medical history of the patient and lies within the discretion of the administering physician. www.freepatentsonline.com /6756364.html   (5380 words)

NHLBI-CHD Cholesterol Lowering Medicines   (Site not responding. Last check: ) Bile acid sequestrants bind with cholesterol-containing bile acids in the intestines and are then eliminated in the stool. Bile acid sequestrants are sometimes prescribed with a statin to increase cholesterol reduction. Bile acid sequestrant powders must be mixed with water or fruit juice and taken once or twice (rarely three times) daily with meals. www.nhlbisupport.com /chd1/meds2.htm   (253 words)

Bile Acid Sequestrants   (Site not responding. Last check: ) Cholestyramine (Questran®) and colestipol (Colestid®) are bile acid sequestrants—a class of drugs that binds bile acids, prevents their reabsorption from the digestive system, and reduces cholesterol levels. Bile acids are produced in the liver from cholesterol and secreted into the small intestine to help with the absorption of dietary fat and cholesterol. Bile acid sequestrants bind bile acids in the small intestine and carry them out of the body. www.dillons.com /hn/Drug/Bile_Acid_Sequestrants.htm   (555 words)

Bile acid sequestrants for high cholesterol Sequestrants bind to bile acids in the intestine and prevent them from being reabsorbed into the blood. Bile acid sequestrants are considered safe for long-term use. Bile acid sequestrants may interfere with the absorption of other drugs and vitamins. hw.healthdialog.com /kbase/topic/detail/drug/hw114997/detail.htm   (455 words)

Lipids Online Slides: bile acid resins, bile acid sequestrants, efficacy Bile acid sequestrants (resins) were among the first lipid-altering drugs to show an ability to reduce the risk for CHD. Colesevelam is a unique bile acid sequestrant polymer that has been shown to have favorable lipid effects, better tolerability, and fewer potential drug interactions than other bile acid sequestrants. Bile acid resins bind bile acids in the intestine, which reduces the enterohepatic recirculation of bile acids. www.lipidsonline.org /slides/slide01.cfm?q=bile+acid+resins   (1493 words)

[Frontiers in Bioscience 3, d176-193, February 15, 1998]   (Site not responding. Last check: ) Bile acid biosynthesis via acidic pathway is initiated by mitochondrial sterol 27-hydroxylase (CYP27) toconvert cholesterol to 27-hydroxycholesterol and 3beta-hydroxy-5-cholestenoic acid (figure 1). Both 27-hydroxycholesterol and 3beta-hydroxy-5-cholestenoic acid are 7alpha-hydroxylated by enzyme activity in human liver microsomes, whereas 3beta-hydroxy-5-cholestenoic acid is 7alpha-hydroxylated in human liver mitochondria to 3beta, 7alpha-dihydroxy-5-cholestenoic acid (14, 15). Recent observation that both cholic acid and chenodeoxycholic acid can be formed when cholesterol 7alpha-hydroxylase is inhibited in rat hepatocytes provided a suggestive evidence that a pathway may also hydroxylate intermediates at 12alpha position to produce cholic acid via the acidic pathway (8). bioscience.igh.cnrs.fr /1998/v3/d/chiang/3.htm   (1127 words)

NOW Foods - Colestipol Colestipol is a bile acid sequestrant (prevents absorption of bile acids in the digestive system). Bile acids may facilitate the absorption of cholesterol. Bile acid sequestrants should be taken with plenty of water before meals. www.nowfoods.com /?action=itemdetail&item_id=5226   (561 words)

High Cholesterol Bile acid sequestrants are sometimes prescribed with a statin to enhance cholesterol reduction. Bile acid sequestrant powders must be mixed with water or fruit juice and must be taken once or twice (rarely, 3 times) daily with meals. The bile acid sequestrants are not prescribed as the sole medicine to lower your cholesterol if you have high triglycerides or a history of severe constipation. www.webmd.com /cholesterol-management/compare-statin-drugs   (1931 words)

Colestipol Bile acid sequestrants are the most difficult of these agents to administer concomitantly, because their nonspecific binding results in decreased bioavailability of a number of other drugs, including thiazide diuretics, digitalis preparations, beta-blockers, coumarin anticoagulants, thyroid hormones, fibric acid derivatives and certain oral antihyperglycaemia agents. It is suggested that STC level changes are related to alterations in the absorption of carotenoids during bile acid sequestrant administration. This strategy might make bile acid sequestrants, which are seldom used because they cause adverse effects such as bloating and constipation, more tolerable and less expensive. home.caregroup.org /clinical/altmed/interactions/Drugs/Colestipol.htm   (2807 words)

Bile Acid Sequestrants Cholestyramine (Questran®) and colestipol (Colestid®) are bile acid sequestrants—a class of drugs that binds bile acids, prevents their reabsorption from the digestive system, and reduces cholesterol levels. Bile acids are produced in the liver from cholesterol and secreted into the small intestine to help with the absorption of dietary fat and cholesterol. This causes the body to use more cholesterol to make more bile acids, which are secreted into the small intestine, bound to bile acid sequestrants, and carried out of the body. www.pccnaturalmarkets.com /health/Drug/Bile_Acid_Sequestrants.htm   (567 words)

Cholesterol-Lowering Drugs Another class of drugs for lowering LDL is the bile acid sequestrants — colesevelam, cholestyramine and colestipol — and nicotinic acid (niacin). Nicotinic acid is preferred in patients with triglyceride levels that exceed 250 mg/dL because bile acid sequestrants tend to raise triglyceride levels. For patients with severe hypercholesterolemia, combining a bile acid sequestrant with either nicotinic acid or lovastatin has the potential to markedly lower LDL cholesterol. www.americanheart.org /presenter.jhtml?identifier=4510   (650 words)

Comparative Cost-Effectiveness of Bile Acid Sequestering Resins, HMG Co-A Reductase Inhibitors, and Their Combination ... To determine the cost-effectiveness of bile acid sequestrants (resins) alone, HMG Co-A reductase inhibitors alone, and a combination of a resin with an HMG Co-A reductase inhibitor in patients with hypercholesterolemia. Patients were treated with a bile acid sequestrant alone, an HMG Co-A reductase inhibitor alone, or a combination of both drugs to achieve an LDL-C of less than 130 mg/dL. Patients were followed for 12 months after initiation of therapy with a bile acid sequestering resin alone, an HMG Co-A reductase inhibitor alone, or a combination of a bile acid sequestering resin and an HMG Co-A reductase inhibitor. www.amcp.org /data/jmcp/vol1/num3/comparative.html   (2871 words)

Addition Of A Bile Acid Sequestrant (WelChol, Colesevelam HCl) To Statin Therapy Significantly Reduces Median Hs-CRP ... This is the first data to demonstrate that WelChol, a bile acid sequestrant (BAS), when added to statin therapy, reduces hs-CRP levels, which is a marker for inflammation and also a strong predictor of coronary heart disease (CHD) events(1, 2). "Bile acid sequestrants were one of the first approved cholesterol- lowering drugs, having been studied in the 1970s, before hs-CRP was routinely measured," said lead study investigator Harold E. Bays, MD, FACP, Louisville Metabolic and Atherosclerosis Research Center Inc., Louisville, KY. Because WelChol is engineered for affinity, specificity and high capacity bile acid binding, it may have a lower potential for drug-drug interaction. www.medicalnewstoday.com /medicalnews.php?newsid=41805   (1458 words)

Bile Acid Sequestrant Drugs The bile acid sequestrant drugs are among the earliest class of medications used to lower cholesterol. Bile acid sequestrants have been reported to impair the absorption of numerous nutrients, including calcium, folate, iron, vitamin A, vitamin B 12, and vitamin E. Although the bile acid sequestrant used in the studies interfered with the absorption of the other nutrients, their levels remained in the normal range. www.upmc.com /HealthManagement/ManagingYourHealth/HealthReference/Diseases/InBrief/?chunkiid=21493   (272 words)

Colestipol Colestipol is a bile acid sequestrant (prevents absorption of bile acids in the digestive system). Bile acids may facilitate the absorption of cholesterol. zinc may be depleted by taking cholestyramine, another bile acid sequestrant. www.cncahealth.com /health-notes.htm?org=cnca&ContentID=1125006   (530 words)

Lipids Online Slides: bile acid sequestrants, combination therapy Statins are currently the most prescribed lipid-altering drugs because of their efficacy in favorably altering blood lipid levels, safety and tolerability, and proven benefits on reducing atherosclerotic CHD events. The bile acid–binding resins can achieve additional LDL cholesterol lowering when used with a statin, although GI side effects of the older resins may be particularly problematic in patients with diabetes. Newer, more potent bile acid sequestrants, such as colesevalem, may increase their efficacy in the diabetic population. www.lipidsonline.org /slides/slide01.cfm?q=bile+acid+sequestrants&pg=2   (1190 words)

Cholesterol-Lowering Drugs The first medication of this class, ezetimibe (Zetia®), was approved in 2002 for the treatment of high cholesterol and certain inherited lipid abnormalities. Your body uses cholesterol to make bile, an acid used in the digestive process. These medicines bind to bile, so it can't be used during digestion. www.americanheart.org /presenter.jhtml?identifier=163   (606 words)

Bile acid sequestrants for high cholesterol - [Medication] Since the body needs cholesterol to make bile, the liver uses up the cholesterol in the blood, which reduces the amount of LDL cholesterol circulating in the blood. Some of these medicines are a powder that you mix with water, fruit juice, or milk (mixing them with carbonated beverages causes belching). For people who have very high cholesterol levels (over 240 mg/dL or 6.21 mmol/L), these drugs also may be prescribed in combination with medicines called statins. www.peacehealth.org /kbase/topic/detail/drug/hw114997/detail.htm   (452 words)

NMR characterization of a novel bile acid sequestrant, DMP 504 DMP 504, a potential bile acid sequestrant for the treatment of hypercholesterolemia, is a highly insoluble, cross-linked polymer which does not lend itself to ordinary means of characterization used for drug substances in the pharmaceutical industry. The primary motivation for determining the structure of the polymer chain is to relate the DMP 504 structure to its performance properties as a bile acid sequestrant. Characterization of the polymer chain and understanding of the structural basis of its properties is essential in optimizing and controlling the manufacture of reproducible drug substance. www.aapspharmaceutica.com /search/view.asp?ID=26766   (276 words)

Business Website Bile Acid Sequestrants lower LDL (bad lipid) up to 20% - at maximum doses. Omacor® is a prescription medication that consists of a high concentration of highly purified omega-3 fatty acid ethyl esters. These are predominantly ethyl esters of eicosapentaenoic acid (EPA) 460 mg and docosahexaenoic acid (DHA) 380 mg. www.lipid-clinic.com /medicines.html   (572 words)

Familial hypercholesterolemia - Wikpedia   (Site not responding. Last check: ) In case statins are not effective, either a drug from the fibrate or bile acid sequestrant class can be added, as well as nicotinic acid/acipimox. In this case, high amounts of bile acid sequestrants are often given; occasionally high-dosed statins can help express a dysfunctional (but working) LDL receptor. Other treatments used are LDL apheresis (clearing LDL by blood filtration, similar to dialysis) and - as a last resort - a liver transplant. www.bostoncoop.net /~tpryor/wiki/index.php?title=Familial_hypercholesterolemia   (666 words)

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