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Topic: Bioassay

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	Bioassay
		Bioassay is a method for the quantitative estimation of the effects that result in a biological system after its exposure to a substance.
		Bioassays allow for a quantitative measurement of the effect of a substance on a biological system.
		Bioassays are most frequently used when there are a number of steps, usually poorly understood, between the substance exposure and the behaviour observed, or when the substance is a complex mixture of materials and it is not clear what the active components are.
	www.iscid.org /encyclopedia/Bioassay (234 words)

	Radiation Safety Training - Idaho State University
		The bioassay interval for a particular radionuclide is determined by its physical and metabolic characteristics, and by the instrumentation used for the measurement.
		A bioassay is required within the normal bioassay interval for each individual who was present in an area during a time when removable contamination exceeding 10 RCL was present on any readily accessible surface.
		Routine bioassays may be waived at the discretion of the RSO if the records of contamination surveys of both the user and the RSO verify that there was no exposure to unconfined radioactive materials exceeding the levels specified above and no incidents of personal contamination since the last bioassay.
	www.physics.isu.edu /health-physics/tso/rad_training/radbioassay.html (912 words)

	S90.70_Bioassays.htm
		Bioassays permit the estimation of the radiation dose to the body from the concentration of internally-deposited radionuclides.
		A bioassay is required for an individual involved in a radiation incident in which radioactive iodine may have entered the body or been internally deposited.
		Either radiochemical bioassay of urine or in vivo counting is acceptable for estimating internal radioactivity burdens or intakes.
	www.wsu.edu /manuals_forms/HTML/SPPM/S90_Radiation_Safety/S90.70_Bioassays.htm (2385 words)

	[No title] (Site not responding. Last check: 2007-10-20)
		A bioassay is a technique for determining if herbicide (or other chemical) residues are present in soil or water at high enough concentrations to adversely affect plant growth.
		However, scientists sometimes use sensitive bioassays to estimate herbicide concentrations in soil and water, and to identify unknown herbicide residues from the symptoms of injury.
		A bioassay is a simple, inexpensive, and accurate way to determine if herbicide residues are present at high enough concentrations to affect seedling emergence or plant growth.
	www.hort.cornell.edu /weston/weedfacts/wdfct3.html (781 words)

	BioAssay Works home page, colloidal gold, gold sols, sol
		With the authority of a miner who already knows the lay of the land, BioAssay chemists develop gold sols and assays that are essential to the integrity of their clients' research and diagnostic efforts.
		BioAssay Works' highly concentrated 12 to 50 OD Naked gold nanoparticles are produced by a proprietary process that does not involve the traditional boiling and centrifugation methods.
		BioAssay Works offers kits to quickly determine (in less than one hour) the optimal colloidal gold binding conditions for attaching soluble proteins, and the Fc portion of purified monoclonal and polyclonal antibodies.
	www.bioassayworks.com (765 words)

	Fluoride's link to bone and joint cancers
		The cancer bioassay of fluoride, the broader scientific literature on fluoride as well as that of the ad hoc PHS panel that was convened because of the cancer concern generated by unofficial reports that NaF was a carcinogen.
		In assessing the NTP NaF cancer bioassay it is essential that one understand what such bioassays are, what their goals are, how they should be interpreted and what relevance they have to humans.
		Mice and rats in embryonic, fetal and neonatal stages are not exposed in NTP bioassays.
	www.fluoridation.com /cancer2.htm (2812 words)

	Easy-To-Use Bioassay Spots Varroa Resistance
		Entomologist Jeffery S. Pettis and colleagues at ARS's Bee Research Laboratory, in Beltsville, Maryland, devised a do-it-yourself bioassay that determines, within 6 hours, whether a hive's mite population is fully resistant, approaching resistance, or still vulnerable to chemical treatment.
		Pettis based the bioassay on one that he and ARS entomologists Mark F. Feldlaufer and Hachiro Shimanuki (now retired) designed in 1998 to detect mites resistant to fluvalinate, another compound used to control mite infestations.
		Pettis verified the bioassay's reliability at commercial apiaries in Maine and Florida and on hives at ARS's Beltsville bee lab.
	www.ars.usda.gov /is/AR/archive/apr05/varroa0405.htm (591 words)

	Bioassay Development and Validation - By Dr.david Lansky, USA
		Substantial time will be devoted to basic statistical concepts and their relevancy to the practical limitations of bioassays, particularly when performed in 96 well cell culture plates.
		The course develops tools for bioassay development and enables participants to place bioassay validation in the larger context of bioassay development.
		Validation of bioassays will also be addressed in detail in the context of satisfying both USP 28 <111> and <1225>.
	www.forumsci.co.il /newsletters/Bioassay-Lansky.htm (418 words)

	Auxins Bioassay FAQ
		That isnt to say that bioassays should be long winded and filled with an excess of details, but rather that a good bioassay should clearly outline all relevant aspects of the experience.
		Because you want your bioassays to be understandable to the common person, rather than just doctors, your terminology should be sufficient to clearly define the individual effects noted durring your bioassay but should be free of excessively complex medical terms.
		In the bioassays you write such terms should be avoided to maintain their usefulness for the masses.
	www.shaman-australis.com /~auxin/bioassay.html (1591 words)

	Brine shrimp "bioassay" problems
		The term bioassay is both misdefined and misapplied, and the wide scattering of the data suggest that the method may be inaccurate.
		There are several phytohormone bioassays that have been used in teaching including the lettuce hypocotyl elongation bioassay for gibberellins (Reiss 1994), the oat coleoptile curvature test for auxins, the dandelion leaf disk chlorophyll retention bioassay for gibberellins and the soybean callus bioassay for cytokinins (Witham et al.
		A bioassay quantifies the amount of a chemical, such as auxin, by using a living organism or living tissue as a substitute for an analytical technique or analytical instrument, such as a high performance liquid chromatograph.
	www.fortunecity.com /greenfield/clearstreets/84/brine.htm (622 words)

	ToxiLight Non-Destructive Cytotoxicity BioAssay Kit from Cambrex is a bioluminescent, non-destructive cytolysis assay ...
		BioAssay Kit is a bioluminescent, non-destructive cytolysis assay kit designed to measure the release of the enzyme, adenylate kinase (AK), from damaged cells.
		Because the ToxiLight BioAssay Kit exploits the fact that AK is released from cells when they die, there is no need for cell lysis (unlike many other cytotoxicity assays).
		The ToxiLight BioAssay Kit also facilitates high content screening by allowing other tests to be performed on the original cells For example, the ToxiLight BioAssay Kit is fully compatible with the ReportaLight BioAssay Kit, thus facilitating measurement of cytotoxicity and gene expression in the same sample.
	www.lonzabioscience.com /Lonza_Catnav.oid.690.prodoid.LT0717 (626 words)

	ARS \| Publication request: Comparison of a Bioassay and a Liquid Chromatography - Fluorescence-Mass Spectrometry(n) ...
		All samples determined to be above tolerance levels by the instrumental method were similarly determined to be above tolerance by the bioassay, illustrating the utility of the bioassay as a screening method.
		Both methods were able to detect enrofloxacin at and below the tolerance level in the tissues, with limits of detection of 26 ppb (bioassay) and 0.1 ppb for enrofloxacin and 0.5 ppb for the enrofloxacin metabolite ciprofloxacin (liquid chromatography-fluorescence-mass spectrometry(n)).
		These results support the use of this bioassay as a screening method for examining large numbers of samples for regulatory monitoring.
	www.ars.usda.gov /research/publications/publications.htm?seq_no_115=155318 (495 words)

	Bioassay Development
		Bioassay development and validation are visible components of a product’s path to market.
		The process of designing, optimizing, validating and implementing your bioassay should be a transparent part of the biologic development cycle that fast-tracks your commercial objectives—not a bottleneck brought about by imprecise science or regulatory inexperience.
		And once development and validation are completed, we can transfer your bioassay to your site or continue to run it in our facilities.
	www.bioresearchonline.com /Content/ProductShowcase/product.asp?DocID={AD93A0C5-5923-401E-B85C-D8E8978D18DD}&VNETCOOKIE=NO (135 words)

	BioAssay Works FAQ
		BioAssay Works was organized for the purpose of creating the "Magic Gold" used in ultra-sensitive diagnostic tests.
		BioAssay Works uses proprietary methods to create gold sols with a 10- to 15-fold increase in gold particle concentration over existing technology.
		BioAssay Works' highly concentrated 12 to 50 OD Naked gold is produced by a proprietary process that does not involve the traditional boiling and centrifugation methods.
	www.bioassayworks.com /faq.html (2083 words)

	PubChem Help
		In the BioAssay summary, you may view a histogram for distribution of one assay readout and scatter plot for relationships between two assay readouts.
		You may view a histogram for distribution of one bioassay readout and scatter plot for relationships between the two bioassay readouts from different assays.
		BioAssays can be clustered based on the activity of the selected compounds in these BioAssays, or the sequence similarity of the BioAssay targets, which are the proteins interacting with the compounds in the BioAssays.
	pubchem.ncbi.nlm.nih.gov /help.html (9393 words)

	Oilfield Glossary: Term 'bioassay'
		Bioassay tests of drilling fluids are required by governmental agencies throughout the world prior to discharge of mud or cuttings.
		The organisms used in bioassays are those found in the area that would be most affected by contact with the proposed drilling fluid.
		Chronic bioassay tests indicate sublethal effects, such as changes in growth or reproduction of the organism over a longer period of time.
	www.glossary.oilfield.slb.com /Display.cfm?Term=bioassay (155 words)

	BioAssay Pro - Adept Scientific plc - The Technical Computing People
		BioAssay Pro helps scientists integrate chemical and biological data for enhanced research management.
		The underlying requirement that follows from this variability is for a flexible data management system that can adapt quickly to different assays and biological models.
		With BioAssay, researchers or IT support staff simply define the observables and calculations that make up the assay.
	www.adeptscience.co.uk /products/lab/chemoffice/bioassay_pro.html (301 words)

	Gene Therapy Program: Bioassay Core, main page (Site not responding. Last check: 2007-10-20)
		The mission of the Bioassay Core is to provide accurate information on the quality of viral vectors submitted to the core and to continually strive to improve the accuracy and scope of services offered by the core by developing novel assays useful for assessing the efficacy of gene therapy vectors.
		Investigators interested in requesting services for quality control tests of your vectors offered by the QC group should see Grants Section or contact the Vector Core to determine their eligibility for subsidies to cover a percentage of the cost of the service to the investigator.
		Such tests include bioassays such as plaque assays, assays for replication competent virus, and infectious center assays.
	www.uphs.upenn.edu /penngen/gtp/bioassay.html (316 words)

	JCL bioassay Inc.
		JCL bioassay, Japan's Number One provider of precise bioanalysis, now offers its high-quality services throughout the United States.
		JCL bioassay is proud of its world-leading bioanalysis capabilities, which have earned it the Number One market position among Japanese contract research organizations (CRO) specializing in bioanalysis.
		Life sciences organizations consistently utilize our bioanalysis data and rely upon JCL bioassay's expertise as part of their new drug development processes.
	www.jclbio.com /inc/index.html (188 words)

	Bioassay Project Team Homepage
		DOE regulations require routine bioassay monitoring for all workers who have a reasonable potential for intakes of radioactive materials.
		The C Division Bioassay Project provides radio-analytical services in support of the in vitro (materials removed from the body) portion of the LANL internal dosimetry program, managed by ESH Division.
		The C Division Bioassay Project team responds to crisis sample requests to provide quick and reliable information to potentially exposed workers -- both a legal and moral obligation.
	pearl1.lanl.gov /bioassay (248 words)

	Enterprise Solutions - CambridgeSoft (Site not responding. Last check: 2007-10-20)
		BioAssay Enterprise provides flexible storage, retrieval and analysis of biological data.
		BioAssay has been designed to provide a powerful, easy-to-use method to upload assay data from multiple sources to a central, secure location.
		BioAssay Workgroup is included in ChemOffice Workgroup Ultra and is sold as an option to ChemOffice Workgroup Pro and ChemOffice Workgroup Std.
	www.cambridgesoft.com /solutions/bioassay.cfm (155 words)

	Bioassays
		In addition to answering a different question, the bioassay is also more sensitive than it's immunoassay counterpart and can detect hormones at levels which would be otherwise undetectable in an immunoassay.
		The bioassay is often used to validate the corresponding immunoassay for that hormone.
		Because the bioassay requires a testosterone RIA follow-up assay making the bioassay more expensive, often the immunoassay is preferred over the bioassay if the values for both assays are highly similar.
	ink.primate.wisc.edu /~assay/bioassay.html (253 words)

	Bioassay
		A bioassay is a single step within a microarray experiment.
		A physical bioassay is created by applying some amount of some biomaterial to a microarray.
		Bioassay treatment events (e.g., wash, apply blocking agent etc.) transform physical bioassays into new physical bioassays.
	www.mged.org /Workgroups/MAGE/bioassay.html (127 words)

	EnviroScience, Inc. - Bioassay Laboratory
		Quality assurance is achieved through strict adherence to guidelines established by state and federal regulatory agencies, in-house culturing, and a dedicated staff.
		Aquatic toxicity tests, also known as bioassays or Whole Effluent Toxicity (WET) Testing, are used to monitor the toxicity of discharge waters.
		Bioassays are a cost effective evaluation of potential environmental impacts and provide a measure of the interaction between constituents in a wastewater discharge.
	www.enviroscienceinc.com /web/bioassay.html (157 words)

	Bioassay or Biological Assay
		A bioassay or biological assay is a biological testing procedure for estimating the concentration of a pharmaceutical active substance in a formulated product or bulk material.
		The general approach of most bioassays (biological assays) is to perform a dilution assay, which measures the biological responses at several doses.
		A key assumption of a dilution assay is that the active component follows the same principle of activity in standard and sample preparation.
	www.bioassay.de /index.php?id=bioassay (212 words)

	BioAssay Home - Adept Scientific plc - The Technical Computing People
		Query by structure or text with ChemFinder and set up Excel templates for reporting and graphing.
		BioAssay is available for the Windows platform only.
		BioAssay Pro is designed for scientists wishing to integrate chemical and biological data for enhanced research management.
	www.adeptscience.co.uk /products/lab/chemoffice/bioassay.html (128 words)

	NTP: Abstract for TR-41 - Chlorothalonil (Site not responding. Last check: 2007-10-20)
		A bioassay of technical-grade chlorothalonil for possible carcinogenicity was conducted by administering the test chemical in the diet to Osborne-Mendel rats and B6C3F
		Groups of 50 rats of each sex were administered chlorothalonil at one of two doses for 80 weeks, then observed for 30-31 weeks.
		It is concluded that under the conditions of this bioassay, technical-grade chlorothalonil was carcinogenic to Osborne-Mendel rats, producing tumors of the kidney.
	ntp.niehs.nih.gov /index.cfm?objectid=0703268C-9F3D-3689-C93A5C84BD4D6B16 (530 words)

	Amazon.com: bioassay (Site not responding. Last check: 2007-10-20)
		Contaminated sediments and bioassay responses of three macroinvertebrates, the midge larva Chironomus riparius, the water louse Asellus aquaticus and the mayfly nymph Ephoron virgo by H.J. De Lange, E.M. De Haas, H. Maas, and E.T.H.M. Peeters
		The application of bioassays as indicators of petroleum-contaminated soil remediation by G. Plaza, G. Nalecz-Jawecki, K. Ulfig, and R.L. Brigmon (April 2005)
		A duplex-PCR bioassay to detect a Trichoderma virens biocontrol isolate in non-sterile soil by S.L. Dodd, R.A. Hill, and A. Stewart (Dec 2004)
	www.amazon.com /s?ie=UTF8&keywords=bioassay&tag=icongroupinterna&index=blended&link_code=qs&page=1 (535 words)

	47th Annual BAER Conference (Site not responding. Last check: 2007-10-20)
		The Conference has been crucial to foster technical excellence and act as a forum for the development of common but essential technical philosophies and practices that are used by federal and state government, national, contract, academic, and regulatory radioassay laboratories nationally and internationally.
		In workshops, oral presentations and their defense, posters and discussions, technical workgroup sessions, and informal discussions, old and new colleagues meet to find out what are the latest, hottest developments amongst practitioners of bioassay, analytical and environmental radiochemistry.
		The fundamental benefits for the participants are new ideas and approaches that can be taken back and directly applied in their laboratory or office to improve their capabilities.
	www.bioassay.org /2002 (1572 words)

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