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| | Monoamine-oxidase inhibitors (Group PIM G025) |
 | | Co-ingestion of other medications enhancing the availability of biogenic amines should be suspected and the diagnosis of the serotonin syndrome should be considered in the presence of three or more of the following symptoms: behavioural change (confusion or hypomania), agitation, myoclonus, hyperreflexia, sweating, shivering, tremor, diarrhoea, motor incoordination, muscle rigidity, fever. |
 | | The increased availability of biogenic amines (such as noradrenaline and serotonin) is thought to be linked with the improvement in depression accounted for by IMAO treatment. |
 | | In more severe intoxications or where there are other substances ingested, more aggressive measures such as establishment of an airway, ventilation, administration of intravenous fluids, control of seizures, and control of hyperthermia may be necessary. |
| www.intox.org /databank/documents/pharm/maoi/pimg025.htm (2258 words) |
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