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Ziac Warnings, Precautions, Pregnancy, Nursing, Abuse - Bisoprolol and Hydrochlorothiazide - RxList Monographs |
 | | Bisoprolol Fumarate: The mutagenic potential of bisoprolol fumarate was evaluated in the microbial mutagenicity (Ames) test, the point mutation and chromosome aberration assays in Chinese hamster V79 cells, the unscheduled DNA synthesis test, the micronucleus test in mice, and the cytogenetics assay in rats. |
 | | Bisoprolol fumarate and hydrochlorothiazide doses used in the rat study are, as multiples of the MRHD in the combination, 129 and 514 times greater, respectively, on a body-weight basis, and 26 and 106 times greater, respectively, on the basis of body-surface area. |
 | | Bisoprolol Fumarate: In rats, bisoprolol fumarate was not teratogenic at doses up to 150 mg/kg/day, which are 375 and 77 times the MRHD on the basis of body-weight and body-surface-area, respectively. |
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