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Bleomycin - Drugs & Vitamins - Drug Library - DrugDigest Bleomycin can be used alone or in combination with other anti cancer medicines. Bleomycin is also used to stop fluid from gathering around your lungs (i.e., effusions) and to treat warts. Bleomycin is for injection into a muscle or under the skin, or infusion into a vein. www.drugdigest.org /DD/DVH/Uses/0,3915,82|Bleomycin,00.html   (615 words)

MedlinePlus Drug Information: Bleomycin (Systemic)   (Site not responding. Last check: 2007-10-03) Bleomycin seems to act by interfering with the growth of cancer cells, which are eventually destroyed. Bleomycin is to be administered only by or under the immediate supervision of your doctor. Bleomycin is used to treat severe cases of warts when other treatments have not worked. www.nlm.nih.gov /medlineplus/druginfo/uspdi/202093.html   (1314 words)

Bleomycin fact sheet Bleomycin sulfate occurs as a cream-colored, amorphous powder and is very soluble in water and sparingly soluble in alcohol. The potency of bleomycin is assayed microbiologically; the activity of 1 unit of bleomycin is equivalent to the activity of 1 mg of bleomycin A Induction of arginase I and II in bleomycin induced fibrosis of mouse lung. bleomycin.4mg.com   (378 words)

Fluoromicroscopic Studies of Bleomycin-induced Intracellular Oxidation in Alveolar Macrophages and Its Inhibition by ...   (Site not responding. Last check: 2007-10-03) These results demonstrate a stimulation-inhibition relationship between bleomycin and taurine on the cellular oxidation at a subcytotoxic dose of bleomycin, suggesting that the oxidative effect of the intracellular bleomycin-Fe complex is important in the initiation of the fibrotic process. Bleomycin is a glycopeptide antineoplastic agent that acts by forming intracellular bleomycin-Fe complexes capable of producing oxygen free radicals and causing DNA damage (5,6). The bleomycin effect is also associated with a rapid increase in intracellular calcium that appears to precede the oxidation, suggesting that intracellular calcium mobilization may play a role in the internalization of the drug. ehp.niehs.nih.gov /members/1994/Suppl-10/bhat-full.html   (4799 words)

bleomycin Consumer Drug Information Bleomycin interferes with the growth of cancer cells and slows their growth and spread in the body. Bleomycin is used to treat squamous cell carcinoma (skin cancer) of the head and neck, penis, cervix, and vulva; lymphomas; and testicular cancer. Bleomycin is in the FDA pregnancy category D. This means that bleomycin is known to be harmful to an unborn baby. www.drugs.com /MTM/bleomycin.html   (996 words)

Antisense Oligonucleotides to NF-kappa B Improve Survival in Bleomycin-induced Pneumopathy of the Mouse -- ZHANG et al. ... Bleomycin injection produced an increase in FITC-positive cells not only in the number but also in the intensity of fluorescence which was localized at the center of the cells. Bleomycin injection increased the p65 levels, which were inhibited by the antisense oligonucleotides and not by the sense oligonucleotides. Inheritance of susceptibility to bleomycin-induced pulmonary fibrosis in the mouse. ajrccm.atsjournals.org /cgi/content/full/162/4/1561   (4452 words)

Bleomycin - Wikipedia, the free encyclopedia It acts by induction of DNA strand breaks and is used in the treatment of lymphomas, squamous cell carcinomas, and testicular cancer as well as pleurodesis. Some studies suggest that bleomycin also inhibits incorporation of thymidine into DNA strands. Its use is limited by the increased risk of pulmonary fibrosis. en.wikipedia.org /wiki/Bleomycin   (147 words)

Bleomycin upregulates expression of gamma -glutamylcysteine synthetase in pulmonary artery endothelial cells -- Day et ... Nrf-1 and -2 activation by bleomycin is inhibited by the ROS quenching Bleomycin is believed to induce oxidative stress on cells by the generation of ROS through a bound ferrous ion. mRNA is increased by 30 min in response to 1 µg/ml of bleomycin. ajplung.physiology.org /cgi/content/full/282/6/L1349   (4761 words)

Prevention of Bleomycin-induced Pulmonary Fibrosis After Adenovirus-mediated Transfer of the Bacterial Bleomycin ... Lung injury induced by bleomycin is characterized by an increased the bleomycin hydrolase gene that encodes a cathepsinlike proteinase alveolitis and alterations caused by bleomycin in the parenchyma www.jci.org /cgi/content/full/99/4/608   (5350 words)

Epithelial-Fibroblast Interactions in Bleomycin-induced Lung Injury and Repair Rats received bleomycin intratracheally, and after 10 days, when acute epithelial injury occurs, and at 6 weeks, when repair with fibrosis is found, pure populations of type 2 epithelial cells and lung fibroblasts were prepared to study interactions with respect to growth control. It is not known whether this change in the local microenvironment alters proliferation of either cell type and induces abnormal repair, which is characterized by epithelial proliferation, abnormal differentiation, and extensive underlying fibrosis. The pathogenesis of bleomycin induced pulmonary fibrosis in mice. ehp.niehs.nih.gov /members/1993/101-1/young-full.html   (4242 words)

Bleomycin injection for warts Although nongenital warts are not cancerous, bleomycin injection is sometimes used to kill skin cells, effectively stopping wart growth. Bleomycin is considered too toxic to safely treat children or pregnant or breast-feeding women. Bleomycin should not be used in people with Raynaud's phenomenon or peripheral arterial disease. www.webmd.com /hw/health_guide_atoz/tn8304.asp   (184 words)

News - Bleomycin Successful In Treating Resistant Hand Warts Initial treatment with pulsed dye laser prepares the wart for the bleomycin injection and ensures it goes into the base of the wart to minimise the risk of infiltration of normal skin. Bleomycin (0.5 IU/ml) was then injected into the base of the wart and subjects were followed-up with monthly treatment. They found the combination of pulsed dye laser and intralesional bleomycin was safe, rapid and well tolerated but suggest a larger controlled study is needed to confirm these findings. docguide.com /news/content.nsf/news/8525697700573E1885256B7A00594ED4   (478 words)

Attenuation of Bleomycin-Induced Pulmonary Fibrosis by a Catalytic Antioxidant Metalloporphyrin -- Oury et al. 25 (2): ... Bleomycin is a commonly used chemotherapeutic agent that can cause dose-dependent pulmonary fibrosis (5). Bleomycin given by intratracheal instillation produces a marked airway and alveolar fibrotic response (24). Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse. ajrcmb.atsjournals.org /cgi/content/full/25/2/164   (4062 words)

A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis - Nature Medicine   (Site not responding. Last check: 2007-10-03) Bleomycin treatment elicited alveolar thickening and subpleural fibrous foci in wild-type mice. In the wild-type group, bleomycin administration increased protein content and the numbers of macrophages, polymorphonuclear leukocytes (PMNs) and lymphocytes in bronchoalveolar lavage fluid (BALF), indicating bleomycin-induced protein leakage and leukocyte infiltration (Table 1 and Fig. significantly attenuated pulmonary fibrosis and inflammation induced by bleomycin. www.nature.com /nm/journal/v8/n5/full/nm0502-480.html   (2936 words)

Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis -- Bowler et al. 282 (4): 719 -- AJP ... Bleomycin is a commonly used chemotherapeutic agent that has severe pulmonary side effects. Bleomycin cytotoxicity is prevented by superoxide dismutase in vitro. Bleomycin induces strain-dependent alterations in the pattern of epithelial cell-specific marker expression in mouse lung. ajplung.physiology.org /cgi/content/full/282/4/L719   (5025 words)

The Nucleic Acid Binding Activity of Bleomycin Hydrolase Is Involved in Bleomycin Detoxification -- Zheng and Johnston ... By sequence comparison, bleomycin hydrolase is highly conserved from bacteria to mammals (3, 12). Yeast bleomycin hydrolase is a DNA-binding cysteine protease. The cysteine-protease bleomycin hydrolase is a new component of the galactose regulon in yeast. mcb.asm.org /cgi/content/full/18/6/3580   (4325 words)

Bleomycin Bleomycin kills cells by binding and then degrading genetic material (DNA) by cutting a strand of DNA. Successful treatment depends on the administration of the next course of therapy before the cancer has regrown to its previous size and the net effect is to decrease the amount of cancer with each successive course. Bleomycin is used on its own or in combination with other anticancer medicines. www.netdoctor.co.uk /medicines/100000316.html   (939 words)

Predicting the risk of bleomycin lung toxicity in patients with germ-cell tumours -- O’Sullivan et al. 14 (1): 91 ... Bleomycin is excreted renally, with 70% of the dose excreted Bleomycin injury of the lung in a mast-cell-deficient model. Equivalence of three or four cycles of bleomycin, etoposide, and cisplatin chemotherapy and of a 3- or 5-day schedule in good-prognosis germ cell cancer: a randomized study of the European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group and the Medical Research Council. annonc.oxfordjournals.org /cgi/content/full/14/1/91   (2942 words)

ADAP drugs: bleomycin   (Site not responding. Last check: 2007-10-03) Bleomycin is a chemotherapeutic drug used in combination with two others to treat Kaposi's sarcoma (KS) when it does not respond to standard treatment. The two other drugs used with bleomycin are adriamycin (Doxorubicin) and vincristine, and the combination is referred to as ABV. Bleomycin may cause fever and chills 2-6 hours after infusion which can last for 4-6 hours. www.atdn.org /access/drugs/bleo.html   (340 words)

Lymphoma Information Network - Bleomycin Bleomycin (common brand name blenoxane) is a chemotherapy agent used in the treatment of Hodgkin's Lymphoma / Disease. It is an antineoplastic - bleomycin is an antitumor antibiotic, interfering with the growth of cancer cells. You may wish to consult your medical team on the effects of bleomycin prior to starting treatment. www.lymphomainfo.net /therapy/drugs/bleomycin.html   (400 words)

Treatment with {alpha}-Galactosylceramide Attenuates the Development of Bleomycin-Induced Pulmonary Fibrosis -- Kimura ... Bleomycin is an antitumor drug often used as an inducing agent 1 mg of bleomycin and concluded that 0.5 mg of bleomycin was The degree of pulmonary fibrosis was markedly decreased in the www.jimmunol.org /cgi/content/full/172/9/5782   (4062 words)

P-selectin upregulation in bleomycin induced lung injury in rats: effect of N-acetyl-L-cysteine -- Serrano-Mollar et ... Bleomycin is a glycopeptide antibiotic used in the chemotherapy Inhibition of bleomycin lung toxicity by N-acetylcysteine in the rat. Role of E-selectin in bleomycin induced lung fibrosis in mice. thorax.bmjjournals.com /cgi/content/full/57/7/629   (3542 words)

Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats -- Cortijo et al. 17 (6): 1228 -- ... to the bleomycin model 14, and influenced by taurine 21. Fourteen days after intratracheal bleomycin, a marked peribronchial interstitial infiltration with inflammatory cells, oedema and fibrosis were patent (A and B). in the pulmonary lesions induced by bleomycin 2. erj.ersjournals.com /cgi/content/full/17/6/1228   (3620 words)

Bleomycin-Induced Pneumonitis -- Sleijfer 120 (2): 617 -- Chest   (Site not responding. Last check: 2007-10-03) Bleomycin is mainly excreted by the kidneys, and deterioration Abbreviations: BEP = bleomycin, etoposide, cisplatin; BIP = Giri, SN, Hyde, DM, Hollinger, MA (1993) Effect of antibody to transforming growth factor ß on bleomycin induced accumulation of lung collagen in mice. www.chestjournal.org /cgi/content/full/120/2/617   (4844 words)

Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats -- Dik et al. 58 (9): ... Alveolar accumulation of fibronectin and hyaluronan precedes bleomycin- induced pulmonary fibrosis in the rat. Effect of corticosteroids on lung volume-pressure curves in bleomycin- induced lung injury in the rat. Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters. thorax.bmjjournals.com /cgi/content/full/58/9/765   (4229 words)

Role of Repeated Lung Injury and Genetic Background in Bleomycin-Induced Fibrosis -- Chung et al. 29 (3): 375 -- ... Collagen in the bleomycin-exposed animals is expressed relative to the collagen content of control animals not exposed to bleomycin. DBA/2 mice were treated with either single or multiple bleomycin exposures (Figure 1). The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance. ajrcmb.atsjournals.org /cgi/content/full/29/3/375   (3270 words)

Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats -- Mata et al. 22 (6): ... bleomycin or saline, the animals were killed by a lethal injection Bleomycin increased the expression of Muc5ac protein and treatment with NAC reduced this effect. P-selectin upregulation in bleomycin induced lung injury in rats: effect of N-acetylcysteine. erj.ersjournals.com /cgi/content/full/22/6/900   (3191 words)

BLEOMYCIN - INJECTION (Blenoxane) side effects, medical uses, and drug interactions. Because bleomycin is a useful drug for treating lymphoma, the manufacturer recommends giving a lower dosage for the first two doses while checking for signs of this serious reaction. Rarely, this drug can also cause swelling/inflammation of the lungs (pneumonitis), which could lead to permanent lung damage (pulmonary fibrosis). USES: Bleomycin is used in combination with other medicines to treat various forms of cancer. www.medicinenet.com /bleomycin-injection/article.htm   (423 words)

PG490-88, a Derivative of Triptolide, Blocks Bleomycin-Induced Lung Fibrosis -- Krishna et al. 158 (3): 997 -- American ... fibrosis in the bleomycin model of mouse lung fibrosis. In the bleomycin plus PG490-88 (5 days) group, PG490-88 was administered 5 days after bleomycin. bleomycin were also sacrificed on day 15 so that they received treatment ajp.amjpathol.org /cgi/content/full/158/3/997   (3772 words)

How Important Is Bleomycin in the Adriamycin + Bleomycin + Vinblastine + Dacarbazine Regimen? -- Canellos et al. 22 ... or MOPP–adriamycin + bleomycin + vinblastine (-ABV) hybrid, Cancer and Leukemia Group B 8251 and 8952: cumulative incidence of recurrent Hodgkin's disease (HD) by treatment. ABVD, adriamycin + bleomycin + vinblastine + dacarbazine; Bleo, bleomycin. www.jco.org /cgi/content/full/22/8/1532   (598 words)

Bleomycin BLEOMYCIN (Blenoxane®) is a chemotherapy used for treating many kinds of cancer including cervical cancer, head and neck cancer, lymphomas, and testicular cancer. Bleomcyin may also be given through a special tube into the cavity around your lungs. What do I need to watch for while I receive bleomycin? www.lafn.org /medical/po.bd.treatment.Bleomycin.html   (518 words)

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