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| | A hierarchical, building-block-based computational scheme for protein structure prediction |
 | | Hence, this implies that if we were to cut the building block from the protein chain and place it as a peptide in solution, the most highly populated conformation of this peptide would very likely be similar to that of the building block when it is in the native protein fold. |
 | | Hence, the two most important points here are, first, that in the absence of such a critical building block to mediate the interactions of most of the other building blocks, the native conformations of these other building blocks are retained; and second, that what is altered here is their association [27]. |
 | | Three elements in the building block folding model are useful: First, we have a collection of building blocks, their sequences and their conformations, as observed in the native structure of the proteins from which they were derived. |
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