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Topic: Bone maturation

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	Bone age - Wikipedia, the free encyclopedia
		Bone age is a way of describing the degree of maturation of a child's bones.
		The "bone age" of a child is the average age at which children reach this stage of bone maturation.
		Bone maturation is delayed with the variation of normal development termed constitutional delay of growth and puberty, but delay also accompanies growth failure due to growth hormone deficiency and hypothyroidism.
	en.wikipedia.org /wiki/Bone_maturation (814 words)

	Method for inducing bone growth - Patent 5208219 (Site not responding. Last check: 2007-10-14)
		A method for inducing deposition and maturation of bone in a subject in need thereof, which comprises administering an osteogenically effective amount of activin in a pharmaceutically acceptable excipient to said subject.
		Bone growth and maturation are enhanced by administering activin in a formulation and in an amount sufficient for inducing bone tissue deposition.
		The term "mature bone" relates to bone that is mineralized, in contrast to non-mineralized bone such as osteoid.
	www.freepatentsonline.com /5208219.html (6750 words)

	Bone maturation in girls with Turner's syndrome. (Site not responding. Last check: 2007-10-14)
		The present study was undertaken to evaluate the maturation of individual bones of the hand and wrist in girls with Turner's syndrome and thereby obtain information which may aid in elaborating the possible mechanism of the growth retardation in girls with Turner's syndrome.
		During childhood the Turner patients showed the greatest delay in bone age of the phalangeal bones while the least delayed were the radius and ulna (long bones) and metacarpals.
		The unique profile of bone maturation in Turner's syndrome suggests an insult to chondroplasia, which may be related to estrogen deficiency or to an as yet undetermined endocrine or paracrine derangement.
	www.arclab.org /medlineupdates/abstract_9461317.html (220 words)

	Dulles Institute of Oral & Maxillofacial Surgery - Bone Grafting
		Over a period of time, the bone in the upper jaw (maxilla) and lower jaw (mandible) will resorb if a tooth is missing or a tooth that was affected by an infection (periodontal disease).
		Therefore, to replace the missing bone and to augment the bone to its natural and original state, we graft the socket and surrounding tissue immediately after the extraction.
		The bone is obtained from a bone bank and is in the form of particles.
	www.dullesoms.com /pro/pro_bone.html (636 words)

	Link between lead and osteoporosis strengthens (Site not responding. Last check: 2007-10-14)
		For decades, scientists have known that the human skeleton is a repository for lead in people who were exposed to high levels of this environmental toxin in their childhood, but thought this storage to be benign.
		Recently, a growing body of research is showing that the opposite is true, and that lead in bone actually sets off a bizarre chain reaction, first accelerating bone growth, and then eventually limiting it so that a high peak bone mass is not achieved.
		It is characterized by low bone mass that eventually leads to fractures, mostly of the hip and vertebrae.
	www.news-medical.net /?id=17043 (752 words)

	Untitled Document
		Early B cells migrate to the human "bursa equivalent" (fetal liver) where they become morphologically mature and immunocompetent; the latter is accomplished by the appearance of a unique surface immunoglobulin that acts as an antigen receptor.
		These rearrangements occur very early in the normal maturation of every B and T cell, and the pattern of rearranged genes is maintained for the life of the cell.
		They are able to proliferate and mature morphologically, and yet they are clonal, do not function as normal cells, have escaped normal negative feedback inhibitory growth controls, and are, therefore, malignant.
	www.uvm.edu /~jkessler/HEME/HEEL/HE1stpar.htm (1494 words)

	MR Imaging of Bone Marrow in Glycogen Storage Disease Type IB in Children and Young Adults -- Scherer et al. 177 (2): ...
		as a consequence of abnormalities in myeloid maturation and
		Photomicrograph of histopathologic specimen of bone marrow aspiration of iliac bone shows marked hypercellularity of marrow cavity with clusters and reduction of total fatty marrow and normal width of trabecular bone.
		MR imaging of bone marrow in children with osteosarcoma: effect of granulocyte colony-stimulating factor.
	www.ajronline.org /cgi/content/full/177/2/421 (2702 words)

	Identification and Isolation of Rat Bone Marrow-derived Mast Cells Using the Mast Cell-specific Monoclonal Antibody AA4 ...
		Mature mast cells (A) were readily recognized on the basis of their morphology alone.
		Mature bone marrow-derived mast cells (arrows) are metachromatic after staining with Toluidine Blue (A) and stain positively with berberine sulfate (B), confirming that they are connective tissue-type mast cells.
		Thompson HL, Burnbelo PD, Metcalfe DD (1990) Regulation of adhesion of mouse bone marrow-derived mast cells to laminin.
	www.jhc.org /cgi/content/full/49/2/219 (4363 words)

	Maturation Rate of Mouse Neutrophilic Granulocytes: Acceleration by Retardation of Proliferation, but No Detectable ...
		H activity to density fractions F2 (with the less mature granulocytes) and F3 (with the more mature granulocytes), it increased with decreasing expansion of the cultured cell populations.
		Maturation of bone marrow cells cultured in vivo with or without stromal cells.
		Maturation of bone marrow cells on stromal cells cultured in vivo with or without exposure to rhG-CSF, as assessed with density gradient separation.
	stemcells.alphamedpress.org /cgi/content/full/17/5/253 (4178 words)

	Bone Maturation Reflects the Secular Trend in Growth - Karger Publishers
		The skeletal maturity score using the Tanner-Whitehouse 2-RUS method was used as the fundamental datum.
		The 1996 children had not matured more than the 1986 children; children in both groups reached the given scores at almost the same ages.
		We did not detect much of a difference in bone maturation between the 1986 and 1996 groups of children, and no differences in height during the same period.
	content.karger.com /ProdukteDB/produkte.asp?Doi=23448 (331 words)

	Grow Taller And Increase Height
		Researchers are currently using a potent P450-aromatase inhibitor, letrozole, because of its ability to delay bone maturation and increase final adult height.
		Estrogen plays an essential role in the regulation of bone maturation and ultimately causes bones to fuse resulting in increased adult height.
		Studies have proven and shown that letrozole is the key inhibitor in stopping estrogen from causing bone maturation.
	www.betaller.com /article13.htm (192 words)

	Obesity during childhood and adolescence augments bone mass and bone dimensions -- Leonard et al. 80 (2): 514 -- ...
		Whole-body bone area for height obtained with the use of dual-energy X-ray absorptiometry in obese and nonobese children and adolescents according to sex.
		Although bone area was significantly greater in the obese females than in the nonobese females across the range of heights, the increase in bone area with an increase in height (slope) was not as great in the obese females as in the nonobese females.
		Bone mineral density and body composition in boys with distal forearm fractures: a dual-energy x-ray absorptiometry study.
	www.ajcn.org /cgi/content/full/80/2/514 (5598 words)

	The Association between Environmental Lead Exposure and Bone Density in Children
		Accelerated maturation of bone may ultimately result in a lower peak BMD being achieved in young adulthood, thus predisposing to osteoporosis in later life.
		We hypothesized that the bone density of children with high lead exposure would be lower than the bone density of children with low lead exposure.
		Bone mineral density in children and adolescents: relation to puberty, calcium intake, and physical activity.
	www.ehponline.org /members/2004/6555/6555.html (3309 words)

	Skeletal Complications in Pediatric Oncology Patients -- Roebuck 19 (4): 873 -- RadioGraphics
		bone expansion and a sclerotic pattern may also be seen (50).
		Bone marrow magnetic resonance studies in childhood leukemia: evaluation of osteonecrosis.
		MR imaging of bone marrow in children with osteosar-coma: effect of granulocyte colony-stimulating factor.
	radiographics.rsnajnls.org /cgi/content/full/19/4/873 (4496 words)

	Maturation of bone and dentin matrices in rats flown on the Soviet biosatellite Cosmos 1887 -- Simmons et al. 4 (1): 29 ...
		Maturation of bone and dentin matrices in rats flown on the Soviet biosatellite Cosmos 1887 -- Simmons et al.
		Maturation of bone and dentin matrices in rats flown on the Soviet biosatellite Cosmos 1887
		Bone hydroxyapatite crystal growth in the mandibles of
	www.fasebj.org /cgi/content/abstract/4/1/29 (393 words)

	Immunomagnetic Isolation of Rat Bone Marrow-derived and Peritoneal Mast Cells -- Jamur et al. 45 (12): 1715 -- Journal ...
		Mast cells in all stages of maturation were isolated with MAb AA4-conjugated beads and immunostained with mast cell-specific antibodies.
		Mature mast cells are readily induced to degranulate and are
		Mendonça VO, Vugman I, Jamur MC (1986) Maturation of adult rat peritoneal and mesenteric mast cells.
	www.jhc.org /cgi/content/full/45/12/1715 (3093 words)

	Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone ...
		bones are restricted to the head and part of the clavicle.
		The arrow in F indicates less mature chondrocytes surrounding the population of hypertrophic cells.
		chondrocyte maturation; and (3) absence of mature osteoblasts.
	www.genesdev.org /cgi/content/full/13/16/2072 (6985 words)

	High dose growth hormone treatment induces acceleration of skeletal maturation and an earlier onset of puberty in ...
		bone age and induces an earlier onset of puberty.
		Pubertal growth and final height in hypopituitary boys: a minor role of bone age at onset of puberty.
		Effect of long-term growth hormone therapy on bone age and pubertal maturation in boys with and without classic growth hormone deficiency.
	adc.bmjjournals.com /cgi/content/full/87/3/215 (4446 words)

	Cortical bone growth and maturational changes in dwarf rats induced by recombinant human growth hormone -- Martinez et ...
		Cortical bone growth and maturational changes in dwarf rats induced by recombinant human growth hormone -- Martinez et al.
		Cortical bone growth and maturational changes in dwarf rats induced by recombinant human growth hormone
		maturation, and mean hydroxyapatite crystal size may be independently
	ajpendo.physiology.org /cgi/content/abstract/270/1/E51 (243 words)

	The effect of microgravity on morphology and gene expression of osteoblasts in vitro -- CARMELIET and BOUILLON 13 ...
		bone is correlated to the mechanical stresses exerted on it, resulting
		During spaceflight mechanical loading of bone is minimal.
		Simmons, D. J., Russell, J. E., Grynpas, M. (1986) Bone maturation and quality of bone material in rats flown on the space shuttle "Spacelab-3 Mission.".
	www.fasebj.org /cgi/content/full/13/9001/S129 (3139 words)

	Flutamide, Testolactone, and Reduced Hydrocortisone Dose Maintain Normal Growth Velocity and Bone Maturation Despite ...
		Flutamide, Testolactone, and Reduced Hydrocortisone Dose Maintain Normal Growth Velocity and Bone Maturation Despite Elevated Androgen Levels in Children with Congenital Adrenal Hyperplasia -- Merke et al.
		Bone age was determined from a radiograph of the
		A and B include all subjects; C and D show children who remained prepubertal at 2 yr and exclude the six children who were receiving GnRH analog.
	jcem.endojournals.org /cgi/content/full/85/3/1114 (3577 words)

	Sex Steroid Treatment of Constitutionally Tall Stature -- Drop et al. 19 (5): 540 -- Endocrine Reviews
		Longitudinal bone growth is the result of expansion of the growth
		The effect of therapy was calculated by multiple regression analysis using final height as dependent variable and treatment, and CA, BA, and height prediction (and their interactions) as independent variables.
		Using the height prediction according to the index of potential height for bone age, the estimated treatment effect was a linear function related to BA (Greulich and Pyle) in the form: Effect (cm) = 44.19–3.15
	edrv.endojournals.org /cgi/content/full/19/5/540 (8023 words)

	eMedicine - Scurvy : Article by Bruce M Rothschild, MD (Site not responding. Last check: 2007-10-14)
		Scurvy results from vitamin C deficiency and manifests as collagen defects, hemorrhagic diathesis, abnormalities in bone maturation, epiphyseal disease, lifting of the periosteum, and hemarthroses.
		This ring of increased opacity formed around the ossification center of long bone epiphyses is known as the Wimburger sign, which perhaps results from bleeding or attachment movement.
		Costochondral junctions of the first 6 or 8 thoracic ribs are expanded; this change may be related to fracturing of the zone of provisional calcification during normal respiration.
	www.emedicine.com /radio/topic628.htm (1784 words)

	Salmonella enterica Serovar Typhimurium-Induced Maturation of Bone Marrow-Derived Dendritic Cells -- Svensson et al. 68 ...
		Salmonella enterica Serovar Typhimurium-Induced Maturation of Bone Marrow-Derived Dendritic Cells -- Svensson et al.
		DC were cultured from murine bone marrow in the presence of granulocyte-M
		Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures.
	iai.asm.org /cgi/content/full/68/11/6311 (6964 words)

	Effect of Obesity on Estradiol Level, and Its Relationship to Leptin, Bone Maturation, and Bone Mineral Density in ...
		Effect of Obesity on Estradiol Level, and Its Relationship to Leptin, Bone Maturation, and Bone Mineral Density in Children -- Klein et al.
		with the increased bone maturation of the obese children.
		equivalent bone ages at a younger chronological age than nonobese children.
	jcem.endojournals.org /cgi/content/abstract/83/10/3469 (1141 words)

	Bcl-2 Lies Downstream of Parathyroid Hormone-related Peptide in a Signaling Pathway That Regulates Chondrocyte ...
		bone, and the presence of a marrow cavity.
		and alterations in chondrocyte maturation and apoptotic cell death.
		Condensation of hypertrophic chondrocytes at the chondro-osseous junction of growth plate cartilage in yucatan swine: relationship to long bone growth.
	www.jcb.org /cgi/content/full/136/1/205 (6270 words)

	Endocrine Effects on Bone (Site not responding. Last check: 2007-10-14)
		Similar levels of estrogen and androgen receptors in bone cells of males and females, some possibility that the receptors are indiscriminant and will bind either
		Leptin known to be involved in regulation of body adiposity, lead to idea that leptin was involved in regulation of bone
		High bone mass due to increased formation of both cortical and trabecular bone
	jan.ucc.nau.edu /~pe/exs490web/490Bonehormonept1.htm (926 words)

	Lead May Be the Bullet Causing Osteoporosis in Senior Citizens (Site not responding. Last check: 2007-10-14)
		March 27, 2006 - A growing body of research is putting yet one more notch in the belt of diseases attributed to lead, and this time, researchers say, its target is older adults at risk for osteoporosis.
		To help seniors learn more about this serious bone disease, information about the prevention and treatment of osteoporosis has just been added to the Website named NIHSeniorHealth.
		"When everyone begins to lose bone mass starting at around age 50, lead-exposed individuals are at a higher risk for bone fractures and osteoporosis — and probably at an earlier age than the typical osteoporosis patient."
	www.seniorjournal.com /NEWS/Health/6-03-27-LeadMayBetheBullet.htm (986 words)

	JBJS -- Sign In Page
		Stanford University Libraries' HighWire Press (TM) assists in the publication of JBJS Online.
		Copyright © 2003 by The Journal of Bone and Joint Surgery, Inc. Online ISSN: 1535-1386.
		The Journal of Bone and Joint Surgery®, JBJS®, JB&JS®, and eJBJS® are registered in the U.S. Patent and Trademark Office.
	www.ejbjs.org /cgi/content/full/85/suppl_3/29 (148 words)

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