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Whooping Cough Whooping cough (pertussis) is caused by the bacterium Bordetella pertussis, B. The S1 subunit of pertussis toxin is the A component with ADP ribosylating activity, and the function of S2 and S3 is presumed to be involved in binding the intact (extracellular) toxin to its target cell surface. Thus, pertussis toxin is clearly an important virulence factor in the initial colonization stage of the infection. www.textbookofbacteriology.net /pertussis.html   (2907 words)

Pertussis -- Facts, Info, and Encyclopedia article   (Site not responding. Last check: 2007-10-15) Pertussis, also known as whooping cough, is a highly contagious (An impairment of health or a condition of abnormal functioning) disease that is one of the leading causes of (Immunogen consisting of a suspension of weakened or dead pathogenic cells injected in order to stimulate the production of antibodies) vaccine-preventable deaths. The disease is characterized initially by mild respiratory infection symptoms such as (Sudden expulsion of air from the lungs that clears the air passages; a common symptom of upper respiratory infection or bronchitis or pneumonia or tuberculosis) cough, (A symptom consisting of the involuntary expulsion of air from the nose) sneezing, and runny nose. Pertussis (Immunogen consisting of a suspension of weakened or dead pathogenic cells injected in order to stimulate the production of antibodies) vaccines were initially formulated in 1926—most notable by of (additional info and facts about Northwestern University) Northwestern University—as whole-cell preparations, but are now available as acellular preparations, which cause fewer side effects. www.absoluteastronomy.com /encyclopedia/p/pe/pertussis.htm   (535 words)

Pertussis - Wikipedia, the free encyclopedia Pertussis, also known as whooping cough, is a highly contagious disease that is one of the leading causes of vaccine-preventable deaths. pertussis was isolated in pure culture in 1906 by Jules Bordet and Octave Gengou. Bordetella pertussis elaborates several virulence factors, including: pertussis toxin, an adenylate cyclase toxin, filamentous hemagglutinin, a tracheal cytotoxin, fimbriae, and pertactin. en.wikipedia.org /wiki/Pertussis   (486 words)

CDC - Adaptation of Bordetella pertussis to Vaccination: A Cause for Its Reemergence? CDC - Adaptation of Bordetella pertussis to Vaccination: A Cause for Its Reemergence? Adaptation of Bordetella pertussis to Vaccination: A Cause for Its Reemergence? Bordetella pertussis and Bordetella parapertussis are the etiologic agents of whooping cough or pertussis, a respiratory disease that is most severe in infants and young children. www.cdc.gov /ncidod/eid/vol7no3_supp/mooi.htm   (2133 words)

Medmicro Chapter 31 Pertussis is a common and dangerous childhood disease in unvaccinated populations. Bordetella pertussis is a small (approximately 0.8 µm by 0.4 µm), rod-shaped, coccoid, or ovoid Gram-negative bacterium that is encapsulated and does not produce spores. Bordetella pertussis organisms grown under such conditions are avirulent and are characterized by the loss of the capacity to synthesize the numerous toxic factors and other structural components. gsbs.utmb.edu /microbook/ch031.htm   (3900 words)

Bordetella   (Site not responding. Last check: 2007-10-15) Bordetella cause disease by producing toxins that impair ciliary function in the respiratory tract. Whooping cough results from colonization and multiplication of Bordetella pertussis on the mucus membranes of the respiratory tract, in particular, the ciliated epithelial cells. Pertussis is generally a disease of infants (50% of cases occur in children less than 1 year old). www.cehs.siu.edu /fix/medmicro/borde.htm   (361 words)

Pertussis   (Site not responding. Last check: 2007-10-15) Whooping cough (pertussis) is caused by the bacterium Bordetella pertussis. The S1 subunit of pertussis toxin is the A component with ADP ribosylating activity, and the function of S2 and S3 is presumed to be involved in binding the intact (extracellular) toxin to its target cell surface. One hypothesis is that new strains of Bordetella pertussis may have evolved that are not affected by the vaccines used in the Netherlands and Canada. www.bact.wisc.edu /Bact330/lecturebpertussis.1   (2825 words)

Pertussis vaccine   (Site not responding. Last check: 2007-10-15) Pertussis occurs mostly in infants and young children, and severe disease and death are reported mainly in infancy. Bordetella pertussis, the causative agent of pertussis, is a Gram-negative rod with affinity to the mucosal layers of the human respiratory tract. Although the level of antibodies to pertussis toxin or to the filamentous haemagglutinin are sometimes used as serological indicators of protection, lack of generally accepted correlates of immunity and animal models are impediments to the evaluation of new pertussis vaccine candidates and the monitoring of the consistency of production. www.who.int /vaccines/en/pertussis.shtml   (2705 words)

eMedicine - Pertussis : Article by Hazel Guinto-Ocampo, MD Pertussis is a 6-week disease divided into catarrhal, paroxysmal, and convalescent stages, each lasting from 1-2 weeks. Pertussis is most infectious when patients are in the catarrhal phase, but pertussis may remain communicable for 3 or more weeks after the onset of cough. B pertussis and B parapertussis are the causative organisms for pertussis infection in humans. www.emedicine.com /ped/topic1778.htm   (3949 words)

Bordetella pertussis Most infants receive the well-known DTP (diphtheria, tetanus, and pertussis) vaccine, followed by several "booster" shots throughout the course of their childhood. Well, enough said about myself, Bordetella pertussis, the agent of pertussis, is a very small Gram-negative coccobacillus that appears singly or in pairs. pertussis colonizes the cilia of mammalian respiratory epithelium, and although it is not known to invade the tissues, recent findings have shown the bacterium in alveolar macrophages. web.umr.edu /~microbio/BIO221_2001/bordetella_pertussis.html   (620 words)

Nebraska HHS System: Epidemiology of Bordetella pertussis in Nebraska   (Site not responding. Last check: 2007-10-15) Nationwide, the incidence of pertussis peaked during the pre-vaccine era in 1934, with approximately 260,000 reported cases and 7,000 deaths. Mild pertussis is usually not recognized unless the affected person is epidemiologically associated with a case of classic pertussis. The U.S. Centers for Disease Control and Prevention (CDC) has calculated pertussis vaccine effectiveness, using the traditional DTP vaccine, to be 64% among children aged 19-47 months given three doses, and 82% among children aged 19-47 months given four or more doses, when compared with children receiving zero doses of pertussis vaccine. www.hhs.state.ne.us /epi/whooplong.htm   (1845 words)

Bordetella Pertussis Diagnostic Test Update These cultures were sent in conjunction with Bordetella pertussis PCR testing being performed in the SLCH Virology Laboratory. In a study performed in the SLCH Virology Laboratory on nasopharyngeal swab specimens from over 500 patients, the sensitivity of PCR for the detection of Bordetella pertussis was 100 percent versus 35 percent for culture. In the history of Bordetella pertussis PCR testing at SLCH there has never been an instance of a Bordetella pertussis culture positive that was Bordetella pertussis PCR negative. www.stlouischildrens.org /tabid/96/itemid/1773/Bordetella-Pertussis-Diagnostic-Test-Update.aspx   (224 words)

BD - Diagnostic Systems: FA Bordetella Pertussis, 5 mL Difco™ FA Bordetella Pertussis and Difco FA Bordetella Parapertussis are recommended for use in the direct fluorescent antibody technique for the identification of Bordetella pertussis and Bordetella parapertussis. Bordetella parapertussis is associated with a milder, less frequently occurring form of the disease. Pertussis is endemic in the United States, with most disease occurring as isolated cases. www.bd.com /ds/productCenter/223591.asp   (1616 words)

Bordetella pertussis: the intersection of genomics and pathobiology -- Preston 173 (1): 55 -- Canadian Medical ... Bordetella pertussis: the intersection of genomics and pathobiology Bordetella pertussis is the causative agent of whooping cough. Pertussis is a frequent cause of prolonged cough illness in adults and adolescents. www.cmaj.ca /cgi/content/full/173/1/55   (3592 words)

JAMA -- Abstract: Whooping Cough Caused by Bordetella pertussis and Bordetella parapertussis in an Immunized ... JAMA -- Abstract: Whooping Cough Caused by Bordetella pertussis and Bordetella parapertussis in an Immunized Population, August 19, 1998, He et al. Whooping Cough Caused by Bordetella pertussis and Bordetella parapertussis in an Immunized Population Bordetella parapertussis infection was as common as B pertussis jama.ama-assn.org /cgi/content/abstract/280/7/635   (451 words)

Polymorphism of Bordetella pertussis Isolates Circulating for the Last 10 Years in France, Where a Single Effective ... of pertussis toxin, and the prn gene, encoding the adhesin pertactin. Bordetella pertussis, a gram-negative bacterium, is the agent of whooping cough. Use of pertussis toxin encoded by ptx genes from Bordetella bronchiseptica to model the effects of antigenic drift of pertussis toxin on antibody neutralization. jcm.asm.org /cgi/content/full/39/12/4396   (4343 words)

Emerging Infectious Diseases: Bordetella pertussis isolates, Finland   (Site not responding. Last check: 2007-10-15) To the Editor: Pertussis, or whooping cough, is a highly contagious respiratory disease in humans caused by Bordetella pertussis. This observation has raised the question of whether vaccination has caused selection for the variant strains, and whether the reemergence of pertussis in vaccinated populations is due to vaccination not protecting against these antigenic variants as effectively as it protects against vaccine type strains. The incidence of pertussis is highest in infants <1 year of age and in schoolchildren from 6 to 14 years old, although about 30% of the cases occur in adults older than 20 years. www.findarticles.com /p/articles/mi_m0GVK/is_1_11/ai_n8966548   (1340 words)

In Vitro Susceptibilities of Bordetella pertussis and Bordetella parapertussis to Two Ketolides (HMR 3004 and HMR ... In Vitro Susceptibilities of Bordetella pertussis and Bordetella parapertussis to Two Ketolides (HMR 3004 and HMR 3647), Four Macrolides (Azithromycin, Clarithromycin, Erythromycin A, and Roxithromycin), and Two Ansamycins (Rifampin and Rifapentine) -- Hoppe and Bryskier 42 (4): 965 -- Antimicrobial Agents and Chemotherapy Antimicrobial susceptibility of Bordetella pertussis strains isolated from 1960 to 1981. Susceptibility of Bordetella pertussis to doxycycline, cinoxacin, nalidixic acid, norfloxacin, imipenem, mecillinam, and rifampicin. aac.asm.org /cgi/content/full/42/4/965   (858 words)

HPA | Bordetella pertussis RSIL Respiratory and Systemic Infection Laboratory National surveillance of pertussis is undertaken by Dr Natasha Crowcroft who can be contacted on 0208 200 6868 (extension 7437). The identification and characterisation of isolates of Bordetella spp. Specimen submissions regarded by the sending laboratory as urgent should be notified to APU by telephone (020 8327 7331/6906/7222) to ensure that the appropriate level of priority is accorded to these specimens immediately upon receipt. www.hpa.org.uk /cfi/rsil/bordetella.htm   (566 words)

Clinical Findings in Bordetella pertussis Infections: Results of a Prospective Multicenter Surveillance Study -- ... On follow-up, typical symptoms of pertussis such as paroxysms and whooping were reported in 90.2% and 78.9% of patients, respectively. Finger H, Wirsing von König CH, Tacken A, Wassilak SGF The epidemiological situation of pertussis in the Federal Republic of Germany. Cherry JD The epidemiology of pertussis and pertussis immunization in the United Kingdom and the United States: a comparative study. pediatrics.aappublications.org /cgi/content/full/100/6/e10   (3820 words)

Annual report of Bordetella for year 2001 Bacteria from the Bordetella genus are responsible for respiratory infections in humans (Bordetella pertussis and Bordetella parapertussis and whooping cough) and in animals (Bordetella bronchiseptica and atrophic rhinitis and kennel cough). pertussis, is responsible in vivo and in vitro of alveolar macrophages death via apoptosis but is not cytotoxic for epithelial cells. The use of specific antibodies able to neutralize toxins and adhesins activities could be a useful tool to decrease symptoms during infection and to stop transmission of the bacteria. www.pasteur.fr /recherche/RAR/RAR2001/Bordetel-en.html   (1257 words)

Bordetella pertussis View the organsim: Bordetella under the microscope (Courtesey D. Kunkel) Bacteriology 330 Lecture Topics: Bordetella pertussis and Whooping Cough (Kenneth Todar Uni Wisconsin Dept Bacteriology) Structure of Bordetella pertussis virulence factor P.69 pertactin (by Emsley et al) www.bacteriamuseum.org /species/Bpertussis.shtml   (157 words)

Disease Listing, Pertussis, Additional Information | CDC Bacterial, Mycotic Diseases The incidence in 2002 was 3.01/100,000 when 8,296 cases of pertussis were reported. Children who are too young to be fully vaccinated and those who have not completed the primary vaccination series are at highest risk for severe illness. Like measles, pertussis is highly contagious with up to 90% of susceptible household contacts developing clinical disease following exposure to an index case. www.cdc.gov /ncidod/dbmd/diseaseinfo/pertussis_t.htm   (272 words)

Healthopedia.com - Pertussis (Whooping Cough) The bacteria Bordetella pertussis causes pertussis, a respiratory illness characterized by severe episodes of cough. Pertussis is spread from person to person through respiratory secretions. The time between when a person is exposed to pertussis and when symptoms begin is usually 1 to 2 weeks. www.healthopedia.com /pertussis   (294 words)

BORDETELLA   (Site not responding. Last check: 2007-10-15) Bordetella organisms are small, Gram-negative coccobacilli which are strict aerobes. Under the microscope, Bordetella are often bipolar stained and appear singly or in pairs. Bordetella bronchiseptica is usually a cause of pneumonia, otitis media, and other respiratory infections in animals. medic.med.uth.tmc.edu /path/00001492.htm   (295 words)

Bordetella pertussis Lipopolysaccharide Resists the Bactericidal Effects of Pulmonary Surfactant Protein A -- Schaeffer ... Bordetella pertussis Lipopolysaccharide Resists the Bactericidal Effects of Pulmonary Surfactant Protein A -- Schaeffer et al. Pertussis toxin and lipopolysaccharide influence phagocytosis of Bordetella pertussis by human monocytes. Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, cyaC, for activation. www.jimmunol.org /cgi/content/full/173/3/1959   (4417 words)

Identification and Cloning of waaF (rfaF) from Bordetella pertussis and Use To Generate Mutants of Bordetella spp. with ... Bordetella pertussis is a gram-negative pathogen causing whooping cough in children and increasingly being implicated in respiratory Pneumonia caused by Bordetella bronchiseptica in a patient with a thoracic trauma. The differentiation of Bordetella parapertussis and Bordetella bronchiseptica from humans and animals as determined by DNA polymorphism mediated by two different insertion sequence elements suggests their phylogenetic relationship. jb.asm.org /cgi/content/full/180/1/35   (3430 words)

whooping cough --  Encyclopædia Britannica It is caused by the bacterium Bordetella pertussis; a similar illness is caused by B. parapertussis. The number of cases of whooping cough (pertussis), a serious disease that is frequently fatal in infancy, can be dramatically reduced by the use of the pertussis vaccine. Diphtheria and Tetanus Toxoids and Pertussis Vaccine Adsorbed USP www.britannica.com /eb/article-9076901   (771 words)

Comparison of culture and PCR for detection of Bordetella pertussis and Bordetella parapertussis under routine ... Douglas, E., Coote, J. G., Parton, R. and McPheat, W. Identification of Bordetella pertussis in nasopharyngeal swabs by PCR amplification of a region of the adenylate cyclase gene. McLafferty, M. A., Harcus, D. and Hewlett, E. Nucleotide sequence and characterization of a repetitive DNA element from the genome of Bordetella pertussis with characteristics of an insertion sequence. Polymerase chain reaction assay for pertussis: simultaneous detection and discrimination of Bordetella pertussis and Bordetella parapertussis. jmm.sgmjournals.org /cgi/content/full/53/8/749   (4179 words)

Sequences Required for Expression of Bordetella pertussis Virulence Factors Share Homology with Prokaryotic Signal ... The bvg locus of Bordetella pertussis is required for coordinate regulation of several factors associated with virulence. Polymorphism of Repeated Regions of Pertactin in Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica Contribution of Regulation by the bvg Locus to Respiratory Infection of Mice by Bordetella pertussis www.pnas.org /cgi/content/short/86/17/6671   (1135 words)

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