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	Bornavirus
		BDV is a noncytolytic, neurotropic RNA virus and the causative agent of Borna disease, a severe (frequently fatal) neurological disease of horses and sheep, characterised by progressive, nonpurulent encephalomyelitis.
		In 1926 the cause of Borna disease was identified as Borna disease virus (BDV).
		The symptoms of Borna disease in horses and sheep include behavioural changes, hyperactivity and disturbances in gait during the early stages of infection, with ataxia and partial paralysis being observed during the terminal stages of the disease.
	www-micro.msb.le.ac.uk /3035/Bornavirus.html (1250 words)

	EID V3 N2: Borna Disease
		Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells.
		Behavorial disease in rats caused by immunopathological responses to persistent Borna virus in the brain.
		Borna disease virus in peripheral blood mononuclear and bone marrow cells of neonatally and chronically infected rats.
	www.cdc.gov /ncidod/EID/vol3no2/hatalski.htm (3726 words)

	APHIS \| News
		Borna disease is a sporadic, transmissible, progressive neurologic disease of horses, cats, cattle, and sheep.
		Borna disease is a subacute, viral encephalomyelitis, which is a type of brain infection.
		Microscopically, the disease is characterized by an inflammation of nerve cells in the brain.
	www.aphis.usda.gov /lpa/pubs/fsheet_faq_notice/fs_ahborna.html (754 words)

	"TGF-beta and CFS" and "Borna Disease Virus (BDV) and CFS"
		"TGF-beta and CFS" and "Borna Disease Virus (BDV) and CFS"
		BDV codes for at least five proteins; nucleoprotein (p40), phosphoprotein (polymerase cofactor: p24), Matrix (gp18), Envelope protein (gp 56) and polymerase (p180) as shown in Figure 1.
		Positive signal of BDV gene was detected in 3 of 25 patients (12%) and anti-BDV antibody was detected in 6 of 25 patients (24%) with serological diagnosis using ELISA and immunoblot.
	www.co-cure.org /jp/cfsfmn/Borna.htm (3507 words)

	EID V3N3 Borna Disease Virus Infection in Animals and Humans
		BDV or a related agent was detected in the CSF of three neuropsychiatric patients (two patients with acute lymphocytic meningoencephalitis, one patient with acute schizophrenic psychosis; 67).
		Characterization of a Borna disease virus glycoprotein, gp18.
		Inhibition of immune-mediated meningoencephalitis in persistently Borna disease virus-infected rats by Cyclosporine A. J Immunol 1989;143:4250-6.
	www.cdc.gov /ncidod/eid/vol3no3/richt.htm (5825 words)

	Borna Virus and Psychiatric Disorders
		Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies--the key marker triplet determining infection and prevailing in severe mood disorders.
		Borna disease virus (BDV), an unique type of non-segmented negative-stranded enveloped RNA virus, is known as an animal pathogen that causes behavioral diseases in higher vertebrates.
		BDV isolates were identified by infectivity, analysis of viral antigens, sequencing of one viral gene, and successful infection of animals.
	www.psycom.net /borna.html (2715 words)

	Borna Disease Virus Glycoprotein Is Required for Viral Dissemination in Neurons -- Bajramovic et al. 77 (22): 12222 -- ...
		the necessity of BDV-GP for BDV dissemination in neurons.
		GP in BDV dissemination in the CNS is controversial (16).
		Borna disease and enzootic encephalomyelitis of sheep and cattle.
	jvi.asm.org /cgi/content/full/77/22/12222 (6161 words)

	Borna Virus and Disease - Review (Promed Ahead)
		Borna Disease Virus (BDV) is a unique agent associated with neurologic disease in a broad array of animals, and has recently been implicated as a possible cause of human affective disorders.
		BDV is a non-classified, enveloped, nonsegmented, negative-strand RNA virus (2) which replicates in cell nuclei.
		Bode L, Dietrich DE, Stoyloff R, Emrich HM and Ludwig H, "Amantadine and human Borna disease virus in vitro and in vivo in an infected patient with bipolar depression," Lancet, 349:178, 1997.
	members.iinet.net.au /~rabbit/bornapro.htm (1589 words)

	Borna Virus Linked to Mental Illness
		Borna disease is common in horses, where it can cause encephalitis.
		How Borna disease is transmitted is also a mystery, although there's evidence in animals that it may spread via nasal passages, Lipkin notes in an article in the July issue of Trends in Microbiology.
		Despite progress in understanding the molecular biology and pathobiology of Borna disease virus, its epidemiology and role in human disease remain controversial.
	www.namiscc.org /newsletters/July01/borna.htm (675 words)

	Persistence of Borna Disease Virus in Naturally Infected Sheep -- Vahlenkamp et al. 76 (19): 9735 -- The Journal of ...
		Spontaneous Borna disease in sheep and horses: immunophenotyping of inflammatory cells and detection of MHC-I and MHC-II antigen expression in Borna encephalitis lesions.
		Borna disease in Switzerland and in the principality of Liechtenstein.
		Adaptation of Borna disease virus to the mouse.
	jvi.asm.org /cgi/content/full/76/19/9735 (5118 words)

	Borna 2000
		"Pathogenesis of borna disease virus: granulocyte fractions of psychiatric patients harbor infectious virus in the absence of antiviral antibodies".
		It was determined a few years ago that BDV is present in the brains of a significant portion of patients exhibiting behavioral anomalies.
		"Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders." Journal of Infectious Diseases, 1999 Nov, 180(5):1695-9.
	www.stanford.edu /group/virus/borna/2000/update.html (979 words)

	Borna Disease Virus - Search Results - MSN Encarta
		Borna Disease Virus (BDV), disease-causing virus that consists of a single strand of ribonucleic acid (RNA) and is distantly related to the rabies...
		Human Disease, in medicine, any harmful change that interferes with the normal appearance, structure, or function of the body or any of its parts....
		Diseases of Plants : specific diseases: calico virus
	encarta.msn.com /Borna_Disease_Virus.html (149 words)

	HealthGene - Borna Disease Virus
		Borna Disease Virus (BDV) is an RNA virus and causes a disease of the central nervous system in several vertebrate species.
		The viral antigen and nucleic acid of BDV persists in the brain tissue of cats causing chronic inflammatory lesions.
		Subclinical infection with BDV is probably common in cats, because serological surveys reveal large numbers of clinically normal, seropositive cats in Borna disease-endemic areas.
	www.healthgene.com /vet/d309.asp (272 words)

	Borna Disease virus (Site not responding. Last check: 2007-11-01)
		The Borna virus was named after the region in Germany where it was first described.
		The borna virus, a virus that has been linked to mental disorders in animals has been isolated in humans.
		Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders.
	members.iinet.net.au /~rabbit/bornamy.htm (268 words)

	Borna Disease Virus Linked to Psychiatric Disorders
		For example, antibodies to the virus have been found with higher frequency in the blood of people with diseases such as panic disorder than in controls.
		Scientists only suspect that the virus is transmitted through the nasal passage, and it is not clear whether the virus passes from animals to humans or if there is a specific human strain.
		Also, the disease occurs only sporadically in a small endemic region in central Europe, which suggests there is an animal reservoir, such as a rodent, but so far none has been identified.
	earthops.org /borna1.html (542 words)

	borna virus disease
		In studies conducted on animals, immunocompromisedd and immunosuppressed rats did not become ill with borna disease despite viral replication in the CNS.
		In animals, BDV clinical manifestations range from inapparent infections, behavioral abnormalities (including depression, circular movement, standing in awkward positions, collapsing, and running into obstacles) obesity, fertility problems, and neurological diseases such as paralysis.
		Studies have indicated that cases of inapparent BDV infection may be common in humans as well.
	www.stanford.edu /group/virus/borna/2000/bornavirusdisease.htm (352 words)

	Epidemiology of Borna disease virus -- Staeheli et al. 81 (9): 2123 -- Journal of General Virology
		BDV is the causative agent of Borna disease (BD), a mostly fatal
		Borna virus infections in cattle associated with fatal neurological disease.
		Caplazi, P. and Ehrensperger, F. Spontaneous Borna disease in sheep and horses: immunophenotyping of inflammatory cells and detection of MHC-I and MHC-II antigen expression in Borna encephalitis lesions.
	vir.sgmjournals.org /cgi/content/full/81/9/2123 (7546 words)

	ARS \| Publication request: Maturation of Borna Disease Virus Glycoprotein (Site not responding. Last check: 2007-11-01)
		Borna disease is actually caused by side effects of the immune response to the viral infection, not by the virus itself.
		BDV can infect a wide range of warm-blooded animals with horses and sheep being the main natural hosts; there is speculation that BDV can also infect humans.
		Technical Abstract: The maturation of Borna disease virus (BDV) glycoprotein GP was studied in regard to intracellular compartmentalization, compartmentalization signal-domains, proteolytic processing, and packaging into virus particles.
	www.ars.usda.gov /research/publications/publications.htm?seq_no_115=190001 (322 words)

	CRISP - Computer Retrieval of Information on Scientific Projects, Abstract Display
		Although a genetic component is likely, discordance for disease in monozygotic twin studies and epidemiology suggest the presence of cofactors.
		BDV is a neurotropic RNA virus, worldwide in distribution, that causes movement and behavior disturbances in warmblooded animal hosts ranging from birds to primates.
		Thus, the significance of BDV for pathogenesis of neuropsychiatric disease remains controversial.
	crisp.cit.nih.gov /crisp/CRISP_LIB.getdoc?textkey=6392274&p_grant_num=7R01MH057467-03&p_query=&ticket=5598757&p_audit_session_id=25340857&p_keywords= (367 words)

	81.0.1.0.001 Borna disease virus
		Virus is listed in the plant virus database VIDEdB.
		Virus is the type species of the genus.
		All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.
	www.ictvdb.rothamsted.ac.uk /ICTVdB/01.081.0.01.001.htm (238 words)

	Virus Diseases
		Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider.
		West Nile Virus, and Migratory Birds and Spread of the West Nile Virus in the Western Hemisphere - CDC, Jul '00
		Borna Virus Suspected Cause for Neuropsychiatric Disorders in Humans [B Williams]
	www.mic.ki.se /Diseases/c2.html (2412 words)

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