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	Borna disease - Wikipedia, the free encyclopedia
		Borna disease in sheep and horses arises after a four week incubation period followed by the development of immune-mediated meningitis and encephalomyelitis.
		Borna virus appears to have a wide host range, having been detected in horses, cattle, sheep, dogs and foxes.
		In 1995, the virus was isolated from cats suffering from a "staggering disease" in Sweden.
	en.wikipedia.org /wiki/Borna_virus (817 words)

	Borna Disease (Site not responding. Last check: 2007-09-20)
		Borna disease virus in peripheral blood mononuclear and bone marrow cells of neo...
		"TGF-beta and CFS" and "Borna Disease Virus (BDV) and CFS"...
		High-Dose Borna Disease Virus Infection Induces a Nucleoprotein-Specific Cytotox...
	www.scienceoxygen.com /disease/86.html (474 words)

	EID V3 N2: Borna Disease
		Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells.
		Behavorial disease in rats caused by immunopathological responses to persistent Borna virus in the brain.
		Borna disease virus in peripheral blood mononuclear and bone marrow cells of neonatally and chronically infected rats.
	www.cdc.gov /ncidod/EID/vol3no2/hatalski.htm (3726 words)

	EID V3N3 Borna Disease Virus Infection in Animals and Humans
		BD is characterized by a disseminated nonpurulent meningoencephalomyelitis with infiltration of mononuclear cells (1,8,18,19) and a predilection for the gray matter of the cerebral hemispheres and the brain stem (8,19).
		Behavioral disease in rats caused by immunopathological responses to persistent Borna virus in the brain.
		Inhibition of immune-mediated meningoencephalitis in persistently Borna disease virus-infected rats by Cyclosporine A. J Immunol 1989;143:4250-6.
	www.cdc.gov /ncidod/eid/vol3no3/richt.htm (5825 words)

	It Kills Horses, Doesn’t It? - - science news articles online technology magazine articles It Kills Horses, Doesn’t ... (Site not responding. Last check: 2007-09-20)
		If Borna virus really was related to psychiatric illness, Bode figured, the best time to look for evidence was when the patients were actually ill. She contacted a psychiatrist in Berlin named Ron Ferszt, who worked in the Crisis Intervention Center of the Free University hospital.
		A blood test showed that Borna virus antigen had reappeared in her bloodstream; Dietrich thinks the problem was that he had reduced her dose of amantadine too much.
		Her model of how Borna virus is involved in psychiatric disturbance is one that permits it to be one of many causes--a risk factor, the way smoking is for lung cancer--and to have one of many effects.
	www.discover.com /issues/oct-97/features/itkillshorsesdoe1239 (6430 words)

	BORNA VIRUS
		Borna disease can also cause neurological symptoms in domestic animals, which is where it gets its nickname, 'crazy virus'.
		Early research indicated that the virus has a tropism for a specific group of neurons in the limbic system, the part of the brain associated with moods and emotions.
		Although definitive proof of active virus in these patients must await isolation of the virus, the demonstration of BDV DNA is exciting and important evidence supporting the ability of BDV to give rise to human neuropsychiatric disease," said Dr. Bode.
	www.accessexcellence.org /WN/SUA02/borna_virus.html (784 words)

	Borna Virus Suspected Cause for Neuropsychiatric Disorders in Humans
		Until recently borna virus of the family Bornaviridae was believed to be nonpathogenic in humans, although in many other mammals and even marsupials (opossums) it was known to cause a wide array of neurological manifestations, many of which are fatal.
		It would appear that if Borna virus does prove to be a major factor in neuropsychiatric illness the current best approach would be the development of a vaccine against it in order to reduce the occurrence of depression in the uninfected population.
		Borna Disease Virus Infection in Animals and Humans, by Jurgen A. Richt, Islode Pfeuffer, Matthias Christ, Knut Frese, Karl Bechter, and Sibylle Herzog, Emerging Infections Diseases, Vol.
	www.doofus.org /mercatroid/borna.html (1284 words)

	Borna Virus and Psychiatric Disorders
		Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies--the key marker triplet determining infection and prevailing in severe mood disorders.
		Borna disease virus (BDV), a noncytolytic neurotropic nonsegmented negative-stranded RNA virus with a wide geographic distribution, infects several vertebrate animal species and causes an immune-mediated central nervous system (CNS) disease with various manifestations, depending on both host and viral factors.
		Borna disease virus (BDV), an unique type of non-segmented negative-stranded enveloped RNA virus, is known as an animal pathogen that causes behavioral diseases in higher vertebrates.
	www.psycom.net /borna.html (2715 words)

	Borna Virus and Disease - Review (Promed Ahead)
		Borna Disease Virus (BDV) is a unique agent associated with neurologic disease in a broad array of animals, and has recently been implicated as a possible cause of human affective disorders.
		The rabies virus is an example of a zoonotic neurotropic viral agent, transmitted by saliva and spread intra-axonally to the central nervous system causing a fatal encephalitis.
		Bode L, Dietrich DE, Stoyloff R, Emrich HM and Ludwig H, "Amantadine and human Borna disease virus in vitro and in vivo in an infected patient with bipolar depression," Lancet, 349:178, 1997.
	members.iinet.net.au /~rabbit/bornapro.htm (1589 words)

	Borna Virus in Psychiatric Patients -- Neurotransmitter.net
		The possibility that the Borna virus is associated with mental disorders in humans was evaluated by examining serum samples from 979 psychiatric patients and 200 normal volunteers for the presence of Borna virus-specific antibodies.
		Borna disease virus antibodies and the deficit syndrome of schizophrenia.
		Borna disease virus and schizophrenia in Surinamese immigrants to the Netherlands.
	www.neurotransmitter.net /bornavirus.html (14166 words)

	[No title]
		Borna disease (BD), first described more than 200 years ago in southern Germany as a fatal neurologic disease of horses and sheep, owes its name to the town Borna in Saxony, Germany, where a large number of horses died during an epidemic in 1885.
		Other milestones in BD-related research were the demonstration of virus growth in cell cultures (2-4); the finding that the pathogenesis of BD is caused by a T-cell-dependent immune mechanism (5-8); and most recently, the molecular characterization of the etiologic agent of BD, the highly neurotropic Borna disease virus (BDV) (9-17).
		This review discusses the etiology of Borna disease, the natural and experimental infection in various animal species, the pathogenesis of the disease in the experimental rat model, the genetic stability of BDV, and the possible link between BDV or a similar agent and human neuropsychiatric disorders.
	ftp.cdc.gov /pub/EID/vol3no3/ascii/richt.txt (5823 words)

	Borna Disease Virus and Human Disease -- Carbone 14 (3): 513 -- Clinical Microbiology Reviews
		an RNA virus (88, 143) and the sequencing of the BDV genome
		Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation.
		Adaptation of Borna disease virus to the mouse.
	cmr.asm.org /cgi/content/full/14/3/513 (8629 words)

	HealthGene - Borna Disease Virus
		Borna Disease Virus (BDV) is an RNA virus and causes a disease of the central nervous system in several vertebrate species.
		In human beings, Borna Disease Virus could be responsible for certain psychiatric disorders.
		(1999) Borna disease virus infection in domestic cats: evaluation by RNA and antibody detection.
	www.healthgene.com /vet/d309.asp (272 words)

	Borna Virus Linked to Mental Illness
		Using a new diagnostic tool to screen blood for a pathogen known as the Borna virus, a team of German researchers from major academic institutions found that it infects up to 30 percent of healthy people and up to 100 percent of people with severe mood disorders.
		How Borna disease is transmitted is also a mystery, although there's evidence in animals that it may spread via nasal passages, Lipkin notes in an article in the July issue of Trends in Microbiology.
		Despite progress in understanding the molecular biology and pathobiology of Borna disease virus, its epidemiology and role in human disease remain controversial.
	www.namiscc.org /newsletters/July01/borna.htm (675 words)

	CNN - Research suggests virus may play role in depression - August 31, 1998
		Scientists are still unraveling the causes of the disease: genetics, stress and possibly a virus.
		The virus was first identified in the late 1800s among horses near the town of Borna, Germany.
		Autopsies led scientists to the virus in the region of the horses' brains that controls emotions.
	www.cnn.com /HEALTH/9808/31/depression.virus (392 words)

	Evidence of Borna disease virus genome detection in French domestic animals and in foxes (Vulpes vulpes) -- Dauphin et ...
		Cubitt, B. and de la Torre, J. Borna disease virus (BDV), a nonsegmented RNA virus, replicates in the nuclei of infected cells where infectious BDV ribonucleoproteins are present.
		Ludwig, H. and Bode, L. Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology.
		Sorg, I. and Metzler, A. Detection of Borna disease virus RNA in formalin-fixed, paraffin-embedded brain tissues by nested PCR.
	vir.sgmjournals.org /cgi/content/full/82/9/2199 (3140 words)

	Borna Disease Virus - Search Results - MSN Encarta (Site not responding. Last check: 2007-09-20)
		Borna Disease Virus - Search Results - MSN Encarta
		Borna Disease Virus (BDV), disease-causing virus that consists of a single strand of ribonucleic acid (RNA) and is distantly related to the rabies...
		Human Disease, in medicine, any harmful change that interferes with the normal appearance, structure, or function of the body or any of its parts....
	encarta.msn.com /Borna_Disease_Virus.html (177 words)

	Borna Disease virus (Site not responding. Last check: 2007-09-20)
		The Borna virus was named after the region in Germany where it was first described.
		The borna virus, a virus that has been linked to mental disorders in animals has been isolated in humans.
		Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders.
	members.iinet.net.au /~rabbit/bornamy.htm (268 words)

	High-Dose Borna Disease Virus Infection Induces a Nucleoprotein-Specific Cytotoxic T-Lymphocyte Response and Prevention ...
		infection of the CNS and induces Borna disease (BD), an immune-mediated
		virus infection with the consequence of a persistent infection
		Borna virus infections in cattle associated with fatal neurological disease.
	jvi.asm.org /cgi/content/full/75/23/11700 (4621 words)

	New Scientist Breaking News - Virus causes mental illness symptoms in mice (Site not responding. Last check: 2007-09-20)
		The effects of the protein, produced by a common pathogen called the Borna disease virus (BDV), may help scientists understand how viruses could contribute to psychiatric disease in humans.
		While one in three healthy people are infected with BDV - which attacks the central nervous system nearly 100 per cent of people with severe mood disorders have the virus, found a study in 2001.
		However, he adds that most human studies linking virus and disease have found that infection must occur at a specific point in development to have behavioural consequences.
	www.newscientist.com /article.ns?id=dn3913 (370 words)

	Borna Disease Virus Nucleoprotein (p40) Is a Major Target for CD8+-T-Cell-Mediated Immune Response -- Planz and Stitz ...
		Brain cell lesions in Borna disease are mediated by T cells.
		Sequence similarity between Borna disease virus p40 and a duplicated domain within the paramyxovirus and rhabdovirus polymerase proteins.
		Persistence of Borna disease virus-specifc nucleic acid in blood of psychiatric patient.
	jvi.asm.org /cgi/content/full/73/2/1715 (2294 words)

	Arch Gen Psychiatry -- Abstract: Borna disease virus. A possible etiologic factor in human affective disorders?, ...
		Borna disease virus is a unique neurotropic agent that appears to have a
		Borna Disease Virus RNA in Immunocompromised Patients in Southwestern France
		Detection of Borna Disease Virus-Reactive Antibodies from Patients with Psychiatric Disorders and from Horses by Electrochemiluminescence Immunoassay
	archpsyc.ama-assn.org /cgi/content/abstract/42/11/1093 (322 words)

	Epidemiology of Borna disease virus -- Staeheli et al. 81 (9): 2123 -- Journal of General Virology
		Caplazi, P. and Ehrensperger, F. Spontaneous Borna disease in sheep and horses: immunophenotyping of inflammatory cells and detection of MHC-I and MHC-II antigen expression in Borna encephalitis lesions.
		Carbone, K. M., Duchala, C. S., Griffin, J. W., Kincaid, A. and Narayan, O. Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation.
		Nowotny, N. and Kolodziejek, J. Demonstration of Borna disease virus nucleic acid in a patient suffering from chronic fatigue syndrome.
	jgv.sgmjournals.org /cgi/content/full/81/9/2123 (7569 words)

	Virus Diseases
		Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider.
		West Nile Virus, and Migratory Birds and Spread of the West Nile Virus in the Western Hemisphere - CDC, Jul '00
		Borna Virus Suspected Cause for Neuropsychiatric Disorders in Humans [B Williams]
	www.mic.ki.se /Diseases/c2.html (2391 words)

	borna virus disease
		In addition to the CNS, T-cells play in important role in the pathology of BDV.
		In studies conducted on animals, immunocompromisedd and immunosuppressed rats did not become ill with borna disease despite viral replication in the CNS.
		Studies have demonstrated that rats injected with BDV-specific T cells before infection were protected against borna disease when infected.
	www.stanford.edu /group/virus/borna/2000/bornavirusdisease.htm (352 words)

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