British anti-Lewisite

British anti-Lewisite - Factbites
Where results make sense
About us | Why use us? | Reviews | PR | Contact us

Topic: British anti-Lewisite

Note: these results are not from the primary (high quality) database.

In the News (Wed 30 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Lewisite - Wikipedia, the free encyclopedia
		After BAL, British anti-Lewisite, was discovered, rendering Lewisite obsolete, the US neutralized its stockpile of Lewisite with bleach and dumped it into the Gulf of Mexico.
		Lewisite is usually found as a mixture of isomers, 2-chlorovinylarsonous dichloride should predominate but often bis (2-chloroethenyl)arsinous dichloride and tris (2-chlorovinyl) arsine are present.
		Lewisite is a chemical compound from a chemical family called arsines.
	en.wikipedia.org /wiki/Lewisite

	British anti-Lewisite - Wikipedia, the free encyclopedia
		British Anti Lewisite, often referred to by its acronym BAL, is a compound developed by the British biochemists of Oxford University during World War II.
		It was developed secretly as an antidote for Lewisite poisoning, which is a now-obsolete chemical warfare agent.
		It converts Lewisite into a non-toxic cyclic compound and also forms protective complexes with arsenic within the body of an Lewisite-exposed victim.
	www.wikipedia.org /wiki/Dimercaprol

	Mitretek Systems :: Chemistry of Lewisite
		Following World War II, Lewisite was considered obsolete by the major powers because of the discovery that 2,3-dimercaptopropanol ("British anti-Lewisite") was an inexpensive and effective antidote to Lewisite exposure.
		Lewisite was never used because of the armistice; a shipload of Lewisite-filled munitions was crossing the Atlantic at the cessation of hostilities.
		Lewisite was discovered near the end of World War I by a team of Americans headed by Capt. W.
	www.mitretek.org /home.nsf/homelandsecurity/Lewisite

	Virtual Naval Hospital: United States Army Medical Research Institute of Chemical Defense: Medical Management of Chemical Casualties Handbook, Third Edition
		The Lewisite antidote, British-Anti-Lewisite (BAL), finds medicinal use today as a heavy-metal chelator.
		Lewisite is sometimes mixed with mustard to achieve a lower freezing point of the mixture for ground dispersal and aerial spraying.
		Lewisite attacks the butyl rubber in the chemical protective gloves and boots, which nevertheless are expected to protect against field concentrations of Lewisite until they can be exchanged for fresh gloves and boots.
	www.vnh.org /CHEMCASU/04Vesicants.html

	NorthStar Preparedness Network - Arsenical Vesicants-Lewisite Treatment
		Dimercaprol is the current therapy for lewisite poisoning.
		BAL ointment is spread on the skin in a thin film and allowed to remain at least 5 minutes.
		BAL given to rabbits poisoned with sodium arsenite produced an increase in brain arsenic levels.
	www.preparednessnetwork.org /northstar/warfare/arstreat.html

	A Role for a Wortmannin-Sensitive Phosphatidylinositol-4-Kinase in the Endocytosis of Muscarinic Cholinergic Receptors -- Sorensen et al. 53 (5): 827 -- Molecular Pharmacology
		BAL for 15 min before the addition of vehicle or Oxo-M. Incubations were allowed to proceed for an additional 30 min, followed by quantification of mAChR endocytosis as described in the legend to Fig.
		PAO-mediated inhibition of mAChR endocytosis and phosphoinositide synthesis is reversed by BAL.
		PAO inhibits agonist-induced mAChR endocytosis and is readily reversed by BAL.
	www.molpharm.org /cgi/content/full/53/5/827

	Chelation therapy - Iridis Encyclopedia
		The first widely used chelating agent was called British Anti- Lewisite, or BAL, a name given to dimercaprol.
		Lewisite gas was an arsenic based organic compound used in gas warfare; BAL bound the arsenic compounds from lewisite in the body and enabled it to be excreted harmlessly.
		Chelation therapy is used as a treatment for acute mercury, arsenic, lead, plutonium and other forms of heavy metal poisoning, where the amounts are so high that there is enough risk to the health of the patient to justify the therapy.
	www.iridis.com /Chelation_therapy

	Comparison of the Effects of British Anti-Lewisite (BAL) and Beta Mercapto Ethanol on the Reduction and Cleavage of Disulfide Bonds in IgG and Human Keratinocyte Proteins - Storming Media
		British anti-lewisite and beta mercapto ethanol both caused alterations in the electrophoretic migration patterns of each protein population, but it was not possible to determine which compound was the more active with regard to denaturing human cellular proteins.
		BAL was proposed because of data regarding its efficacy, and it has been cleared for therapeutic use in humans.
		The results indicate that BAL is capable of reducing both inter and intrachain disulfide bridges in proteins, thus denaturing them and possibly causing a loss of function.
	www.stormingmedia.us /98/9832/A983291.html

	Probert Encyclopaedia: Abbreviations (B)
		BA is an abbreviation for British Association screw thread
		BWI is an abbreviation for British West Indies
		BTU is an abbreviation for British Thermal Unit
	www.probertencyclopaedia.com /N2.HTM

	Wilson's Disease Glossary
		BAL (British Anti-Lewisite) = The first drug discovered to be effective in the treatment of Wilson's Disease.
		BAL was originally developed as an antidote for Lewisite.
		Lewisite a chemical warfare agent similar to mustard gas.
	www.gourmandizer.com /wilsons/glossary.html

	Nat' Academies Press, Veterans at Risk: The Health Effects of Mustard Gas and Lewisite (1993)
		Lewisite injuries cause necrosis of the deep corneal layers with loss of nuclei of all keratocytes and loss of normal staining characteristics in collagen fibers (Adler et al., 1947).
		Many of the rabbits in the Lewisite study were watched for more than one year; no secondary lipoid degeneration or cholesterin deposition was noted, nor any long-term effect, in particular (Mann et al., 1946).
		A summary of the toxicology of Lewisite liquid and vapor is separately tabulated in Table 8-2.
	books.nap.edu /books/030904832X/html/131.html

	Rocky Mountain Arsenal (RMA) - United States Nuclear Forces
		Development of an effective antidote, British Anti-Lewisite (BAL) rendered Lewisite obsolete by the end of 1943; therefore, it was never used in combat.
		Lewisite, a blistering agent intended for use in combat during WWII, was produced at RMA from April 1943 through November 1943.
		Lewisite production was effected by allowing arsenic trichloride to react with acetylene in the presence of a hydrochloric acid solution of mercuric chloride.
	www.globalsecurity.org /wmd/facility/rocky.htm

	IU Research and Creative Activity Magazine
		British biochemists at Oxford University first formulated this antidote in 1940, and it was further refined at DuPont Laboratories in the United States.
		Conant joined the research on lewisite, developing a method to reduce its volatility so that it could be considered seriously as a potential weapon.
		Contact with lewisite can certainly have horrifying effects, however, including painful blistering of the skin, damage to the eyes and respiratory system, and, because of its arsenic content, death.
	www.indiana.edu /~rcapub/v26n1/strange.shtml

	Arsenic
		British anti-lewisite (BAL, dimercaprol) was developed during WWII as an antidote for the arsenic-containing German vesicant gas lewisite.
		The organic arsenic compound lewisite was used in chemical warfare during WWII.
		It is a dithiol-containing chelator and contains sulfhydryl groups, which combine with arsenic to form a five-membered dimercaprol-arsenic ring, which is more stable than the six-membered lipoate-arsenic ring so arsenic combines with dimercaprol in preference to lipoate (Kosnett, 1998).
	www.portfolio.mvm.ed.ac.uk /studentwebs/session2/group12/arsenic.htm

	Chemical Warfare Agents
		Lewisite is irritating to nasal passages and produces a burning sensation followed by profuse nasal secretion and violent sneezing.
		In a pure form lewisite is a colorless and odourless liquid, but usually contains small amounts of impurities that give it a brownish colour and an odour resembling geranium oil.
		Chemical inactivation using chlorination is effective against mustard and Lewisite, less so against HN, and is ineffective against phosgene oxime.
	www.fas.org /nuke/intro/cw/agent.htm

	Applications
		British Anti-Lewisite (BAL) was developed as an antidote.
		Lewisite acts by reacting with the SH groups (usually cysteine residues) of various enzymes.
		BAL can be used for mercury and lead poisoning, but not for cadmium poisoning as it forms a soluble complex that can disperse throughout the body.
	www.chem.shef.ac.uk /level-4/cha99kw/apply/apply4.html

	Sound Medicine for April 5, 2003
		British Anti-Lewisite, a heavy metal chelating agent, is an antidote capable of removing heavy metals such as arsenic, copper, mercury and lead from the human body.
		He explains how the antidote for Lewisite, BAL, is still an excellent way to rid the human body of arsenic and heavy metal toxins.
		Known as BAL, the compound was created out of fear that the German Army would use Lewisite, a deadly arsenic-based liquid similar to mustard gas.
	soundmedicine.iu.edu /archive/2003/040503.html

	British anti-Lewisite :: Introduction
		British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years.
		Although other chelators have now been developed with less toxicity, British anti-Lewisite maintains a prominent role in the treatment of various medical conditions.
		It is also well-known for its role in World War II (WWII) as an antidote to the chemical warfare agent Lewisite (2-chlorovinyldichloroarsine).
	www.chm.bris.ac.uk /motm/bal

	WWII Discovery May Counter Bioterrorists
		Today, BAL is one recommended treatment for children with very high blood lead levels in conjunction with other agents, the IU School of Medicine researchers noted in their article.
		BAL is a medical therapy to remove metal poisonings from the body.
		After the war, BAL was put to clinical use by becoming the first successful treatment for Wilson's disease, a genetic disorder that causes the body to retain copper.
	www.sciencedaily.com /releases/2003/02/030228072906.htm

	BAL - Basic Assembly Language
		British Anti-Lewisite – A name for the drug dimecaprol–a treatment for toxic inhalations.
		British Anti-Lewisite - A name for the drug dimecaprol - a treatment for toxic inhalations.
		The usual ratio standards are the number of grams of alcohol either per 100 milliliters of blood, or per 210 liters of breath.
	www.auditmypc.com /acronym/BAL.asp

	Dartmouth Toxic Metal Research - Toxic Metals!
		This effective antidote became known by the acronym of BAL, for British Anti-Lewisite.
		The British response to this threat was an intensive research program that culminated in the discovery of a simple sulfur-containing organic molecule which was highly effective in inactivating Lewisite on the skin, since it attracted arsensic away from biologically more important sites.
		On contact with the skin the gas reacted with sulfur on keratin, a skin protein, to produce huge blisters that were made worse by the release of caustic hydrochloric acid, also produced by the chemical reaction.
	www.dartmouth.edu /%7Etoxmetal/TXSHas.shtml

	Bal
		Synonyms: Dimercaprol; British Anti-Lewisite; 2,3-dimercapto-1-propanol; 3-hydroxy-1,2-propanedithiol; dicaptol; dimercaprol propanol; 2,3-dimercaptopropan-1-ol; dithioglycerol; 1,2-dithioglycerol; sulfactin; 2,3-dimercaptopropanol
	www.iephb.nw.ru /~spirov/hazard/bal.html

	Antimony potassium tartrate (UK PID)
		Antidotes Dimercaprol (British anti-lewisite, BAL) (Braun et al, 1946; Thompson and Whittaker, 1947), dimercaptosuccinic acid (DMSA, Succimer) (Basinger and Jones, 1981) and dimercaptopropane sulphonate (DMPS, Unithiol) (Basinger and Jones, 1981; Hruby and Donner, 1987) have antidotal activity in experimental systemic antimony poisoning (see below).
		The efficacy of 2,3-dimercaptopropanol (BAL) in the therapy of poisoning by compounds of antimony, bismuth, chromium, mercury and nickel.
		These findings have not been confirmed in controlled studies in man. Dimercaprol In vitro studies Using the pyruvate oxidase system of pigeon brains as a test model, dimercaprol in a molar ratio of 6:1 dimercaprol: antimony was able to protect the enzyme system from inhibition by several antimony salts (Thompson and Whittaker, 1947).
	www.intox.org /databank/documents/pharm/anttart/ukpid37.htm

	dimercaprol. The American Heritage® Dictionary of the English Language: Fourth Edition. 2000.
		, used as an antidote for poisoning caused by lewisite, organic arsenic compounds, and heavy metals including mercury and gold.
	www.bartleby.com /61/71/D0227100.html

	Bal
		BAL may stand for: Bangladesh Awami League British anti-Lewisite...
		British anti-Lewisite, the antidote for the blister agent Lewisite
		bal ( on) VolapÃ¼k Noun one ---- Dutch Noun (1) bal...
	www.33beat.com /Bal.html

	Virtual Naval Hospital: Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare: Chapter 3
		The Americans developed Lewisite, an arsenical, at the end of World War I. It did not turn out to be a particularly effective agent, although it did lead to the development of British anti-Lewisite (BAL), which is useful as a chelating agent in metal poisoning.
		In 1916, the British developed a “box respirator” (Figure 3-8), in which the mask was connected by a hose to a canister filled with protective chemicals and filters and carried in a canvas pouch.
		The British rapidly developed a flannel hood, in which a flannel bag with eyepieces was soaked glycerin and sodium thiosulfate and then pulled over the head (Figure 3-4).
	www.vnh.org /MedAspChemBioWar/chapters/chapter_3.htm

	Chemical Agent Terrorism
		The antidote for Lewisite, British-Anti-Lewisite (BAL), is useful if applied early.
		Lewisite and phosgene oxime cause pain on contact with agent vapor or with liquid agent.
		Sulfur mustard is the most widely known of this class; others are Lewisite and phosgene oxime.
	www.nbc-med.org /SiteContent/MedRef/OnlineRef/Other/chagter.html

	Inhibition of cell wall associated peroxidase isozymes with British Anti Lewisite.
		Inhibition of cell wall associated peroxidase isozymes with British Anti Lewisite.
	www.uga.edu /srel/Reprint/0726.htm

	British Journal of Pharmacology - The phosphatidylinositol 4-kinase inhibitor phenylarsine oxide blocks evoked neurotransmitter release by reducing calcium entry through N-type calcium channels
		This partial reversal of both the peak Ca current and the restoration of repetitive firing by BAL is illustrated in Figure 2d.
		Co-application of BAL in the same experiment both reversed the increase in steady-state inward current and partially restored the depolarization-evoked Ca current ( Figure 4d).
		The experiment of Figure 4b also illustrates that co-application of BAL with PAO both stopped the reduction in Ca current and produced a partial reversal of its inhibition.
	www.nature.com /bjp/journal/v130/n2/full/0703299a.html

Try your search on: Qwika (all wikis)

Topic: British anti-Lewisite

Ads by Google

Related Topics

In the News (Wed 30 Dec 09)