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Topic: Brugada syndrome

Related Topics

Sudden cardiac death

Long QT syndrome

Hypertrophic cardiomyopathy

Cardiac arrhythmia

Atrial flutter

Cardiology

Atrial fibrillation

Ischaemic heart disease

Tachycardia

Electrical conduction system of the heart

Hyperthyroidism

Cardioversion

The Bellmaker

Bernardo Accolti

Willard Phelps

	Brugada syndrome - Wikipedia, the free encyclopedia
		, the Brugada syndrome causes sudden death by causing ventricular fibrillation (a lethal arrhythmia) in the heart.
		Brugada syndrome is due to a mutation in the gene that encodes for the sodium ion channel in the cell membranes of the muscle cells of the heart (the myocytes).
		The cause of death in Brugada syndrome is ventricular fibrillation.
	en.wikipedia.org /wiki/Brugada_syndrome (462 words)

	Indian Pacing and Electrophysiology Journal - Brugada Syndrome (Site not responding. Last check: 2007-10-12)
		The manifestations of the syndrome are caused by episodes of polymorphic VT/VF.
		The diagnosis of the syndrome is easily obtained by electrocardiography as long as the patient presents the typical ECG pattern and there is a history of aborted sudden death or syncopes caused by a polymorphic VT. The ST segment elevation in V1 to V3 with the right bundle branch block pattern is characteristic.
		In the Brugada syndrome, as in the long QT syndrome, the best candidate genes are those that are responsible for the formation of the cardiac action potential, namely the genes that encode for the cardiac ionic channels.
	www.ipej.org /0101/brugada.htm (2543 words)

	Baylor Health Care System: Brugada syndrome
		The characteristic electrocardiographic abnormality may be difficult to distinguish from that of the early repolarization syndrome, a benign condition that usually shows an elevated ST segment in V2 through V4 associated with upward concavity of the ST segment and upright T wave.
		Initial observations of asymptomatic patients with the Brugada pattern (whether the pattern was present spontaneously or induced by drugs) showed a prognosis that was poor and essentially similar to that of patients who had experienced aborted sudden death (10).
		Brugada J, Brugada P. Further characterization of the syndrome of right bundle branch block, ST segment elevation, and sudden cardiac death.
	www.baylorhealth.edu /proceedings/14_2/14_2_scheinman.html (1540 words)

	CJEM \| JCMU 2005; 7(5):347-50 :: Case Report (Site not responding. Last check: 2007-10-12)
		Brugada syndrome was described by Pedro and Josep Brugada in 1992 as a cause of sudden cardiac death.
		Brugada syndrome is most prevalent in young adult males of Southeast Asian descent, but it has been documented in both genders, all age groups and a variety of ethnic populations, accounting for 0.05%-0.6% of cases of SCD, depending on the population studied.
		Brugada syndrome is a significant cause for SCD in young patients and is imminently treatable.
	www.caep.ca /004.cjem-jcmu/004-00.cjem/vol-7.2005/v75.347-50.htm (1598 words)

	The Calicut Medical Journal
		The initial description of this entity by Brugada brothers was in 1992.[1] This new syndrome is characterised by syncopal episodes and/or sudden death in patients with a structurally normal heart and a characteristic electrocardiogram (ECG) with a pattern of right bundle branch block (RBBB) with ST segment elevation in leads V1 to V3.
		Pedro and Josep Brugada, presented as an abstract in the North American Society of Pacing and Electrophysiology (NASPE) meeting, three cases of a new clinical and electrocardiographic syndrome, characterised by the association of RBBB, persistent ST segment elevation, normal QT interval and SCD in 1991[5].
		Brugada Syndrome is a clinical entity which has been described in the last decade of the 20th century.
	www.calicutmedicaljournal.org /2003;1(1)e3.htm (1595 words)

	Brugada syndrome - Genetics Home Reference
		Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm.
		Sudden unexplained nocturnal death syndrome (SUNDS) is a condition characterized by unexpected cardiac arrest in young adults, usually during sleep.
		Mutations in the SCN5A gene cause Brugada syndrome.
	ghr.nlm.nih.gov /condition=brugadasyndrome (677 words)

	MMRL Brochures -- Brugada Syndrome, 2003 (Site not responding. Last check: 2007-10-12)
		It was a great opportunity for Dr. Ramon Brugada, the Brugada Foundation and MMRL to incorporate a patient-focused program dealing with the genetics of familial arrhythmias with the ongoing cardiac research at the Laboratory.
		A parent with the Brugada syndrome usually has a 1 in 2 chance of transmitting the disease to their son or daughter.
		Investigations conducted at the MMRL have delineated the ionic and cellular mechanism responsible for the arrhythmias that cause sudden death in patients with the Brugada syndrome.
	www.mmrl.edu /pubs/bro-brugada.htm (1345 words)

	Brugada Sydrome - Literature Related to Brugada Syndrome 2000 To Present
		Brugada P, Brugada R, Brugada J. Sudden death in patients and relatives with the syndrome of right bundle branch block, ST segment elevation in the precordial leads V1 to V3 and sudden death.
		Overdose of cyclic antidepressants and the Brugada syndrome.
		Brugada syndrome masquerading as acute myocardial infarction in a patient presenting with ventricular fibrillation.
	www.brugada.org /NewsAndLit/rellit_2000-2002.html (6714 words)

	Brugada syndrome - The Doctors Lounge(TM)
		The symptom of Brugada Syndrome is sudden death by heart failure - at any time, without warning.
		Brugada syndrome (at least sometimes) is associated with a disorder of sodium ion channels - they overly restrict the movement of sodium ions into the cell, interfering with the regulation of the electric field, and hence the electrical signaling.
		Brugada syndrome, which is mostly seen in males, is believed to be second to traffic accidents as a cause of death to Thai men.
	www.thedoctorslounge.net /cardiology/diseases/brugada.htm (439 words)

	Cogprints - Role of pharmacotherapy in Brugada syndrome
		Brugada et al., 3 suggested that among the asymptomatic patients, the inducibility of VT during the EP study might be a prognostic marker of risk.
		In patients with asymptomatic Brugada syndrome who are family members of symptomatic Brugada syndrome patients, the same strategy as that for the symptomatic Brugada syndrome patients should be considered 2,3,4.
		In another asymptomatic-patient group in whom an ECG that discloses the Brugada sign is performed for routine reasons such as a workup prior to surgery or sport license or screening for insurance, risk stratification to find the patients at high risk is needed because in most cases these patients have a benign prognosis3,22,23.
	cogprints.org /4236 (1075 words)

	Genaissance - Brugada Syndrome (Site not responding. Last check: 2007-10-12)
		Like Long QT Syndrome (LQT), Brugada Syndrome is caused by abnormalities in cardiac ion channels and can result in abnormal electrical activity in the heart.
		Thus, Brugada Syndrome is very similar to LQT Syndrome but the electrocardiogram may look different and distinct.
		The abnormal heart function of Brugada Syndrome may cause a very fast heartbeat called ventricular fibrillation, which is a very disorganized beating of the heart that compromises blood flow to the body.
	www.genaissance.com /pharmacogenomics/brugada_syndrome.asp (142 words)

	Indian Pacing and Electrophysiology Journal - Maury (Site not responding. Last check: 2007-10-12)
		The Brugada syndrome was diagnosed by abnormal QRST complexes in leads V1 and V2 with a coved ST segment elevation in 4 patients, one who had a familial
		Brugada syndrome had been diagnosed 9 months and 3 years prior to the clinical episodes of VF in 2 patients.
		Premature beats in the Brugada syndrome were monomorphic in all, coming from the RVOT in three patients (left bundle branch-inferior axis morphology, coupling interval of 343 ± 59 ms) and with left bundle branch block-superior axis morphology in one (coupling interval 278 ± 29 ms).
	www.ipej.org /0501/maury.htm (3643 words)

	Brugada Syndrome (Site not responding. Last check: 2007-10-12)
		Brugada syndrome is an abnormality of the heart cells that disrupts the electrical activity in the heart and can cause life-threatening heart rhythms.
		Because Brugada syndrome disturbs the heart's rhythm, blood is not pumped effectively through the body.
		In many cases, the cause of Brugada syndrome is not known.
	www.csmc.edu /pf_8645.html (361 words)

	Long QT Syndrome and Brugada Syndrome
		The proteins involved in the Long QT Syndrome consist of two of the potassium "channels" which regulate the behaviour of potassium ions moving from the inside to the outside of the cell.
		In addition, a sodium "channel" is also affected and this regulates the behaviour of sodium ions that move from the outside to the inside of cells.
		The potassium channel Long QT syndrome is associated with sudden death related to exercise or when startled or aroused suddenly, while the sodium channel form is associated with death while asleep.
	www.c-r-y.org.uk /long_qt_syndrome.htm (1229 words)

	Brugada Sydrome - Literature Related to Brugada Syndrome 2000 To Present (Site not responding. Last check: 2007-10-12)
		Hong K, Brugada J, Oliva A, Berruezo-Sanchez A, Potenza D, Pollevick GD, Guerchicoff A, Matsuo K, Burashnikov E, Dumaine R, Towbin JA, Nesterenko V, Brugada P, Antzelevitch C, Brugada R. Value of electrocardiographic parameters and ajmaline test in the diagnosis of Brugada syndrome caused by SCN5A mutations.
		Pseudopseudo-Brugada syndrome is a preferred term to variants of the variants of the Brugada syndrome.
		Prevalence of drug-induced electrocardiographic pattern of the Brugada syndrome in a healthy population.
	www.brugada.org /NewsAndLit/rellit_2004.html (2282 words)

	EMINTER : Notice
		Since its introduction as a new clinical entity in 1992, the Brugada syndrome has attracted great interest because of its high incidence in many parts of the world and its association with high risk for sudden death in infants, children and young adults.
		Recent years have witnessed an exponential rise in the number of reported cases and a striking proliferation of papers serving to define the clinical, genetic, cellular, ionic and molecular aspects of the disease.
		The book handles this topic in a very comprehensive manner with the clinical, molecular, genetic, and cellular aspects of the Brugada syndrome authored by the leading experts in the field.
	www.eminter.fr /fr/not.asp?id=RKOUARL3LLSOPJ (211 words)

	Brugada syndrome--the missed epidemic -- Butler 17 (6): 426 -- Emergency Medicine Journal
		Brugada syndrome is a cause of sudden cardiac death
		Brugada P, Brugada J. Right bundle branch block and ST segment elevation in leads V1-V3.
		Brugada syndrome: syncope in the younger patient and the risk of sudden cardiac death
	emj.bmjjournals.com /cgi/content/full/17/6/426 (1228 words)

	Brugada syndrome - MayoClinic.com
		The term "Brugada sign" refers to an abnormal finding on an electrocardiogram (ECG) that may indicate Brugada syndrome.
		Brugada syndrome is an abnormality in the heart's electrical system that causes life-threatening heart rhythm disturbances (arrhythmias).
		In Brugada syndrome, a defect in these channels causes episodes of abnormal electrical function.
	www.mayoclinic.com /health/brugada-syndrome/AN00551 (377 words)

	Brugada syndrome: an electrocardiographic diagnosis not to be missed -- BRUGADA 84 (1): 1 -- Heart
		Brugada syndrome: an electrocardiographic diagnosis not to be missed -- BRUGADA 84 (1): 1 -- Heart
		Brugada syndrome: an electrocardiographic diagnosis not to be missed
		Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden death: a distinct clinical and electrocardiographic syndrome.
	heart.bmjjournals.com /cgi/content/full/84/1/1 (652 words)

	Brugada syndrome associated with an autonomic disorder -- CHENG 81 (3): 330 -- Heart
		I read with interest the case report from Japan of a patient with Brugada syndrome associated with an autonomic disorder.
		The diagnosis of Brugada syndrome calls for implantation of an implantable cardioverter defibrllator
		Epidemiology of sudden unexplained death syndrome among Thai migrant workers in Singapore.
	heart.bmjjournals.com /cgi/content/full/81/3/330a (320 words)

	Variable presentation of Brugada syndrome: lessons from three generations with syncope -- Plunkett et al. 326 (7398): ... (Site not responding. Last check: 2007-10-12)
		Brugada syndrome is an inherited cardiac disease causing ventricular
		The syndrome is inherited as an autosomal dominant
		Naccarelli GV, Antzelevitch C. The Brugada syndrome: clinical, genetic, cellular, and molecular abnormalities.
	bmj.bmjjournals.com /cgi/content/full/326/7398/1078 (975 words)

	Brugada syndrome
		Inherited brugada and LQT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes.
		Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome.
		Brugada P, Geelen P, Brugada R, Mont L, Brugada J. Prognostic value of electrophysiologic investigations in Brugada syndrome.
	www.orpha.net /data/patho/GB/uk-BrS.html (2217 words)

	Brugada Syndrome (Site not responding. Last check: 2007-10-12)
		Second, the delineation of the disease coincided with a burst of activity in molecular biology and at the beginning of a golden age with the Human Genome.
		Third, once thought to be rare, the Brugada syndrome is now recognized to have a relatively high incidence, particularly in Southeast Asia.
		Basic research into the mechanisms underlying the Brugada syndrome is in its infancy and the next 10 years will provide a greater understanding of this lethal disease.
	www.dekker.com /sdek/85391319-30793549/abstract~db=enc~content=a713544899~words= (304 words)

	Proposed Diagnostic Criteria for the Brugada Syndrome: Consensus Report -- Wilde et al. 106 (19): 2514 -- Circulation (Site not responding. Last check: 2007-10-12)
		Brugada syndrome and sudden cardiac death in children.
		Body surface distribution and response to drugs of ST segment elevation in Brugada syndrome: clinical implications of eighty-seven-lead body surface potential mapping and its application to twelve-lead electrocardiograms.
		Brugada syndrome: a case report of monomorphic ventricular tachycardia.
	circ.ahajournals.org /cgi/content/full/106/19/2514 (3985 words)

	Cardiac Na+ Channel Dysfunction in Brugada Syndrome Is Aggravated by {beta}1-Subunit -- Makita et al. 101 (1): 54 -- ...
		in the Brugada syndrome: a splice-donor mutation, a frame-shift
		Brugada syndrome and LQT3 are distinct entities from both a
		Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome: a multicenter report.
	circ.ahajournals.org /cgi/content/full/101/1/54 (3458 words)

	Ionic Mechanisms Responsible for the Electrocardiographic Phenotype of the Brugada Syndrome Are Temperature Dependent ...
		Ionic Mechanisms Responsible for the Electrocardiographic Phenotype of the Brugada Syndrome Are Temperature Dependent -- Dumaine et al.
		Whole-cell current for WT and Brugada syndrome mutant (Thr1620Met) in transiently transfected TSA201 cells at room temperature (22°C) and 32°C. A, Location of the missense mutations Arg1232Trp (R1232W) and Thr1620Met (T1620M) previously described by Chen et al.
		Shown are current recordings obtained at different test potentials from -70 to -25 mV (32°C) and -65 to -20 (22°C) in increments of 5 mV from a holding potential of -120 mV for 4 representative cells.
	circres.ahajournals.org /cgi/content/full/85/9/803 (4588 words)

	The Inherited Cardiac Disease Center at Beth Israel treats Brugada syndrome, Long QT syndrome and other cardiac ...
		Brugada syndrome and Long QT syndrome are inherited cardiac conditions that can produce arrhythmias, which may result in sudden cardiac death.
		The director of the ICD Center is Steven J. Evans, MD, section Chief of Electrophysiology at Beth Israel Medical Center.
		Diagnosis and therapy for Brugada syndrome and Long QT syndrome are always tailored to the needs of the individual patient.
	wehealny.org /services/icdcenter (278 words)

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