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Topic: Bumetanide

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	bumetanide - High Blood Pressure (hypertension) and related information on MedicineNet.com
		One mg of bumetanide is approximately equivalent to 10-20 mg of torsemide and 40 mg of furosemide.
		Bumetanide was approved for use by the FDA in 1983.
		PRESCRIBED FOR: Bumetanide is used in the treatment of mild to moderate hypertension (high blood pressure), and in the management of edema (excessive fluid accumulation) associated with congestive heart failure, renal disease and liver cirrhosis.
	www.medicinenet.com /bumetanide/article.htm (647 words)

	OhioLINK ETD: TILLOTSON, JOHN
		Extended-release tablets of bumetanide were developed and evaluated for the impact on bumetanide release by: extended-release polymer concentration, filler excipient type and concentration, pH of dissolution media, ICH accelerated storage conditions, formula reproduction, and media pH and solubility modifiers.
		Bumetanide release was slowed as the fraction of the extended-release polymer was increased from 20-60%.
		Bumetanide tablets exhibited pH-dependent drug release based upon bumetanide solubility in the study media, releasing slowest in pH 1.5 HCl buffer followed by pH 4.5 phthalate buffer, USP purified water pH 5.8, and pH 6.8 phosphate buffer.
	www.ohiolink.edu /etd/view.cgi?ucin1085067185 (355 words)

	Bumetanide (Site not responding. Last check: 2007-10-21)
		Bumetanide is a loop diuretic; "loop" refers to the part of the kidney where bumetanide works.
		Bumetanide is given as a diuretic in conditions that make the body retain water and produce swelling (edema), like heart failure, liver or kidney problems.
		Bumetanide is for injection into a muscle or a vein.
	www.stjohn.org /HealthInfoLib/swArticle.aspx?26,74 (1094 words)

	Bumetanide Injection 0.5mg/ml, solution for injection (Leo Laboratories Ltd) , SPC from the eMC
		Bumetanide is indicated whenever diuretic therapy is required in the treatment of oedema, e.g.
		Although bumetanide can be used to induce diuresis in renal insufficiency, any marked increase in blood urea or the development of oliguria or anuria during treatment of severe progressing renal disease are indications for stopping treatment with bumetanide.
		Bumetanide is contra-indicated in hepatic coma and care should be taken in states of severe electrolyte depletion.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?DocumentID=7755 (1117 words)

	Bumetanide
		Bumetanide, a sulfonamide-type loop diuretic structurally related to furosemide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.
		Bumetanide inhibits sodium reabsorption in the ascending limb of the loop of Henle.
		Bumetanide interferes with renal cAMP and/or inhibits the sodium-potassium possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule.
	www.mongabay.com /health/medications/Bumetanide.html (595 words)

	bumetanide Consumer Drug Information
		Bumetanide is a loop diuretic (water pill) that prevents your body from absorbing too much salt, allowing the salt to instead be passed in your urine.
		Bumetanide treats fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome.
		Bumetanide is sometimes used only once, so you may not be on a dosing schedule.
	www.drugs.com /MTM/bumetanide.html (1309 words)

	Bumetanide - Wikipedia, the free encyclopedia
		Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure.
		Bumetanide is completely absorbed (80%), and the absorption is not altered when it is taken with food.
		Bumetanide is 40 times more potent than furosemide (for patients with normal renal function).
	en.wikipedia.org /wiki/Bumetanide (186 words)

	Bumetanide - Patient UK
		Bumetanide is used to treat oedema (water retention), caused by heart failure.
		Bumetanide may cause your skin to become more sensitive to sunlight than it is usually.
		Bumetanide can occasionally cause you to lose too much potassium or sodium from the body, which are essential for good health.
	www.patient.co.uk /showdoc/30002802 (1066 words)

	Bumex Online, Description, Chemistry, Ingredients - Bumetanide - RxList Monographs
		Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion.
		Bumetanide is a loop diuretic, available as scored tablets.
		Chemically, bumetanide is %(butylamino)- 4- phenoxy5- sulfamoylbenzoic acid.
	www.rxlist.com /cgi/generic2/bumetan.htm (206 words)

	Furosemide and bumetanide, but not nedocromil sodium, modulate nonadrenergic relaxation in guinea pig trachea in vitro ...
		Furosemide and bumetanide, but not nedocromil sodium, modulate nonadrenergic relaxation in guinea pig trachea in vitro -- Verleden et al.
		Furosemide and bumetanide, but not nedocromil sodium, modulate nonadrenergic relaxation in guinea pig trachea in vitro
		furosemide at 16 Hz and 44.2 +/- 4.1% with 10 microM bumetanide at 4 Hz).
	ajrccm.atsjournals.org /cgi/content/abstract/149/1/138 (301 words)

	Bumetanide
		Hypersensitivity to bumetanide, any component of the formulation, or sulfonylureas; anuria; patients with hepatic coma or in states of severe electrolyte depletion until the condition improves or is corrected; pregnancy (based on expert analysis)
		Use in patients with sulfonylurea allergy is specifically contraindicated in product labeling, however a risk of cross-reaction exists in patients with allergy to any of these compounds; avoid use when previous reaction has been severe.
		Bumetanide is a potent diuretic that may be used in patients who cannot tolerate or who may be allergic to furosemide.
	www.musc.edu /pharmacyservices/Drugs/B/Bumetanide.htm (1046 words)

	Drug Information: Bumetanide (Print Version)
		Bumetanide, a 'water pill,' is used to reduce the swelling and fluid retention caused by various medical problems, including heart or liver disease.
		They may include a daily exercise program and a low-sodium or low-salt diet, potassium supplements, and increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet.
		Frequent urination may last for up to 6 hours after a dose and should decrease after you take bumetanide for a few weeks.
	www.nlm.nih.gov /medlineplus/print/druginfo/medmaster/a684051.html (634 words)

	MedlinePlus Drug Information: Bumetanide
		Bumetanide comes as a tablet to take by mouth.
		Bumetanide controls high blood pressure but does not cure it.
		tell your doctor and pharmacist if you are allergic to bumetanide, sulfa drugs, or any other drugs.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a684051.html (653 words)

	Bumetanide annihilation of amphotericin B-induced apoptosis and cytotoxicity is due to its effect on cellular K+ flux ...
		Bumetanide annihilation of amphotericin B-induced apoptosis and cytotoxicity is due to its effect on cellular K+ flux -- Marklund et al.
		Bumetanide annihilation of amphotericin B-induced apoptosis and cytotoxicity is due to its effect on cellular K
		the fungus to amphotericin B is not affected by bumetanide.
	jac.oxfordjournals.org /cgi/content/full/48/6/781 (2341 words)

	Bumetanide Liquid 0.2mg/ml oral solution , SPC from the eMC
		This should be borne in mind when bumetanide is given in high doses.
		Bumetanide should be used with caution in patients already receiving nephrotoxic or ototoxic drugs.
		Bumetanide is a potent, high ceiling diuretic with a rapid onset and a short duration of action.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?DocumentID=7758 (886 words)

	Protection of ischemic myocardium in diabetics by inhibition of electroneutral Na+-K+-2Cl{-} cotransporter -- Ramasamy ...
		Rb in the absence and presence of bumetanide was measured in the
		sodium in the presence and in the absence of bumetanide, it is
		Bumetanide perfusion did not alter intracellular pH in diabetic hearts before ischemia (Table 3).
	ajpheart.physiology.org /cgi/content/full/281/2/H515 (4759 words)

	Molecular and functional evidence for Na+-K+-2Cl- cotransporter expression in rat skeletal muscle -- Wong et al. 277 ...
		K uptake was not bumetanide sensitive (3, 4).
		In the presence of bumetanide, ~15% of the
		Rb uptake was bumetanide sensitive and ouabain insensitive.
	ajpregu.physiology.org /cgi/content/full/277/1/R154 (4691 words)

	Bumetanide - Buy Bumetanide Online - Fda approved Bumetanide without a Prescription at NPMeds.com
		Bumetanide is Dispatched from outside the United States.
		A: No, the Bumetanide prescription is not required.
		If Bumetanide will not be delivered to you within 20 days, we will repeat the sending or we will return your money.
	www.npmeds.com /fda/online/Bumetanide.shtml (190 words)

	Na-K-2Cl cotransporter inhibition impairs human lung cellular proliferation -- Iwamoto et al. 287 (3): L510 -- AJP - ...
		Concentrations of bumetanide from 1 to 100 µM resulted in significant decreases in cell count (n = 5–10, P < 0.05).
		At physiological, near-equivalent diuretic concentrations, bumetanide (1 µM) showed a greater effect on cell proliferation compared with furosemide (30 µM, Comparison of BSMC and NHLF.
		The effects of bumetanide were examined in BSMC and normal human lung fibroblasts (NHLF, A).
	ajplung.physiology.org /cgi/content/full/287/3/L510 (3031 words)

	Bumetanide
		If you have an allergy to sulfonylureas, bumetanide, or any other part of the medicine.
		It can be used to reduce blood pressure in these patients whose high blood pressure is due to extra salt and water.
		Bumetanide acts on the kidney to eliminate more water and salt in the urine.
	www.umm.edu /altmed/ConsDrugs/Bumetanidecd.html (602 words)

	Bumetanide - Talk Medical
		· Bumetanide is used to reduce swelling in the body caused by congestive heart failure, liver disease, or kidney disease.
		· Bumetanide is in the FDA pregnancy category D. This means that Bumetanide is known to be harmful to an unborn baby.
		Continue to take Bumetanide and talk to your doctor if you experience ·dry mouth or increased thirst; ·dizziness or lightheadedness; ·constipation; ·headache; ·increased sensitivity to sunlight; ·jaundice (yellow skin or eyes); ·ringing in the ears; ·nausea; ·easy bleeding or bruising; ·numbness in the hands or feet; or ·a rash.
	www.talkmedical.com /medications/905/Bumetanide (693 words)

	The Role of NaKCl Cotransport in Blood-to-Aqueous Chloride Fluxes across Rabbit Ciliary Epithelium -- Crook et al. 41 ...
		The indicated concentrations of bumetanide were added to the PE side of the bilayer, and the change in Isc was recorded.
		Bumetanide (100 µM) was added to either the PE or NPE side of the bilayer and the change in Isc recorded.
		Bumetanide (BUM; 100 µM) or vehicle was added to the PE side.
	www.iovs.org /cgi/content/full/41/9/2574 (6144 words)

	Intestinal ion transport in NKCC1-deficient mice -- Grubb et al. 279 (4): 707 -- AJP - Gastrointestinal and Liver ...
		(bumetanide insensitive) in tissue incubated in KBR for the respective genotype;
		Bumetanide caused a 34 ± 2.9% inhibition of basal I
		The inhibition of the forskolin response by bumetanide,
	ajpgi.physiology.org /cgi/content/full/279/4/G707 (5156 words)

	Serotoninergic Modulation of Chloride Homeostasis during Maturation of the Locomotor Network in Zebrafish -- Brustein ...
		Bumetanide fragmented the robust and consistent swimming pattern into clusters of activity by causing the appearance of long rest intervals lasting over 30 s.
		Bumetanide (3 min) caused clustering of fictive swim episodes that were separated by long quiescent intervals.
		5HT, methysergide, ketanserin, and bumetanide on the amplitude
	www.jneurosci.org /cgi/content/full/25/46/10607 (6419 words)

	NKCC1 inhibitor bumetanide shows promise for treatment : Epilepsy.com
		In a study conducted by Dzhala and coauthors, the "NKCC1 blocker bumetanide shifted ECl negative in immature neurons, suppressed epileptiform activity in hippocampal slices in vitro, and attenuated electrographic seizures in neonatal rats in vivo."
		"Bumetanide had no effect in the presence of the GABAA-R antagonist bicuculline, nor in brain slices from NKCC1-knockout mice," test results indicated.
		These findings "provide evidence that NKCC1 facilitates seizures in the developing brain, and indicate that bumetanide should be useful in the treatment of neonatal seizures," the researchers concluded.
	www.epilepsy.com /newsfeed/pr_1136298608.html (351 words)

	Bumex bumetanide at discount prices from Canadian Online Pharmacy
		Bumex (bumetanide) is used to lower the amount of excess salt and water in your body by increasing the output of urine.
		Before using Bumex (bumetanide), tell your health care provider about any of the following: if you are pregnant, planning to become pregnant, or breastfeeding if you are taking any other prescription or nonprescription medicine if you have any other medical condition like heart disease, lung disease, impairment of kidney or liver functions.
		Bumex (bumetanide) is only to be used by the patient for whom it is prescribed.
	www.candrugstore.com /SiteMap/Bumex_bumetanide.htm (775 words)

	Effects of Na-K-2Cl Cotransport Regulators on Outflow Facility in Calf and Human Eyes In Vitro -- Al-Aswad et al. 40 ...
		bumetanide under isotonic conditions causes the cells to shrink.
		The effect of bumetanide on C is sustained.
		One eye from a 58-year-old man was perfused at a constant pressure of 15 mm Hg at 37°C in a humid 5% CO environment, as described in the Methods section.
	www.iovs.org /cgi/content/full/40/8/1695 (4441 words)

	Bumetanide Reduces Cerebral Edema Formation in Rats With Diabetic Ketoacidosis -- Lam et al. 54 (2): 510 -- Diabetes
		Bumetanide (Bumet) reduction of brain edema in DKA rats.
		Bumetanide is well known to have renal diuretic actions.
		Bumetanide (Bumet) reduction of edema in insulin/saline infused DKA rats.
	diabetes.diabetesjournals.org /cgi/content/full/54/2/510 (4358 words)

	Buy Bumetanide - FDA approved Prescription Drug at AllFDAMeds.com
		All will depend on Bumetanide which you have ordered, manufacturer and from the wholesale seller who delivers Bumetanide.
		The recipe on Bumetanide is not necessary for you.
		If do not receive the Bumetanide order within 29 days (about 1 % of orders will be lost at the post office), we shall send a new order free of charge.
	www.allfdameds.com /rx/Bumetanide.htm (379 words)

	Mechanisms of K+ transport across basolateral membranes of principal cells in Malpighian tubules of the yellow fever ...
		of Ba and bumetanide on the basolateral membrane voltage and
		Fluid secreted under experimental conditions was collected at the end of the experiment, 25–70 min after introducing the agent of interest to the peritubular Ringer bath.
		After the usual initial 30 min control period, fluid secreted by the tubules was removed for analysis with an electron microprobe, and barium and/or bumetanide was added to the peritubular Ringer solution.
	jeb.biologists.org /cgi/content/full/207/10/1655 (4155 words)

	An existing diuretic may suppress seizures in newborns
		The study findings could lead to clinical trials of bumetanide in newborns, whose immature, rapidly-developing brains are especially vulnerable to seizures.
		The researchers knew that the diuretic bumetanide inhibits NKCC1 activity in the kidney, and reasoned that the drug might have a similar effect in the brain, lowering chloride levels and making nerve cells responsive to GABA activation.
		Staley and colleagues in Colorado conducted a trial in baby rats and found that bumetanide indeed inhibited seizure activity, while phenobarbital, as in humans, worked poorly.
	www.eurekalert.org /pub_releases/2005-10/chb-aed103105.php (860 words)

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