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Topic: Buprenorphine

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Thebaine

	Buprenorphine - Wikipedia, the free encyclopedia
		Buprenorphine is a thebaine derivative, and its analgesic effect is due to partial agonist activity at μ-opioid receptors, i.e., when the molecule binds to a receptor, it is only partially activated in contrast to a full agonist such as morphine.
		Buprenorphine is indicated for the treatment of moderate to severe pain, peri-operative analgesia, and opioid dependence.
		Buprenorphine sublingual preparations are often used in the management of opioid dependence (that is, dependence on heroin, oxycodone, hydrocodone, morphine, or other opioids).
	en.wikipedia.org /wiki/Buprenorphine (1871 words)

	Buprenorphine-About Buprenorphine Therapy
		Buprenorphine is unlikely to be as effective as more optimal-dose methadone, and therefore may not be the treatment of choice for patients with higher levels of physical dependence.
		Buprenorphine, however, is known to cause a milder withdrawal syndrome compared to methadone and for this reason may be the better choice if opioid withdrawal therapy is elected.
		Buprenorphine for induction therapy is administered when an opioid-addicted individual has abstained from using opioids for 12–24 hours and is in the early stages of opioid withdrawal.
	buprenorphine.samhsa.gov /about.html (1393 words)

	Heroin - Wikipedia, the free encyclopedia
		The first is to substitute a longer-acting opioid such as methadone or buprenorphine for heroin or another short-acting opioid and then slowly taper the dose.
		Buprenorphine is one of the most recent opioid agonist/antagonist used for treating addiction.
		As of 2005, the μ-opioid agonist buprenorphine is also being used to manage heroin addiction, being a superior, though still imperfect and not yet widely known alternative to methadone.
	en.wikipedia.org /wiki/Heroin (4926 words)

	Buprenorphine (Buprenex®) - PetPlace.com (Site not responding. Last check: 2007-11-01)
		Buprenorphine is 30 times as potent as morphine and does not result in the negative gastrointestinal effects typically associated with morphine.
		Buprenorphine is rapidly absorbed after injection and the effects are usually felt within 15 to 30 minutes, lasting about 8 hours.
		Buprenorphine should be used with caution in animals with head trauma, compromised cardiovascular function and geriatric or severely debilitated animals.
	www.petplace.com /drug-library/buprenorphine-buprenex/page1.aspx (578 words)

	Erowid Buprenorphine Vault : Legal Status
		Buprenorphine (Temgesic, Subutex, Buprenex, Suboxone) is Schedule III in the U.S. This means it is illegal to sell without a license and illegal to possess without a valid license or prescription.
		Buprenorphine was rescheduled in 2002 by the DEA from Schedule V to Schedule III.
		Buprenorphine is Schedule 3, Class C in the U.K. It requires a prescription or a license to possess legally.
	www.erowid.org /pharms/buprenorphine/buprenorphine_law.shtml (385 words)

	Buprenorphine
		Like methadone and LAAM, buprenorphine is potent (30 to 50 times the analgesic potency of morphine), has a long duration of action, and does not need to be injected.
		Buprenorphine is currently available in the United States as an injectable Schedule V narcotic analgesic (Buprenex®) for human and veterinary use.
		On October 8, 2002 the Schedule III narcotic medications Subutex® (buprenorphine hydrochloride) and Suboxone® tablets (buprenorphine hydrochloride and naloxone hydrochloride) received FDA approval for the treatment of opioid addiction.
	www.streetdrugs.org /buprenorphine.htm (126 words)

	buprenorphine - [Medication]
		Buprenorphine is similar to other opioids such as morphine, codeine, and heroin however, it produces less euphoric ("high") effects and therefore may be easier to stop taking.
		Buprenorphine is used as a pain reliever and to treat opiate addiction.
		Buprenorphine is in the FDA pregnancy category C. This means that it is not known whether buprenorphine will be harmful to an unborn baby.
	www.peacehealth.org /kbase/multum/d00840a1.htm (1718 words)

	buprenorphine and naloxone - [Medication]
		Buprenorphine and naloxone is not for occasional ("as needed") use.
		Buprenorphine and naloxone is in the FDA pregnancy category C. This means that it is not known whether buprenorphine and naloxone will be harmful to an unborn baby.
		Buprenorphine and naloxone passes into breast milk and may be harmful to a nursing baby.
	www.peacehealth.org /kbase/multum/d04819a1.htm (1865 words)

	NIDA - Buprenorphine Update
		Most recently, buprenorphine tablets (either buprenorphine alone or the combination with naxolone) were shown in a large clinical trial to be superior to placebo treatment in reducing opiate use (Fudala et al, CPDD, 1998).
		Additional clinical studies have shown that the addition of naxolone to the buprenorphine tablet decreased the response to buprenorphine when the combination is injected under controlled conditions.
		Another benefit of buprenorphine is that the withdrawal syndrome seen upon discontinuation with buprenorphine is, at worst, mild to moderate and can often be managed without administration of narcotics.
	www.nida.nih.gov /Bupupdate.html (1356 words)

	Buprenorphine
		Buprenorphine is partially active at the mu receptor.Â While it is considered approximately 30 times stronger than morphine because morphine is more active at the mu receptor, morphine is a much a stronger pain reliever.
		A two week waiting period is recommended if buprenorphine or any other narcotic is to be used in a patient on such a drug (usually a dog with canine cognitive dysfunction taking seligiline).
		Buprenorphine definitely crosses the placenta to unbornÂ young and is secreted in mother's milk, possibly in a concentrated form.
	www.marvistavet.com /html/body_buprenorphine.html (295 words)

	Intelligence Bulletin: Buprenorphine: Potential for Abuse
		Buprenorphine is a derivative of thebaine, an extract of opium.
		Buprenorphine is estimated to be effective for approximately one-half to two-thirds of the opiate abuser population.
		Buprenorphine is a synthetic opiate and produces the euphoric effects sought by opiate abusers; therefore, it is susceptible to abuse in both of the forms approved for treating opiate addiction.
	www.usdoj.gov /ndic/pubs10/10123 (2056 words)

	Buprenorphine Subutex Detox Suboxone Detox Rehabilitation Detox Drug Suboxone Drug Rehab Treatment Centers
		Buprenorphine, a derivative of thebaine, is an opiate that has been marketed in the United States as the Schedule V parenteral analgesic Buprenex®.
		The agonist effects of buprenorphine increase linearly with increasing doses of the drug until at moderate doses they reach a plateau and no longer continue to increase with further increases in dose—the so-called “ceiling effect.” Thus, buprenorphine carries a lower risk of abuse, dependence, and side effects compared to full opioid agonists.
		Buprenorphine for induction therapy is administered when an opioid-dependent individual has abstained from using opioids for 12–24 hours and is in the early stages of opioid withdrawal.
	www.drug-rehabs.com /buprenorphine-detox.htm (1364 words)

	Buprenorphine Education: Buprenorphine Treatment with suboxone or subutex
		Buprenorphine is a generic name for a chemical compound and is short for Buprenorphine Hydrochloride and is a semi-synthetic opioid.
		Buprenorphine is a semi-synthetic opioid with properties of a partial agonist, and partial antagonist.
		Buprenorphine is different; its effects level off at a relatively low dose.
	naabt.org /education/buprenorphine_treatment.cfm (699 words)

	Buprenorphine Glossary of Terms
		Buprenorphine: A medication used to treat adults addicted to or dependent on opiates such as pain medications, heroin or methadone.
		Buprenorphine blocks the effects of other opiates and eliminates cravings and symptoms of withdrawal.
		Maintenance: The patient is given a prescription for an amount of buprenorphine (determined during the stabilization phase of treatment) and monitored by the physician on a weekly or monthly basis, depending on the patient’s needs.
	cpmcnet.columbia.edu /dept/bup/glossary.htm (184 words)

	News: About Buprenorphine (Site not responding. Last check: 2007-11-01)
		Buprenorphine eases the withdrawal process during detoxification from opiates, such as pain medications and heroin, and reduces drug craving.
		Buprenorphine acts as a “partial opiate agonist”, meaning that it blocks withdrawal and craving without producing a strong narcotic high.
		Buprenorphine is a medical intervention which is most effective when integrated within a substance abuse treatment program, including professional therapeutic interventions and peer support activities.
	www.tarzanatc.org /News/news_buprenorphine.php (564 words)

	Buprenorphine
		Buprenorphine (‘bup’, ‘B’) is available by prescription, under the name of Subutex, as a treatment for Opioid dependence.
		When first starting on buprenorphine maintenance, it may take a number of days (typically from three to seven days) for the effects of buprenorphine to become stable in the body.
		Buprenorphine may only be prescribed by a doctor who has a permit from the Department of Human Services (DHS).
	www.tnclearinghouse.com /factsheets/buprenorphine.htm (1183 words)

	BUPRENORPHINE \| SUBOXONE \| BUPE (Site not responding. Last check: 2007-11-01)
		The partial agonist/antagonist activity of buprenorphine means that it may precipitate withdrawal symptoms when an opioid-dependent patient is commenced on the drug soon after the use of another opioid drug.
		Buprenorphine treatment typically lasts several months (though sometimes for only a few weeks or up to two or three years), as opposed to an indefinite, often life-long methadone regimen.
		Buprenorphine, as a partial μ-opioid receptor agonist, has been claimed to have a less euphoric effect compared to the full agonist methadone, and was therefore predicted to be less likely to be diverted to the fl market.
	www.detox911.com /buprenorphine.html (1356 words)

	USATODAY.com - New drug treats the new face of addiction (Site not responding. Last check: 2007-11-01)
		Buprenorphine is the first medication available from the doctor's office for treating addiction to opioids, which are narcotic painkillers and heroin.
		Buprenorphine patients were three times more likely to work full time and about a third less likely to have tried methadone.
		Although the number of buprenorphine doses dispensed in the USA increased from 1.9 million in 2003 to 14.9 million in the first eight months of 2005, it pales compared with methadone, says Nicholas Reuter, a senior public health adviser in Lubran's division.
	www.usatoday.com /news/health/2006-01-23-bupe-treatment_x.htm (2160 words)

	FDA Approves Two Forms of Buprenorphine for Opiate Treatment
		Buprenorphine is less powerful than methadone but is considered to be somewhat safer and causes fewer side-effects, making it especially attractive for patients who are mildly or moderately addicted.
		Buprenorphine is a partial opiate agonist: it blocks withdrawal and craving without producing a strong narcotic high.
		Buprenorphine advocates have been restlessly awaiting FDA approval almost from the moment that Congress passed the Drug Abuse Treatment Act of 2000 (DATA), which cleared the way for doctors to prescribe anti-opiate medications in their offices, rather than limiting treatment to methadone clinics.
	www.jointogether.org /sa/news/features/reader/0,1854,554695,00.html (2048 words)

	DrugInfo Clearinghouse (ADF) - Drug facts - Buprenorphine (Site not responding. Last check: 2007-11-01)
		Buprenorphine (‘bup’, ‘B’) is available by prescription, under the name of Subutex, as a treatment for heroin dependence.
		Buprenorphine is one in a number of maintenance treatments for heroin dependence.
		buprenorphine may impair the ability to drive and operate machinery safely, so it may not be appropriate for people in certain occupations.
	www.druginfo.adf.org.au /article.asp?ContentID=buprenorphine (1293 words)

	Buprenorphine : Chemical Dependency : NYC DOHMH
		With the recent FDA approval of buprenorphine for use in the treatment of opioid dependency, buprenorphine is now available as a prescription medication under the brand names of Subutex7 and Suboxone7, both of which are taken sublingually (under the tongue).
		Because buprenorphine is a partial opioid agonist, its opioid effects, such as euphoria and respiratory depression, as well as its side effects reach a ceiling of maximum effect, unlike with methadone or heroin.
		For this reason, buprenorphine may be safer than methadone, as long as it is not combined with sedatives such as tranquilizers or alcohol.
	www.nyc.gov /html/doh/html/basas/buprenorphine-fact.shtml (769 words)

	The Buprenorphine FAQ - Version 2.01 WIP
		Buprenorphine, exactly like methadone, is a medication given to keep people off of heroin and improve their, and society in general's, quality of life.
		Buprenorphine lowers his tolerance and addiction level, and seems to fit right, and gives him the proper maintenance that he needs.
		I do believe the reason this holds true is after being on buprenorphine for a long period of time, which the studies regarding this do not properly account for, your tolerance is lowered to such a large extent that you can get high easily.
	www.geocities.com /nephalim1327/Bupe-FAQ-201-WIP.htm (8753 words)

	Suboxone Online, Description, Chemistry, Ingredients, Blackbox - Buprenorphine HCl and naloxone HCl - RxList Monographs
		Buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor.
		Buprenorphine is a Schedule III narcotic under the Controlled Substances Act.
		Buprenorphine hydrochloride is a white powder, weakly acidic with limited solubility in water (17mg/mL).
	www.rxlist.com /cgi/generic3/suboxone.htm (276 words)

	About buprenorphine, subutex, and suboxone
		Buprenorphine is the first medication for opioid maintenance and detoxification that physicians can dispense in their private practice.
		Buprenorphine is a partial agonist that blocks the effects of other opioids.
		Buprenorphine interacts in similar, but significantly different ways, at the same mu receptors in the brain where heroin, methadone, and prescription pain relievers such as oxycontin initiate their effects.
	cpmcnet.columbia.edu /dept/bup/aboutbup.htm (112 words)

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