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Stadol Online, Description, Chemistry, Ingredients - Butorphanol Tartrate - RxList Monographs Butorphanol tartrate is a synthetically derived opioid agonist-antagonist analgesic of the phenanthrene series. The n-octanol/aqueous buffer partition coefficient of butorphanol is 180:1 at pH 7.5. STADOL NS (butorphanol tartrate) is an aqueous solution of butorphanol tartrate for administration as a metered spray to the nasal mucosa. www.rxlist.com /cgi/generic2/butor.htm   (339 words)

Butorphanol Nasal Spray for Headache Butorphanol (Stadol) nasal spray (n.s.) is a mixed agonist-antagonist narcotic analgesic. Butorphanol (Stadol) nasal spray (n.s.) is a mixed agonist-antagonistopioid analgesic. This was a retrospective study assessing the results of the utilization of butorphanol n.s., in headache patients. www.headachedrugs.com /archives/butorphanol.html   (933 words)

Butorphanol Tartrate Butorphanol is able to slow the heart rate though this is rarely of meaningful significance to normal patients. Butorphanol should be used cautiously or not at all in patients with: liver disease, kidney failure, hypothyroidism, hypoadrenocorticism (“Addison's disease”), head trauma, hydrocephalus, or in very debilitated patients. Butorphanol should not be used in respiratory conditions where cough suppression is not desired (such as pneumonia). www.marvistavet.com /html/butorphanol_tartrate.html   (548 words)

Butorphanol Tartrate Butorphanol is well distributed, with highest levels (of the parent compound and metabolites) found in the liver, kidneys, and intestine. Butorphanol is metabolized in the liver, primarily by hydroxylation. Supplemental butorphanol (20 mg) was given during the second immobilization 77 min after xylazine injection and the subsequent phase of the immobilization was rated as fair. www.elephantcare.org /Drugs/butorph.htm   (2027 words)

Comprehensive Stadol information, uses and side effects. Stadol Injection and Stadol NS are contraindicated in patients hypersensitive to butorphanol tartrate or the preservative benzethonium chloride in Stadol NS or Stadol Injection in the multi-dose vial. As with other opioids, the use of butorphanol in patients with head injury may be associated with carbon dioxide retention and secondary elevation of cerebrospinal fluid pressure, drug-induced miosis, and alterations in mental state that would obscure the interpretation of the clinical course of patients with head injuries. Butorphanol and its metabolites are known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. www.drugs.com /pro/stadol.html   (6863 words)

Butorphanol - Wikipedia, the free encyclopedia Butorphanol exhibits partial agonist and antagonist activity at the μ opioid receptor and agonist activity at the κ opioid receptor. The most common indication for butorphanol is management of migraine using the intranasal spray formulation. Butorphanol is available in the U.S. as a generic drug; it is available in vaious nations under one of any number of trade names, including Moradol, Beforal, Stadol, and Stadol NS; veterinary trade names include Butorphic, Dolorex, Morphasol, Torbugesic, and Torbutrol. en.wikipedia.org /wiki/Butorphanol   (358 words)

Butorphanol Information on Healthline Butorphanol is in the FDA pregnancy category C. This means that it is not known whether butorphanol will harm an unborn baby. Butorphanol is not recommended for use by children younger than 18 years of age. Since butorphanol is used as needed to relieve pain, missing a dose is not usually a problem. www.healthline.com /multumcontent/butorphanol   (826 words)

MedicineHouse.com A synthetic benzomorphan derivative, butorphanol is a potent opioid agonist-antagonist with analgesic potency 3.5 to 7 times that of morphine or 30 to 40 times that of meperidine. Butorphanol is a competitive antagonist at mu receptors and an agonist at delta and kappa receptors. Butorphanol is not recommended for patients with cancer pain and may precipitate withdrawal in patients who have received opioids on a long term basis. www.medicinehouse.com /cgi-bin/drug.php?drug=butorphanol   (1006 words)

Butorphanol for migraine   (Site not responding. Last check: 2007-10-09) Butorphanol is effective for the acute treatment of migraine. In all three, butorphanol 1 to 2 mg was effective from as early as 15 minutes. In the active controlled trial, butorphanol was significantly better than 1 capsule fiorinal C (caffeine 40 mg, butalbital 50 mg, aspirin 325 mg, codeine 30 mg) for up to two hours. www.jr2.ox.ac.uk /bandolier/booth/Migraine/Butoracu.html   (628 words)

MedlinePlus Drug Information: Butorphanol (Nasal-Systemic)   (Site not responding. Last check: 2007-10-09) Butorphanol (byoo-TOR-fa-nole) is a narcotic analgesic (pain medicine) that is sprayed into the nose. Breast-feeding—Although butorphanol may pass into the breast milk, it is not expected to cause problems in nursing babies. Butorphanol will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). www.nlm.nih.gov /medlineplus/druginfo/uspdi/202796.html   (1797 words)

Stadol Butorphanol (Stadol) is a highly addictive older narcotic pushed by Bristol-Myers-Squibb. Dog Surgery: NSAID Ketoprofen (Orudis) Did Better than Butorphanol for Post-Surgical Hind Limb Pain in Dogs: In a random-assignment study of 70 dogs undergoing orthopedic surgery on a hind limb, ketoprofen, oxymorphone hydrochloride, and butorphanol were compared for the control of postoperative pain. Comparison of detomidine, butorphanol, flunixin meglumine and xylazine in clinical cases of equine colic. www.modern-psychiatry.com /stadol.htm   (849 words)

Butorphanol Tartrate (Torbugesic®, Torbutrol®) Butorphanol is used primarily for pain relief and to treat coughing. Butorphanol should be used with caution in animals with an under active thyroid, kidney impairment, elderly or severe illness. Butorphanol is also available in 0.5 mg/ml, 1 mg/ml, 2 mg/ml and 10 mg/ml injectable form. www.petplace.com /drug-library/butorphanol-tartrate-torbugesic-torbutrol/page1.aspx   (703 words)

Butorphanol Tartrate Drug Information, Professional A 2-mg dose of intranasal butorphanol produces analgesic and/or respiratory depressant effects equivalent to those produced by 2 mg of intravenous butorphanol, 10 mg of intramuscular morphine or methadone, or 75 mg of intramuscular meperidine Butorphanol clearance is decreased in geriatric patients, resulting in a prolonged elimination half-life. Due to the increase in sensitivity to the butorphanol induced side effects, it is recommended that the dosage and dosing interval be adjusted in elderly patients. www.drugs.com /MMX/Butorphanol_Tartrate.html   (3136 words)

Butorphanol Butorphanol decreases the pain of migraine headaches, and labor and delivery. Butorphanol is for injection into a muscle or a vein. Avoid accidental use of butorphanol by someone (especially children) other than the person for whom it was prescribed as this may result in severe effects and possibly death. www.stjohn.org /HealthInfoLib/swArticle.aspx?26,80   (1231 words)

Transnasal butorphanol American Family Physician - Find Articles Butorphanol is a noncontrolled substance with relatively low abuse potential and has been available in an injectable form since 1979. With the advent of a transnasal formulation, butorphanol may be an appropriate alternative for the management of moderate to severe acute pain in hospital and outpatient settings. Butorphanol is a synthetic agonist-antagonist opioid analgesic that exerts its pharmacologic effects on the mu, kappa and sigma opioid receptors. www.findarticles.com /p/articles/mi_m3225/is_n1_v49/ai_14786254   (744 words)

Canadian Adverse Drug Reaction Newsletter-Volume 7, Number 2, April 1997 Although butorphanol nasal spray may have a lower abuse potential than morphine, reports suggestive of possible abuse are mentioned in the precautions section of the current product monograph. Butorphanol nasal spray (Stadol NS) is a controlled drug under Schedule G of the Food and Drugs Act and was approved for marketing in Canada in July 1994. The analgesic potency of butorphanol is about 4 to 8 times that of morphine, 30 to 40 times that of meperidine and 16 to 24 times that of pentazocine. www.hc-sc.gc.ca /dhp-mps/medeff/bulletin/carn-bcei_v7n2_e.html   (1826 words)

Enadoline and Butorphanol: Evaluation of kappa -Agonists on Cocaine Pharmacodynamics and Cocaine Self-Administration in ... Butorphanol doses were prepared from a commercial stock solution (Stadol 2 mg/ml) by diluting to the correct volume with saline. Leander JD (1983) Evidence that nalorphine, butorphanol, and oxilorphan are partial agonists at a kappa-opioid receptor. Walker JM, Thompson LA, Frascella J and Friederich MW (1987) Opposite effects of mu and kappa opiates on the firing-rate of dopamine cells in the substantia nigra of the rat. jpet.aspetjournals.org /cgi/content/full/299/1/147   (6937 words)

Butorphanol-Mediated Antinociception in Mice: Partial Agonist Effects and Mu Receptor Involvement, -- Garner et al. 282 ... Butorphanol was effective as an analgesic in the mouse radiant-heat tail-flick test, but less-than-maximal analgesia was obtained. Dykstra, L. Butorphanol, levallorphan, nalbuphine and nalorphine as antagonists in the squirrel monkey. Picker, M. Negus, S. and Craft, R. Butorphanol's efficacy at mu and kappa opioid receptors: Inferences based on schedule-controlled behavior of nontolerant and morphine-tolerant rats and on the responding of rats under a drug discrimination procedure. jpet.aspetjournals.org /cgi/content/full/282/3/1253   (5522 words)

Texas Medicaid Vendor Drug Program, Butorphanol Tartrate Nasal Spray (Stadol NS®) Butorphanol is a potent opioid analgesic exhibiting both narcotic agonist and antagonist effects. Butorphanol is supplied as a 2.5 ml metered dose spray pump containing 10 mg/ml of active ingredient. Combined administration of naltrexone and opioid analgesics such as butorphanol is contraindicated as naltrexone reverses the pharmacologic effects of the opioid analgesic. www.hhsc.state.tx.us /HCF/vdp/Criteria/butorph.html   (849 words)

DEA Briefs & Background, Drugs and Drug Abuse, Drug Descriptions, Butorphanol While butorphanol can be made from thebaine, it is usually manufactured synthetically. More recently, a nasal spray (Stadol NS®;) became available, and significant diversion and abuse of this product led to the 1997 control of butorphanol in Schedule IV of the CSA. Butorphanol is a clear example of a drug gaining favor as a drug of abuse only after it became available in a form that facilitated its mode of administration (nasal spray v. www.usdoj.gov /dea/concern/butorphanol.html   (101 words)

butorphanol - [Medication] Symptoms of a butorphanol overdose include slow breathing, seizures, dizziness, weakness, loss of consciousness, coma, confusion, tiredness, cold and clammy skin, and small pupils. Butorphanol may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), other pain relievers, anxiety medicines, and muscle relaxants. Butorphanol is available with a prescription under the brand name Stadol NS Nasal Spray and Stadol. www.peacehealth.org /kbase/multum/d04251a1.htm   (1086 words)

Director's Report 5/96 - Behavioral Research Butorphanol is effective in treating migraine headache and post operative pain. Although butorphanol has been reported to have a low potential for abuse in opioid abusers, this study is the first to demonstrate that butorphanol also has significant effects on psychomotor function and mood in normal volunteers. It is noteworthy, however, that in the present study clinically-relevant doses of butorphanol did not increase drug-liking ratings in normal volunteers. www.drugabuse.gov /DirReports/DirRep596/DirectorReport2.html   (1450 words)

Medication Guide: Butorphanol Tartrate The agonist activity of butorphanol is believed to be exerted at the kappa and sigma receptors. Butorphanol binds to opiate receptors at sites in the central nervous system and alters perception and response to pain. Butorphanol, if used with other central nervous system depressants may increase the CNS or respiratory depression of those drugs. ratguide.com /meds/analgesics/butorphanol_tartrate.php   (358 words)

Public Citizen | Publications - Comments supporting the Drug Enforcement Administration's proposed placement of ... At the same time that butorphanol was being approved, the FDA also disregarded the dependence caused by pentazocine (Talwin), another potent pain reliever, and chemical cousin to butorphanol. Experts predicted that pentazocine, like butorphanol, would cause dependence, but pentazocine was approved without control in 1967 and was marketed for 12 years as a non-addicting pain reliever before being regulated as a controlled substance in 1979, shortly after the approval of butorphanol in 1978. Butorphanol, pentazocine and now tramadol raise serious questions about the effectiveness of controlled substance regulatory policy in protecting the public's health. www.citizen.org /publications/release.cfm?ID=6620   (1032 words)

Butorphanol ( Stadol )   (Site not responding. Last check: 2007-10-09) The analgesic efficacy of transnasal butorphanol was generally superior to that of placebo in clinical trials in patients with moderate to severe postoperative pain or migraine headache. Thus, transnasal butorphanol is a novel formulation of an established analgesic which appears suitable for the short term treatment of moderate to severe pain, especially in an ambulatory setting. Transnasal butorphanol is likely to provide an alternative to oral opioid analgesics, particularly in the presence of nausea or vomiting, or to parenteral opioids when the oral route of administration is not appropriate. www.opioids.com /butorphanol   (290 words)

Butorphanol (Nasal-Systemic) Although butorphanol may pass into the breast milk, it is not expected to cause problems in nursing babies. Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of butorphanol in children with use in other age groups. Elderly people are especially sensitive to the effects of butorphanol. healthqa.stbernards.info /html_healthgate/html/0_272/27214.php   (1582 words)

Medbroadcast Drug Info Medical conditions: Butorphanol should be taken with caution by people with liver, kidney, or heart disease. People who have a respiratory impairment should be cautious when taking butorphanol, as it may worsen their condition. Butorphanol has the potential to become habit forming as well. www.medbroadcast.com /drug_info_details_pf.asp?brand_name_id=989   (1160 words)

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