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Topic: C elegans

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	Caenorhabditis elegans WWW Server (Site not responding. Last check: 2007-11-07)
		Caenorhabditis elegans is a small (about 1 mm long) soil nematode found in temperate regions.
		Sydney Brenner began using it to study the genetics of development and neurobiology.
		Users in Europe may find access to the Greek mirror of the C elegans WWW Server more convenient.
	elegans.swmed.edu (68 words)

	Press Release: The 2002 Nobel Prize in Physiology or Medicine
		By establishing and using the nematode Caenorhabditis elegans as an experimental model system, possibilities were opened to follow cell division and differentiation from the fertilized egg to the adult.
		elegans, being multi-cellular, yet relatively simple, was therefore chosen as the most appropriate model system, which has then led to characterization of these processes also in humans.
		elegans and developed techniques to study all cell divisions in the nematode, from the fertilized egg to the 959 cells in the adult organism.
	nobelprize.org /medicine/laureates/2002/press.html (1590 words)

	Worm Development
		elegans is a free-living organism, which normally lives in the soil, where it feeds mainly on bacteria.
		The earliest events after fertilization are summarized in the movie by Steven Herd in the Strome lab of the 1-cell embryo (note that anterior is to the right.) In this sequence, the maternal pronucleus migrates from the anterior to the posterior, through the pseudocleavage furrow.
		elegans investigators were convinced that development was directed entirely by the parceling of morphogenic determinants during cleavage.
	www.ucalgary.ca /UofC/eduweb/virtualembryo/worms.html (711 words)

	Celegans Gene Knockout Lab OMRF (Site not responding. Last check: 2007-11-07)
		The C. elegans gene knockout facility at the Oklahoma Medical Research Foundation was established in 1998 with funding from the National Institutes of Health.
		This C. elegans gene knockout facility is a member of an international consortium C.
		elegans Gene Knockout Consortium whose ultimate goal is to produce null alleles of all known genes in the C. elegans genome.
	www.mutantfactory.ouhsc.edu (132 words)

	Caenorhabditis Genetics (Site not responding. Last check: 2007-11-07)
		Most cells in the hatching larva have arisen through invariant cell lineages: that is their origins can be traced back unambiguously to founder blastomeres.
		This allows the effects of disruption of embryonic development (by physical manipulation or mutation) to be traced with relative ease.
		elegans is diploid and has five pairs of autosomal chromosomes (named I, II, III, IV and V) and a pair of sex chromosomes (X).
	nema.cap.ed.ac.uk /Caenorhabditis/C_elegans.html (825 words)

	Caenorhabditis elegans
		Caenorhabditis elegans is a microscopic (~1 mm) nematode (roundworm) that normally lives in soil.
		elegans was the first multicellular eukaryote to have its entire genome sequenced.
		Like all animals, C. elegans starts life as a fertilized egg (zygote) which then undergoes the mitotic divisions needed to produce the adult.
	users.rcn.com /jkimball.ma.ultranet/BiologyPages/C/Caen.elegans.html (755 words)

	Characteristics of C. elegans
		Caenorhabditis elegans (Caeno, recent; rhabditis, rod; elegans, nice), is a free-living, non-parasitic soil nematode that can be safely used in the laboratory and is common around the world (Donald, 1997).
		elegans is a model experimental organism that possesses simplicity, is small in size physically and genomically.
		elegans and culture it in the classroom is the first step to use it in teaching.
	www.nbr.wisc.edu /outreach/text/celegans.html (1783 words)

	nature genome gateway - papers - Caenorhabditis elegans (Site not responding. Last check: 2007-11-07)
		In December 1998 the Caenorhabditis elegans Genome Sequencing Consortium published the complete genome sequence of the invertebrate nematode -- the first genome sequence of a multicellular organism.
		Research had already revealed the cell lineage map of this nematode worm and all the connections of the 302 neurons in the adult hermaphrodite (the wiring diagram), and had developed a number of genetic techniques that allowed researchers to manipulate the genes of C.
		The genome sequence of the nematode worm Caenorhabditis elegans is now "essentially complete", and this achievement is marked by the publication of a series of papers.
	www.nature.com /genomics/papers/c_elegans.html (217 words)

	The Sanger Institute: C. elegans Project
		The Sanger Institute and the Genome Sequencing Center at the Washington University School of Medicine, St. Louis have collaborated to sequence the genomes of both C.
		elegans sequence was published in Science in December 1998 (additional notes here including the full list of authors) and the last remaining gap in the sequence was finished in October 2002.
		elegans genomic clones to Audrey Fraser (aef@sanger.ac.uk) with a cc to Ratna Shownkeen (rs2@sanger.ac.uk); include a FedEx or DHL account number.
	www.sanger.ac.uk /Projects/C_elegans (339 words)

	The G-protein {gamma} subunit gpc-1 of the nematode C.elegans is involved in taste adaptation -- Jansen et al. 21 (5): ... (Site not responding. Last check: 2007-11-07)
		Bargmann,C.I., Hartwieg,E. and Horvitz,H.R. (1993) Odorants-selective genes and neurons mediate olfaction in C.
		Brundage,L., Avery,L., Katz,A., Kim,U.J., Mendel,J.E., Sternberg,P.W. and Simon,M.I. (1996) Mutations in a C.
		Perkins,L.A., Hedgecock,E.M., Thomson,J.N. and Culotti,J.G. (1986) Mutant sensory cilia in the nematode Caenorhabditis elegans.
	embojournal.npgjournals.com /cgi/content/full/21/5/986 (5316 words)

	http://eatworms (Site not responding. Last check: 2007-11-07)
		Cosmid clones generated by the consortium are named on the basis of the vector, either pJB8 (initial letters B, C, D, E, R, M, ZC) or a Lorist vector (initial letters K, T, W, F, ZK).
		elegans cytogenetics; these are given italicized names consisting of the laboratory mutation prefix, the relevant abbreviation, and a number, optionally followed by the affected linkage groups in parentheses (e.g.,
		Strains can and should be preserved as frozen stocks at –70˚ C or ideally in liquid nitrogen, in order to ensure long-term maintenance and to avoid drift or accumulation of modifier mutations.
	biosci.umn.edu /CGC/Nomenclature/nomenguid.htm (2842 words)

	HHMI News: New Brain-Signaling Chemical Identified in C. elegans
		elegans is an excellent model organism for such studies, said Alkema, because researchers can manipulate its genes easily to perturb production of a particular neurotransmitter, such as octopamine.
		elegans behavior, the researchers generated mutant worms that lacked the two enzymes required first to convert the amino acid tyrosine to tyramine and then to convert tyramine to octopamine.
		They found that the worms that could not produce tyramine and octopamine had two behavioral deficits distinct from those of worms that could not produce octopamine: Such worms showed hyperactive egg-laying, and, when touched with an eyelash and caused to move backwards, they failed to suppress exploratory head movements.
	www.hhmi.org /news/horvitz4.html (751 words)

	C. elegans
		The syncyticial epidermis (or hypodermis; labeled H) is very thin where body wall muscle (M) is present, but becomes thicker in lateral regions near the alae and in proximity to the ventral and dorsal nerve cords.
		elegans are found in ganglia that reside just anterior and posterior of the nerve ring and a set of ganglia in the tail.
		elegans have a soma positioned in the "brain of the animal"; the nerve ring and ganglia that surround it.
	thalamus.wustl.edu /nonetlab/ResearchF/elegans.html (1650 words)

	Amazon.com: Books: C. elegans: A Practical Approach (Site not responding. Last check: 2007-11-07)
		Caenorhabditis Elegans has been a popular model organism for biological research for over thirty years and has been used to investigate many aspects of animal development, for example apoptosis, the Hox genes, signal transduction pathways, and the development of the nervous system.
		Chapter 6 covers reverse genetics and describes strategies for gene inactivation that are known to work in C elegans: epigenetic inactivation and mutational germ line inactivation.
		elegans is not the ideal organism for biochemical studies, but chapter 11 describes several procedures for producing biochemically useful quantities of pure tissues.
	www.amazon.com /exec/obidos/tg/detail/-/0199637385?v=glance (1000 words)

	Blaxter Lab (Site not responding. Last check: 2007-11-07)
		Caenorhabditis elegans is a small, freeliving nematode that is the subject of an extensive integrated analysis of the genetics of development.
		As a nematode it is also an excellent model nematode, and we use C.
		An introduction to the biology and genetics of C.
	nema.cap.ed.ac.uk /C_elegans.html (136 words)

	Caenorhabditis elegans lin-25: A Study of Its Role in Multiple Cell Fate Specification Events Involving Ras and the ...
		elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.
		, 1993 The gut esterase gene (ges-1) from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae.
		elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
	www.genetics.org /cgi/content/full/156/3/1083 (7446 words)

	Requirements of Multiple Domains of SLI-1, a Caenorhabditis elegans Homologue of c-Cbl, and an Inhibitory Tyrosine in ...
		C, E, and F are phenotypically Vul, where all VPCs have generated epidermal progeny (note the lack of vulval openings in these panels).
		Ferguson, E.L., and Horvitz, H.R. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode C.
		Kornfeld, K., Guan, K.-L., and Horvitz, H.R. The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
	www.molbiolcell.org /cgi/content/full/11/11/4019 (7622 words)

	daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 ...
		Arantes-Oliveira, N., Apfeld, J., Dillin, A., and Kenyon, C. Regulation of life-span by germ-line stem cells in Caenorhabditis elegans.
		Dusenbery, D.B., Sheridan, R.E., and Russell, R.L. Chemotaxis-defective mutants of the nematode Caenorhabditis elegans.
		elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene.
	www.genesdev.org /cgi/content/full/17/7/844 (7827 words)

	The Caenorhabditis elegans EGL-15 Signaling Pathway Implicates a DOS-Like Multisubstrate Adaptor Protein in Fibroblast ...
		Soc mutations in sem-5, the GRB2 ortholog in C.
		elegans ras allele, let-60(n1046gf), for comparison at 15 and 25°C. The penetrance of the Clr or Muv phenotype is represented as a percentage of the total population examined; error bars represent 95% confidence intervals.
		Mutating all 12 tyrosines in the C terminus of SOC-1 to phenylalanine
	mcb.asm.org /cgi/content/full/21/23/8104 (7785 words)

	RNA and sex determination in Caenorhabditis elegans: Post-transcriptional regulation of the sex-determining tra-2 and ... (Site not responding. Last check: 2007-11-07)
		RNA and sex determination in Caenorhabditis elegans: Post-transcriptional regulation of the sex-determining tra-2 and fem-3 mRNAs in the Caenorhabditis elegans hermaphrodite -- Puoti et al.
		EMBO J. Barton, M.K., Schedl, T.B. and Kimble, J. (1987) Gain-of-function mutations of fem-3, a sex-determination gene in Caenorhabditis elegans.
		Graham, P.L. and Kimble, J. (1993) The mog-1 gene is required for the switch from spermatogenesis to oogenesis in Caenorhabditis elegans.
	emboreports.npgjournals.com /cgi/content/full/2/10/899 (3648 words)

	The Caenorhabditis elegans EGL-15 Signaling Pathway Implicates a DOS-Like Multisubstrate Adaptor Protein in Fibroblast ...
		EGL-15 is a fibroblast growth factor receptor in the nematode Caenorhabditis elegans.
		Fleming, T. C., Wolf, F. W., Garriga, G. Sensitized genetic backgrounds reveal a role for C. elegans FGF EGL-17 as a repellent for migrating CAN neurons.
		Arnaud, M., Crouin, C., Deon, C., Loyaux, D., Bertoglio, J. Phosphorylation of Grb2-Associated Binder 2 on Serine 623 by ERK MAPK Regulates Its Association with the Phosphatase SHP-2 and Decreases STAT5 Activation.
	mcb.asm.org /cgi/content/abstract/21/23/8104 (548 words)

	The Intronerator (Site not responding. Last check: 2007-11-07)
		elegans," Nucleic Acids Research Jan. 1, 2000; 28(1):91-93 and "Conservation, Regulation, Synteny, and Introns in a Large-scale C.
		Tracks Display- View splicing diagrams for any gene in the Sanger C. elegans database alongside cDNA and EST alignments.
		Worm Align - Paste in a piece of cDNA and see where it aligns with the C. elegans genome.
	www.soe.ucsc.edu /~kent/intronerator (252 words)

	Changes in Gene Expression Associated with Developmental Arrest and Longevity in Caenorhabditis elegans -- Jones et al. ...
		C oxidase (dauer 120; mixed 143), and a gene of unknown function
		elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis.
		Taub, J., Lau, J.F., Ma, C., Hahn, J.H., Hoque, R., Rothblatt, J., and Chalfie, M. A cytosolic catalase is needed to extend adult lifespan in C.
	www.genome.org /cgi/content/full/11/8/1346 (4460 words)

	Vancouver Lab Home (Site not responding. Last check: 2007-11-07)
		elegans Gene Knockout Laboratory is part of an international consortium, working to produce null mutations in all identified and predicted genes in the C. elegans genome.
		Knockout mutations have been generated by the consortium in about 900 genes, with nearly 2000 genes in the request queue or in active screening.
		elegans DNA sequence makes possible the targeting of all genes in this organism, which in turn will help elucidate the detailed information necessary to build a worm.
	ko.cigenomics.bc.ca (107 words)

	SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A -- Anders ... (Site not responding. Last check: 2007-11-07)
		Buelt,M.K., Glidden,B.J. and Storm,D.R. (1994) Regulation of p68 RNA helicase by calmodulin and protein kinase C. Biol.
		Goetinck,S. and Waterston,R.H. (1994) The Caenorhabditis elegans muscle-affecting gene unc-87 encodes a novel thin filament-associated protein.
		Pulak,R. and Anderson,P. (1993) mRNA surveillance by the Caenorhabditis elegans smg genes.
	embojournal.npgjournals.com /cgi/content/full/22/3/641 (5657 words)

	C. elegans expression topomap
		C, D. Correlation of VxInsight mountains with biological functions
		This figure shows that the gene mountains formed by VxInsight (based on expression data) correlate with sets of genes that have similar biochemical functions.
		Heat shocks were for 15 minutes at 33 °C, and RNA expression levels were measured 30 minutes after heat shock.
	cmgm.stanford.edu /~kimlab/topomap/c._elegans_topomap.htm (720 words)

	WormBase - Home Page
		A profile of embryonic unc-4::GFP motor neurons generated using MAPCeL (MicroArray Profiling C. elegans cells) from Fox, et.al, 2005 is now available in WormBase.
		WormBook include: Genetic enhancers, Genomic classification of protein-coding gene families, Alternative splicing in C. elegans, C. elegans microRNAs, Cell cycle regulation, Mitochondrial genetics, Gastrulation in C. elegans.
		Analyses include a variety of gene model predictions, protein and EST alignments, and nucleotide-level alignments to C. elegans and C. briggsae.
	www.wormbase.org (661 words)

	[No title] (Site not responding. Last check: 2007-11-07)
		Studies from our lab have led to the discovery that aging in C.
		Mutations in genes that encode components of this system double the lifespan of the animal and keep it active and youthful much longer than normal.
		We are also starting to investigate the role of these genes in mammals, in hopes of staying youthful ourselves.
	wormworld.ucsf.edu /Kenyonintro.html (108 words)

	Caenorhabditis elegans lin-25: A Study of Its Role in Multiple Cell Fate Specification Events Involving Ras and the ...
		Caenorhabditis elegans lin-25: A Study of Its Role in Multiple Cell Fate Specification Events Involving Ras and the Identification and Characterization of Evolutionarily Conserved Domains -- Nilsson et al.
		Caenorhabditis elegans lin-25: A Study of Its Role in Multiple Cell Fate Specification Events Involving Ras and the Identification and Characterization of Evolutionarily Conserved Domains
		C. Rocheleau, R. Howard, A. Goldman, M. Volk, L. Girard, and M. Sundaram
	www.genetics.org /cgi/content/abstract/156/3/1083 (357 words)

	Identified neurons in C. elegans coexpress vesicular transporters for acetylcholine and monoamines -- Duerr et al. 280 ...
		elegans: identification of a third gene (ace-3) and mosaic mapping of a synthetic lethal phenotype.
		Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans.
		elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway.
	ajpcell.physiology.org /cgi/content/full/280/6/C1616 (3635 words)

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