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Topic: CD3

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		The CD3 complex is a group of cell surface molecules that associates with the T-cell antigen receptor (TCR) and functions in the cell surface expression of TCR and in the signaling transduction cascade that originates when a peptide:MHC ligand binds to the TCR.
		CD3 is composed of invariant subchains belonging to the immunoglobulin superfamily.
		The genes coding for the CD3 subchains are transcribed and translated before the genes encoding for the TCR subchains are transcribed and translated, leading researchers to believe that the TCR α and β subchains associate with the CD3 complex only after all four of its subchains have been assembled successfully.
	www.bio.davidson.edu /Courses/Immunology/Students/spring2006/Walter/CD3.html (1530 words)

	CD3 T-Cell, Polyclonal (Site not responding. Last check: 2007-10-25)
		The expression of the CD3 antigen is detectable in early thymocytes and is assumed to be an early sign to a T cell lineage.
		The sub-cellular localization of CD3 is predominantly intracytoplasmic in cortical thymocytes and membrane-based in medullary thymocytes.
		CD3 antigen is highly specific for T cells and is present in majority of T cell neoplasms.
	www.signetlabs.com /products/625.htm (85 words)

	CD3 - Audio Research CD Player - Transport
		The CD3 has been a remarkable success since its introduction two years ago, clearly demonstrating how much musical information is buried in compact discs.
		The engineering focus of the CD3 is to maximize performance with the prevailing music format by keeping the overall player design simple, reliable and optimized for the one task it must accomplish.
		Primary control functions of the CD3 are accessible by buttons on the front panel and by the handheld remote control, which also has additional capabilities.
	www.audioresearch.com /CD3.htm (1059 words)

	GTX20022-CD3 antibody [UCH-T1]-GeneTex Inc.
		These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11.
		The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules.
		CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
	www.genetex.com /ccp27989-cd3-antibody-5buch-t15d-uch-t1-gtx20022.htm (156 words)

	CD^3
		From the side is a motorized tray that ejects to load a compact disc, and around the sides and rear are headphone connections, a RJ-11 telco connector, an AC power connector, and a DB-9 serial connector.
		The CD3 discs use the standard CD-R media, however with advanced encoding and compression techniques, the discs contain over 200 songs each with full CD quality audio (*all calculations based on 3.5 minute song).
		For example, if you were listening to a CD^3 disc that contained a compilation of Top-40 music from the 80's, and only wanted to hear the Alternative Rock tracks from 1988, CD^3 would make that simple.
	cd3.kinetic.org /cd3.html (515 words)

	Cooperative Interactions of Simian Immunodeficiency Virus Nef, AP-2, and CD3-{zeta} Mediate the Selective Induction of ...
		Histograms of CD3 cell surface expression for populations of cells with identical levels of GFP fluorescence, gated as indicated in panels 1 and 5, are shown for cells expressing 239.Nef together with GFP or GFP alone (panels 3 and 7).
		The rates of CD3 endocytosis in the absence or presence of 239.Nef, determined by a fluorescence-activated cell sorting-based endocytosis assay, are shown in panels 4 and 8.
		Flow cytometry analysis of steady-state CD3, CD4, and class I MHC expression in Jurkat T cells transiently expressing wild-type or mutant 239.Nef proteins and GFP reporter from bicistronic transcription units is shown.
	jvi.asm.org /cgi/content/full/77/14/8116 (6212 words)

	Product Detail for CD3 (IM1301) (Site not responding. Last check: 2007-10-25)
		The CD3 antigen is a complex of 5 invariable polypeptidic chains; gamma, delta, epsilon, zeta and eta whose molecular weights are respectively: 25-28, 21, 20, 16 and 22 kDa.
		CD3 is part of a bigger complex which includes the T Cell Receptor (TCR).
		It was used as a CD3 reference monoclonal antibody (mAb) (ref.6T-CD3.1) during HLDA 6.
	www.beckman.com /products/instrument/flowcytometry/ecatalog/ProductDetail_Scalar.asp?partnumber=IM1301 (279 words)

	Diatec.com AS - high quality monoclonal antibodies
		This antibody recognises the CD3 antigen of the TCR/CD3 complex on mature human T-cells.
		The UCHT-1 antibody reacts with the epsilon chain of the CD3 complex.
		The epitope for UCHT-1 a-CD3 is resistant to fixation.
	www.diatec.com /product.asp?pg_id=11 (451 words)

	Pharmacokinetics of Murine Anti-Human CD3 Antibodies in Man Are Determined by the Disappearance of Target Antigen -- ...
		Originally, T cell depletion was supposed to be the central mechanism by which the murine CD3 mAb OKT3 exerted its action.
		CD3 mAb levels in serum were measured in a sandwich ELISA for murine IgA.
		B, CD3 antigen expression after 4 h of incubation for these same nine subjects (mean and standard deviation).
	jpet.aspetjournals.org /cgi/content/full/300/1/346 (4393 words)

	Evidence for a Stepwise Evolution of the CD3 Family -- Göbel and Dangy 164 (2): 879 -- The Journal of Immunology
		CD3 (7), the present experiments were performed to reveal the
		Approximate sizes of the CD3 genes and the intervening sequences are given.
		CD3 gene with variations occurring only at the ends of the CD3 genes.
	www.jimmunol.org /cgi/content/full/164/2/879 (2670 words)

	Specific Interaction of Topoisomerase IIbeta and the CD3[IMAGE] Chain of the T Cell Receptor Complex -- Nakano et al. ...
		CD3 complex is composed of six different subunits: TCR
		Antigen recognition signals are transduced from TCR to the cytoplasm through the cytoplasmic domain of the CD3 chains.
		Since this region appears to be the regulatory region of the enzymatic activity, the binding of CD3
	www.jbc.org /cgi/content/abstract/271/11/6483 (472 words)

	A New Monoclonal Anti-CD3{varepsilon} Antibody Reactive on Paraffin Sections -- Alibaud et al. 48 (12): 1609 -- Journal ...
		CD3 complexes were obtained by affinity chromatography of 2%
		Cibull ML, Stein H, Gatter KC, Mason DY (1989) The expression of the CD3 antigen in Hodgkin's disease.
		Manolios N, Letourneur F, Bonifacino JS, Klausner RD (1991) Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor.
	www.jhc.org /cgi/content/full/48/12/1609 (3525 words)

	human CD3 antibody: purified antibody
		Along with the other CD3 subunits γ and δ, the ε chain is required for proper assembly, trafficking and surface expression of the TCR complex.
		CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells.
		It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
	www.ebioscience.com /ebioscience/specs/antibody_14/14-0038.htm (331 words)

	Chemicon - Product #CBL150 - Anti-CD3, clone UCHT1 [TCR]
		CD3 is closely associated on the lymphocyte cell surface with the T cell antigen receptor TcR (2-4).
		It is believed that the CD3 complex transmits activational signals to the T cell's interior upon antigen recognition by TcR.
		CD45 (LCA), a protein tyrosine phosphatase, is a potent regulator of signal transduction by the CD3 complex.
	www.chemicon.com /browse/productdetail.asp?ProductID=CBL150 (551 words)

	Immunohistochemistry - In Situ Hybridization
		If doing double staining eg cd3 and cd20, its usually easier with a cd3 rabbit/cd20 mouse than two mouse ab.
		CD3, as far as i know is a highly spesific T-cell marker, i cant see ive noticed any B-cell staining with our CD3.
		I saved the last drop of A0452 (the good old) to use as a supplement on problem cases, i used the last drop on the cd3+ myelomatosis.
	www.immunoportal.com /modules.php?name=Forums&file=viewtopic&t=16 (889 words)

	Clinical Significance of Poor CD3 Response in Head and Neck Cancer -- Shibuya et al. 8 (3): 745 -- Clinical Cancer ... (Site not responding. Last check: 2007-10-25)
		TcR or CD3 are responsible for the immune deficiencies observed
		CD3 (OKT3) MoAb was purchased from Caltag Corp. (Burlingame,
		CD3 receptor function of T cells from the regional cervical
	clincancerres.aacrjournals.org /cgi/content/full/8/3/745 (3447 words)

	ARCDB - CD3
		It is better to leave it plugged into a live outlet at all times for best sonics.
		After plugging it into a live outlet, the CD3 (like the CD2) will mute its output for approximately 45 seconds as the unit stabilizes.
		The power cord is a grounded three pin 14 gauge cord with detachable IEC connector.
	www.arcdb.ws /CD3/CD3.html (1051 words)

	RedOrbit - Health - A Single Course of Anti-CD3 Monoclonal Antibody hOKT3[Gamma]1(Ala- Ala) Results in Improvement in ... (Site not responding. Last check: 2007-10-25)
		Cell-bound mAb was measured by flow cytometry during drug administration by competition with OKT3-fluorescein isothiocyanate, and modulation of CD3 was detected by comparing the binding of OKT3d- fluorescein isothiocyanate, which recognizes anepitope on CD3 diiferent from OKT3, in the drug-treated patient to a control subject.
		In addition to measuring the coating and modulation of CD3, samples for complete blood counts and blood chemistry analyses were drawn throughout the 14-day drug infusion period and at 2- to 3- month intervals afterward in the drug-treated patients.
		Chatenoud L: Use of CD3 antibodies in transplantation and autoimmune diseases.
	www.redorbit.com /news/display?id=156842&source=r_health (4853 words)

	Crystal structure of a human CD3-{epsilon}/{delta} dimer in complex with a UCHT1 single-chain antibody fragment -- ...
		(a) Schematic representation of TCR and CD3 assembly.
		The requirement that TCR and CD3 TM domains interact, the shape of the membrane-proximal surface of the TCR, and the positions of conserved residues in the three heterodimers suggest that the paddle-shaped CD3 ectodomains lie at an angle relative to the membrane.
		The stoichiometry and interspecies promiscuity of TCR/CD3 interactions suggest that both CD3 dimers interact through their heterodimeric faces with the conserved nonglycosylated bottom and side of the TCR.
	www.pnas.org /cgi/content/full/101/46/16268 (3485 words)

	IQ Products : (Site not responding. Last check: 2007-10-25)
		Monoclonal antibodies clustered as CD3 recognize the constant structure of the CD3/T
		The function of a/b and g/d heterodimers is the recognition of peptide antigen bound to MHC, followed by T cell activation [3,4].
		Recent data suggest that the CD3 chains are each able to function autonomously in signal transduction.
	www.iqproducts.nl /product.php?p=20&id=3 (127 words)

	Kinks Come Dancing CD3 Singles Discography
		Their packaging however left a lot to be desired as it was difficult to remove the CD from its long cardboard sleeve with the bottom half being perforated so that you could tear off the mini sleeve.
		Storing and protecting your valuable CD3 compact discs can be easier if you use the plastic sleeves [Pro Sleeves] like the ones sold by Case Logic or the ones that come in a large binder.
		One side stores the mini sleeve / artwork while the reverse holds the CD3 single in its 5 inch adaptor.
	www.cd3music.com /cd-singles-02/145_0_2_0_C (263 words)

	CD3 antibody [PS1] (ab699) datasheet (Site not responding. Last check: 2007-10-25)
		If CD3 antibody [PS1] (ab699) does not perform as described on this datasheet, notify us within 90 days of delivery by going to www.abcam.com/technical, so that we can help you or offer you a replacement or a refund.
		Prokaryotic fusion protein corresponding to the epsilon chain of CD3
		The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum.
	www.abcam.com /?datasheet=699 (544 words)

	CD3 MicroBead Kit - Rhesus monkey T cells
		The CD3 MicroBead Kit consists of a biotinylated anti-simian CD3 antibody and Anti-Biotin MicroBeads.
		CD3 is expressed on all T cells and is associated with the T cell receptor.
		The non-human primate CD3 MicroBead Kit can be used for positive selection or depletion of T cells from rhesus monkey PBMCs.
	www.miltenyibiotec.com /index.php?site=pp-130-092-012 (144 words)

	CD3 antibody [LT3] (ab8362) datasheet (Site not responding. Last check: 2007-10-25)
		If CD3 antibody [LT3] (ab8362) does not perform as described on this datasheet, notify us within 90 days of delivery by going to www.abcam.com/technical, so that we can help you or offer you a replacement or a refund.
		This antibody reacts with CD3 antigen (MW 26/20/16 kDa).
		May be used to enumerate T cells in peripheral blood and tissue.
	www.abcam.com /?datasheet=8362 (423 words)

	The CD3{gamma} Leucine-Based Receptor-Sorting Motif Is Required for Efficient Ligand-Mediated TCR Down-Regulation -- ...
		B, Cells were incubated with various concentrations of the PKC activator PDB for 1 h, and TCR down-regulation was determined as described in Materials and Methods.
		TCR down-regulation was unaffected by mutations in the CD3
		The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex: effects of stimulation with soluble or immobilized CD3 Abs.
	www.jimmunol.org /cgi/content/full/168/9/4519 (3293 words)

	Down-regulation of CD3 antigen on adult T cell leukemia cells.
		Down-regulation of CD3 antigen on adult T cell leukemia cells.
		The immunological abnormality of T lymphocytes in patients with adult T cell leukemia (ATL) is characterized by the abnormal enhanced expression of the 55 kDa chain of the receptor for interleukin 2 (IL-2R/p55) (Tac), and down-regulation of CD3 antigen.
		Using serum and culture supernatants of leukemic cells from ATL patients (Group A) whose CD3 expression was down-regulated and those whose CD3 was not low (Group B), the possible mechanism of CD3 down-regulation on ATL cells was investigated.
	www.aegis.com /aidsline/1994/nov/M94B0632.html (435 words)

	GTX20828-CD3 antibody-GeneTex Inc.
		However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions and antibody dilutions should be determined by the user.
		The usefulness of this product in other applications has not been determined.
		This antibody reacts with a intracytoplasmic portion of the CD3 antigen on T cells.
	www.genetex.com /ccp2597-cd3-antibody-ab828-gtx20828.htm (272 words)

	CD3 Storage Systems, Inc. - Discgear: Organize your Digital Life!
		Creators of Discgear, CD3 Storage Systems Inc. is a fourteen-year-old media storage company that focuses on providing innovative solutions for organizing and storing media discs.
		The company was founded in Austin, Texas in 1991 by Ron Hunt and Gene Whitehead, former IBM engineers with vast experience in system design and manufacturing.
		The strength of this fast-paced, entrepreneurial company is its ability to design and manufacture innovative, well-engineered products at an affordable cost for consumers.
	www.cd3.com (225 words)

	ARUP Laboratories: Lymphocyte Transplantation CD3 (Site not responding. Last check: 2007-10-25)
		Some medications may affect immunophenotyping results and should be listed on the patient test request form.
		WBC and lymph % with the same draw date and time as the CD3 sample must be provided by the client.
		In this test, the percent CD3 cells are those cells that are positive for both CD3 and the alpha-beta chain of the T-cell receptor and are presumed immunologically competent.
	www.aruplab.com /guides/ug/tests/0095949.jsp (190 words)

	Protein Kinase C-theta Participates in NF-kappa B Activation Induced by CD3-CD28 Costimulation through Selective ...
		One class of signaling components that play important roles in T cells is the family of protein kinase C (PKC) enzymes.
		About 15 h after the transfection, the cells were stimulated for 5 h with antibodies specific for CD3 (2 µg/ml) and CD28 (2 µg/ml), either alone or in combination as indicated.
		Twenty hours after transfection, the cultures were stimulated with antibodies specific for CD3 (2 µg/ml) and CD28 (2 µg/ml), either alone or in combination as indicated.
	mcb.asm.org /cgi/content/full/20/8/2933 (4119 words)

	Activation-induced Modification in the CD3 Complex of the {gamma}{delta} T Cell Receptor -- Hayes et al. 196 (10): 1355 ...
		Activation-induced Modification in the CD3 Complex of the {gamma}{delta} T Cell Receptor -- Hayes et al.
		Activation-induced Modification in the CD3 Complex of the
		Further analyses revealed that this protein is not CD3
	www.jem.org /cgi/content/abstract/196/10/1355 (403 words)

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