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Topic: CP55940

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	British Journal of Pharmacology - Differential effects of anandamide on acetylcholine release in the guinea-pig ileum ... (Site not responding. Last check: 2007-10-17)
		Guinea-pig ileum, acetylcholine release, anandamide, vanilloid receptors, cannabinoid receptors, SR141716A, CP55940, capsazepine
		Stimulation of cannabinoid receptors by exogenous agonists, such as CP55940 or WIN 55,212-2, causes inhibition of the electrically-evoked release of acetylcholine and motor activity in the guinea-pig ileum (see review by Pertwee, 1999), and these effects are competitively antagonized by the specific CB receptor antagonist SR141716A (Pertwee et al., 1996; Coutts and Pertwee, 1997).
		Inhibition by CP55940 of the electrically-evoked release of [
	www.labanimal.com /bjp/journal/v134/n1/full/0704220a.html (4227 words)

	Tramadol, buy tramadol, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, weight loss, ... (Site not responding. Last check: 2007-10-17)
		CP55,940 induced quench of fura-2 fluorescence by Mn2+ (50 microM), suggesting the presence of Ca2+ influx across the plasma membrane.
		CP55,940 (10 microM)-induced [Ca2+]i increase in Ca(2+)-free medium was inhibited by 84% by pretreatment with 1 microM thapsigargin, an endoplasmic reticulum Ca2+ pump inhibitor.
		CP55,940 (20 microM) did not induce acute cell death after incubation for 30 min as assayed by trypan blue exclusion.
	ultram-online-rx.com /ref-nifedipine/nifedipine-research-abs3.570.html (830 words)

	Cannabinoid CB1 Receptor Agonists Produce Cerebellar Dysfunction in Mice -- Patel and Hillard 297 (2): 629 -- Journal ...
		Mice were injected intraperitoneally with the CB receptor agonist CP55940 at 0.3, 1, or 3 mg/kg.
		Mice were treated with vehicle, CP55940, SR141716, or the combination of the two by i.p.
		To evaluate the contribution of the CB receptor to the effects of CP55940 on cerebellar function, animals were pretreated
	jpet.aspetjournals.org /cgi/content/full/297/2/629 (4923 words)

	Director's Report 5/02 - Basic Research
		Treatment of neonatal rat brain cortical microglial cells with the cannabinoid paired enantiomers CP55940 and CP56667 resulted in a stereoselective differential effect on inducible NO production.
		The analog CP55940 exerted a dose-dependent inhibition of interferon gamma (IFN gamma)/bacterial lipopolysaccharide (LPS)-inducible NO production which was significantly greater than that exerted by CP56667.
		Collectively, these results indicate that the cannabinoid analog CP55940 selectively inhibits inducible NO production by microglial cells and that this inhibition is effected, at least in part, through the CB1 receptor.
	www.nida.nih.gov /DirReports/DirRep502/DirectorReport1.html (4240 words)

	Regulation of Exocytosis from Single Visualized GABAergic Boutons in Hippocampal Slices -- Brager et al. 23 (33): 10475 ...
		The cannabinoid CB1 receptor agonist, CP55940, inhibits vesicular release evoked with 2 Hz stimulation.
		CP55940 slowed the release elicited by 2 Hz stimulation, and this was prevented by AM251.
		G, The transient enhancement of f induced by 10 Hz stimulation is prevented by baclofen, although not by CP55940.
	www.jneurosci.org /cgi/content/full/23/33/10475 (7105 words)

	International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors -- Howlett et al. 54 (2): 161 -- ...
		CP55940 behaves as a full agonist for both receptor
		cannabinoids share the ability of CP55940 to interact with CB receptors; however, this remains to be established.
		Until the early 1990s, all the compounds known to act as cannabimimetics were structurally derived from THC.
	pharmrev.aspetjournals.org /cgi/content/full/54/2/161 (5904 words)

	The Therapeutic Potential of Drugs That Target Cannabinoid Receptors or Modulate the Tissue Levels or Actions of ...
		Thus, levels of anandamide, although not of 2-arachidonoyl glycerol or palmitoylethanolamide, increased in the small intestine in response to cholera toxin as did the expression of CB receptors.
		The intestinal fluid accumulation induced by cholera toxin was increased by SR141716A but not by SR144528 and was reduced by CP55940 and ACEA pretreatment in a manner that was sensitive to antagonism by SR141716A but not SR144528.
		The sensitivity of croton oil-treated mice to CP55940 and cannabinol-induced inhibition of gastrointestinal transit of an orally administered charcoal suspension increased as well.
	www.aapsj.org /view.asp?art=aapsj070364 (9022 words)

	The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic ...
		) is expressed for CP55940 in picomolars and for 2-AG in nanomolars.
		CP55940 mediates a decrease of neutrophilic differentiation, and 2-AG induces migration of Cb2-expressing bone marrow precursors
		(A) Morphologic analysis of May-Grünwald Giemsa-stained cytospins of 1 representative Cb2-expressing clone cultured in G-CSF and 100 nM 2-AG or CP55940 (CP) in the presence or absence of 1 µM Cb2 (C2) or Cb1 (C1) inverse agonist.
	www.bloodjournal.org /cgi/content/full/104/2/526 (5835 words)

	Cannabinoids and the gastrointestinal tract -- PERTWEE 48 (6): 859 -- Gut
		or CP55940 at doses that inhibit upper intestinal transit.
		CP55940, and cannabinol on gastric emptying in rats and of
		In vitro effects of the cannabinoid, CP55,940, and of its (+)-enantiomer, CP56,667.
	gut.bmjjournals.com /cgi/content/full/48/6/859 (6295 words)

	APStracts 7:0151J, 2000. (Site not responding. Last check: 2007-10-17)
		EPSCs were evoked in patch-clamped layer V pyramidal cells by stimulation of layer V afferents.
		Monosynaptic EPSCs were strongly depressed by bath application (1?M) of the cannabinoid receptors agonists WIN55212-2 (-50,4 ± 8,8 %) and CP55940 (-42,4 ± 10,9 %).
		Unexpectedly, SR141716A alone produced a significant increase of glutamatergic synaptic transmission (+46,9 ± 11,2 %) which could be partly reversed by WIN55212-2.
	www.uth.tmc.edu /apstracts/2000/jn/February/151j.html (367 words)

	Cannabinoids Inhbit Vomiting at 5-HT3A Receptors
		In addition, binding studies with radioligands for 5-HT3 as well as for cannabinoid CB1 and CB2 receptors were carried out.
		In competition experiments on membranes of HEK293 cells transfected with the h5-HT3A receptor cDNA, WIN55,212-2, CP55940, anandamide and SR141716A did not affect [3H]-GR65630 binding, but 5-HT caused a concentration dependent-inhibition.
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	www.annieappleseedproject.org /caninvomat5h.html (331 words)

	Endocannabinoid Signaling Negatively Modulates Stress-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis -- ...
		CP55940, the eCB transport inhibitor AM404, or the fatty acid
		CP55940 produced a significant biphasic effect on restraint-induced
		A, Effects of CP55940 (CP; 0.03 and 0.3 mg/kg) on restraint-induced CORT release.
	endo.endojournals.org /cgi/content/full/145/12/5431 (4175 words)

	British Journal of Pharmacology - Abstract of article: Evidence that the plant cannabinoid ...
		In the vas deferens, it antagonized several cannabinoids more potently than THC and was also more potent against CP55940 and R-(+)-WIN55212 in this tissue than in brain membranes.
		The bases of these agonist- and tissue-dependent effects remain to be established.
		-tetrahydrocannabinol, R-(+)-WIN55212, anandamide, methanandamide, CP55940, cannabinoids, mouse vas deferens, CB receptor antagonist, CB receptor antagonist
	www.nature.com /bjp/journal/v146/n7/abs/0706414a.html (311 words)

	Involvement of Cannabinoid Receptors in the Regulation of Neurotransmitter Release in the Rodent Striatum: A Combined ...
		CP55940 inhibited the evoked release by 26% already at 3 µ
		The release is slightly but significantly altered in the CB -/- mouse compared with the wild-type mouse.
		2 and CP55940 was prevented by the CB antagonist AM251 (1 µ
	www.jneurosci.org /cgi/content/full/25/11/2874 (5937 words)

	[No title] (Site not responding. Last check: 2007-10-17)
		Non-specific binding was defined with 100 µM CP55940.
		Such a shift in potency is likely to be reflected in a decrease in the pEC
		for CP55940 was 8.03 ± 0.36 and 8.00 ± 0.49 (1mM and 50 mM GDP, respectively); the pEC
	www.pa2online.org /Vol2Issue1abst021P.html (385 words)

	Cannabinol Enhancement of Interleukin-2 (IL-2) Expression by T Cells Is Associated with an Increase in IL-2 Distal ...
		CB1/CB2 high-affinity ligand CP55940 and the low-affinity ligand
		Concentration-dependent enhancement by CBD and CP55,940 of IL-2 secretion by sCD3/CD28-activated splenocytes.
		cells/ml) were either untreated (NA), or pretreated for 30 min with CBD (0.01-20 µM) and/or VH (0.1% ethanol) (A) or CP55940 (0.01-15 µM) and/or VH (0.15% DMSO) (B).
	molpharm.aspetjournals.org /cgi/content/full/61/2/446 (5419 words)

	Cannabinoid Receptor Agonists Protect Cultured Rat Hippocampal Neurons from Excitotoxicity -- Shen and Thayer 54 (3): ...
		In a previous study, we found that CP55940 and Win55212-2 inhibited glutamatergic synaptic transmission, in identically prepared
		The neuroprotective efficacy of the compound CP55940 was of particular interest.
		Abele A and Miller R (1990) Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons.
	molpharm.aspetjournals.org /cgi/content/full/54/3/459 (2844 words)

	Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid ...
		from ICN Biomedicals (Zoetermeer, The Netherlands) and CP55940
		(C) Cb2 receptor density and receptor affinity for CP55940 on the NFS cell lines was assessed by saturation radioligand receptor binding experiments using [
		(B) Cb2 receptor density and receptor affinity for CP55940 on 2 Cb2 exon-1B/exon-2 clones and 2 empty vector control clones.
	www.bloodjournal.org /cgi/content/full/99/8/2786 (5769 words)

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