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Topic: CXCR4

In the News (Sat 26 Dec 09)

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	Identification of CXCR4 domains that support coreceptor and chemokine receptor functions.
		Using CXCR4 chimeras and mutants, we determined that SDF-1 requires the CXCR4 amino terminus for binding and activates downstream signaling pathways by interacting with the second extracellular loop of CXCR4.
		SDF-1-mediated activation of CXCR4 required the Asp-Arg-Tyr motif in the second intracellular loop of CXCR4, was pertussis toxin sensitive, and did not require the distal C-terminal tail of CXCR4.
		Several CXCR4 mutants that were not capable of binding SDF-1 or signaling still supported HIV-1 infection, indicating that the ability of CXCR4 to function as a coreceptor is independent of its ability to signal.
	www.aegis.com /aidsline/1999/jul/a9970813.html (520 words)

	The stromal cell-derived factor-1{alpha}/CXCR4 ligand-receptor axis is critical for progenitor survival and migration ...
		/CXCR4 ligand–receptor axis is critical for progenitor survival and migration in the pancreas
		Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
		The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.
	www.jcb.org /cgi/content/full/163/4/859 (6310 words)

	CXCR4 Regulates Interneuron Migration in the Developing Neocortex -- Stumm et al. 23 (12): 5123 -- Journal of ...
		or its receptor CXC chemokine receptor 4 (CXCR4) is lethal
		CXCR4 mRNA expression is absent from the ventricular germinal zone of the neocortex (VZ).
		Patterns of CXCR4, glutamic acid decarboxylase (GAD), somatostatin (SRIF), and neuropeptide Y (NPY) expression in the forebrain of E18.5 SDF-1-deficient mice.
	www.jneurosci.org /cgi/content/full/23/12/5123 (5669 words)

	Ligand Binding Characteristics of CXCR4 Incorporated into Paramagnetic Proteoliposomes -- Babcock et al. 276 (42): ...
		CXCR4 is a member of the GPCR family of proteins and is the receptor for the chemokine stromal cell-derived factor (SDF-1
		CXCR4 is also a relevant molecule in human immunodeficiency virus type 1 (HIV-1) infection.
		the chemokine receptors CXCR4 (15) and CCR5 (16-20).
	www.jbc.org /cgi/content/full/276/42/38433 (6325 words)

	CXCR4
		CXCR4 is a G-protein-coupled, 7-transmembrane domain receptor whose physiological ligand is the Stromal Cell-Derived Factor-1 (SDF-1) chemokine (2, 13).
		CXCR4 expression is induced by phytohemagglutinin (PHA) stimulation of peripheral blood mononuclear cells (PBMCs) (3).
		X4 strains differ significantly in their use of CXCR4 extracellular domains (4,12); for example: HIV-1(NDK) and HIV-2(ROD) are unable to use CXCR-4 in which most of the amino-terminal domain is deleted, while HIV-1(LAI) is able to use the truncated receptor (4).
	www.niaid.nih.gov /daids/dtpdb/cxcr4.asp (702 words)

	Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency ...
		Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency viruses.
		CXCR4 is also a receptor for the feline immunodeficiency virus (FIV).
		The rat CXCR4 cannot mediate infection by HIV-1NDK or by FIVPET (both cell line-adapted strains) because of sequence differences with human CXCR4 in the second extracellular loop (ECL2).
	www.aegis.com /aidsline/1999/jul/A9970819.html (570 words)

	Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome ...
		CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not.
		CXCR4 is a major chemokine receptor on glioma cells and mediates their survival.
		Zeelenberg IS, Ruuls-Van Stalle L, Roos E. Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma.
	annonc.oxfordjournals.org /cgi/content/full/15/4/613 (2531 words)

	Down-Regulation of CXCR4 by Human Herpesvirus 6 (HHV-6) and HHV-7 -- Yasukawa et al. 162 (9): 5417 -- The Journal of ...
		Since the CXCR4 transcription level in HHV-6A-infected cells was low, the exposure time for the membrane-bearing mRNAs from HHV-6A-infected cells was longer than that for the membrane-bearing mRNAs from mock-infected cells.
		B, The half-life of CXCR4 mRNA was estimated by plotting the densitometric ratio of CXCR4 mRNA/GAPDH mRNA.
		receptors, CXCR4 and CCR5, in HHV-6 and HHV-7 infection.
	www.jimmunol.org /cgi/content/full/162/9/5417 (4073 words)

	A syndecan-4/CXCR4 complex expressed on human primary lymphocytes and macrophages and HeLa cell line binds the CXC ...
		Coassociation of syndecan-4 with CXCR4 at the plasma membrane of MDMs and PBLs.
		Mbemba, E., Saffar, L., and Gattegno, L. (2002) Role of N-glycans and SDF-1alpha on the coassociation of CD4 with CXCR4 at the plasma membrane of monocytic cells and blood lymphocytes.
		McGrath, K.E., Koniski, A.D., Maltby, K.M., McGann, J.K., and Palis, J. (1999) Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4.
	glycob.oxfordjournals.org /cgi/content/full/14/4/311 (6986 words)

	Mutation of Asp171 and Asp262 of the Chemokine Receptor CXCR4 Impairs Its Coreceptor Function for Human ...
		The CXCR4 expression of the transfectants was analyzed at both the mRNA and the protein levels.
		The ratios of CXCR4 band intensity to the respective GAPDH band intensity were determined by densitometric analysis.
		Brelot A, Heveker N, Montes M and Alizon M (2000) Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities.
	molpharm.aspetjournals.org /cgi/content/full/60/1/164 (6112 words)

	Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling -- Roland et al. 101 (2): 399 -- Blood
		The intracellular loops of CXCR4 subjected to mutagenesis are represented in bold.
		and the anti-CXCR4 antibody (MAB173) to CXCR4, sequential incubation
		CXCR4 endocytosis is not necessary for ERK activation.
	www.bloodjournal.org /cgi/content/full/101/2/399 (5966 words)

	CXCR4/fusin Is Not a Species-specific Barrier in Murine Cells for HIV-1 Entry -- Tachibana et al. 185 (10): 1865 -- The ...
		CXCR4 that was shown to be a receptor for CXC chemokine PBSF/SDF-1
		CXCR4 is an intrinsic barrier in mouse cells for viral entry.
		CXCR4 may be involved in initiation and exacerbation of the shift
	www.jem.org /cgi/content/full/185/10/1865 (3020 words)

	Progressive and Persistent Downregulation of Surface CXCR4 in CD4+ T Cells Infected With Human Herpesvirus 7 -- ...
		In (D), surface CXCR4 was analyzed in combination with surface CD4 in SupT1 cells, either uninfected or infected with HIV-1 (12 days PI).
		for intracellular CXCR4 and the fluorescence intensity of intracellular
		Horizontal axis, relative intracellular CXCR4 expression detected by PE fluorescence intensity; vertical axis, isotype-matched antibody staining or relative surface CXCR4 expression detected by FITC fluorescence intensity.
	www.bloodjournal.org /cgi/content/full/92/12/4521 (3886 words)

	Structural and Functional Characterization of Human CXCR4 as a Chemokine Receptor and HIV-1 Co-receptor by Mutagenesis ...
		The human CXC chemokine receptor 4 (CXCR4) is a receptor for the chemokine stromal cell-derived factor (SDF-1
		CXCR4 was involved in receptor signaling (17, 20, 22).
		The chemokine receptor CXCR4 and its ligand SDF-1
	www.jbc.org /cgi/content/full/276/46/42826 (5336 words)

	CXCR4 and CXCL12 (SDF-1) in Prostate Cancer: Inhibitory Effects of Human Single Chain Fv Antibodies -- Vaday et al. 10 ...
		receptor CXCR4 and its ligand, CXCL12 (stromal cell-derived
		In contrast, CXCR4 mRNA was detected in all of the 10 cancer
		Geminder H, Sagi-Assif O, Goldberg L, et al A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma.
	clincancerres.aacrjournals.org /cgi/content/full/10/16/5630 (5548 words)

	Use of the Stromal Cell-derived Factor-1/CXCR4 Pathway in Prostate Cancer Metastasis to Bone -- Taichman et al. 62 (6): ...
		CXCR4 function-blocking antibody (Ab) or isotype-matched control (Cont) were used to evaluate specificity.
		Mohle R., Failenschmid C., Bautz F., Kanz L. Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1).
		Geminder H., Sagi-Assif O., Goldberg L., Meshel T., Rechavi G., Witz I. P., Ben-Baruch A. A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma.
	cancerres.aacrjournals.org /cgi/content/full/62/6/1832 (5552 words)

	Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome ...
		Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome -- Spano et al.
		Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome
		Stromal Cell-Derived Factor-1{alpha} and CXCR4 Expression in Hemangioblastoma and Clear Cell-Renal Cell Carcinoma: von Hippel-Lindau Loss-of-Function Induces Expression of a Ligand and Its Receptor
	annonc.oxfordjournals.org /cgi/content/abstract/15/4/613 (572 words)

	Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor -- ... (Site not responding. Last check: 2007-10-21)
		of CCR2 with the CCR5 or CXCR4 viral coreceptors.
		CXCR4 heterodimerizes with CCR2 (Mellado et al, 1999, 2001b).
		CCR2-01 immunoprecipitated CCR5 or CXCR4 receptors in the absence
	embojournal.npgjournals.com /cgi/content/full/23/1/66 (6501 words)

	CXCR4 Enhances Adhesion of B16 Tumor Cells to Endothelial Cells in Vitro and in Vivo via {beta}1 Integrin -- Cardones ...
		CXCR4 Enhances Adhesion of B16 Tumor Cells to Endothelial Cells in Vitro and in Vivo via {beta}1 Integrin -- Cardones et al.
		CXCR4 Enhances Adhesion of B16 Tumor Cells to Endothelial Cells in Vitro and in Vivo via ß
		CXCR4 inhibitor was used daily throughout the course of the
	cancerres.aacrjournals.org /cgi/content/full/63/20/6751 (4533 words)

	Transcriptional targeting in renal cancer cell lines via the human CXCR4 promoter -- Haviv et al. 3 (6): 687 -- ...
		The RCC cell lines A498, SN12C, SN12C-MMP, 786-0, and CAKI-1 or the normal control primary mesothelial human cells and normal keratinocytes were infected in triplicates at multiplicity of infection of 400 with either AdGL3BCXCR4 or the isogenic control vectors AdCMVLuc or AdFltLuc.
		The RCC cell lines 786-0, A498, SN12C, and CAKI-1 were incubated with either anti-human CXCR4 antibody (shaded histograms) or the control isotype-matched antibody (gray line) followed by incubation with FITC-labeled secondary antibody.
		A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma.
	mct.aacrjournals.org /cgi/content/full/3/6/687 (2894 words)

	Up-regulation of HIV coreceptor CXCR4 expression in human T lymphocytes is mediated in part by a cAMP-responsive ...
		Up-regulation of HIV coreceptor CXCR4 expression in human T lymphocytes is mediated in part by a cAMP-responsive element -- CRISTILLO et al.
		Up-regulation of HIV coreceptor CXCR4 expression in human T lymphocytes is mediated in part by a cAMP-responsive element
		Ma, Q., Jones, D., Springer, T. (1999) The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment.
	www.fasebj.org /cgi/content/full/16/3/354 (6220 words)

	Identification of CD4 and transferrin receptor antibodies by CXCR4 antibody-guided Pathfinder selection -- Sui et al. ... (Site not responding. Last check: 2007-10-21)
		CXCR4 receptors on the cell surface (163 521 ± 35 875
		McKnight, A., Wilkinson, D., Simmons, G., Talbot, S., Picard, L., Ahuja, M., Marsh, M., Hoxie, J.A. and Clapham, P.R. (1997) Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent.
		Hesselgesser, J., Liang, M., Hoxie, J., Greenberg, M., Brass, L.F., Orsini, M.J., Taub, D. and Horuk, R. (1998) Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity.
	content.febsjournal.org /cgi/content/full/270/22/4497 (4582 words)

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