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Topic: C-myc

    Note: these results are not from the primary (high quality) database.

Inhibition of Human Immunodeficiency Virus Type 1 Rev Function by a Dominant-Negative Mutant of Sam68 through Sequestration of Unspliced RNA at Perinuclear Bundles -- Soros et al. 75 (17): 8203 -- The Journal of Virology C was determined by immunostaining with an anti-myc antibody followed by a secondary anti-mouse antibody conjugated to Texas Red (upper panel). C were immunostained with an anti-myc antibody followed by a secondary anti-mouse antibody conjugated to Texas Red (middle panels). C is a consequence of its mislocalization to the cytoplasm, jvi.asm.org /cgi/content/full/75/17/8203

Overexpression of c-Myc in {beta}-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes -- Laybutt et al. 51 (6): 1793 -- Diabetes C and E : The expected nuclear staining for Nkx6.1 ( C) and PDX-1 ( E) in a normal, well-defined islet in wild-type mice. C is the merged image of A and B. Vasavada RC, Cavaliere C, D’Ercole AJ, Dann P, Burtis WJ, Madlener AL, Zawalich K, Zawalich W, Philbrick W, Stewart AF: Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia. diabetes.diabetesjournals.org /cgi/content/full/51/6/1793

Molecular Biology of Burkitt's Lymphoma -- Hecht and Aster 18 (21): 3707 -- Journal of Clinical Oncology of c- myc translocation and dysregulation in BL. Felsher DW, Bishop JM: Reversible tumorigenesis by MYC in hematopoietic lineages. Positions of the c- myc coding sequence (blackened portions of exons), the P1 and P2 c- myc promoters, and subtype-specific BL breakpoints are depicted (arrowheads). www.jco.org /cgi/content/full/18/21/3707

BCL2 Accelerates Inflammation-induced BALB/c Plasmacytomas and Promotes Novel Tumors with Coexisting T(12;15) and T(6;15) Translocations -- Silva et al. 63 (24): 8656 -- Cancer Research by spontaneous PCT (incidence, 7%) with rearrangements of Myc C mice (9), illustrating the critical role of IL-6 in PCT development. PCTs are abrogated in C mice homozygous for an IL-6 null allele cancerres.aacrjournals.org /cgi/content/full/63/24/8656

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis -- You et al. 157 (3): 429 -- The Journal of Cell Biology Wnt-1 inhibits the release of cytochrome c induced by c-Myc. 1 C. (D) Inhibition of c-Myc– induced apoptosis by Wnts in RIE cells. (A) The cytosolic release of cytochrome c was inhibited by Wnt-1. www.jcb.org /cgi/content/full/157/3/429

Cell Cycle-Dependent Expression of Mammalian E2-C Regulated by the Anaphase-Promoting Complex/Cyclosome -- Yamanaka et al. 11 (8): 2821 -- Molecular Biology of the Cell (C) A recombinant GST fusion protein of mE2-C was incubated for 1 h at 37°C in the absence (-) or presence of various concentrations (0.25 µg/µl, 0.5 µg/µl, 1.0 µg/µl, 2.5 µg/µl, and 5.0 µg/µl) of cell extract prepared from HeLa cells 2 h after release from nocodazole-induced arrest. Yamano, H., Tsurumi, C., Gannon, J., and Hunt, T. The role of the destruction box and its neighboring lysine residues in cyclin B for anaphase ubiquitin-dependent proteolysis in fission yeast: defining the D-box receptor. (C) Recombinant wild-type (wt) or mutant (C114S) mE2-C was subjected to in vitro ubiquitination assay in the presence of purified human APC/C and was processed as in (B). www.molbiolcell.org /cgi/content/full/11/8/2821

Multiple antigens recognized by anti-c-myc antibodies in human cells and Xenopus oocytes myc gene, and that detection of these antigens is sensitive to the method of sample preparation and antigen presentation. myc family of oncogenes has been implicated as a causative factor in a wide diversity of vertebrate malignancies. myc protein in insect cells infected with a baculovirus expression vector. web.mala.bc.ca /gibsona/biol341/ANTIGENS.htm

Selection for c-myc Integration Sites in Polyclonal T-Cell Lymphomas -- Broussard et al. 76 (5): 2087 -- The Journal of Virology (C) DNA (600 ng) from the primary or passaged T623B was subjected to threefold serial dilutions and used for PCRs with an antisense primer in c- myc exon 1 (c- myc 585-) and a sense primer in the TBLV LTR (LTR408+). of c -myc, exon 1, intron 1, and 15 bp of exon 2. The nontranslated exon 1 of c- myc is depicted as a white box, while the two coding exons (exons 2 and 3) are represented by the solid gray boxes. jvi.asm.org /cgi/content/full/76/5/2087

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc -- Salghetti et al. 18 (3): 717 -- The EMBO Journal the Myc degron that stabilizes the A21 allele. Bello-Fernandez, C., Packham, G. and Cleveland, J.L. The ornithine decarboxylase gene is a transcriptional target of c-Myc. Myc is a potent regulator of cellular proliferation. embojournal.npgjournals.com /cgi/content/full/18/3/717

MySQL Lists: mysql: Re: MyC - A C wrapper for MySQL MyC - A C wrapper for MySQL - Ed Carp, March 18 1999 7:30pm Ed Carp wrote: > MyC is a C API wrapper for writing applications for the MySQL database under > Linux. Re: MyC - A C wrapper for MySQL - Ed Carp, March 18 1999 7:54pm lists.mysql.com /mysql/510

Translation Factor eIF4E Rescues Cells from Myc-dependent Apoptosis by Inhibiting Cytochrome c Release -- Li et al. 278 (5): 3015 -- Journal of Biological Chemistry Release of cytochrome c from mitochondria was determined by quantifying cytochrome c concentration in the cytoplasm by enzyme-linked immunosorbent assay. Cytochrome c was detected in cell extracts (cytosolic fraction and pellet) by immunoblot analysis (with actin shown as a loading control). Ectopic Expression of eIF4E Blocks Release of Cytochrome c from Mitochondria-- The cleavage of PARP into an 85-kDa daughter fragment is a downstream step common to most forms of apoptosis. www.jbc.org /cgi/content/full/278/5/3015

Distinct Families of Z-line Targeting Modules in the COOH-terminal Region of Nebulin -- Ojima et al. 150 (3): 553 -- The Journal of Cell Biology Stained with anti-MYC (A, B, and C), anti-titin Z1Z2 (A'), anti-MHC (B'), Rho-phalloidin (C'), and DAPI (A'', B'', and C''). Arrowheads in C'' mark large nuclei in substrate adherent fibroblasts that lie beneath the myotube, whereas the 2 myotube nuclei are globular. Fig C, Fig 6A and Fig E, and Fig 7 A). www.jcb.org /cgi/content/full/150/3/553

Bax Is a Transcriptional Target and Mediator of c-Myc-induced Apoptosis -- Mitchell et al. 60 (22): 6318 -- Cancer Research c, c-Myc -null and c-Myc -wild-type cells were transfected with the indicated plasmids and assayed as in b. He T. C., Sparks A. B., Rago C., Hermeking H., Zawel L., da Costa L. T., Morin P. J., Vogelstein B., Kinzler K. Identification of c-Myc as a target of the APC pathway. Hurlin P. J., Queva C., Eisenman R. Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. cancerres.aacrjournals.org /cgi/content/full/60/22/6318

[Frontiers in Bioscience, 3, d250-268, February 15, 1998] Perez-Roger I., D. Solomon, A. Sewing and H. Land: Myc activation of cyclin E/CDK2 kinase involves induction of cyclin E gene transcription and inhibition of p27Kip1 binding to newly formed complexes. Ittmann M., J. Ali, A. Greco and C. Basilico: The gene complementing a temperature-sensitive cell cycle mutant of BHK cells is the human homologue of the yeast RPC53 gene, which encodes a subunit of RNA polymerase C (III). Rinker-Schaeffer C. Graff, A. De Benedetti, S. Zimmer and R. Rhoads: Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts. www.bioscience.org /1998/v3/d/amati/10.htm

Nitric oxide negatively regulates proliferation and promotes neuronal differentiation through N-Myc downregulation -- Ciani et al. 117 (20): 4727 -- Journal of Cell Science The intensity of the N- Myc mRNA signal was measured by laser densitometry of autoradiographs from northern blots and plotted as a function of time after exposure to actinomycin D. Parental and clone-4 cells treated with RA did not show alteration in the half-life of N- Myc mRNA. Keim, D. R., Hailat, N., Kuick, R., Reynolds, C. P., Brodeur, G. M., Seeger, R. and Hanash, S. PCNA levels in neuroblastoma are increased in tumors with an amplified N- Myc gene and in metastatic stage tumors. Perez-Juste, G., Garcia-Silva, S. and Aranda, A. An element in the region responsible for premature termination of transcription mediates repression of c- Myc gene expression by thyroid hormone in neuroblastoma cells. jcs.biologists.org /cgi/content/full/117/20/4727

All HLH / Leucine Zipper WB c Myc, Cellular myelocytomatosis oncogene, Myc protein, Myc proto oncogene prote... ELISA, ICC, WB c Myc, Cellular myelocytomatosis oncogene, Myc protein, Myc proto oncogene prote... Expected to cross-react with Rabbit (90% identity with immunogen), Cat (90% identity with immunogen) and Chimpanzee (100% identity with immunogen) due to sequence homology. www.abcam.com /?c=3417

Upregulation of the oncogene c-myc in Barrett's adenocarcinoma: induction of c-myc by acidified bile acid in vitro -- Tselepis et al. 52 (2): 174 -- Gut (C) High grade dysplasia exhibiting both nuclear and cytoplasmic c-myc immunoreactivity, which was further accentuated in adenocarcinoma (D). Induction of c -myc protein at 24 hours was confirmed by immunofluorescence (FITC) in DCA (pH 4) or CDCA (pH 4) stimulated (B) compared with unstimulated (A) cells ( the C terminus of the protein, reducing the efficiency of nuclear gut.bmjjournals.com /cgi/content/full/52/2/174

c-Myc Cancer Gene The purpose of this website is to provide a hub for the integration of information on Myc target genes, the role of Myc in human cancers, and proteins that interact with the Myc transcription factors. This complexity becomes more challenging as certain genes, such as MYC that encodes a transcription factor, switch on other genes. For a description of the Myc Target Gene Database, read: this publication. www.myccancergene.org

dBforums - Re: Help: Invalid declaration while calling C function Re: Help: Invalid declaration while calling C function It's so nice of you giving this detailed answer. > I wanted to call a C function from my Fortran program, but I got an www.dbforums.com /t1124996.html

c-Myc Cancer Gene Regulated in Response to Myc ER De Novo Protein Synthesis There are 1697 genes in this Myc database. Use the numbers below to page through the genes. www.myccancergene.org /site/mycTargetDB.asp

c-myc, p53, and Bcl-2 expression and clinical outcome in uveal melanoma -- Chana et al. 83 (1): 110 -- British Journal of Ophthalmology Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Evan GI, Wyllie AH, Gilbert CS, et al. Hockenbery D, Nunez G, Milliman C, et al. bjo.bmjjournals.com /cgi/content/full/83/1/110

41st  Annual Dauphin Island Race  --  Results Mobile Bay Cruising Assoc., 1 st Overall PHRF Spinnaker: White Trash, Greg Smith MYC; YC 243 0: 0: 0 2180 - DNF DNF 520 MAGIC HUNTER 25 BROWN, R. COURSE LENGTH: 16.9 Miles 1999 DAUPHIN ISLAND RACE 24 APRIL 1999 Date: Apr 27, 1999 (c)BUCCANEER YACHT CLUB Time: 10:43pm Yacht Race Scoring Systems *************************************** R A C E #1 D E T A I L *************************************** PHRF SPINNAKER www.schurrsails.com /archive/di1999.htm

All HLH / Leucine Zipper WB c Myc, Cellular myelocytomatosis oncogene, Myc protein, Myc proto oncogene prote... ELISA, IHC-Fr, IHC-P, WB c Myc, Cellular myelocytomatosis oncogene, Myc protein, Myc proto oncogene prote... ELISA, IHC-Fr, IHC-P, IP, WB c Myc, Cellular myelocytomatosis oncogene, Myc protein, Myc proto oncogene prote... www.abcam.com /?c=3417

Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions -- Li et al. 24 (2): 809 -- Molecular and Cellular Biology The cells were transfected by plasmids encoding myc-tagged Foxp1 (Foxp1), myc-tagged Foxp2 (Foxp2), myc-tagged Foxp4 (Foxp4), myc-tagged Foxp1 and FLAG-tagged Foxp1 (p1/p1), myc-tagged Foxp2 and FLAG-tagged Foxp2 (p2/p2), myc-tagged Foxp4 and FLAG-tagged Foxp4 (p4/p4), myc-tagged Foxp1 and FLAG-tagged Foxp2 (p1/p2), myc-tagged Foxp1 and FLAG-tagged Foxp4 (p1/p4), myc-tagged Foxp2 and FLAG-tagged Foxp4 (p2/p4) proteins. The leucine zipper motif in Foxp1, Foxp2, and Foxp4 mediates homo- and heterodimerization. The presence of Foxp1 and Foxp2 coimmunoprecipitating with CtBP-1 is indicated by arrows. mcb.asm.org /cgi/content/full/24/2/809   (7719 words)

Disruption of Myc-Tubulin Interaction by Hyperphosphorylation of c-Myc during Mitosis or by Constitutive Hyperphosphorylation of Mutant c-Myc in Burkitt's Lymphoma -- Niklinski et al. 20 (14): 5276 -- Molecular and Cellular Biology The hyperphosphorylation of c-Myc and its altered migration Constitutively hyperphosphorylated mutant c-Myc from BL cells is associated with defective Myc-tubulin binding in vivo. Disruption of Myc-Tubulin Interaction by Hyperphosphorylation of c-Myc during Mitosis or by Constitutive Hyperphosphorylation of Mutant c-Myc in Burkitt's Lymphoma -- Niklinski et al. mcb.asm.org /cgi/content/full/20/14/5276   (7719 words)

Fission yeast Clp1p phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation -ubiquitin, and mts3-1 cut2-myc (KGY 1923) (lane 2) and mts3-1 cdc25-myc (KGY 4366) (lane 6) transformed with empty vector were grown at 25°C for 22 h in the absence of thiamine to induce His (KGY 878) (lane 5), mts3-1 cdc25-myc (KGY 4366) (lane 7), mts3-1 lid1-6 cdc25-myc (KGY 100) (lane 8), mts3-1 skp1-A4 cdc25-myc (KGY 102) (lane 9), and mts3-1 clp1 mts3-1 (KGY 574) (lane 1), mts3-1 cut2-myc (KGY 1923) (lane 3), mts3-1 cut2-myc lid1-6 (KGY 1948) (lane 4), mts3-1 cut2-myc clp1 www.nature.com /emboj/journal/v23/n4/fig_tab/7600103f3.html   (7719 words)

N-Myc shares cellular functions wiht c-Myc. These results indicate that N-MYC and c-MYC share many properties, supporting the model that MYC-specific roles during embryonic development are mediated, at least in part, via their specific profile of expression rather than by their different protein functions. N-Myc shares cellular functions wiht c-Myc.However, the role of N-MYC in instigating cell-cycle progression has not been clearly demonstrated. Recent studies have also shown that N-MYC can enhance apoptosis and shorten the G1 phase of the cell cycle. www.pdg.cnb.uam.es /UniPub/iHOP/gp/8390567.html   (199 words)

N and C-terminal Sub-regions in the c-Myc Transact... Autos.NewsWired.net The N-terminal half (Myc(1-88)) is unfolded and does not alone bind to target proteins, whereas the C-terminal half (Myc(92-167)) has a partly helical fold and specifically binds both MM-1 and TBP. Although this might suggest a bipartite organization in the c-Myc TAD, none of the N and C-terminal fragments bind target protein with as high affinity as the entire Myc(1-167), or display molten globule properties. Myc(1-167) is partly helical, binds both to the target proteins Myc modulator-1 (MM-1) and TATA box-binding protein (TBP), and displays the characteristics of a molten globule. autos.newswired.net /Article/74278/Page_Article.aspx   (366 words)

L-Myc protein synthesis is initiated by internal ribosome entry -- JOPLING et al. 10 (2): 287 -- RNA The sequence of the junction between the L-myc 5' UTR and the firefly luciferase-coding region is identical to that shown in Figure 2A The short isoform of the L-myc 5' UTR is composed of exon 1 and 10 nucleotides of exon 2, whereas the long isoform also retains intron A. A DNA fragment encoding the short isoform was amplified from HL60 cDNA using the primers LF2 and LR2 (see Materials and Methods). Given that the L-myc gene is homologous to the N-myc and c-myc www.rnajournal.org /cgi/content/full/10/2/287   (6609 words)

Cyclins D1 and D2 mediate Myc-induced proliferation via sequestration of p27Kip1 and p21Cip1 Myc−Max heterodimers activate transcription ( Amati et al., 1992 ; Kretzner et al., 1992) and are required for Myc-induced cell transformation, cell cycle progression and apoptosis ( Amati et al., 1993a, b). Moreover, Myc activity is sufficient to drive resting cells into the cell cycle ( Eilers et al., 1991) and homozygous inactivation of c- myc in rat fibroblasts caused a marked prolongation of cell doubling time ( Mateyak et al., 1997). Wild-type, cyclin D1 and cyclin D2 cells infected with the Myc-expressing or a control retrovirus were plated and grown to confluency in 10% serum. www.nature.com /cgi-taf/DynaPage.taf?file=/emboj/journal/v18/n19/full/7591939a.html   (6609 words)

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