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Topic: Cachexia

Related Topics

Marasmus

Anorexia nervosa

Anorexia

Dehydration

Delirium

Patient refusal of nutrition and hydration

Kwashiorkor

Starvation

Hunger

Fasting

Satyr

Greek mythology

	Annals of Internal Medicine: Article
		Cachexia is now seen as a multidimensional adaptation encompassing a variety of alterations that range from physiologic to behavioral (Table 1).
		Cachexia is also characterized by changes in fat metabolism, including hypertriglyceridemia, increased hepatic secretion of very-low-density lipoproteins, decreased lipoprotein lipase activity, increased de novo triglyceride synthesis and esterification, increased release of free fatty acid from the periphery, and a futile cycle of fatty acids between the liver and adipose tissue beds.
		Cardiac cachexia is a classic clinical entity that is seen in about 20% of patients with congestive heart failure (60) and is an independent risk factor for death.
	members.tripod.com /~enotes/cachexia.htm (3429 words)

	Untitled Document (Site not responding. Last check: 2007-11-03)
		Cachexia, characterized by tissue wasting, involuntary weight loss, anorexia, psychological stress, inanition and ultimately death, is a condition of advanced protein calorie malnutrition which afflicts upwards of 90% of all advanced cancer patients.
		Cachexia is among the most devastating and life-threatening aspects of cancer and its prevalence, not the cancer itself, is the main cause of death in 50% of all cancer patients.
		Cachexia, which generally occurs during advanced stages of cancer when metastatic tumors are present in the body, is now regarded as part of the body's reaction to the presence of cancer.
	www.phytomedical.com /Cachexia/Cachexia.asp (1046 words)

	Improving Functional Ability in Patients with Cachexia - April 15, 2001 - American Family Physician
		Cachexia, which means "poor condition" in Greek, is a multidimensional set of adaptations encompassing a variety of alterations that range from physiologic to behavioral.
		Cachexia resulting from a rise in acute-phase reactants can occur with cancer, infection, rheumatologic disease, congestive heart failure, end-stage renal disease, chronic obstructive pulmonary disease and other inflammatory conditions.
		Cachexia is usually evident in the clinical evaluation but can also exist in cancer patients with only slight weight changes.
	www.aafp.org /afp/20010415/tips/2.html (851 words)

	Cachexia in Cancer Patients
		Cachexia is the loss of body weight that occurs in a large number of cancer patients, and is mainly limited to the loss of fat and skeletal muscle.
		Cachexia has often been attributed to anorexia, which is the loss of appetite with a corresponding reduction in food intake.
		Cachexia is not unique to cancer, but is seen in a variety of stress conditions, including infection, inflammation and tissue injury.
	www.suite101.com /article.cfm/new_cancer_treatments/96707 (487 words)

	ITL Alternative Cancer Treatment Clinic: Cachexia Vaccine
		Cachexia is estimated to be a major contributing cause of death in between 20-50% of cancer patients.
		Cachexia is thought to be caused by chemical messengers, also called immune cytokines, which are produced by the tumor itself, and by the body's immune system in response to the tumor.
		Cancer cachexia is a syndrome of progressive wasting which has been suggested to be mediated by tumour-necrosis factor-alpha, interleukins 1 and 6, interferon-gamma and leukaemia-inhibitory factor.
	www.immunemedicine.com /cachexia-vaccine.asp (2025 words)

	Musings on Cachexia and Anorexia?
		However, cachexia and anorexia do not exist in isolation in any individual patient, and a careful and accurate assessment is essential for applying therapeutic options at our disposal.
		Cachexia may in fact occur before the patient or family notices any loss of appetite.
		The degree to which cachexia and anorexia drive from identical pathophysiologies is uncertain, and while in the latter stages of advanced disease they are commonly associated, it would be unwise to assume that they always appear in tandem.
	www.palliative.org /PC/ClinicalInfo/Editorials/CachexiaAnorexia.html (704 words)

	OHSU News Release
		Cachexia is a state of malnutrition or wasting away.
		To track cachexia to a specific region of the brain, OHSU researchers targeted a group of receptors, known as the MC4 receptors in a portion of the hypothalamus.
		The absence of cachexia in AIDS and cancer patients would allow physicians to use a wider range of therapies including aggressive treatments like radiation and chemotherapy.
	www.ohsu.edu /unparchive/2001/021501cachexia.html (498 words)

	Cachexia in Dogs and Cats
		Cachexia or muscle wasting is usually associated with cancer in dogs and cats.
		Cancer cachexia is a poorly understood syndrome of anorexia, weight loss, and muscle wasting that negatively impacts quality of life and survival in cancer patients.
		It is concluded that OCT may be useful, either as a single agent or in combination with bisphosphonates, for the treatment of cancer-associated hypercalcemia and cachexia.
	www.thensome.com /cachexia.htm (3222 words)

	University of Texas MD Anderson Cancer Center - Community Oncology and Prevention Trials Research Group
		Cachexia is a consequence of a variety of clinical disorders including cancer, AIDS and autoimmunity and is characterized by dramatic weight loss and muscle atrophy.
		The onset of cachexia is associated with a progressive and debilitating weakness leading to a dramatic decline in the quality of life of the patient.
		Cachexia is often seen in conditions associated with immune deficiency and this has led us to speculate that a deficiency in the immune system might play a direct role in the development of cachexia, and that correcting or inhibiting the immune deficiency might allow protection from cachexia.
	www.cancer.gov /PREVENTION/coptrg/supportivecare/projects/davies-j.html (278 words)

	NIH Guide: CACHEXIA: RESEARCH INTO BIOBEHAVIORAL MANAGEMENT AND QUALITY OF LIFE
		Research findings are reported in the literature which address individual symptoms and speculated causes of cachexia but data are not available to provide a scientific base for a multidisciplinary approach to prevent cachexia and manage the associated symptoms to improve the quality of life for patients suffering from cachexia.
		The physiological, metabolic, and behavioral changes in cachexia are associated with patient complaints of weakness, fatigue, gastrointestinal distress, sleep/wake disturbances, pain, listlessness, shortness of breath, lethargy, depression, malaise and the fear of being a burden on family and friends.
		Muscle cachexia is associated with increased gene expression and activity of the calcium/calpain and ubiquitin/proteasome-proteolytic pathways.
	grants.nih.gov /grants/guide/pa-files/PA-01-109.html (3556 words)

	Cancer cachexia (Site not responding. Last check: 2007-11-03)
		Cachexia is a common problem in the clinical management of cancer patients, particularly those with solid tumors.
		Cachexia is most obviously manifested as weight loss with massive depletion of both adipose tissue and muscle mass, and death is probably due to loss of lean body tissue.
		This suggests that cachexia is due to metabolic abnormalities produced by the tumor in addition to the underlying anorexia.
	www.meb.uni-bonn.de /cgi-bin/mycite?ExtRef=MEDL/93257719 (272 words)

	Management of Common Symptoms in Terminally Ill Patients: Part I. - September 1, 2001 - American Family Physician
		Anorexia and cachexia caused by wasting syndromes are best managed with patient and family education, as well as a possible trial of appetite stimulants such as megestrol or dexamethasone.
		Treatable causes of anorexia and cachexia in patients who are near the end of life include chronic pain, mouth conditions, gastrointestinal motility problems and reflux esophagitis.
		Treatable causes of anorexia and cachexia in patients who are near the end of life include chronic pain, mouth conditions (dryness, mucositis resulting from chemotherapy, and infections such as oral candidiasis or oral herpes), gastrointestinal motility problems (e.g., constipation) and reflux esophagitis.
	www.aafp.org /afp/20010901/807.html (2890 words)

	Treatment of cachexia with ghrelin in patients with COPD CHEST - Find Articles (Site not responding. Last check: 2007-11-03)
		Cachexia, which is a catabolic state characterized by weight loss and muscle wasting, occurs frequently in patients with COPD and is a strong independent risk factor for mortality.
		Thus, the purpose of this study was to investigate the effects of repeated administration of ghrelin on body composition, peripheral and respiratory muscle strength, and functional capacity in cacheetic patients with COPD.
		Cachexia was defined as those patients with documented nonedematous and nonintentional weight loss of > 7.5% of their previous normal weight over a period of at least 6 months.
	www.findarticles.com /p/articles/mi_m0984/is_3_128/ai_n15655943 (894 words)

	COX-2 inhibitors limit cachexia as well as tumor progression
		Despite the number of available cancer therapeutics, heavy RandD investment has driven over one thousand innovative compounds into clinical development, many of which are now reaching, or are about to reach the market, fuelling further expansion (for an analysis of the mid-term cancer market click here or here).
		Cachexia, characterized by a selective loss of lean body mass, is a critical problem in cancer patients (as well as patients with other chronic disease), with up to 20% of cancer deaths directly attributable to this syndrome.
		Cachexia differs from anorexia or starvation in that weight is lost from skeletal muscle and fat stores equally.
	www.bioportfolio.com /LeadDiscovery/PubMed-040405.html (965 words)

	Cachexia
		Cachexia (tissue wasting), anorexia (lack of appetite), and asthenia (weakness) frequently arise in palliative care and often overlap.
		Although the details of how cancer-related cachexia differs from starvation are probably beyond the understanding of most patients and families, we often need to summarize this information for them.
		Although similar processes may be involved in cachexia related to other diseases, such as congestive heart failure and dementia (although these and other diseases with associated cachexia are poorly studied), a special cautionary note must be voiced relating to AIDS.
	www.mywhatever.com /cifwriter/library/70/4943.html (614 words)

	Anorexia/ Cachexia
		The effects of cachexia include: decreased survival; increased complications of surgery, radiation, chemotherapy; weakness, anorexia and chronic nausea; psychological distress.
		Patients and their loved ones need to be educated that anorexia and cachexia is a common part of the dying process.
		Anorexia and cachexia are signs of disease progression and are not generally reversible.
	www.caringtotheend.ca /body.php?id=489 (440 words)

	Medical Dictionary: Cachexia - WrongDiagnosis.com - WrongDiagnosis.com
		Cachexia: A condition of general poor health involving weakness and a gaunt appearance usually resulting from severe diseases such as cancer.
		Cachexia: state of general ill health characterized by malnutrition, weakness, and emaciation; occurs during the course of a chronic disease.
		Cachexia : state of general ill health characterized by malnutrition, weakness, and emaciation; occurs during the course of a chronic disease.
	www.wrongdiagnosis.com /medical/cachexia_printer.htm (199 words)

	Journal Watch:Anorexia Cachexia. (Site not responding. Last check: 2007-11-03)
		Background: Cancer-related cachexia is caused by a diverse combination of accelerated protein breakdown and slowed protein synthesis.
		The syndrome of cancer cachexia is common and difficult to treat.
		Two main mechanisms of cachexia are a reduced food intake and an abnormal host metabolism resulting from factors produced by the cancer, e.g.
	www.palliative.org /pc/clinicalinfo/JournalWatch/AnorexiaCachexia.html (1950 words)

	Health Sciences Institute\|Omega 3’s may help address cachexia
		Secondly, if their doctor is well versed in nutritional regimens for the treatment of cancer and cachexia, he may be aware of studies that have shown omega-3 fatty acids to be useful in addressing this condition.
		The word cachexia is derived from two Greek words - kakos and hexis - combined to mean "bad condition." It's not very descriptive, but all too true.
		Cachexia is characterized by a loss of vitality, poor appetite, weight loss, decomposition of muscle and depression.
	www.thehealthierlife.co.uk /article/3560/omega3-cachexia.html (755 words)

	cachexia,anorexia and cachexia (Site not responding. Last check: 2007-11-03)
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	cachexia.sunxe.com (337 words)

	Managing cancer cachexia - Tips from Other Journals American Family Physician - Find Articles
		Cancer cachexia is a wasting syndrome in which fat and muscle are lost because of the presence of a tumor.
		The former two classes are characterized by decreased quantity of and response to anabolic factors such as insulin, thyroid hormone, and testosterone, and an increase in quantity of or response to catabolic agents such as glucagon, cortisol, and proinflammatory cytokines.
		Clinical therapeutic agents for cancer cachexia are being explored, but studies often are limited to a single tumor group and require corroboration.
	www.findarticles.com /p/articles/mi_m3225/is_4_69/ai_112915249 (529 words)

	Cachexia - Symptom (Site not responding. Last check: 2007-11-03)
		It is generally agreed to mean loss of weight, muscle wasting, fatigue, weakness and loss of appetite in someone who is not actively trying to do so.
		Cachexia occurs with various diseases especially those that are chronic and debilitating.
		Diseases commonly associated with cachexia are cancer, chronic infection and heart diseases.
	www.virtualcancercentre.com /symptoms.asp?sid=33 (410 words)

	Cachexia
		People with cancer and other chronic diseases often experience cachexia; a general loss of vitality characterised by poor appetite, weight loss, decomposition of muscle and depression.
		Nor is it clear that this sort of supplement might have the same effect on patients suffering from cachexia due to other types of cancers or diseases.
		But as we read more and more studies about the wide-ranging benefits of omega-3 fatty acids, it's clear that this remarkable nutrient provides excellent preventive and therapeutic qualities for cancer patients as well as those who are healthy.
	www.thehealthierlife.co.uk /article/3163/cachexia.html (693 words)

	New Treatment Available for AIDS Cachexia - The Body
		She said that many patients with AIDS also have AIDS cachexia, a condition where the person is unusually tired, which may be the result of a loss of important tissue that makes up their muscles, organs and body fluid known as lean body mass.
		Symptoms of AIDS cachexia may include weight loss, muscle and organ weakness, a lack of energy and an overall feeling of tiredness.
		He or she will probably run a series of tests to measure your testosterone level as well as BIA (Bioelectrical Impedance Analysis), a simple test requiring a few electrodes attached to a finger and toes to measure lean body mass.
	www.thebody.com /asp/septoct03/cachexia.html?m12 (1011 words)

	Improvement by Eicosanoids in Cancer Cachexia Induced by LLC-IL6 Transplantation
		Cachexia frequently occurs in the late stages of cancer, and is difficult to manage.
		This was thought to be a useful experimental model of cancer cachexia.
		However, body weight, a marker of cachexia, was significantly higher in treated mice than in the control group.
	www.chiro.org /nutrition/ABSTRACTS/EFA_Cachexia.shtml (235 words)

	The Scientist : Cornering Cachexia
		Cachexia adds significantly to the morbidity of cancer and chronic infectious diseases such as AIDS.
		Many cachexia researchers focus on the preferential loss of muscle mass, which is cachexia's hallmark.
		Lee and coworkers show that chronic exposure of mice to myostatin induces rapid cachexia and reduces the diameter of muscle fibers.
	www.the-scientist.com /article/display/13180 (873 words)

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