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Topic: Cadherins

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	Functional cis-Heterodimers of N- and R-Cadherins -- Shan et al. 148 (3): 579 -- The Journal of Cell Biology
		Kemler, R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion.
		Redies, C. Cadherin expression in the developing vertebrate CNS: from neuromeres to brain nuclei and neural circuits.
		Redies, C. Cadherins and the formation of neural circuitry in the vertebrate CNS.
	www.jcb.org /cgi/content/full/148/3/579 (5590 words)

	cadsubfamiliesshort
		These cadherins have two CDs and one LG domain (found in all but KIAA0726), and are related in sequence throughout much of the protein including the cytoplasmic domain.
		Ret cadherins are part of a receptor complex for the neurotrophic factors neurturin and glia-cell-line-derived neurotrophic factor.
		The main difference to classic cadherins is found in the cytoplasmic domain of desmosomal cadherins that interacts not with catenins but with a different group of cytoplasmic adapter proteins including plakoglobin, desmoplakin and the plakophillins.
	www.zoo.utoronto.ca /utepass/cadsubfamshort.html (726 words)

	ECM Proteins in C. elegans
		Cadherins are a family of adhesion molecules that mediate Ca -dependent cell-cell adhesion in all solid tissues of the organism which modulate a wide variety of processes including cell polarisation and migration [MEDLINE:2197976], [MEDLINE:],[MEDLINE:14570569].
		Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.
		Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding, to confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion.
	www.zoology.ubc.ca /~alorch/ecm/newmod.php?modgrep=CA (801 words)

	Template for Protein Report (PUT THE NAME OF YOUR PROTEIN HERE)
		Cadherins are a protein family of Ca -dependent transmembrane cell adhesion molecules that play important roles in cell morphogenesis, motility, wound healing, and the maintenance of organized tissues (see Ringwald 1994, Takeichi 1991).
		Cadherins are normally anchored via their cytoplasmic region through catenins to cytoskeletal actin microfilaments.
		The interactions of cadherins with the action filament network in the cytoplasm and with other submembranous elements are regarded as the key functions in cell-cell adhesin.
	www.arches.uga.edu /~johnchen/bcmb8010/index.html (398 words)

	Cadherin-specific antibodies and hybridoma cell lines - Patent 5597725
		Eight of the novel rat cadherin cDNAs were isolated using degenerate PCR primers based on highly conserved regions of the cytoplasmic domain of known cadherins and one was isolated using degenerate PCR primers based on moderately conserved regions of the extracellular domain of known cadherins.
		The assignment of the cadherin-8, -11 and -13 genes was to mouse chromosome 8 and the assignment of the cadherin-10 gene was to mouse chromosome 15.
		Therefore, the chimeric cadherin molecules comprising the extracellular and transmembrane domains of one of the two cadherins and the cytoplasmic domain of the other cadherin were constructed to investigate the role of the cadherin extracellular and cytoplasmic domains in cell-cell aggregation.
	www.freepatentsonline.com /5597725.html (12735 words)

	ScienceWeek
		Cadherins are a family of cell adhesion receptors that are crucial for the mutual association of vertebrate cells.
		Moreover, pathology studies suggest that the down-regulation of cadherin expression is associated with the invasiveness of tumor cells.
		Hints that cadherins might have roles in compartmentalizing neuronal populations came from their expression patterns in a number of regions of the nervous system [2-4], and the observation that misexpression of cadherins disrupts partitioning of the cortex and striatum [5].
	scienceweek.com /2004/sc040514-4.htm (1329 words)

	Caltech Press Release, 6/26/1998, Erin Schuman, Lixin Tang
		This would indicate that the cadherins are used very specifically by the nerves for changing the strength of synapses, but not for the basic transmission of nerve impulses.
		This suggests that cadherins might be able to work as "activity sensors" outside nerve cells by monitoring changes in calcium and then changing their binding to one another.
		Taken together, the new results suggest that the cadherins are important in changing synapses in ways thought to be important to learning and memory.
	pr.caltech.edu /media/Press_Releases/PR11903.html (593 words)

	Role of cadherins and plakoglobin in interendothelial adhesion under resting conditions and shear stress -- Schnittler ...
		The role of cadherins and the cadherin-binding cytosolic protein plakoglobin in intercellular adhesion was studied in cultured
		In the present study, we focused on endothelial cadherins and their associated cytoplasmic protein, plakoglobin (4, 11).
		In EGTA-treated and untreated cultures, bulk of cadherins and plakoglobin was associated with membrane fraction.
	ajpheart.physiology.org /cgi/content/full/273/5/H2396 (4427 words)

	Barry Honig
		This cell-cell specificity is difficult to understand at the molecular level since individual cadherins within a given subfamily are highly similar to one another both in sequence and structure and dimerize with remarkably low binding affinities.
		The model is based in part on the fact that cadherins bind to one another by "swapping" the amino-terminal β strands between the extracellular domains presented from interacting cells.
		Remarkably, the only factor that we could identify involves a single hydrogen bond formed at the periphery of the interface in N cadherin but absent in E cadherin where the polar groups that are present appear to interact with the solvent but not with each other.
	www.hhmi.org /research/investigators/honig.html (1147 words)

	The sequence determinants of cadherin molecules -- Kister et al. 10 (9): 1801 -- Protein Science
		Gallin, W.J. Evolution of the classical cadherin family of cell adhesion molecules in vertebrates.
		Takeichi, M. Cadherin cell adhesion receptors as a morphogenetic regulator.
		Shapiro, L. and Colman, D.R. The diversity of cadherins and implications for a synaptic adhesive code in the CNS.
	www.proteinscience.org /cgi/content/full/10/9/1801 (4015 words)

	Int. J. Dev. Biol. Transcriptional regulation of cadherins during development and carcinogenesis (Site not responding. Last check: 2007-11-07)
		During development, the expression of different cadherins is highly dynamic, since they are associated with the morphogenesis, establishment and/or maintenance of different tissues.
		Alterations in cadherin expression or function occur frequently during carcinogenesis, such as the loss of the epithelial cadherin (E-cadherin) and/or the aberrant expression of other cadherins.
		Indeed, the aberrant expression of cadherins has been detected during carcinoma invasion, a process which is reminiscent of the epithelial-mesenchymal transition (EMT) so important in many critical developmental processes.
	www.ijdb.ehu.es /abstract.04056/a365.htm (232 words)

	VE-cadherin: adhesion at arm's length -- Vincent et al. 286 (5): C987 -- AJP - Cell Physiology
		Cadherins form cis dimers by the lateral binding of cadherins within the plasma membrane of a single cell.
		cadherins is by triggering endocytosis and lysosomal degradation
		The role of cadherin endocytosis in endothelial barrier regulation: involvement of protein kinase C and actin-cadherin interactions.
	ajpcell.physiology.org /cgi/content/full/286/5/C987 (6503 words)

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