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Topic: Calcitonin

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	Calcitonin - Wikipedia, the free encyclopedia
		Calcitonin is a a 32 amino acid polypeptide hormone that is produced in humans primarily by the C cells of the thyroid, and in many other animals in the ultimobrachial body.
		Calcitonin was purified in 1962 by Copp and Cheney.
		While it was initially considered a secretion of the parathyroid glands, it was later identified as the secretion of the C-cells (parafollicular cells) of the thyroid.
	en.wikipedia.org /wiki/Calcitonin (186 words)

	Journal of Family Practice: Calcitonin in the treatment of osteoporotic bone pain
		Calcitonin may have an advantage over other analgesics in the treatment of bone pain resulting from an osteoporotic compression fracture, because, in addition to the observed analgesic effect, it is useful in treating the underlying disorder.
		Calcitonin, a natural hormone produced by the parafollicular "C" cells of the thyroid, has been investigated for its potential role in halting or reversing the progression of osteoporosis.[1-5] In humans, calcitonin is believed to inhibit osteoclastic bone resorption and to exert an analgesic effect on diseases associated with bone pain.[6-16]
		Calcitonin was first discovered in 1962, but its exact physiologic role is still uncertain.[17] Its principal actions are inhibiting osteoclastic bone resorption, and, in higher doses, lowering serum calcium.[17] Calcitonin has been approved for treatment of osteoporosis, hypercalcemia, and Paget's disease because of this positive effect on bone mass.
	www.findarticles.com /p/articles/mi_m0689/is_n1_v35/ai_12436052 (1160 words)

	Miacalcin Online, Description, Chemistry, Ingredients - Calcitonin (salmon) - RxList Monographs
		Calcitonin is a polypeptide hormone secreted by the parafollicular cells of the thyroid gland in mammals and by the ultimobranchial gland of birds and fish.
		Calcitonin (salmon) is a synthetic polypeptide of 32 amino acids in the same linear sequence that is found in calcitonin of salmon origin.
		The activity of calcitonin (salmon) nasal spray is stated in International Units based on bioassay in comparison with the International Reference Preparation of calcitonin (salmon) for Bioassay, distributed by the National Institute of Biologic Standards and Control, Holly Hill, London.
	www.rxlist.com /cgi/generic2/calcit.htm (246 words)

	Calcitonin for osteoporosis - [Medication]
		Calcitonin is used in women with osteoporosis to reduce bone loss.
		Calcitonin can be used in men with osteoporosis who have normal levels of the male sex hormone testosterone or whose osteoporosis does not get better with testosterone treatment.
		Calcitonin slows thinning of bone in the spine, hip (pelvis), and ends of the long bones (trabecular bone), although it does not appear to be as effective as other medicines, such as raloxifene or alendronate, at building bone mass and reducing the risk of fractures.
	www.peacehealth.org /kbase/topic/detail/drug/hw128456/detail.htm (321 words)

	MedlinePlus Medical Encyclopedia: Calcitonin
		Calcitonin may also be elevated in other tumors such as insulinomas, VIPomas, and lung cancer.
		Calcitonin is a hormone produced in the C cells of the thyroid gland.
		Calcitonin inhibits bone resorption and can be used as a medication to treat several bone diseases and calcium problems, including osteoporosis, Paget's disease, and hypercalcemia (high blood calcium).
	www.nlm.nih.gov /medlineplus/ency/article/003699.htm (606 words)

	ARUP: Calcitonin (Site not responding. Last check: 2007-10-08)
		Elevated levels of calcitonin (>100 pg/mL) may be encountered in a variety of pathological conditions including leukemias and myeloproliferative disorders.
		Calcitonin levels may be elevated before there is any clinical evidence of a tumor.
		Calcitonin as a tumor marker: use of the radioimmunoassay for calcitonin in the post-operative evaluation of patients with medullary thyroid carcinoma.
	www.aruplab.com /guides/clt/tests/clt_a137.jsp (308 words)

	Osteoporosis: Treating with Miacalcin and Fosamax.
		Calcitonin is a hormone which is naturally produced in the thyroid.
		Calcitonin is a powerful inhibitor of osteoclastic activity (the cells which continuously reabsorb bone: see our page on this).
		Synthetic calcitonin is FDA approved for the treatment of osteoporosis.
	www.endocrineweb.com /osteoporosis/fosamax.html (511 words)

	Progesterone Induces Calcitonin Expression in the Baboon Endometrium Within the Window of Uterine Receptivity -- Kumar ...
		The expression of calcitonin in the endometrium of nonhuman
		The intensities of the signals corresponding to the calcitonin mRNA were quantitated by densitometric scanning followed by normalization against the GAPDH mRNA signals of the autoradiogram of the Southern blot shown in the upper panel.
		Calcitonin is a progesterone regulated marker which forecasts the receptive state of endometrium during implantation.
	www.biolreprod.org /cgi/content/full/68/4/1318 (3210 words)

	calcitonin - Osteoporosis: health and medical information about Osteoporosis, bone loss and bone density
		Bone is in a constant state of remodeling, whereby old bone is removed by cells called osteoclasts, and new bone is laid down by cells called osteoblasts.
		In women with osteoporosis, the net result of using calcitonin is an increase in bone mass (density).
		PRESCRIBED FOR: Injectable calcitonin is used to treat osteoporosis (thinning of bone) and Paget's disease.
	www.medicinenet.com /calcitonin/article.htm (590 words)

	Calcitonin Information and Resources Online at The Drug Database - Find Useful Articles and Websites on Calcitonin ...
		Calcitonin is a hormone known to participate in calcium and phosphorus metabolism.
		In mammals, the major source of calcitonin is from the parafollicular or C cells in the...
		Calcitonin secretion in the pregnant uterus is tightly regulated by the ovarian hormones, estrogen and...
	www.thedrugdatabase.com /directory/C/Calcitonin (315 words)

	Human Calcitonin Acetate - HOR- 266 (Site not responding. Last check: 2007-10-08)
		Calcitonin (CT) is a peptide hormone produced by the parafollicular cells of the thyroid gland in mammals and by the ultimobranchial gland of birds and fish.
		Human Calcitonin Acetate is a synthetic polypeptide of 32 amino acids and 3.4kD in the same linear sequence that is found in clacitonin of Human origin.
		Early stages of salmon calcitonin aggregation: effect induced by ageing and oxidation processes in water and in the presence of model membranes.
	www.prospec.co.il /~prospec/cart/catalog/hCT.html (352 words)

	MedlinePlus Drug Information: Calcitonin (Systemic) (Site not responding. Last check: 2007-10-08)
		However, in animal studies, calcitonin has been shown to lower the birth weight of the baby when the mother was given a dose of calcitonin many times the human dose.
		Although there is no specific information comparing the use of calcitonin in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
		Calcium and vitamin D may cause the calcitonin to be less effective in treating a high blood calcium.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202106.html (1387 words)

	Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo -- Dacquin et al. 164 ...
		This was surprising as the calcitonin receptor (CALCR)
		Expression of the calcitonin receptor in bone marrow cell cultures and in bone: a specific marker of the differentiated osteoclast that is regulated by calcitonin.
		Calcitonin receptor antibodies in the identification of osteoclasts.
	www.jcb.org /cgi/content/full/164/4/509 (3595 words)

	Calcitonin Injections (Site not responding. Last check: 2007-10-08)
		Calcitonin is a natural hormone produced by cells in the thyroid gland.
		Calcitonin controls the level of calcium in the blood and assists the body in absorbing calcium into bones.
		Calcitonin cannot be taken orally (by mouth) because stomach acids cause the medicine to become inactive.
	www.clevelandclinic.org /health/health-info/docs/0600/0667.asp (310 words)

	Calcitonin for Paget's disease - [Medication]
		Calcitonin is used to control symptoms of Paget's disease and to slow the process of bones breaking down and rebuilding too quickly.
		Calcitonin may prevent future hearing loss, but it will not repair hearing loss that has already occurred.
		The benefits of calcitonin may take many weeks to notice, and they often go away soon after the medication is stopped.
	www.peacehealth.org /kbase/topic/detail/drug/hw189307/detail.htm (346 words)

	Calcitonin
		Calcitonin is a hormone that is used to decrease bone destruction caused by metastatic cancer.
		Calcitonin should not be used during pregnancy or while you are breast-feeding.
		Calcitonin as a nasal spray must be used several times a week.
	my.webmd.com /hw/osteoporosis/tv7369.asp (256 words)

	Calcitonin definition - Medical Dictionary definitions of popular medical terms
		Calcitonin: A hormone produced by the thyroid gland that lowers the levels of calcium and phosphate in the blood and promotes the formation of bone.
		Calcitonin inhibits bone removal by the osteoclasts and at the same time promotes bone formation by the osteoblasts.
		Calcitonin is given in hypercalcemia (high blood calcium) to lower the calcium level; in osteoporosis to increases bone density and decrease the risk of a fracture; and in Paget disease to decrease bone turnover and bone pain.
	www.medterms.com /script/main/art.asp?articlekey=16051 (239 words)

	calcitonin nasal
		Calcitonin is important for the proper functioning of bone, stomach and intestines, and kidneys.
		Before using calcitonin nasal, tell your doctor if you have any nasal or sinus problems such as nasal deformities, a chronic infection, or nasal pain.
		Calcitonin nasal is in the FDA pregnancy category C. This means that it is not known whether calcitonin will harm an unborn baby.
	hw.healthdialog.com /kbase/multum/d04232a1.htm (993 words)

	Calcitonin (Site not responding. Last check: 2007-10-08)
		Calcitonin, produced by cells in the thyroid gland, acts directly on osteoclasts (via receptors on the cell surface for calcitonin).
		Calcitonin does not reduce the serum calcium levels below normal in patients with postmenopausal osteoporosis.
		A clinical trial of calcitonin enrolled 1255 women with postmenopausal osteoporosis, in whom 975 had vertebral fractures.
	courses.washington.edu /bonephys/opcalcitonin.html (187 words)

	Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice -- Aoki-Nagase et al. 283 (5): 963 -- ...
		Coexistence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin.
		Ultrastructural studies on calcitonin gene-related peptide-, tachykinin-, and somatostatin-immunoreactive neurons in rat dorsal root ganglia: evidence for the colocalization of different peptides in single secretory granules.
		Calcitonin gene-related peptide is localized to human airway nerves and potently constricts human airway smooth muscle.
	ajplung.physiology.org /cgi/content/full/283/5/L963 (4088 words)

	Calcitonin and bone formation: a knockout full of surprises -- Zaidi et al. 110 (12): 1769 -- Journal of Clinical ...
		of calcitonin was revisited shortly thereafter, and a thyroid
		Evidence that the action of calcitonin on rat osteoclasts is mediated by two G proteins acting via separate post-receptor pathways.
		The calcitonin receptor stimulates shc tyrosine receptor phosphorylation and Erk1/2 activation.
	www.jci.org /cgi/content/full/110/12/1769 (1645 words)

	Calcitonin (Nasal-Systemic) - MayoClinic.com
		Calcitonin (kal-si-TOE-nin) is used to treat women with postmenopausal osteoporosis (bone loss).
		Calcitonin nasal solution should not be used by women during pregnancy.
		Calcitonin nasal solution has been tested in elderly patients and has not been found to cause different side effects or problems in older people than it does in younger adults.
	www.mayoclinic.com /invoke.cfm?id=DR203482 (1158 words)

	Bronchoprotector Properties of Calcitonin Gene-related Peptide in Guinea Pig and Human Airways . Effect of Pulmonary ...
		Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin.
		Calcitonin gene-related peptide and the lung: neuronal coexistence with substance P, release by capsaicin and vasodilatory effect.
		Evidence for the involvement of calcitonin gene-related peptide in the eptihelium-dependent contraction of guinea pig trachea in response to capsaicin.
	www.ajrccm.org /cgi/content/full/159/1/235 (5680 words)

	Loss of {alpha}CGRP Reduces Sound-Evoked Activity in the Cochlear Nerve -- Maison et al. 90 (5): 2941 -- Journal of ...
		Calcitonin gene-related peptide regulates phosphorylation of the nicotinic acetylcholine receptor in rat myotubes.
		Calcitonin generelated peptide enhances the rate of desensitization of the nicotinic acetylcholine receptor in cultured mouse muscle cells.
		Co-existence of tyrosine hydroxylase and calcitonin gene-related peptide in cochlear spiral modiolar artery of guinea pigs.
	jn.physiology.org /cgi/content/full/90/5/2941 (5726 words)

	Receptor Activity Modifying Proteins (RAMPs) and Calcitonin Receptor Like Receptor (CRLR)
		Calcitonin causes hypercalcemia by acting as an inhibitor of osteoclast induced bone resorption.
		Calcitonin is the major product in the thyroid, whereas CGRP is the major product in neural tissues.
		Other members of calcitonin peptide family were candidate for CRLR but CRLR seemed not to be a receptor for CGRP.
	www.4adi.com /flr/rampflr.html (678 words)

	Calcitonin Gene-Related Peptide Regulates Expression of Neurokinin1 Receptors by Rat Spinal Neurons -- Seybold et al. ...
		Kangrga I, Randic M (1990) Tachykinins and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice.
		Morton CR, Hutchison WD (1989) Release of sensory neuropeptides in the spinal cord: studies with calcitonin gene-related peptide and galanin.
		Tuchscherer MM, Seybold VS (1989) A quantitative study of the coexistence of peptides in varicosities within the superficial laminae of the dorsal horn of the rat spinal cord.
	www.jneurosci.org /cgi/content/full/23/5/1816 (6529 words)

	Healthopedia.com Drugs Information - Calcitonin
		Calcitonin (kal-si-TOE-nin) is used to treat Paget's disease of bone.
		It also may be used to prevent continuing bone loss in women with postmenopausal osteoporosis and to treat hypercalcemia (too much calcium in the blood).
		USP DI® and Advice for the Patient® are registered trademarks of USP used under license to Micromedex, a business of Thomson Healthcare Inc. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.
	www.healthopedia.com /drugs/detailed/calcitonin-systemic (248 words)

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