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Topic: Calcitriol

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	Calcitriol - Wikipedia, the free encyclopedia
		It is produced in the kidneys by conversion from 25-hydroxycholecalciferol (calcidiol) and regulates calcium levels by increasing the absorption of calcium from the gastrointestinal tract.
		Calcitriol is also commonly used as a medication in the treament of hypocalcaemia and osteoporosis.
		Calcitriol is also sometimes used topically in the treament of psoriasis, however the evidence to support its efficacy is inconclusive.
	en.wikipedia.org /wiki/Calcitriol (211 words)

	Calcitriol
		Calcitriol and 1,25 dihydroxycholecalciferol are both scientific names for active vitamin D. The biochemistry of vitamin D is very different from that of other vitamins; vitamin D is actually a hormone.
		To understand how calcitriol is helpful in the treatment of chronic renal failure, it is helpful to understand some background infromation about vitamin D, its metabolic opposite “Parathyroid hormone,” and the general calcium and phosphorus balance within the body.
		Calcitriol is able to elevate serum calcium in some cases which can further destabilize the calcium phosphorus balance and can create further toxicity issues to the kidney.
	www.marvistavet.com /html/body_calcitriol.html (1148 words)

	MedlinePlus Drug Information: Calcitriol
		Calcitriol is a form of vitamin D that is used to treat and prevent low levels of calcium in the blood of patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally.
		Calcitriol is also sometimes used to treat rickets (softening and weakening of bones in children caused by lack of vitamin D), osteomalacia (softening and weakening of bones in adults caused by lack of vitamin D), and familial hypophosphatemia (rickets or osteomalacia caused by decreased ability to break down vitamin D in the body).
		Calcitriol is also sometimes used to increase the amount of calcium in the blood of premature (born early) babies.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682335.html (971 words)

	calcitriol Information on Healthline
		Calcitriol is a synthetic (man-made) form of vitamin D. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.
		Calcitriol is used in the treatment of low levels of calcium in the body of patients on chronic renal dialysis and patients with hypoparathyroidism.
		Calcitriol is also used to treat secondary hyperparathyroidism and resultant metabolic bone disease in patients with kidney failure who are not yet receiving dialysis.
	www.healthline.com /multumcontent/calcitriol (636 words)

	CALCITRIOL Drug Information CALCITRIOL
		Rocaltrol (calcitriol) is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body.
		The kidneys of uremic patients cannot adequately synthesize calcitriol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure.
		The metabolites of calcitriol are excreted primarily in feces.
	www.drugs.com /pdr/CALCITRIOL.html (4947 words)

	CALCITRIOL (Site not responding. Last check: 2007-10-30)
		Calcitriol is actually the active form of vitamin D. Vitamin D needs to undergo several conversions in the body to become calcitriol.
		Calcitriol inhibits the growth of a number of these malignant cells, both in vitro (as in a laboratory setting), as well as in vivo (in animals).
		With calcitriol, there is some risk of kidney stone formation and high calcium levels, and in patients with a prior history of kidney stones, many experts recommend avoiding calcitriol.
	www.prostatepointers.org /leibowitz/calcitriol.html (1590 words)

	Howstuffworks "Calcitriol: A Profile of a Vitamin D Drug"
		Calcitriol is one of the active forms of vitamin D. This drug is used to treat bone disease and hypocalcemia (low blood calcium levels) in dialysis patients.
		Calcitriol can be taken either on an empty stomach or with food or milk (as directed by your doctor).
		Although calcitriol appears to be safe during pregnancy in humans, birth defects have been reported in the offspring of animals that received large doses of the medication during pregnancy.
	health.howstuffworks.com /define-calcitriol.htm (494 words)

	Calcitriol - Frequestly Ased Questions
		Calcitriol also induces renal transport mechanisms which are activated by PTH to bring about increased tubular reabsorption of calcium from the glomerular filtrate thus preventing calcium loss in urine.
		When calcitriol is chronically insufficient as in chronic renal failure, the calcium receptor is present in insufficient levels and the system for control of PTH secretion by calcium fails in that PTH continues to be secreted at levels of blood calcium which would normally suppress it.
		We strongly believe in the wisdom of use of a daily calcitriol dose of at least 2.5 ng/kg in all dogs or cats known to be in chronic renal failure as blood chemistry does not change until a minimum of 2/3 to 3/4 of renal parenchyma is lost in these patients.
	mysite.verizon.net /~vze2r6qt/calcitriol/calcitriol1.htm (5783 words)

	Rocaltrol - Rocaltrol Side Effects - Rocaltrol Information - Canada Pharmacy - Canada Drugs
		Calcitriol stimulates bone resorption which serves to mobilize calcium for the circulation, when an intestinal source of calcium is absent.
		Calcitriol's effects on the renal transport of calcium and phosphate appear to be influenced by the presence or absence of the parathyroid glands, vitamin D status, volume expansion and the dose of vitamin D metabolite used.
		Since calcitriol is a potent cholecalciferol derivative with profound effects on intestinal absorption of dietary calcium and inorganic phosphate, it should not be used concomitantly with other vitamin D products or their derivatives.
	www.rxcarecanada.com /Rocaltrol.asp?prodid=1537 (2698 words)

	RemedyFind: patient ratings of Silkis (Calcitriol) for Psoriasis
		Silkis (Calcitriol) is a nonsteroidal antipsoriatic agent, derived from the naturally occurring vitamin D. Calcitriol is not as potent as Calcipotriol, another topical vitamin D analogue.
		Calcitriol ointment appears to be better tolerated and more effective than calcipotriol ointment for the treatment of plaque psoriasis involving facial, hairline, retroauricular and flexural areas.
		Several clinical trials have demonstrated that calcitriol, the naturally occurring and hormonally active form of vitamin D3, is effective and safe at the dose of 3 microg g(-1) for the treatment of psoriasis affecting the trunk and limbs.
	www.remedyfind.com /treatments/74/1055 (457 words)

	Benefits of Calcitriol (summary)
		Calcitriol is prescribed as a treatment in uremic patients for its effects to suppress serum levels of parathyroid hormone (PTH).
		Calcitriol therapy can be considered for treatment of chronic renal failure after serum phsophorus has been decreased to less than 6.0 mg/dL in patients in whom it was initially elevated.
		Exogenous supplemental calcitriol administration allows concentrations of calcitriol in the bloodstream to remain normal without the toxic consequences of excessive PTH secretion that would otherwise be provoked.
	www.simplyschnauzer.net /calcitriol.html (924 words)

	Calcitriol (Rocaltrol) - VeterinaryPartner.com - a VIN company!
		To understand how calcitriol is helpful in the treatment of chronic renal failure, it is helpful to understand some background information about vitamin D, its metabolic opposite parathyroid hormone, and the general calcium and phosphorus balance within the body.
		Calcitriol cannot be used in patients that have an elevated (greater than 6 mg/dl) plasma phosphorus level.
		Calcitriol might elevate phosphorus further at this stage, which is exactly what we do not want.
	www.veterinarypartner.com /Content.plx?P=A&A=558 (1230 words)

	Patient Education - Drugs - calcitriol
		Calcitriol is a derivative of vitamin D. This vitamin is necessary and important for the proper absorption and use of calcium in the body.
		Calcitriol may be taken with food, milk or on an empty stomach.
		Calcitriol is ranked C. Always consult your physician before taking any drug during or when planning pregnancy.
	www.endowsec.com /pated/calcitriol.htm (774 words)

	Drugs and Treatments - Calcitriol IV - (Calcijex) - Patient Handout from WebMD
		Calcitriol is a man-made active form of vitamin D (vitamin D3).
		Calcitriol is used to treat or prevent certain problems that can happen with long-term kidney dialysis, such as low levels of calcium or high levels of parathyroid hormone.
		Calcitriol is usually used along with a certain diet, supplements, and sometimes other medications.
	webmd.com /drugs/drug-5917-Calcitriol+IV.aspx?drugid=5917&... (1198 words)

	Vitamin D Compounds May Fight Prostate Cancer
		Calcitriol -- the active form of vitamin D -- is used to treat disorders including rickets (a vitamin D deficiency) and to regulate parathyroid hormone, which affects calcium levels in the blood.
		The effect of hypercalcemia (elevated calcium levels) from the calcitriol limits its ability to be used to fight cancer, write Alagbala and colleagues.
		Calcitriol and QW both slowed the progression of prostate cancer in the mice, the researchers report.
	www.webmd.com /content/article/114/111326.htm (424 words)

	HD Calcitriol
		Beer’s recently published studies of high-dose calcitriol combined with Taxotere, there is considerable interest in the subject of calcitriol as a treatment for prostate cancer and thus, another possible addition to treatments in our arsenal to combat this chimera that invades our bodies and lives.
		Serious studies of the role of calcitriol in the treatments for cancer are reported as early as 1999 concluding that it has considerable anti-tumor effects and recent trials reflect that it enhances the anti-tumor effects of taxanes and platinum analogs.
		Several medical journal studies have explored the use of calcitriol as a single agent, chemotherapy agents as single agents, and calcitriol in combination with chemotherapy and other agents for the treatment of prostate cancer.
	www.hrpca.org /calcitriolhd.htm (1626 words)

	Drugs and Treatments - Calcitriol Oral - (Rocaltrol) - Patient Handout from WebMD (Site not responding. Last check: 2007-10-30)
		Calcitriol is a man-made active form of vitamin D. Most people get enough vitamin D from exposure to the sun and from fortified food products (e.g., dairy products, vitamins).
		Calcitriol is used in patients with kidney disease who can't make enough of the active form of Vitamin D. This medication is also used to prevent and treat certain types of calcium/phosphorus/parathyroid problems that can happen with long-term kidney dialysis or hypoparathyroidism.
		Calcitriol is usually used along with specific diet recommendations and sometimes other medications.
	rxlist.com /drugs/drug-7448-Calcitriol+Oral.aspx?drugid=7448&...+Oral (1299 words)

	Island Pharmacy Services, Inc. - Calcitriol
		Calcitriol continues to be one of the best received human-use drugs in terms of pet owner satisfaction.
		Calcitriol is prepared for individual patients on a prescription basis.
		Calcitriol doses are based on a dosing range of 1.5 ng to 3.5 ng per kilogram of body weight.
	www.islandpharmacy.com /site/1420401/page/768522 (407 words)

	Medical Dictionary: Calcitriol - WrongDiagnosis.com
		Calcitriol: A synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form.
		Calcitriol regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth.
		Calcitriol also induces cell cycle arrest at G0/G1 phase of the cell cycle, cell differentiation, and apoptosis, resulting in inhibition of proliferation of some tumor cell types.
	www.wrongdiagnosis.com /medical/calcitriol.htm (238 words)

	Calcitriol Reference Page
		Calcitriol, phosphate binders, erythropoetin, appetite stimulants, potassium supplementation, subcutaneous fluid therapy: these are the current cornerstones of medical therapy for chronic renal disease in the feline.
		Calcitriol is an easily administered, effective medication that has the potential to substantially increase longevity and quality of life especially when used early in the course of disease.
		Calcitriol deficits cause increased PTH and, as these two hormones are designed to maintain calcium and phosphorus homeostasis, the PTH increase is initially adaptive.
	members.bellatlantic.net /~vze2r6qt/calcitriol (3172 words)

	High Dose Calcitriol Plus Dexamethasone for Hormone Insensitive Prostate Cancer
		Calcitriol (trade name Rocaltrol) is a potent form of vitamin D (1,25(OH)2 Vitamin D3).
		They say that they have shown that "dexamethasone (Dex) enhances calcitriol antitumor effects and reduces calcitriol-induced hypercalcemia." Hypercalcemia is a problem with high doses of calcitriol.
		Calcitriol is given orally in escalating dose levels of 8m g Monday, Tuesday, Wednesday (MTW) weekly x1 month; 10m g MTW, weekly x1 month and then 12m g MTW weekly.
	www.psa-rising.com /medicalpike/rocaltrol-ascomay2000.htm (441 words)

	Island Pharmacy Services, Inc. - Calcitriol - Geriatric Pets
		Calcitriol (1,25 dihydroxycholecalciferol, human-use drug, brand name: Rocaltrol) is prescribed for humans to reduce elevated parathyroid hormone levels (PTH), which are the result of diminished kidney function and calcitriol deficiency.
		Unfortunately, this is not the case and attempts to use calcitriol at an approximate fraction of the human dose result in hypercalcemia, or a level of calcium that is too high.
		As the studies have scientifically confirmed, daily oral calcitriol at low doses is both safe and effective in the control of renal secondary hyperparathyroidism in dogs and cats.
	www.islandpharmacy.com /site/1420401/page/768552 (2542 words)

	Drug Shortage Bulletin: Calcitriol Capsules and Oral Solution—Resolved
		Calcitriol capsules 0.25 mcg and 0.5 mcg, Teva Pharmaceuticals.
		Injectable preparations of calcitriol were not affected by this shortage.
		Activated vitamin D products, such as calcitriol and dihydrotachysterol, are used in patients with renal disease to help prevent hyperparathyroidism and osteodystrophy.
	www.ashp.org /shortage/calcitriol.cfm (562 words)

	Antitumorigenic and Antiinsulinogenic Effects of Calcitriol on Insulinoma Cells and Solid {beta}-Cell Tumors -- ...
		for 48 and 72 h in the presence of calcitriol.
		After 48 and 72 h of exposure, calcitriol dose dependently inhibited cell growth (A) and induced a reduction of number of viable cells (B).
		Treatment with calcitriol did not induce in vivo a decrease in the rate of replication of insulinoma cells.
	endo.endojournals.org /cgi/content/full/143/10/4018 (7085 words)

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