| | Calcium Channels: Critical Targets of Toxicants and Diseases (Site not responding. Last check: ) |
 | | The structure and regulation of voltage-dependent calcium channels and their role in inherited and toxicant-induced neurologic disorders was the topic of a conference sponsored and hosted by the National Institute of Environmental Health Sciences, the U.S. Environmental Protection Agency, Sibia Neurosciences, and the Muscular Dystrophy Association on 6-8 December 1999. |
 | | Calcium channels may be phosphorylated by many protein kinases, including calcium/calmodulin-dependent protein kinases and protein kinases A and C. The effects of such phosphorylation depend on the channel subtype under study, the protein kinase, and other signaling pathways that may be active. |
 | | Second, the complex interplay among calcium channels, calcium influx, intracellular calcium homeostasis, and intracellular signaling is likely to be important both in clinical syndromes attributable to calcium channel mutations and in the neurologic effects of a variety of toxicants. |
| www.cfids-cab.org /cfs-inform/Hypotheses/audesirk.etal00.html (3756 words) |