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Topic: Calreticulin


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 Regulation of Calreticulin Gene Expression by Calcium -- Waser et al. 138 (3): 547 -- The Journal of Cell Biology   (Site not responding. Last check: 2007-10-08)
fragment of the murine calreticulin cDNA; the mouse calreticulin
of "free" calreticulin and/ or PDI in the lumen of the ER (Krause
Calreticulin is a lectin-like molecular chaperone for glycoproteins in the endoplasmic reticulum.
www.jcb.org /cgi/content/full/138/3/547   (7024 words)

  
 Calreticulin recognizes misfolded HLA-A2 heavy chains -- Mancino et al. 99 (9): 5931 -- Proceedings of the National ...
Calreticulin and peptides inhibit thermal aggregation of soluble peptide-deficient HLA-A2.
HLA-A2 (12 µM), calreticulin (12 µM), or HLA-A2+calreticulin (12 µM each) were incubated at 50 or 37°C for 1 h as indicated, followed by immunoprecipitation with the anti-his antibody that recognizes the C-terminal histidine tag present on HLA-A2, or a control antibody (directed against the irrelevant AU5 epitope tag).
HLA-A2 (12 µM) was incubated at 50°C for 1 h in the presence of calreticulin, oligomeric calreticulin (in the same microgram amount as the monomers), IgG, or in the absence of added proteins in the indicated molar ratios.
www.pnas.org /cgi/content/full/99/9/5931   (5007 words)

  
 Bioreagents.com: Calreticulin   (Site not responding. Last check: 2007-10-08)
Calreticulin is the major calcium binding protein found in smooth muscle sarcoplasmic reticulum (SR) and non-muscle endoplasmic reticulum (ER) membranes.
Calreticulin binds calcium with low affinity and high capacity, however it also exhibits a single high affinity binding site.
Recent reports indicate that calreticulin can act as a modulator of the regulation of gene transcription by nuclear hormone receptors and may also act as a molecular chaperone.
www.bioreagents.com /dev/index.cfm/fuseaction/products.detail/CatNbr/PA1-903   (308 words)

  
 Calreticulin Affects beta -Catenin-associated Pathways -- Fadel et al. 276 (29): 27083 -- Journal of Biological ...   (Site not responding. Last check: 2007-10-08)
A, Western blotting shows that the total amount of calreticulin is reduced in L fibroblasts underexpressing calreticulin (under) and elevated in L fibroblasts overexpressing calreticulin (over) in comparison with the control cell line (control).
calreticulin is resident in the lumen of the ER, its modulation
Calreticulin is a relatively unique ER lumenal protein.
www.jbc.org /cgi/content/full/276/29/27083   (4175 words)

  
 Differential Modulation of SERCA2 Isoforms by Calreticulin -- John et al. 142 (4): 963 -- The Journal of Cell Biology   (Site not responding. Last check: 2007-10-08)
Calreticulin interacts with newly synthesized human immunodeficiency virus type I envelope glycoprotein, suggesting a chaperone function similar to that of calnexin.
Presence of inositol 1,4,5-trisphosphate receptor, calreticulin, and calsequestrin in eggs of sea urchins and Xenopus laevis.
Calreticulin is a candidate for a calsequestrin-like function in Ca -storage compartments (calciosomes) of liver and brain.
www.jcb.org /cgi/content/full/142/4/963   (6958 words)

  
 A role for calreticulin in the adult heart? -- Maass and Leinwand 107 (10): 1223 -- Journal of Clinical Investigation   (Site not responding. Last check: 2007-10-08)
Calreticulin is essential for integrin signaling and the dephosphorylation and nuclear translocation of NF-AT3.
Phenotypes of transgenic mice with alterations in connexin40, connexin43, calsequestrin, or calreticulin
Calreticulin is essential for integrin-mediated calcium signaling and cell adhesion.
www.jci.org /cgi/content/full/107/10/1223   (1541 words)

  
 Calcium-binding proteins and calcium-release channels in human maturing oocytes, pronuclear zygotes and early ...
Immunolocalization of calreticulin in a human immature germinal vesicle (GV) oocyte (A), a metaphase II (MII) oocyte (B), a three-pronuclear (3PN) zygote (C) and a 4-cell embryo (D).
Helenius, A., Trombetta, E.S., Hebert, D.N. and Simons, J.F. (1997) Calnexin, calreticulin and the folding of glycoproteins.
Parys, J.B., McPherson, S.M., Mathews, L., Campbell, K.P. and Longo, F.J. (1994) Presence of inositol 1,4,5-trisphosphate receptor, calreticulin, and calsequestrin in eggs of sea urchins and Xenopus laevis.
humrep.oxfordjournals.org /cgi/content/full/17/11/2938   (5299 words)

  
 Calreticulin Expression Is Associated with Androgen Regulation of the Sensitivity to Calcium Ionophore-induced ...   (Site not responding. Last check: 2007-10-08)
Calreticulin Expression Is Associated with Androgen Regulation of the Sensitivity to Calcium Ionophore-induced Apoptosis in LNCaP Prostate Cancer Cells
Calreticulin protein migrates at 60 kDa in the Western blot.
The effect of calreticulin antisense oligonucleotide on the sensitivity of LNCaP to Ca ionophore A23187 in the presence or absence of mibolerone.
cancerres.aacrjournals.org /cgi/content/full/59/8/1896   (4537 words)

  
 Perforin Lytic Activity Is Controlled by Calreticulin -- Fraser et al. 164 (8): 4150 -- The Journal of Immunology
Expression and purification of recombinant and native calreticulin.
Calreticulin, a component of the endoplasmic reticulum and of cytotoxic lymphocyte granules, regulates perforin-mediated lysis in the hemolytic model system.
Calreticulin in T-lymphocytes: identification of calreticulin in T-lymphocytes and demonstration that activation of T cells correlates with increased levels of calreticulin mRNA and protein.
www.jimmunol.org /cgi/content/full/164/8/4150   (3887 words)

  
 Calreticulin: An Intracellular Ca++-Binding Protein Abundantly Expressed and Regulated by Androgen in Prostatic ...   (Site not responding. Last check: 2007-10-08)
The down-regulation of calreticulin by androgen ablation correlates with
of calreticulin correlates with apoptosis of prostatic epithelial
Clearly, the AR is active in the presence of an abundance of calreticulin.
endo.endojournals.org /cgi/content/full/139/10/4337   (5011 words)

  
 Calreticulin Enhances the Transcriptional Activity of Thyroid Transcription Factor-1 by Binding to Its Homeodomain -- ...   (Site not responding. Last check: 2007-10-08)
Calreticulin Enhances the Transcriptional Activity of Thyroid Transcription Factor-1 by Binding to Its Homeodomain -- Perrone et al.
Calreticulin Expression in Thyroid Cells Is Regulated by TSH and Insulin-- The DNA binding activity of TTF-1 in thyroid cells has been reported to be under TSH control because of redox regulation (19)
We show in the present paper that calreticulin binds to the homeodomain of TTF-1 and is capable of stimulating its refolding.
www.jbc.org /cgi/content/full/274/8/4640   (4537 words)

  
 Calreticulin, a Potential Vascular Regulatory Protein, Reduces Intimal Hyperplasia After Arterial Injury -- Dai et al. ...   (Site not responding. Last check: 2007-10-08)
There is a significant decrease in both plaque area and plaque thickness after infusion of rabbit and human calreticulin and the C domain on comparison with saline infusion and infusion of N and P domains, Study 3.
The effects of calreticulin and calsequestrin on monocyte migration in the modified Boyden chamber assay are shown in the line graph (D).
Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein.
atvb.ahajournals.org /cgi/content/full/17/11/2359   (5776 words)

  
 Complete heart block and sudden death in mice overexpressing calreticulin -- Nakamura et al. 107 (10): 1245 -- Journal ...
calreticulin have altered expression of Cx43 and Cx40 in the
Calreticulin, and not calsequestrin, is the major calcium binding protein of smooth muscle sarcoplasmic reticulum and liver endoplasmic reticulum.
Overexpression of calreticulin increases the Ca capacity of rapidly exchanging Ca stores and reveals aspects of their lumenal microenvironment and function.
www.jci.org /cgi/content/full/107/10/1245   (4415 words)

  
 BiP and Calreticulin Form an Abundant Complex That Is Independent of Endoplasmic Reticulum Stress -- Crofts et al. 10 ...
The positions of BiP and calreticulin (Cal) are indicated at left on the autoradiograph.
Nauseef, W.M., McCormick, S.J., and Clark, R.A. (1995) Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase.
Spiro, R.G., Zhu, Q., Bhoyroo, V., and Soling, H. (1996) Definition of the lectin-like properties of the molecular chaperone, calreticulin, and demonstration of its copurification with endomannosidase from rat liver Golgi.
www.plantcell.org /cgi/content/full/10/5/813   (6515 words)

  
 Calreticulin Inhibits Vitamin D's Action on the PTH Gene in Vitro and May Prevent Vitamin D's Effect in Vivo in ...
Calreticulin protein was increased in the nuclear fraction (N) of hypocalcemic rats compared with control rats, but there was no change in calreticulin protein in the cytoplasmic fraction (C) of these rats.
of calreticulin and androgen receptor in Vero fibroblasts transfected
B, The same as in panel A but in addition the cells were cotransfected with a plasmid that expressed the antisense transcript for calreticulin (lanes 1 and 2) or cotransfected with a plasmid that expressed the sense orientation of the calreticulin cDNA (lanes 3 and 4).
mend.endojournals.org /cgi/content/full/12/8/1193   (3687 words)

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