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Topic: Camptotheca


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In the News (Wed 9 Dec 09)

  
  Tissue-specific and developmental regulation of camptothecin and 10-hydroxycamptothecin levels in Camptotheca acuminata
Camptotheca acuminata seeds were obtained from Jintang (30.72° N, 104.61° E), Sichuan Province, China in January 2002.
Camptotheca acuminata has CPT in all organs throughout its life cycle (Lin et al., 1977; Liu and Adams, 1996) but produces little HCPT except in cotyledon and embryonal axis of 9-15 day old seedlings (Lopez-Meyer et al., 1994).
Study on chemical components in Camptotheca acuminata, an anti-cancer plant I. Chemical components in roots of C.
ejournal.sinica.edu.tw /bbas/content/2005/4/Bot464-06.html   (3116 words)

  
  Camptotheca
This herb is the fruit, root, twig, leaf and bark of Camptothecae acu-minata (family Nys-saceae), produced in most provinces south of the Yangtze River.
Psoriasis, 20 percent of ointment of the fruit is used for external application; camptotheca seed injection of seed for intramuscular injection.
Hepatospleno-megaly caused by schistosomiasis:100 percent bark injection is used for intramuscularinjection.
www.healthphone.com /consump_english/encyclopedia/chinese_herbal_files/camptotheca.htm   (208 words)

  
 [No title]   (Site not responding. Last check: 2007-11-02)
The effect of Irinotecan from Camptotheca acuminata in 644 neuroblastoma patients was confirmed by in vivo preclinical studies, and phase I clinical trials conducted in Japan concluded the maximum tolerated dose as 160-180 mg/m2/day.
An antitumor alkaloid 11-hydroxy-(20S)-camptothecin was isolated from woody tissue of Camptotheca acuminata.
DNA topoisomerase I was found to be the cellular target of camptothecin, a cytotoxic alkaloid from Camptotheca acuminata and that DNA topoisomerase I is essential for the survival of mammalian cells.
www.herbmed.org /members/serv/bridgeport/default.asp?getpg=http://www.herbmed.org/members/HerbTemplates/subcategory.asp?varHerb_ID=87   (1997 words)

  
 Untitled Document   (Site not responding. Last check: 2007-11-02)
Camptotheca acuminata is a deciduous tree in the family Nyssaceae (tupelo family).
Camptothecin is derived from the Chinese plant Camptotheca acuminata Decne.
The Camptotheca acuminata Decne is a deciduous tree, native to south China and Tibet.
www.phytomedical.com /plant/9NitroCamptothecin.asp   (1578 words)

  
 MEDLINE Search on Medscape.com
Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots.
Laticifers in Camptotheca acuminata Decne: distribution and structure.
Hydrostachys, a Cornaceae consisting of Cornus and Alangium, a Nyssaceae consisting of Nyssa and Camptotheca, a monogeneric Davidiaceae, a...
search.medscape.com /medline-search?queryText=Nyssaceae   (291 words)

  
 [No title]
Camptotheca acuminata, a deciduous tree also known as Xi Shu, Happy Tree, Han Lian, Huagan Zi Shu, Qian Zhang Shu, and Xi Zhu, contains camptothecins that are among the most promising new cancer drugs.
The investigation of Camptotheca began in the U.S. in the 1950s, when the USDA began a chemical screening program that included thousands of plants.
Camptotheca was the only extract to demonstrate high antitumor activity.
www.herbalgram.org /tomsofmaine/herbclip/review.asp?i=41612   (524 words)

  
 Cyberbotanica: Camptotheca   (Site not responding. Last check: 2007-11-02)
Camptothecin and these analogs are being investigated to treat a wide variety of cancers, but the compounds are quite toxic, and only topotecan (Hycamtin®) and irinotecan HCl (Camptosar®) have met with FDA approval; Hycamtin® has been approved for ovarian cancer theray, and Camptosar® is approved for metastatic colorectal cancers.
Western researchers (Dr. Monroe E. Wall of the USDA and Jonathon Hartwell of the National Cancer Institute) first discovered Camptotheca's anticancer properties in 1958.
Research Triangle Institute, he and other researchers isolated camptothecin.
biotech.icmb.utexas.edu /botany/camphist.html   (210 words)

  
 Untitled Document   (Site not responding. Last check: 2007-11-02)
Camptothecin - a monoterpenoid indole alkaloid derived from the Chinese tree Camptotheca acuminata Decne - and its derivatives are unique in their ability to inhibit DNA topoisomerase.
This is achieved by stabilizing a covalent reaction intermediate, termed as the “cleavable complex” which ultimately causes tumor cell death.
Irinotecan is derived from the Chinese plant Camptotheca acuminata Decne.
www.phytomedical.com /Plant/Irinotecan.asp   (1887 words)

  
 Expression of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene from Camptotheca acuminata Is Differentially ...
Expression of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene from Camptotheca acuminata Is Differentially Regulated by Wounding and Methyl Jasmonate -- Burnett et al.
Expression of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene from Camptotheca acuminata Is Differentially Regulated by Wounding and Methyl Jasmonate
Camptotheca hmg1promoter is sufficient to confer developmental regulation
www.plantphysiol.org /cgi/lookup?vol=103&fp=41&view=abstract   (351 words)

  
 Happy tree - Wikipedia, the free encyclopedia
The Happy tree, Camptotheca acuminata, is a medium-sized deciduous tree native to central China, usually included in the tupelo family Nyssaceae, but sometimes included (with the tupelos) in the dogwood family Cornaceae.
An extract from the Happy tree is used as an anti-cancer treatment in China.
The name 'happy tree' is a direct translation of the Chinese name xi shu.
en.wikipedia.org /wiki/Happy_tree   (107 words)

  
 Tissue-Specific Expression of the beta -Subunit of Tryptophan Synthase in Camptotheca acuminata, an Indole ...
Burnett RJ, Maldonado-Mendoza IE, McKnight TD, Nessler CL (1993) Expression of a 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Camptotheca acuminata is differentially regulated by wounding and methyl jasmonate.
López-Meyer M, Nessler CL (1997) Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminata which are differentially expressed during development and stress.
The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata.
www.plantphysiol.org /cgi/content/full/120/1/43   (4545 words)

  
 MDidea Extracts Professional:Monomer Components Series:Camptothecin Origin from Common Camptotheca Fruit.Narrative
The Lab of MDidea Group is currently one of the international leaders in the development and clinical (human) studies of a new family of anticancer drugs, the camptothecins, which have been in clinical trials since 1997.
More than 30 years ago it was found that extracts from a Chinese tree, Camptotheca Acuminata, had potent anticancer activity against a mouse leukemia.
The active substance, designated Camptothecin, was tried clinically on incurable patients in the early 1970's by physicians at the National Cancer Institute in Washington D.C. It was found to have some anticancer activity, but was too toxic as administered in those days to be of practical use.
www.mdidea.com /products/monomer/mono03.html   (2120 words)

  
 LSU School of RNR Zhijun Liu   (Site not responding. Last check: 2007-11-02)
Effect of NaCl on Growth, Morphology, and Camptothecin Accumulation in Camptotheca acuminata Seedlings.
ffects of benzyladenine and naphthalene acetic acid on growth, morphology, and camptothecin accumulation in Camptotheca acuminata seedlings.
Drought-induced in vivo synthesis of camptothecin in Camptotheca acuminata seedlings.
www.rnr.lsu.edu /Faculty/liu.htm   (319 words)

  
 Untitled Document   (Site not responding. Last check: 2007-11-02)
Previously, the only species known was Camptotheca acuminata which is a tree native to China.
Prior to the research conducted at SFA, the extraction of CPT’s from the Camptotheca tree was a very long and arduous process.
Making CPT production even more difficult, C. acuminata has been listed as a national endangered species in China, and the fruits, as well as the export of related products, are under regulation by the Chinese government.
www.sfasu.edu /physical_plant/Temple_Lab_Cancer.htm   (650 words)

  
 Tryptophan synthase beta subunit expression is restricted to vascular tissues in shoots of Camptotheca acuminata and ...   (Site not responding. Last check: 2007-11-02)
The Camptotheca genome, however, contained a single TSB gene, which must respond to demands from both primary and secondary metabolism.
In Arabidopsis, TSB and all other enzymes of the tryptophan biosynthetic pathway have been localized to chloroplasts, but in Camptotheca, there appeared to be little expression in tissues where the predominant plastids are photosynthetically competent chloroplasts.
Despite the fact that all metabolically active cells require tryptophan, the single gene encoding TSB in Camptotheca is not a uniformly expressed housekeeping gene.
abstracts.aspb.org /pb1998/36/0252.shtml   (301 words)

  
 Camptotheca (Camptotheca) | Genus
Home • Plants  • Kingdom Plantae  • Division Magnoliophyta  • Class Magnoliopsida  • Order Cornales  • Family Cornaceae  • Camptotheca (Camptotheca)
Welcome to Garden Guides' plant type taxonomy guide, currently showing is the Genus Camptotheca (scientific name), commonly known as Camptotheca.
Camptotheca is a member of the Family Cornaceae (Dogwood Family).
www.gardenguides.com /plants/taxonomy.asp?tax=4036456   (56 words)

  
 Perdue (1970) Camptotheca acuminata Decaisne (Nyssaceae) source of camptothecin: An anti-leukemic alkaloid   (Site not responding. Last check: 2007-11-02)
Perdue (1970) Camptotheca acuminata Decaisne (Nyssaceae) source of camptothecin: An anti-leukemic alkaloid
Camptotheca acuminata Decaisne (Nyssaceae) source of camptothecin: An anti-leukemic alkaloid
Prepared in cooperation with National Cancer Institute, Dept. of Health, Education, and Welfare and Research Triangle Institute.
www.getcited.org /pub/101476133   (39 words)

  
 Camptotheca acuminata
Camptotheca acuminata is a member of the family Nyssaceae (tupelo family) and is native only to China and Tibet, where it is known as xi shu ("happy tree").
Its primary anti-cancer ingredient is a quinoline alkaloid called camptothecin, which in turn has been modified to create a host of other anti-cancer drugs, including irinotecan, topotecan, 9-aminocamptothecin, and CPT-11.
In 1966, after Wall joined the Research Triangle Institute, he and other researchers isolated camptothecin.
www.ancientworlds.net /aw/Post/385794   (306 words)

  
 Sustained Harvest of Camptothecin from the Leaves of Camptotheca acuminata   (Site not responding. Last check: 2007-11-02)
Sustained Harvest of Camptothecin from the Leaves of Camptotheca acuminata
Over a 12-week period, new growth was collected at different intervals from Camptotheca acuminata trees to determine whether a leaf harvest strategy would be an efficient means for the production of the alkaloid camptothecin.
Because camptothecin accumulates in young leaves and because the harvesting of young tissue stimulates axillary bud outgrowth, this strategy increased the harvestable amount of camptothecin from trees in a nondestructive manner.
pubs.acs.org /cgi-bin/abstract.cgi/jnprdf/1997/60/i06/abs/np9700228.html   (138 words)

  
 Herbs of Grace - Working with nature to preserve nature™
Using an Aspergillus nidulans mutant sensitive to camptothecin, other factors involved in mediating cellular sensitivity to camptothecin were investigated.
Search for Camptotheca acuminata in Dr. Duke's Phytochemical and Ethnobotanical Databases.
Alcohol depletes the body of important vitamins and minerals.
www.herbsofgrace.co.uk /herbmed.php?hmid=87&vs=fi_tV&id=6yOE32Jg3C0pwhLU   (504 words)

  
 Cancer and Chemotherapy - A Chemical Needle in a Haystack
One chemotherapy agent is the descendant of the insecticide DDT, another is one of a substance found in
Still others are the descendants of a bacterium in the soil, of an evergreen shrub tea, of the Chinese tree Camptotheca acuminata, and of the tree Taxis brevifolia, the Pacific yew.
The last is the best known of the "family tree" of chemotherapeutics—Taxol®—approved for treating ovarian cancer in 1994.
www.chemheritage.org /EducationalServices/pharm/chemo/readings/ages.htm   (2631 words)

  
 Camptotheca acuminata : camptotheca
I just found this near my work places and it has been grown very well.
I wonder which part they are using it.
Add your comments and/or image on Camptotheca acuminata
hortiplex.gardenweb.com /plants/p1/gw1007256.html   (79 words)

  
 Organomed Corporation -- Products
Principal pigment of bile Chromophore responsible responsible for coloration in various forms of jaundice
Camptotheca acuminata Alkaloid with antileukemic and anti tumor activity
Toxic principle from the seed of Laburnum anagyroides
www.organomed.com /products.htm   (100 words)

  
 Camptotheca acuminata, Camptotheca, Happy Tree, Kingherb|Kingherb, Professional supplier of Herb extract, Health ...
Camptotheca acuminata, Camptotheca, Happy Tree, KingherbKingherb, Professional supplier of Herb extract, Health Ingredients
Please input the herb name in Botanical Science name or Commom English name or Chinese Pinyin name.
The Camptotheca Acuminata tree is a large tree (up to 75 feet) that is native to the warm Southwestern region of China
www.kingherb.com /new/herbs/34.htm   (115 words)

  
 Expression of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene from Camptotheca acuminata Is Differentially ...
In Camptotheca, hmg1 transcripts were detected only in young seedlings and
Taken together, these data show that a 165-bp fragment of
Tissue-Specific Expression of the beta -Subunit of Tryptophan Synthase in Camptotheca acuminata, an Indole Alkaloid-Producing Plant
www.plantphysiol.org /cgi/content/abstract/103/1/41   (351 words)

  
 Camptotheca
[ Camptostylus ] [ Camptotheca ] [ Campuloa ]
Vernacular names of plants within the Genus Camptotheca
For a description of the methodology followed in establishing this hierarchy see the note Nomenclature used in The Compleat Botanica.
www.crescentbloom.com /plants/Genus/C/a/Camptotheca.htm   (75 words)

  
 What is Common Camptotheca Fruit P.E., Camptotheci   (Site not responding. Last check: 2007-11-02)
[Key words:Common Camptotheca Fruit P.E.,Camptothecin as DNA Topoisomerase I inh
Camptothecin is a quinoline-based alkaloid found in the barks of the chinese
tree Camptotheca acuminataDecne and the Asian nothapodytes tree.Camptothecin and
forum.agriscape.com /?read=11940   (442 words)

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