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| | PA-04-035: CIRCULATING CELLS IN CANCER DETECTION |
 | | Enrichment will allow exfoliated cells and subcellular molecules, for example from urine, to be used for genomic, proteomic, and epigenomic analyses that may lead to improvements in the detection of bladder cancer through measurements of alterations in expressed genes, peptide profiles, and epigenetic markers. |
 | | With the advent of PCR-based detection of DNA from rare neoplastic cells in body fluids, mutations have been detected in ras genes from the stools of patients with colorectal cancer, in p53 from the urine of patients with bladder cancer, and in p53 genes in the sputum of patients with lung cancer. |
 | | However, the detection of abnormal exfoliated cells, for instance, cancer cells by routine cytopathological examination may be limited because the number of abnormal cells may be very small compared to the number of normal cells, is difficult. |
| grants1.nih.gov /grants/guide/pa-files/PA-04-035.html (3898 words) |
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