
	Where results make sense

Topic: Candidate gene

	Gene detection in Type 2 diabetes
		The candidate genes (summarized in Table I) were selected either because of putative key roles in the biochemical processes that are impaired in Type 2 diabetes or because linkage between them and Type 2 diabetes had been reported in other studies.
		Of further interest is the observation that the diabetes susceptibility genes in the GK rat and tubby mouse models of diabetes are located on the rat and mouse chromosomal regions respectively equivalent to the chromosomal region (11p) where the cholecystokinin B receptor is located.
		While perfectly reasonable candidates can be selected on the basis of our current understanding of the metabolic defects in Type 2 diabetes, it is quite possible that the diabetes genes have yet to be cloned and/or are involved with processes that have yet to be defined.
	www.medforum.nl /idm/gene.htm (817 words)

	Candidate gene - Wikipedia, the free encyclopedia
		A candidate gene is a gene, located in a chromosome region suspected of being involved in the expression of a trait such as a disease, whose protein product suggests that it could be the gene in question.
		A popular way to identify candidate genes is by microarray, this allows the researcher to analyse the expression levels of specific genes in a case control study, therefore if a gene is dysregulated in a disease it may be identified by microarray.
		However microarray has its weaknesses as it identifies all expression in the cell and could be reporting the expression of a gene which is and effect of the disease rather than the cause.
	en.wikipedia.org /wiki/Candidate_gene (166 words)

	Candidate Gene and Mutation Screening
		In a few cases disease genes have been identified by linkage analysis in extended pedigrees, but the rarity of large, affected families limits the pace of discovery.
		Our goal is to identify genes that are important in the pathogenesis of CHD using a candidate gene approach.
		We are currently investigating the role that selected candidate genes play in the development of two forms of human CHD that are among the most common in children, and which cause significant morbidity in adults.
	cardiogenomics.med.harvard.edu /project-detail?project_id=231 (420 words)

	DJO \| Digital Journal of Ophthalmology
		Those genes which code for proteins that are expressed exclusively or predominantly in the photoreceptor cells, or which are involved in biochemical pathways known to be abnormal in a hereditary retinal degeneration, are considered as candidate genes for the diseases.
		In ORDER to carry out the candidate gene studies in dogs, however, it has been necessary to clone the canine specific genes and/or cDNAs, sequence the exon flanking regions to scan for mutations in the coding regions using conformational sensitive gel electrophoresis techniques, or identify intragenic polymorphisms or repeat elements useful for linkage analysis.
		Candidate gene studies indicate that most if not all of these diseases are caused by defects in genes not yet associated with human retinal degenerative disorders.
	www.djo.harvard.edu /site.php?url=/physicians/oa/381 (3745 words)

	Molecular Genetic Association Studies with Candidate Genes for Schizophrenia
		In complex disorders, such as schizophrenia, which result from the interaction of various vulnerability genes and non genetic factors, association studies are the most efficient strategy to explore the putative contribution at candidate gene loci.
		genes hypothesized to be involved in the disease on the basis of knowledge of the pathogenesis.
		Examples of such candidate genes are those involved in dopamine signalling, expression and development, such as dopamine receptors and retinoic acid.
	www.hubin.org /about/projects/genetic_candidate_en.html (972 words)

	Gene Amondson- Alaskan Artist, Pie Book, Prohibition, Radio
		This photo of Gene and his Chainsaw was taken in a bar, published in the Washington Law and Politics Magazine last year and was awarded "Best Portrait for a Magazine" in the Northwest by the Society of Professional Journalists (photographer Rick Dahms).
		Gene is an International Speaker to kids in schools and prisons about drugs and alcohol.
		Gene gives us a glimpse into his private life and his pursuit of "a wife before winter," even appearing several times on the Oprah show.
	www.geneamondson.com (334 words)

	Choosing Targets for Gene Therapy
		Gene therapy could potentially treat certain disorders at the source by repairing the underlying genetic flaws.
		The best candidates for gene therapy are the so-called "single-gene" disorders - which are caused by mutations in only one gene.
		Mutated genes that function this way are called dominant negative and adding back the normal protein won't fix the problem.
	learn.genetics.utah.edu /units/genetherapy/gttargets (427 words)

	Candidate 'Gene Silencers' Found
		Because gene silencing targets specific mRNAs, many people have thought that so-called antisense RNA--RNA with a nucleotide sequence complementary to the gene's mRNA--might be involved, possibly as a tag that marks the mRNA for degradation.
		In two of them, the added gene led to the silencing of the endogenous ACO gene as indicated by the disappearance of its RNA.
		A gene introduced in one place in an organism can silence the corresponding RNA at distant locations, and, in keeping with that, by several weeks later the GFP fluorescence had disappeared throughout the plant.
	www.biotech-info.net /candidate_silencers.html (808 words)

	Autism Speaks, Get Involved, In the News, NAAR Archive, Two Candidate Genes for Autism Identified in NAAR-Funded ...
		A further "coincidence" is that the reelin gene is located on chromosome 7q22--a region in which four genetics teams have each found to be an area of interest on the genome and therefore possibly involved in autism, despite not reaching statistical significance.
		If the reelin gene were found to be abnormal, it could be contributing to the linkage findings even if not strongly enough to emerge as a singular cause of autism.
		To test whether the gene is related to autism, the in-vestigators studied transmission rates of the two versions of the gene to affected and unaffected children in families having a child with an autism spectrum disorder diagnosis.
	www.autismspeaks.org /inthenews/naar_archive/two_candidate_genes.php (2985 words)

	Discovering Addiction Genes Using the Candidate Gene Approach
		That is why researchers often use what they and others know about a disease to narrow their focus down to a smaller number of "candidate genes".
		A smart way to start narrowing down the number of candidate genes is by looking at what we already know.
		In order to determine whether a gene is associated with nicotine addiction, a protein biochemist might need to collaborate with both a clinician and a DNA analyst.
	learn.genetics.utah.edu /units/addiction/genetics/candidate.cfm (422 words)

	Candidate Gene Suggestions (Site not responding. Last check: 2007-10-11)
		As a part of the Maize Diversity project, we will be conducting association studies with a large number of candidate genes for agronomic and developmental traits.
		We will be genotyping diverse samples of maize and teosinte (using SNPs discovered within candidate genes) and phenotyping these same plants for traits of interest to the members of this project.
		We welcome your suggestion of a gene (or several genes) that would be good candidate genes for association studies.
	www.panzea.org /sug (194 words)

	Gene Felton Restorations
		Gene Felton is a racing legend that has been inducted into the Georgia Automobile Racing Hall of Fame and is a candidate for induction into the International Motorsports Hall of Fame.
		Gene Felton's storied career is flush with wins and accolades.
		Gene was involved in a serious accident during a Trans Am race at Riverside in 1984, but he pressed on, racking up more wins.
	www.genefeltonrestorations.com (320 words)

	Identification of Positional Candidate Genes
		Gene identification for genetically complex traits is unlikely to succeed by fine structure mapping of confirmed recombinants, as for Mendelian traits, since recombinants cannot be unequivocally identified.
		Consequently, this argues for a two-step process consisting of identification of positional candidate genes and then defining a high density set of polymorphisms within and around the positional candidate genes.
		For any chosen candidate our object is to include or exclude the gene, with high probability, as being involved in hypertension.
	www.sph.uth.tmc.edu /hgc/fbpp/techSigPCG.htm (262 words)

	BioMed Central \| Full text \| Analysis of IFT74as a candidate gene for chromosome 9p-linked ALS-FTD
		Candidate gene sequencing at this locus revealed the presence of a disease segregating stop mutation (Q342X) in the intraflagellar transport 74 (IFT74) gene in family 476 (F476), but no mutation was detected within IFT74 in family 2 (F2).
		The 14 genes within the 2.1 Mb region of the 9p locus defined by the Dutch, Scandinavian and North American families[14-16] were identified from the NCBI [18] and Ensembl databases [19].
		In the course of sequencing the intraflagellar transport gene (IFT74), we identified a C to T sequence variant at nucleotide 1024 in exon 13 in the proband of F476 (III-3, figures 4a and 5).
	www.biomedcentral.com /1471-2377/6/44 (4058 words)

	Research Projects
		We have preliminary results suggesting that the candidate gene approach wer are employing will be quite productive in identifying genes influencing cancer susceptibility.
		Two-point linkage analysis (candidate gene and marker) have identified numerous potential linkage signals (specifically in our breast and prostate cancer cohorts) that have guided our subsequent multi-point linkage efforts.
		Our ability to identify prominent linkage signals in our candidate genes has been facilitated by our use of clinical data simultaneously collected with our patient DNA samples. This allows us to stratify our affected sibling pairs based upon additional disease criteria such as family history or pathological features.
	www.cityofhope.org /Researchers/KrontirisTheodore/Research.htm (601 words)

	NEW ALZHEIMER'S CANDIDATE GENE (Site not responding. Last check: 2007-10-11)
		The newly discovered mutation of STM-2 is quite rare, but the new gene may code for an unknown protein that is part of the poorly understood process leading to Alzheimer's disease in all patients.
		The discovery of this gene gives researchers an important new clue towards a better understanding of what causes the formation of amyloid-beta, a toxic substance found in the brains of patients with Alzheimer's.
		Determining the function of the proteins associated with the three Alzheimer's genes should help researchers develop a drug to slow or stop the disease process.
	www.accessexcellence.org /WN/SUA06/alz895.html (694 words)

	Researchers close in on stroke 'candidate gene'
		First, he says, the gene was only a predictor of clinically recognized stroke; it was not a predictor of “silent” strokes that are not obvious to the patient.
		Work on this “candidate gene” — meaning it may be responsible for causing disease — offers hope for stroke prevention, writes Robert A. Hegele, M.D., of the Robarts Research Institute in London, Ontario, Canada in an accompanying editorial.
		Two genes called alpha-adducin (ADD) and a G-protein beta 3 (GN3) subunit, have been targeted as stroke “candidate genes” because of their role in hypertension susceptibility.
	www.eurekalert.org /pub_releases/2001-04/AHA-Rcio-0404101.php (562 words)

	Serpine2 identified as novel candidate gene for COPD
		Thomas Mariani, head of the lab said the gene was "the most promising susceptibility candidate due to its biological relevance, its expression correlation with disease characteristics, and the allelic association in COPD families and replication in non-familial COPD patients."
		He added the data strongly suggested Serpine2 was a gene capable of modifying COPD risk, particularly in response to smoking.
		The study, entitled: "Expression of Serine Proteinase Inhibitor E2, a novel candidate COPD susceptibility gene, in the lung was recently presented at the 35th Congress of the International Union of Physiological Sciences in San Diego, March 31 - April 5, 2005.
	www.drugresearcher.com /news/ng.asp?id=59167 (840 words)

	The Gene Letter by GeneSage - Archives (Site not responding. Last check: 2007-10-11)
		To date, identification of human disease genes has been accomplished through one of three principal methods - functional cloning, positional cloning or candidate gene analysis.
		Based on the assumption that genes expressed in a particular tissue may be dysfunctional in diseases affecting that tissue, this method may be especially well-suited for finding genes involved in multigenic human malformation syndromes.
		A test experiment identified the correct gene in four of seven syndromes for which the causative gene was already known.
	www.genesage.com /professionals/geneletter/journalwatch/genomics.html (350 words)

	Baxley Dyslexia gene
		is a strong candidate gene for dyslexia, especially given the evidence that dyslexia is genetic.
		Although the evidence was slightly exaggerated and not much emphasis was place on the fact that this gene is located in one of six regions of the genome linked to dyslexia, ABC provided sufficient information to explain to the public that progress is being made in the field of dyslexic genetics.
		In fact, this gene is not located in the region of chromosome 15 that has been shown to be linked to dyslexia inheritance.
	www.bio.davidson.edu /courses/genomics/2003/baxley/dyslexia.html (953 words)

	RetNet: Disease Table
		candidate gene; CSNB and fundus pallor in Japanese primarily; recessive RP in Japanese
		candidate gene; null mutations in patients with CSNB and defective cone ON ERG responses; distinctive, abnormal rod ERG response to 15 Hz flicker; GRM6 expression is restricted to cone ON bipolar cells and protein is a receptor for neurotransmitter glutamate released from rods and cones; mouse knockout shows absent ON response
		candidate gene; stationary night blindness with subretinal spots and delayed dark adaptation; protein is an RPE microsomal enzyme involved in converting 11-cis retinol to 11-cis retinal; extremely delayed rod and cone resensitization in null mutation; same pathway as RDH12
	www.sph.uth.tmc.edu /retnet/disease.htm (5243 words)

	NIH Guide: POSITIONAL CANDIDATE GENE APPROACHES IN ASTHMA GENE DISCOVERY
		The National Heart, Lung, and Blood Institute (NHLBI) invites research grant applications to employ positional candidate gene approaches to identify the gene or genes in a particular region(s) that are linked to asthma or asthma-associated phenotypes, using traditional and novel genomic technologies.
		The number of biologically plausible candidate genes that might be involved in the determination of asthma and asthma-associated traits in these regions is very large, likely involving hundreds of genes within each of these linkage regions.
		In addition to human studies, in vitro and/or animal studies could be used to explore the functional contribution of various candidate genes to asthma or asthma-associated phenotypes.
	grants.nih.gov /grants/guide/rfa-files/RFA-HL-00-005.html (3669 words)

	Nomination of a Candidate Susceptibility Gene in Sarcoidosis . The Complement Receptor 1 Gene -- Iannuzzi et al. 27 ...
		The role of the C-C chemokine receptor 2 gene polymorphism V64I (CCR2-64I) in sarcoidosis in a Japanese population.
		Interleukin-1 gene cluster polymorphisms in sarcoidosis and idiopathic pulmonary fibrosis.
		The gene polymorphism of tumor necrosis factor-beta, but not that of tumor necrosis factor-alpha, is associated with the prognosis of sarcoidosis.
	ajrcmb.atsjournals.org /cgi/content/full/27/1/3 (2464 words)

	A candidate gene for familial idiopathic pulmonary fibrosis identified
		ELMOD2-gene is a prime candidate gene for familial idiopathic pulmonary fibrosis, suggests the recent study published by the researchers at the University and University Hospital of Helsinki, Finland.
		The critical region harbors two novel candidate genes, ELMOD2, and LOC152586 that both are poorly characterized.
		It is expressed in functionally relevant tissue, in lung and in fibroblasts, and its expression is significantly decreased in IPF lung compared to healthy lung.
	www.eurekalert.org /pub_releases/2006-06/uoh-acg062806.php (480 words)

	PRA in Shetland Sheepdogs
		In this approach instead of just looking at our candidate gene loci we use DNA markers spread across the entire genome (rather than markers selected only to specific gene locations) to see which are linked to the disease locus.
		With the first approach if the disease is not linked to any of your candidate gene loci the second approach must then be used.
		Also it is possible to see which retinal genes are close to the marker and then investigate those genes are candidate for causing PRA in your breed.
	www.nssk.no /PRA/eng/PRA-eng2.html (665 words)

	Integration of text- and data-mining using ontologies successfully selects disease gene candidates -- Tiffin et al. 33 ...
		Likelihood of the known disease gene being selected by chance alone was calculated as the probability of the disease gene falling into the candidate gene set according to the size of the candidate disease gene set (open square).
		The frequency of RefSeq genes at each node was the sum of all annotated RefSeq genes at the node and descendants of the node, compared to total number of annotated RefSeq genes.
		caused by mutation in the beta-globin gene HBB.
	nar.oxfordjournals.org /cgi/content/full/33/5/1544?ijkey=56KyoILM3LsxI&keytype=ref (5009 words)

	IoP: Intelligent candidate gene selection in neurodegenerative disorders
		This makes the identification of the genes responsible for this linkage a considerable task and is typically approached by systematic polymorphism detection and genotyping in large case/control samples (eg Busby et al, 2004).
		While, genes studied are prioritised according to predicted function, this is not usually systematic.
		The aim of this project is to integrate this data, such as gene expression (transciptome), protein-protein interaction (interactome), transcription factor binding motif, gene knock out phenotypes (phenome), with linkage data for complex neurodegenerative disorders in a graphical presentation to predict candidate genes for genetic analysis.
	www.iop.kcl.ac.uk /departments/?locator=639 (340 words)

Try your search on: Qwika (all wikis)