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Topic: Cannabinoid receptor

Related Topics

G protein coupled receptors

receptor biochemistry

sensory receptor

acetylcholine receptor

receptor proteomics

Adrenergic receptor

olfactory receptor neuron

peroxisome proliferator activated receptor

nicotinic acetylcholine receptor

muscarinic acetylcholine receptors

GABA A receptor

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	Cannabinoid receptor - Wikipedia, the free encyclopedia
		The cannabinoid receptors are a class of receptors under the G-protein coupled receptor superfamily.
		The CB2 receptor is not present in the CNS, but mostly in peripheral tissue associated with immune functions, including macrophages and B cells, as well as in peripheral nerve terminals.
		Recently the same group found that anandamide-induced mesenteric vasodilation is mediated by an endothelially located SR 141716A-sensitive "anandamide receptor," distinct from the CB1 cannabinoid receptor, and that activation of such a receptor by an endocannabinoid, possibly anandamide, contributes to endotoxin-induced mesenteric vasodilation in vivo.
	en.wikipedia.org /wiki/Cannabinoid_receptor (964 words)

	British Journal of Pharmacology - Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens (Site not responding. Last check: 2007-10-09)
		H]-noradrenaline release in the absence of cannabinoid agonist.
		COUTTS, A.A. and, PERTWEE, R.G. (1997) Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus..
		DEUTSCH, D.G. and, CHIN, S.A. (1993) Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist..
	www.nature.com /bjp/journal/v132/n6/full/0703930a.html (6550 words)

	Regional Differences in Cannabinoid Receptor/G-protein Coupling in Rat Brain -- Breivogel et al. 282 (3): 1632 -- ...
		Howlett, A. Inhibition of neuroblastoma adenylyl cyclase by cannabinoid and nantradol compounds.
		Howlett, A. Cannabinoid inhibition of adenylate cyclase: Biochemistry of the response in neuroblastoma cell membranes.
		Howlett, A. and Fleming, R. Cannabinoid inhibition of adenylate cyclase: Pharmacology of the response in neuroblastoma cell membranes.
	jpet.aspetjournals.org /cgi/content/full/282/3/1632 (6341 words)

	Cannabinoid Receptor Mrna Primer
		The Cannabinoid CB1 Receptor Antagonist SR141716 Increases Acrp30 mRNA Expression in Adipose Tissue of Obese fa/fa...
		The Cannabinoid CB1 Receptor Antagonist SR141716 Increases Acrp30 mRNA Expression in Adipose Tissue of Obese fa/fa Rats and in Cultured Adipocyte Cells.
		Zebra Finch CB1 Cannabinoid Receptor: Pharmacology and in Vivo and in Vitro Effects of Activation -- Soderstrom and...
	besthomepainting.com /cannabinoid-receptor-mrna-primer.html (1321 words)

	Cannabinoid receptor -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-09)
		The cannabinoid receptors are a class of receptors under the (Click link for more info and facts about G-protein coupled receptor) G-protein coupled receptor superfamily.
		Their (An atom or molecule or radical or ion that forms a complex around a central atom) ligands are known as (Click link for more info and facts about cannabinoids) cannabinoids.
		Cannabinoid receptors work by inhibiting (Click link for more info and facts about adenylate cyclase) adenylate cyclase and thereby inhibit production of the (Click link for more info and facts about second messenger) second messenger molecule (Click link for more info and facts about cyclic AMP) cyclic AMP.
	www.absoluteastronomy.com /encyclopedia/c/ca/cannabinoid_receptor.htm (147 words)

	Deborah L. Lewis, Ph.D. (Site not responding. Last check: 2007-10-09)
		A drug that inhibits the cannabinoid receptor is being marketed to depress the appetite and another drug that stimulates the receptor is being used to stimulate appetite in cancer patients.
		We have found that the aspartate in the second transmembrane domain of the CB1 cannabinoid receptor is responsible for the unique ability of the cannabinoid receptor to be tonically active and to “steal” G proteins.
		Summary of the two mutation studies: Mutation of the aspartate in the second transmembrane domain of the CB1 cannabinoid receptor shifts the receptor into an inactive state that is uncoupled from G proteins.
	www.mcg.edu /SOM/phmtox/lewis (734 words)

	Erowid Cannabis Vaults : Pharmacology : An Overview of the Endogenous Cannabinoid System : Components and Possible ...
		Early fringe speculation suggested that the receptor system might have co-evolved with the ancient use of cannabis, but its natural function is not to mediate the effects of the most widely distributed and used drug of plant origin, but to interact with naturally occurring, or endogenous, cannabinoids.
		These receptors have been found on the sperm cell of the sea urchin, and the ovaries from the same species are known to synthesize and degrade both anandamide and palmitoyl-ethanolamide69.
		(-)-Delta-(9)-Tetrahydro-cannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase.
	www.erowid.org /plants/cannabis/cannabis_pharmacology2.shtml (5988 words)

	Summary
		The long term goal of our cannabinoid research is to elucidate the basis for the actions of the cannabinoids at the molecular level.
		The first receptor (CB) is found largely in the brain [L. Matsuda et al.
		The focus of most of our work has been on the CB receptor because the SAR of this receptor is better developed.
	science.kennesaw.edu /projects/cab/rinfo.htm (491 words)

	Structural Domains of the CB1 Cannabinoid Receptor That Contribute to Constitutive Activity and G-Protein Sequestration ...
		that truncation of the distal C-terminal tail of the CB1 receptor
		The concentration of receptor cDNA that was injected and the application of SR 141716A are indicated in the table.
		CB1 cannabinoid receptors are constitutively active, which results in a tonic inhibition of Ca channels when expressed in SCG neurons.
	www.jneurosci.org /cgi/content/full/21/22/8758 (5297 words)

	Design and Synthesis of the CB1 Selective Cannabinoid Antagonist AM281: A Potential Human SPECT Ligand
		The binding of the novel probes to the cannabinoid receptors was assessed as previously described.
		Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study.
		Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig Myenteric plexus.
	www.aapspharmsci.org /view.asp?art=ps010204 (2898 words)

	Cannabinoid Receptor References
		Romero et.al (1998) Time-course of the cannabinoid receptor down-regulation in the adult rat brain caused by repeated exposure to delta9-tetrahydrocannabinol.
		Cannabinoid receptor down-regulation without alteration of the inhibitory effect of CP 55,940 on adenylyl cyclase in the cerebellum of CP 55,940-tolerant mice.
		Cannabinoid receptors in the human brain: A detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain.
	www.utopiasprings.com /vbiblio.htm (6515 words)

	Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid ...
		The cannabinoid receptors belong to the superfamily of 7-transmembrane
		The genes encoding the peripheral cannabinoid receptor and
		Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells.
	www.bloodjournal.org /cgi/content/full/99/8/2786 (5705 words)

	Bioreagents.com: Cannabinoid Receptor 1
		Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2.
		Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK.
		PA1-745 detects cannabinoid receptor 1 (CB1) from human, rat, monkey, mouse, chicken, salamander and goldfish tissues.
	bioreagents.com /index.cfm/fuseaction/products.detail/CatNbr/PA1-745 (273 words)

	Human protein: Q9BYY6 - Cannabinoid receptor 1 (Fragment). EMBL Bioinformatic Harvester
		The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana.
		The cannabinoid receptors are members of the family of guanine-nucleotide-binding protein (G-protein) coupled receptors which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner.
		The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana.
	harvester.embl.de /harvester/Q9BY/Q9BYY6.htm (661 words)

	Section 3) Scientific knowledge on marijuana's mechanism of action (Site not responding. Last check: 2007-10-09)
		The discovery of a cannabinoid receptor system in the human body began a scientific revolution that radically altered contemporary knowledge about marijuana's effects on the body and brain.
		The existence of the cannabinoid receptor system has clarified concern over marijuana's possible effects on the immune system, giving credence to claims that such effects pose no threat to human health.
		The discovery of the receptor system and the resulting research provides great promise for development of a new class of effective pharmaceutical drugs, and may enable scientists to learn more about the chemistry of emotions.
	www.drugscience.org /Petition/B3.htm (1323 words)

	Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor -- Sánchez et al. 61 ...
		Expression and Dynamics of Cannabinoid Receptors in C6 Glioma Cells in Culture and in Vivo.
		Immunofluorescence analysis of cannabinoid receptor dynamics in cultured glioma cells and in gliomas.
		A, example of CB receptor expression in a grade IV human astrocytoma (HA) as assessed by immunomicroscopy analysis of a tumor section and of cells derived from the tumor.
	cancerres.aacrjournals.org /cgi/content/full/61/15/5784 (4274 words)

	Medical Marijuana - News and Resources (Site not responding. Last check: 2007-10-09)
		This protein, known as the cannabinoid receptor, belongs to a large family of similar receptor proteins that are part of the complex system of chemical communication in the brain - a system in which the receptors recognize and react to chemical messengers released by activated nerve cells.
		That question is similar to one posed by the discovery in the 1970s that some nerve cells possess receptors that selectively recognize morphine, which is derived from the opium poppy.
		In both cases, the answer is that these receptors exist to interact with chemical messengers that the brain itself creates and releases.
	intraspec.ca /marijuana.php (1805 words)

	Lycaeum > Leda > Hedonistic Imperative
		Behavioral, pharmacological, and molecular characterization of an amphibian cannabinoid receptor
		Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism
		Cannabinoid receptors and reward in the rat: a conditioned place preference study
	leda.lycaeum.org /?ID=4185 (725 words)

	Recent MIRG Publications
		Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves.
		Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism.
		Interleukin-1beta, src- and non-Src tyrosine kinases, and nitric oxide synthase induction in rat aorta in vitro.
	www.ucalgary.ca /~mirg/recentpubs.htm (5631 words)

	Publications
		"Cannabinoid Structure-Activity Relationships: Correlation of Receptor Binding and in vivo Activities" D.R. Compton, K.C. Rice, B.R. Decosta, R.K. Razdan, L.S. Melvin, M.R. Johnson and B.R. Maring, J. Pharmacol.
		"Evaluation of Cannabinoid Receptor Binding and in vivo Activities of Anandamide Analogs", I.B. Adams, W. Ryan, M. Singer, B.F. Thomas, D.R. Compton, R.K. Razdan, B.R. Martin, J. Pharmacol.
		"Cannabinoid induced mesentric vasodilation through an endothelial site distinct from CB1 or CB2 receptors", Zolton, J.; Wagner, J. A.; Varga, K.; lake, K. D.; Compton, D. R.; Martin, B. R.; Zimmer, A. M.; Bonner, T. I.; Brickley, N. E.; Mezey, E.; Razdan, R. K.; Zimmer, A.; Kunos, G. Proc.
	www.organixinc.com /Publications.html (4009 words)

	Research onTourette syndrome, ADHD, genetics of behavior and related disorders.
		P#34: Comings, D.E. The role of genetic factors in conduct disorder based on studies of Tourette syndrome and ADHD probands and their relatives.
		P#89 Comings,D.E., Johnson,J.P., Gonzalez,N.S., Huss,M., Saucier,G. and MacMurray,J. Association between the adrenergic a2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects: A study and a replication.
		Comings, D.E. Child Dev 2002 Jul-Aug;73(4):1046-51 Parent-daughter transmission of the androgen receptor gene as an explanation of the effect of father absence on age of menarche.
	www.hopepress.com /html/research.html (2353 words)

	Biotechnology Encyclopedia
		The goal of the company's research effort is to develop products which maintain or improve opioid-like pain relief while reducing or eliminating opioid side effects.
		Entereg is a synthetic chemical compound that selectively blocks the interaction of narcotic analgesics at peripheral mu opioid receptors without blocking the centrally-mediated analgesic effects.
		Opoid receptor pain targets and cannabinoid receptor pain targets
	www.biotech100.com /drugs/adolor.htm (108 words)

	All Cannabinoid Receptor
		ICC, WB CANN6, CB R, CB1, CB1A, CB1K5, Central cannabinoid receptor isoform a, Central c...
		IF, IHC-Fr, WB CANN6, CB R, CB1, CB1A, CB1K5, Central cannabinoid receptor isoform a, Central c...
		CANN6, CB R, CB1, CB1A, CB1K5, Central cannabinoid receptor isoform a, Central c...
	www.abcam.com /?c=458 (157 words)

	Study Finds Cannabis Triggers Transient Schizophrenia-like Symptoms
		New Haven, Conn. -- The principal active ingredient in marijuana causes transient schizophrenia-like symptoms ranging from suspiciousness and delusions to impairments in memory and attention, according to a Yale research study.
		There were no side effects in the study participants one, three and six months after the study.
		The findings of this study go along with several other lines of evidence that suggest a contribution of cannabis and/or abnormalities in the brain cannabinoid receptor system to the pathophysiology of schizophrenia.
	www.sciencedaily.com /releases/2004/06/040615075809.htm (452 words)

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