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Topic: Carboplatin

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	Carboplatin - Wikipedia, the free encyclopedia
		Carboplatin has also proven effective in some strains of cancer that may not be susceptible to cisplatin, including germ-line cell, small and non-small cell lung, ovary, and bladder cancers, as well as acute leukemia.
		The clinical standard of dosage of carboplatin is usually a 4:1 ratio compared to cisplatin; that is, for a dose that usually requires a particular dose of cisplatin, four times more carboplatin is needed to achieve the same effectiveness.
		The stable property of carboplatin is a mixed blessing: although once uptake of the drug occurs, its retention half-life is considerably longer than cisplatin, it is also due to this inertness that causes carboplatin to go right through the human body, and up to 90% of the carboplatin given can be recovered in urine.
	en.wikipedia.org /wiki/Carboplatin (921 words)

	MedlinePlus Drug Information: Carboplatin (Systemic) (Site not responding. Last check: 2007-11-04)
		Carboplatin interferes with the growth of cancer cells, which eventually are destroyed.
		Carboplatin is to be administered only by or under the immediate supervision of your doctor.
		Carboplatin may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202115.html (1529 words)

	Mesothelioma, Asbestosis & Lung Cancer Information
		Carboplatin (Paraplatin) is used to treat cancer of the ovaries, head and neck, or mesothelioma.
		Carboplatin is in a group of medicines known as platinum containing compounds or alkylating agents.
		Carboplatin is given intravenously and works by interfering with the growth of cancer cells, which eventually die.
	www.mesotheliomaoptions.com /carboplatin.htm (279 words)

	Carboplatin - [Medication]
		Carboplatin is an intravenous (IV) medication usually given in a dose based on body surface area.
		Carboplatin is an alkylating agent that slows or stops the growth of the cancer cells.
		Carboplatin should be administered only under the supervision of a gynecological oncologist or medical oncologist.
	www.bchealthguide.org /kbase/topic/detail/drug/tw9438/detail.htm (274 words)

	Carboplatin (Paraplatin®) - PetPlace.com (Site not responding. Last check: 2007-11-04)
		Carboplatin is a platinum-containing drug used to treat malignant cancer.
		Carboplatin is used primarily to treat osteosarcoma, a cancer of the bones.
		Carboplatin should be avoided in dogs with active infections, hearing impairment, kidney or liver disease.
	www.petplace.com /drug-library/carboplatin-paraplatin/page1.aspx (417 words)

	Carboplatin : Cancerbackup
		Carboplatin (pronounced car-bo-pla-tin) is a chemotherapy drug that is given as a treatment for some types of cancer.
		Carboplatin can be given as a drip (infusion) through a fine tube (cannula) inserted into a vein.
		It may also be given through a central line, which is inserted under the skin into a vein near the collarbone, or into a PICC line, which is inserted into a vein in the crook of the arm.
	www.cancerbackup.org.uk /Treatments/Chemotherapy/Individualdrugs/Carboplatin (1137 words)

	Carboplatin : BC Cancer Agency (Site not responding. Last check: 2007-11-04)
		The other two ligands in carboplatin are present in a ring structure rather than as two chloride atoms in cisplatin.
		Carboplatin undergoes intracellular activation to form reactive platinum complexes which are believed to inhibit DNA synthesis by forming interstrand and intrastrand cross-linking of DNA molecules.
		Although NS is compatible with carboplatin, D5W is the preferred IV solution for dilution as carboplatin decomposition is less in D5W than in NS.
	www.bccancer.bc.ca /HPI/DrugDatabase/DrugIndexPro/Carboplatin1of2 (1441 words)

	CARBOPLATIN
		Carboplatin, a platinum coordination compound which contains a platinum atom surrounded with two ammonia groups and two other ligands in a ring structure.
		It is a yellow crystalline powder; soluble in water and saline; administered intravenously.
		It is a white crystalline powder; soluble in water; insoluble in ethanol, acetone, and dimethylacetamide; administered intravenously.
	www.chemicalland21.com /arokorhi/lifescience/phar/CARBOPLATIN.htm (337 words)

	Paraplatin Online, Description, Chemistry, Ingredients - Carboplatin - RxList Monographs
		PARAPLATIN ® (carboplatin for injection) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
		Carboplatin is a platinum coordination compound that is used as a cancer chemotherapeutic agent.
		Carboplatin is a crystalline powder with the molecular formula of C
	www.rxlist.com /cgi/generic3/carboplat.htm (219 words)

	ACS :: Cancer Drug Guide: carboplatin
		Carboplatin is a platinum chemotherapy drug that belongs to a general group of drugs known as alkylating agents.
		Carboplatin stops the growth of cancer cells, causing the cells to die.
		Carboplatin is given as an injection in the vein over 15 to 60 minutes.
	www.cancer.org /docroot/CDG/content/CDG_carboplatin.asp (702 words)

	Carboplatin: Mesothelioma Cancer Treatment (Site not responding. Last check: 2007-11-04)
		Carboplatin (Paraplatin) is a chemotherapy that is most often administered to patients who suffer from either cancer of the ovaries, head and neck or mesothelioma.
		Patients receiving carboplatin may suffer from temporary reduction in bone marrow function, nausea and vomiting, and/or loss of appetite.
		It is not advisable to become pregnant while taking carboplatin since it is possible that treatment could be harmful to a developing fetus.
	www.mesothelioma-cancer-treatment.com /pages/carboplatin.html (444 words)

	Carboplatin - Paraplatin – Chemotherapy Drugs - Chemo
		Carboplatin is also used for other types of cancer, including lung, head and neck, endometrial, esophageal, bladder, breast, and cervical; central nervous system or germ cell tumors; osteogenic sarcoma; and as preparation for a stem cell or bone marrow transplant.
		Carboplatin can also be given intra-peritoneal, directly into the peritoneal cavity in the abdomen.
		Carboplatin may be inadvisable if you have a history of severe allergic reaction to cisplatin, carboplatin, other platinum-containing formulations or mannitol.
	www.chemocare.com /BIO/carboplatin.asp (1565 words)

	CARBOPLATIN, Buy CARBOPLATIN (PARAPLATIN) Online (Site not responding. Last check: 2007-11-04)
		Carboplatin is a kind of drug that is also known as antineoplastic medication.
		Carboplatin belongs to the FDA pregnancy category D that means that this drug could be harmful to an unborn baby.
		Some of the serious side effects of Carboplatin are allergic reaction such as difficulty breathing, closing of the throat, swelling of the lips, or hives; kidney damage; decreased bone marrow function and blood problems; severe nausea, vomiting, and loss of appetite; or blurred vision, altered color perception, temporary blindness, and other visual problems.
	www.drugdelivery.ca /s3362-s-Carboplatin.aspx (706 words)

	CARBOPLATIN (Site not responding. Last check: 2007-11-04)
		Carboplatin is an antineoplastic agent used in the palliative treatment of certain neoplasm.
		The major advantage to Carboplatin over Cisplatin is its reduced toxicity profile, and the fact that Pt is not cell specific.
		Carboplatin has increased permeability over Cisplatin because the Carbo group squashes and pulls the cell membrane, which creates holes or increases pore size.
	www.chem.ox.ac.uk /course/ityearone/week2/CARBOPLATIN2.htm (319 words)

	Carboplatin in the Treatment of Small Cell Lung Cancer -- Brahmer and Ettinger 3 (3): 143 -- The Oncologist
		Carboplatin, ifosfamide and etoposide with mid-course vincristine and thoracic radiotherapy for "limited" stage small cell carcinoma of the bronchus.
		Paclitaxel, carboplatin, and extended-schedule etoposide in the treatment of small-cell lung cancer: comparison of sequential phase II trials using different dose-intensities.
		Superiority of cisplatin or carboplatin in combination with teniposide and vincristine in the induction chemotherapy of small-cell lung cancer.
	theoncologist.alphamedpress.org /cgi/content/full/3/3/143 (4131 words)

	MedlinePlus Drug Information: Carboplatin
		Carboplatin can cause a decrease in the number of blood cells in your bone marrow.
		Carboplatin is in a class of drugs known as platinum-containing compounds; it slows or stops the growth of cancer cells in your body.
		Carboplatin also is used to treat certain types of lung cancer, testicular cancer, head and neck cancer, Wilms' tumor, brain tumors, bladder cancer, and retinoblastoma.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a695017.html (525 words)

	Lung cancer - Wikipedia, the free encyclopedia
		NSCLC: cisplatin or carboplatin, in combination with gemcitabine, paclitaxel, docetaxel, etoposide or vinorelbine.
		In metastatic lung cancer, the addition of bevacizumab when added to carboplatin and paclitaxel was found to improve survival (though in this study, patients with squamous cell lung cancer were excluded because of problems with pulmonary hemorrhage in this group in the past).
		SCLC: cisplatin or carboplatin, in combination etoposide or ifosfamide; combinations with gemcitabine, paclitaxel, vinorelbine, topotecan and irinotecan are being studied
	en.wikipedia.org /wiki/Lung_cancer (3003 words)

	Carboplatin in Combination Therapy for Metastatic Breast Cancer -- Perez 9 (5): 518 -- The Oncologist
		Carboplatin or cisplatin was initially allowed based on the choice of the study center, but the protocol was amended to use carboplatin due to toxicity issues with cisplatin.
		Carboplatin in the treatment of advanced breast cancer: a phase II study using a pharmacokinetically guided dose schedule.
		Paclitaxel and epirubicin versus paclitaxel and carboplatin as first-line chemotherapy in patients with advanced breast cancer: a phase III study conducted by the hellenic cooperative oncology group.
	theoncologist.alphamedpress.org /cgi/content/full/9/5/518 (4105 words)

	I-30F - Carboplatin (Site not responding. Last check: 2007-11-04)
		Although the exact mechanism of action is unknown, action is thought to be similar to that of the bifunctional alkylating agents, that is, possible cross-linking and interference with the function of DNA.
		It is recommended that Carboplatin be administered to patients under supervision of a physician experienced in cancer chemotherapy.
		Carboplatin is not Medicare-covered in cancers where the effectiveness has not been demonstrated.
	www.hgsa.com /professionals/lcd/i30f.html (1197 words)

	Carboplatin - Family factsheets - GOSH and ICH
		This fact sheet explains what Carboplatin is, how it is given and some of the possible side effects.
		Carboplatin is a chemotherapy drug that is used to treat certain types of cancer.
		Your child may have a blood and urine test or a GFR (Glomerular Filtration Rate) before treatment is started and then at stages during and after treatment to monitor kidney function.
	www.gosh.nhs.uk /factsheets/families/F000240 (689 words)

	FDA Approves Carboplatin Injection, 600 Mg - Initial Treatment Of Advanced Ovarian Carcinoma
		Carboplatin is the generic equivalent of Bristol-Myers Squibb Company's Paraplatin(R).
		APP's carboplatin 600 mg is preservative-free and AP rated, and the product vials include a latex-free vial stopper, bar code and Tall Man Lettering label enhancements to help differentiate APP's carboplatin from other commonly used platinum-based chemotherapies with the same name suffix.
		Carboplatin is indicated for the initial treatment of advanced ovarian carcinoma in combination with other established approved chemotherapeutic agents, as well as for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy.
	www.medicalnewstoday.com /medicalnews.php?newsid=37987 (450 words)

	Carboplatin (Paraplatin)
		Carboplatin is a chemotherapy drug that is used widely, especially to treat ovarian and lung cancer.
		Carboplatin may have a harmful effect on a baby that is developing in your womb.
		Carboplatin may affect your ability to hear some high pitched sounds (this usually gets better on its own) and about 1 in 100 people treated have ringing in their ears (tinnitus)
	www.cancerhelp.org.uk /help?page=4001 (997 words)

	New Perspectives on an Old Friend: Optimizing Carboplatin for the Treatment of Solid Tumors -- Alberts and Dorr 3 (1): ...
		Feasibility and pharmacokinetics of paclitaxel, carboplatin, and concurrent radiotherapy for regionally advanced squamous cell carcinoma of the head and neck and for regionally advanced non-small cell lung cancer.
		Carboplatin and granulocyte colony-stimulating factor as first-line treatment for epithelial ovarian cancer: a phase I dose-intensity escalation study.
		Paclitaxel and carboplatin in combination in the treatment of advanced non-small-cell lung cancer: a phase II toxicity, response, and survival analysis.
	theoncologist.alphamedpress.org /cgi/content/full/3/1/15 (8473 words)

	Pharmacokinetics of Systemic Versus Focal Carboplatin Chemotherapy in the Rabbit Eye: Possible Implication in the ...
		Carboplatin concentrations at all time points were analyzed and compared for each tissue.
		Subconjunctival carboplatin in retinoblastoma: impact of tumor burden and dose schedule.
		Subconjunctival carboplatin therapy and cryotherapy in the treatment of transgenic murine retinoblastoma.
	www.iovs.org /cgi/content/full/45/10/3644 (3577 words)

	Carboplatin (Site not responding. Last check: 2007-11-04)
		Carboplatin can decrease the number of white blood cells in your body, cells that usually help you fight infections.
		It can also decrease the number of cells in your blood that help your blood clot (platelets) and the number of red blood cells, cells that carry oxygen to your tissues.
		Carboplatin may cause side effects that do not occur until months or years after you finish chemotherapy, including leukemia or decreased ability to have children.
	www.hci.utah.edu /patientdocs/hci/drugs/carboplatin.htm (311 words)

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