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BioMed Central | Full text | Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ... The precise mechanisms of the IBD-related carcinogenesis process are largely unclear, although it is generally assumed that IBD-related carcinogenesis occurs as a result of chronic inflammation [3]. Several agents, such as folic acid, short chain fatty acid (butyrate), ursodeoxycholic acid, and 5-aminosalicylic acid, have been suggested to be useful for prevention of CRC in UC Epidemiological studies have shown that prolonged use of aspirin is associated with a reduced risk of CRC [5]. The pathogenesis of IBD-associated colorectal carcinogenesis is widely believed to involve a step-wise progression from inflamed and hyperplastic epithelia through flat dysplasia to finally adenocarcinoma [30]. www.biomedcentral.com /1471-2407/5/46   (5556 words)

Carcinogenesis - Wikipedia, the free encyclopedia Carcinogenesis (meaning literally, the creation of cancer) is the process by which normal cells are transformed into cancer cells. Carcinogenesis is caused by this mutation of the genetic material of normal cells, which upsets the normal balance between proliferation and cell death. There are a number of theories of carcinogenesis and cancer treatment which fall outside the mainstream of scientific opinion, due to lack of scientific rationale, logic, or evidence base. en.wikipedia.org /wiki/Carcinogenesis   (2094 words)

Curtis C. Harris, Chief of Laboratory of Human Carcinogenesis   (Site not responding. Last check: 2007-10-31) In 1981, he was appointed Chief of the Laboratory of Human Carcinogenesis and chief of its Molecular Genetics and Carcinogenesis Section. His research on environmental carcinogenesis, cancer risk factors and molecular genetics of human carcinogenesis has significantly impacted the field of cancer risk assessment and our understanding of the molecular pathogenesis of human cancer. He serves as an Executive Editor of the journal, "Carcinogenesis" and has held elected offices in scholarly societies or non-profit foundations including the American Association of Cancer Research, the International Society of Differentiation, the Keystone Symposia of Cellular and Molecular Biology, and the Aspen Cancer Conference. www3.cancer.gov /intra/LHC/curt.htm   (1337 words)

Carcinogenesis This review highlights current knowledge of environmental factors in carcinogenesis and their cellular targets. The hypothesis that environmental factors influence carcinogenesis is widely supported by both epidemiological and experimental studies. The fact that only a small fraction of cancers can be attributed to germline mutations in cancer-related genes further buttresses the importance of environmental factors in carcinogenesis. www.worldoncology.net /carcinogenesis.htm   (102 words)

Journal of Carcinogenesis | Journal of Carcinogenesis considers manuscripts in many areas of carcinogenesis including: physical and chemical carcinogenesis and mutagenesis; processes influencing or modulating carcinogenesis, such as DNA repair; genetics, nutrition, and metabolism of carcinogens; the mechanism of action of carcinogens and modulating agents; epidemiological studies; and, the formation, detection, identification, and quantification of environmental carcinogens. Despite the advances in the treatment of cancer and the increasing knowledge of the processes responsible for the disease, there is a gap in the understanding of molecular events leading to cancer and the mechanisms of action by anticancer agents. Journal of Carcinogenesis considers manuscripts spanning a wide range of scientific interests, as long as the results and conclusions are scientifically justified and not misleading. www.carcinogenesis.com /info/about   (835 words)

Prevention and Therapy of Cancer: Chapter 23 References Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D, L- -difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet. Inhibition of carcinogenesis by difluoromethylornithine in heterotropically transplanted rat urinary bladders. Inhibitory effect of fumaric acid on forestomach and lung carcinogenesis by a 5-nitrofuran naphthyridine derivative in mice. www.gailsbooks.com /chap23r.htm   (10108 words)

EPA - Endocrine | 70714-01 P450 Link Between Hormonal and Chemical Carcinogenesis This concept has evolved from studies of the biogenesis and characteristics of 2- and 4- hydroxylated catechol metabolites of Es (2- and 4-OH-CEs) which may damage DNA via oxygen free radicals generatedby redox cycling of CEs or by causing depurinating adducts via their quinone metabolites. The overall hypothesis states that 2- and 4-OH- CEs generated in the gland, in particular 4-OH-CEs, are important determinants of P450- mediated Es role in carcinogenesis, in particular, in the early initiating stages of thedisease. The relevance of this postulate to breast cancer is supported by recent cytochemical findingsthat all of the forms of P450 required for such a mechanism are expressed in ductal epithelial cells in the normal humanbreast. www.epa.gov /edrlupvx/inventory/NCI-059.html   (454 words)

Overexpression of Protein Kinase C beta II Induces Colonic Hyperproliferation and Increased Sensitivity to Colon ... Colon carcinogenesis is a multistep process involving the progressive loss of growth control mechanisms and accumulation of and increased colon carcinogenesis in transgenic mice (Fig. Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats. www.jcb.org /cgi/content/full/145/4/699   (5901 words)

Multistep carcinogenesis: a 1992 perspective -- Sugimura 258 (5082): 603 -- Science Among the dietary factors that contribute to carcinogenesis are the heterocyclic amines, a group of mutagenic compounds present in cooked meat and fish. Carcinogenesis is a multistep process in which cells accumulate multiple genetic alterations as they progress to a more malignant phenotype. Recognition of the growing number of interacting factors that contribute to carcinogenesis may force reconsideration of current methods of risk assessment. www.sciencemag.org /cgi/content/abstract/258/5082/603   (536 words)

Efficiency of carcinogenesis with and without a mutator mutation -- Beckman and Loeb 103 (38): 14140 -- Proceedings of ... Efficiency of carcinogenesis with and without a mutator mutation -- Beckman and Loeb 103 (38): 14140 -- Proceedings of the National Academy of Sciences Efficiency of carcinogenesis with and without a mutator mutation Involvement of mutator mutations in carcinogenesis is favored www.pnas.org /cgi/content/abstract/103/38/14140   (330 words)

Oral Cavity and Esophageal Carcinogenesis Modeled in Carcinogen-Treated Mice -- Tang et al. 10 (1): 301 -- Clinical ... Carcinogenesis Induced by 4-NQO in Drinking Water in Mouse Tongue and Esophageal Epithelia. and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Carcinogenesis, March 1, 2006; 27(3): 619 - 630. clincancerres.aacrjournals.org /cgi/content/full/10/1/301   (7245 words)

Cancer Spectrum: Hursting et al., pp. 215-225. The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment—twenty-seventh G.H.A. Clowes memorial award lecture. Inhibition of dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats. Calorie restriction induces a p53-independent delay of spontaneous carcinogenesis in p53-deficient and wild-type mice. jncicancerspectrum.oxfordjournals.org /cgi/content/full/jnci;91/3/215   (7034 words)

Sensitivity of the Cervical Transformation Zone to Estrogen-induced Squamous Carcinogenesis -- Elson et al. 60 (5): ... Cancer incidence and histopathology of multistage transformation zone carcinogenesis. b, histopathology of multistage transformation zone carcinogenesis in transgenic (panels 2, 4, 6, and 8) and nontransgenic (panels 1, 3, 5, and 7) mice. Following a squamous cell fate decision, a combination of cell autonomous and non-cell autonomous factors foster multistage carcinogenesis in metaplastic glands. cancerres.aacrjournals.org /cgi/content/full/60/5/1267   (5478 words)

Glossary It is built up by endothelial cells lining the cerebral capillaries. Carcinogenesis: The production of a malignant new growth. Case control study: A study that starts with the identification of persons with the disease (or other outcome) of interest, and a suitable control group of persons without the disease. www.wirc.org /glossary/index.shtml   (2165 words)

EPA - Endocrine | 62269-01a2 Metallotheonein and Cadmium Carcinogenesis in Rat Prostate The aim of this proposal is to determine whether MT plays a protective role inCd carcinogenesis. To measure tumorigenicity per se, tumor incidence will he enumerated histologicallyand malignancy of the primary tumors will be assessed by anchorage-independent growth, cellular ploidy and in vivotumor formation efficiency in isogeneic hosts. Should our theory be proven, we expect to observe either abolition ordelay in development of the early or intermediate biomarkers of carcinogenesis, reduction of tumor incidence, and/orreduced malignancy of the primary tumors formed in the VPs of transgenic rats expressing MT, as compared to thosefound in normal VPs. www.epa.gov /edrlupvx/inventory/NCI-052.html   (401 words)

Fifth Annual Symposium on Hormonal Carcinogenesis The goal of the Fifth International Symposium is to focus on major developments in the rapidly expanding field of Hormonal Carcinogenesis and Hormonal Cancers. A novel format for these Symposia will be used to integrate different disciplines and approaches in each of the sessions, whenever possible, to include basic science, epidemiology, and clinical research. In order to have the fifth volume of Hormonal Carcinogenesis to be as representative as possible, we will continue our policy to have all primary and poster presentations included in the proceedings volume. www.kumc.edu /hormonecancers   (389 words)

Possible Mechanisms Relating Diet and Risk of Colon Cancer -- Bruce et al. 9 (12): 1271 -- Cancer Epidemiology ... With an excess of energy substrates in muscle, liver, and adipose tissue, these organs show insulin resistance, and the colon and other organs are exposed to elevated levels of insulin and intracellular energy substrates. Paulsen J. E., Stamm T., Alexander J. A fish oil-derived concentrate enriched in eicosopentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant cryp foci in rat colon. Carcinogenesis, August 1, 2003; 24(8): 1369 - 1378. cebp.aacrjournals.org /cgi/content/full/9/12/1271   (7048 words)

p53 Tumor Suppressor Gene: At the Crossroads of Molecular Carcinogenesis, Molecular Epidemiology, and Human Risk ... Carcinogenesis, June 1, 2004; 25(6): 931 - 939. Carcinogenesis, March 1, 2003; 24(3): 541 - 546. Carcinogenesis, June 1, 2001; 22(6): 861 - 867. www.annalsnyas.org /cgi/content/abstract/919/1/79   (468 words)

Differentiation Genes: Are They Primary Targets for Human Carcinogenesis? -- Prasad et al. 226 (9): 805 -- Experimental ... This hypothesis is one of the earliest hypotheses of carcinogenesis gene is a common cellular target for human carcinogenesis (60). Orth G, Croissant O. [Human papillomaviruses and carcinogenesis of the uterine cervix: future prospects in the domain of detection and prevention]. www.ebmonline.org /cgi/content/full/226/9/805   (5876 words)

Lipoxygenase Modulation to Reverse Carcinogenesis -- Shureiqi and Lippman 61 (17): 6307 -- Cancer Research Carcinogenesis, December 1, 2004; 25(12): 2467 - 2472. Carcinogenesis, September 1, 2004; 25(9): 1611 - 1617. Carcinogenesis, December 1, 2002; 23(12): 2095 - 2102. cancerres.aacrjournals.org /cgi/content/full/61/17/6307   (6224 words)

CiteULike: Tag carcinogenesis   (Site not responding. Last check: 2007-10-31) Study of the post-natal effects of chemopreventive agents on ethylnitrosourea-induced transplacental carcinogenesis in rats. Influence of low-molecular-weight polypeptide factors from the thymus, pineal gland, bone marrow, anterior hypothalamus, brain cortex and brain white substance. Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats. www.citeulike.org /tag/carcinogenesis   (562 words)

Cancer Spectrum: Sun et al., pp. 662-672. Mechanisms of cancer chemoprevention in hepatic carcinogenesis: modulation of focal lesion growth in mice. Chemoprevention of colon carcinogenesis by dietary perillyl alcohol. Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats. jncicancerspectrum.oxfordjournals.org /cgi/content/full/jnci;96/9/662   (6321 words)

Mechanisms of Chemoprevention -- Walaszek et al. 125 (5 Supplement): 128S -- Chest The concept that carcinogenesis is a multistep and multifunctional Marks, F, Furstenberger, G Cancer chemoprevention through interruption of multistage carcinogenesis: the lessons learnt by comparing mouse skin carcinogenesis and human large bowel cancer. Wattenberg, LW Inhibition of carcinogenesis by minor dietary constituents. www.chestjournal.org /cgi/content/full/125/5_suppl/128S-a   (2490 words)

alpha -difluoromethylornithine, an Irreversible Inhibitor of Ornithine Decarboxylase, Inhibits Tumor Promoter-Induced ... Carcinogenesis, May 1, 2003; 24(5): 945 - 952. Carcinogenesis, January 1, 2001; 22(1): 83 - 88. Difluoromethylornithine Chemoprevention of Epidermal Carcinogenesis in K14-HPV16 Transgenic Mice www.pnas.org /cgi/content/short/79/19/6028   (786 words)

An evolutionary paradigm for carcinogenesis? -- Vineis et al. 57 (2): 89 -- Journal of Epidemiology and Community Health carcinogenesis; selection of mutated clones is a second crucial p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and human risk assessment. Implications of the multistage theory of carcinogenesis applied to occupational arsenic exposure. jech.bmjjournals.com /cgi/content/full/57/2/89   (4857 words)

Definition of carcinogenesis - Merriam-Webster Online Dictionary Learn more about "carcinogenesis" and related topics at Britannica.com Find more about "carcinogenesis" instantly with Live Search See a map of "carcinogenesis" in the Visual Thesaurus www.m-w.com /dictionary/carcinogenesis   (26 words)

Fosamax and carcinogenesis   (Site not responding. Last check: 2007-10-31) fosamax and carcinogenesis then went on to speak in warm terms of, Mombasa conjured up. on closer examination we found that two lions had, features might be, fosamax and carcinogenesis by another leading a goat, felt, interest. life is an evolving succession of births, fosamax and carcinogenesis degree he would be connected with the press, of Mombasa -- appropriately called Vasco da. www.republika.pl /celebrex/fosamax-and-carcinogenesis   (251 words)

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