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Topic: Carcinoma of pancreas

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	Pancreas - Wikipedia, the free encyclopedia
		The pancreas is a retroperitoneal organ located posterior to the stomach on the posterior abdominal wall.
		The portal vein is formed by the union of the superior mesenteric vein and splenic vein posterior to the body of the pancreas.
		Control of the exocrine function of the pancreas are via the enzymes gastrin, cholecystokinin and secretin, which are enzymes secreted by cells in the stomach and duodenum, in response to distension and/or food and which cause secretion of pancreatic juices.
	en.wikipedia.org /wiki/Pancreas (844 words)

	Pancreatic cancer - Wikipedia, the free encyclopedia
		Pancreatic cancer (also called cancer of the pancreas) is represented by the growth of a malignant tumour within the small pancreas organ.
		The most common form of this disease is known as adenocarcinoma of the pancreas.
		Treatment of pancreatic cancer depends on the stage of the cancer [1] Recent advances have made resection of tumors that were previously unrescetable due to blood vessel involvement possible.
	en.wikipedia.org /wiki/Carcinoma_of_pancreas (440 words)

	Pancreas Cancer (Site not responding. Last check: 2007-10-18)
		The expression of MUC1 and CK17 was restricted to pancreatic ductal carcinoma (41 of 46, 89%; 38 of 46, 83%, respectively), the ampullary carcinoma of pancreatobiliary origin (6 of 6, 100%; 5 of 6, 83%, respectively), and intrahepatic cholangiocarcinoma (20 of 24, 83%; 17 of 24, 71%, respectively).
		KOC staining was present in 37 of 38 (97%) carcinomas: the staining reaction was moderate or strong in 36 of 38 (94%) and present in >50% of the tumor cells in 35 of 38 (92%) cases.
		The lesion was interpreted as an acinar cystadenoma, the benign counterpart of the well-established acinar cystadenocarcinoma of the pancreas.
	www.thedoctorsdoctor.com /diseases/pancreas_CA.htm (12728 words)

	Final Diagnosis -- Case 377
		Acinar cell carcinoma of the pancreas is a rare neoplasm, comprising 1-2 % of exocrine pancreatic tumors (Solcia E et al., 1997).
		Ultrastructural studies of acinar cell carcinomas have demonstrated a resemblance to normal pancreatic acinar cells with well-developed endoplasmic reticulum and zymogen granules (mean diameter 400-500nm), which are commonly oriented toward the luminal space.
		Acinar cell carcinomas are aggressive tumors and most patients die from their cancer within a mean of 18 months after diagnosis and a 5 year survival of 5.9%; however, the overall survival is better than pancreatic ductal adenocarcinoma (Klimstra DS et al.).
	path.upmc.edu /cases/case377/dx.html (964 words)

	National Cancer Institute - Islet Cell Carcinoma (Pancreatic) Treatment
		The broader right end of the pancreas is called the head, the middle section is called the body, and the narrow left end is the tail.
		The area of the pancreas that produces digestive juices is called the exocrine pancreas.
		The hormone-producing area of the pancreas has special cells called islet cells and is called the endocrine pancreas.
	www.cancer.gov /cancerinfo/pdq/treatment/isletcell/patient (411 words)

	eMedicine - Pancreas, Adenocarcinoma : Article by Mahesh Kumar Neelala Anand, MBBS, DNB, FRCR (Site not responding. Last check: 2007-10-18)
		On cross-sectional images, the measurements of normal pancreas diameters generally are as follows: head of the pancreas, 3 cm; neck and body of the pancreas, 2.5 cm; and tail, as long as 2 cm.
		The surface of the pancreas is smooth in 80% of patients and lobulated in approximately 20%.
		Pancreatic carcinoma is relatively avascular and associated with neovascularity in 50% of patients.
	www.emedicine.com /radio/topic516.htm (6082 words)

	Final Diagnosis -- Case 384
		Currently, the WHO recognizes clear cell carcinoma as a 'miscellaneous' carcinoma of the pancreas, which characteristically is rich in glycogen and poor in mucin although adenocarcinomatous components, ductal phenotype, and presence of mutations in the k-ras oncogene are recognized (1).
		A handful of cases have been reported as 'clear cell carcinomas of the pancreas' in the setting of anaplastic carcinoma, pleomorphic giant cell carcinoma, solid pseudopapillary tumor, and in a single case of primary intraductal carcinoma with invasive clear cell component (4,5,6,7).
		Although clear cell features have been described in the context of anaplastic carcinoma, pleomorphic giant cell carcinoma, solid pseudopapillary tumor, and in a single case of primary intraductal carcinoma with invasive clear cell component, there is a lack of reported cases in the literature for a conventional ductal adenocarcinoma composed of predominantly clear cells (1-8,14).
	path.upmc.edu /cases/case384/dx.html (1118 words)

	Aqel B, et al. Recurrent Pancreatitis Due to a Cystic Pancreatic Tumor: A Rare Presentation of Acinar Cell Carcinoma. ...
		Context Acinar cell carcinoma is an uncommon malignancy of the pancreas.
		Concurrent chemoradiation is effective in the treatment of alpha-fetoprotein-producing acinar cell carcinoma of the pancreas: report of a case.
		Acinar cell carcinoma of the pancreas successfully treated by en bloc resection and intraperitoneal chemotherapy for peritoneal relapse: a case report of a 15-year survivor.
	www.joplink.net /prev/200405/03_c.html (331 words)

	Nonfunctioning Neuroendocrine Tumor Of Pancreas
		A CT guided percutaneous biopsy was performed and yielded "atypical cells consistent with malignancy, carcinoma of pancreas vs. malignant lymphoma".
		An open surgical resection was performed and the tissue was determined to be consistent with a "neuroendocrine carcinoma" after immunohistochemical evaluation and outside pathologic consultation.
		Berho M, Blaustein A, Willis I, Sorace D, Suster S. Microglandular carcinoma of the pancreas: immunohistochemical and ultrastructural study of an unusual variant of pancreatic carcinoma that may closely resemble a neuroendocrine neoplasm.
	home.flash.net /~drrad/tf/040599.htm (415 words)

	Pancreatic Cancer Information, pancreatic cancer, ductal cell carcinoma (Site not responding. Last check: 2007-10-18)
		Carcinoma of the pancreas - the most common type of pancreatic cancer.
		Synonyms are ductal cell carcinoma and pancreatic adenocarcinoma.
		Your cancer may be located in the head, the tail, or the body of the pancreas.
	www.thehealthresource.com /cancer_info/pancreatic_cancer.html (369 words)

	Pancreatic Acinar Cell Carcinoma
		This appearance is characteristic of acinar cell carcinoma; the diagnosis was confirmed by PAS-D staining, which highlighted cytoplasmic granules in tumor cells, and by immunohistochemical staining, which verified the presence of a1-antichymotrypsin.
		The pancreas is composed predominantly of acinar cells (82%).
		Anaplastic carcinomas typically arise in the head or tail of the pancreas and are widely infiltrative; histologically, they are separated into large, pleomorphic or spindle cell groups.
	brighamrad.harvard.edu /Cases/bwh/hcache/380/full.html (1113 words)

	Islet Cell Carcinoma (Endocrine Pancreas): (Site not responding. Last check: 2007-10-18)
		The pancreas is about 6 inches long and is shaped like a thin pear, wider at one end and narrower at the other.
		The pancreas has two basic jobs in the body.
		The islet cells in the pancreas make many hormones, including insulin, which help the body store and use sugars.
	www.acor.org /cnet/62678.html (1743 words)

	References (Site not responding. Last check: 2007-10-18)
		Halpert B, Makk L, Jordan GL Jr: A retrospective study of 120 patients with carcinoma of the pancreas.
		Miller JR, Baggenstoss AH, Comfort MW: Carcinoma of the pancreas: effect of histological type and grade of malignancy on its behavior.
		Itani KM, Karni A, Green L: Squamous cell carcinoma of the pancreas.
	www.medscape.com /content/2000/00/41/06/410612/410612_ref.html (307 words)

	eMedicine - Pancreatic Cancer : Article by Richard A Erickson, MD, FACP, FACG (Site not responding. Last check: 2007-10-18)
		Approximately 75% of all pancreatic carcinomas occur within the head or neck of the pancreas, 15-20% occur in the body of the pancreas, and 5-10% occur in the tail.
		Interestingly, amylase and lipase are infrequently elevated in pancreatic carcinoma unless the patient is presenting with acute pancreatitis secondary to the pancreatic cancer.
		Additionally, the depth of the pancreas from the abdominal wall limits transcutaneous ultrasonic imaging to lower frequency (2-5 MHz), and thus, a lower-resolution ultrasonographic image is obtained.
	www.emedicine.com /med/topic1712.htm (7909 words)

	Genetic, Immunohistochemical, and Clinical Features of Medullary Carcinoma of the Pancreas : A Newly Described and ...
		K-ras sequencing of codon 12 of a medullary carcinoma (A) and a poorly differentiated conventional adenocarcinoma (B).
		The shifting medullary carcinoma and the normal pancreas are both from the patient with synchronous pancreatic and colonic carcinomas.
		the identification of a medullary carcinoma of the pancreas
	ajp.amjpathol.org /cgi/content/full/156/5/1641 (5118 words)

	MIXED OSTEOCLASTIC AND PLEOMORPHIC GIANT CELL CARCINOMA OF THE PANCREAS
		Cancer of exocrine pancreas comprises approximately 85% of all cases of pancreatic malignancy.
		The OGCT is considered to be a special duct-derived variant of anaplastic carcinoma that contains relatively uniform mesenchymal cells and multinucleated giant cells having an appearance and histochemical profile indistinguishable from that of bone osteoclasts.
		Experimental studies have shown a significant inhibition of adenocarcinoma of the pancreas by gonadoliberin (luteinizing hormone-releasing hormone) and somatostatin.
	www.kfshrc.edu.sa /annals/182/97-183.html (1371 words)

	Islet Cell Carcinoma (Endocrine Pancreas)
		Danforth DN Jr, Gorden P, Brennan MF: Metastatic insulin-secreting carcinoma of the pancreas: clinical course and the role of surgery.
		Evans DB, Skibber JM, Lee JE, et al.: Nonfunctioning islet cell carcinoma of the pancreas.
		At exploration, 85% of these tumors are found in the gastrinoma triangle with 40% on the surface of the pancreas and 40% outside of the pancreas.
	imsdd.meb.uni-bonn.de /cancer.gov/CDR0000062794.html (2348 words)

	Chadha MK, et al. Anaplastic Pancreatic Carcinoma. A Case Report and Review of Literature. JOP. J Pancreas (Online) ...
		Case report We describe the case of a 74-year-old woman with pleomorphic anaplastic carcinoma of the pancreas diagnosed after laparoscopic biopsy.
		A clinicopatholgic and Immunohistochemical Study of 35 Anaplastic carcinomas of the pancreas with a review of the literature.
		Phenotypical characteristics of undifferentiated carcinoma of the pancreas: a comparison with pancreatic ductal adenocarcinoma and relevance of E-cadherin, alpha catenin and beta catenin expression.
	www.joplink.net /prev/200411/12_c.html (390 words)

	ACTA Nov2000: Thyroid Metastasis from Intraductal Papillary-Mucinous Carcinoma of the Pancreas: A . . . (Site not responding. Last check: 2007-10-18)
		ACTA Nov2000: Thyroid Metastasis from Intraductal Papillary-Mucinous Carcinoma of the Pancreas: A.
		Fine needle aspiration of the thyroid yielded papillary fronds of carcinoma cells with nuclear pleomorphism, abundant cytoplasm and prominent nucleoli in a mucinous background.
		Conclusion:This case suggests that papillary carcinoma fronds aspirated from the thyroid should be further differentiated from the primary site and that a pleomorphic nucleus in a mucinous background is a useful feature to exclude a thyroid origin.
	www.acta-cytol.com /Abs/ACTA948.htm (253 words)

	The rare tumors web site - Meeting 2001
		Hsueh C, Kuo TT: Acinar cell carcinoma of the pancreas.
		Klimstra DS et al.: Acinar cell carcinoma of the pancreas.
		Itoh T et al.: Acinar cell carcinoma of the pancreas with elevated serum alpha-fetoprotein levels: a case report and a review of 28 cases reported in Japan.
	www.raretumours.org /ListFound.asp?2 (390 words)

	Cancer Spectrum: Physician Data Query - Treatment - Islet Cell Carcinoma (Endocrine Pancreas)
		It may come back in the pancreas or in another part of the body.
		The doctor may take out the cancer and most or part of the pancreas.
		Surgery to cut the nerve that stimulates the pancreas.
	jncicancerspectrum.oxfordjournals.org /cgi/pdq/jncipdq;CDR0000062678 (1736 words)

	Acinic Cell Carcinoma Definitions
		Cells of the pancreas that secrete digestive enzymes, the archetypal secretory cell upon which much of the early work on the sequence of events in the secretory process was done.
		Acinic Cell Carcinoma of the Pancreas (excerpts): Acinar cell carcinoma (ACC) is a rare type of exocrine pancreatic cancer.
		Exocrine pancreatic cancer as a whole is the most common form of pancreatic cancer when compared to endocrine pancreatic cancer, and acinar cell carcinoma is a rare subtype of exocrine pancreatic cancer.
	www.aciniccell.org /definitions.html (791 words)

	acinar cell carcinoma of the pancreas :: The Doctors Lounge(TM)
		Acinar cell pancreatic cancer is not a common type of cancer of the pancreas.
		Although acinar cells comprise a significant majority of the exocrine porton of the pancreas, they only account for a small portion (probably around 1%) of cancers that arise from the exocrine pancreas.
		Sometimes cancers of the pancreas do shrink, but on CAT scan images, do not appear to have done so and may appear larger than they were before chemotherapy was begun.
	www.thedoctorslounge.net /forums/viewtopic.php?t=118 (978 words)

	MedlinePlus Medical Encyclopedia: Pancreatic carcinoma
		Almost 1/3 of cases of pancreatic carcinoma can be attributed to cigarette smoking.
		When the tumor is confined to the pancreas but cannot be removed, a combination of radiation therapy and chemotherapy may be recommended.
		For pancreatic cancer that cannot be removed completely with surgery, or cancer that has spread beyond the pancreas, cure is not currently possible and the average survival is usually less than 1 year.
	www.nlm.nih.gov /medlineplus/ency/article/000236.htm (709 words)

	PANCREATIC DISEASE (INCLUDING DIABETES)
		You are already familiar with the gross and microscopic structure, and the physiology, of the exocrine and endocrine pancreas.
		A certain percentage of false-positive diagnoses of cancer of the pancreas, and a certain number of Whipple procedures for those without cancer of the pancreas, is acceptable: Br.
		Adenocarcinoma of the pancreas typically metastasizes to lymphatics, and blood-borne metastases to the liver are typically massive.
	www.pathguy.com /lectures/pancreas.htm (11446 words)

	NIH Guide: EARLY DETECTION RESEARCH ON CARCINOMA OF THE PANCREAS
		These research strategies can be devised based upon leads provided by (1) known risk factors identified through epidemiologic or cohort studies, (2) knowledge and research on pancreatitic metabolism or oncogene expression, or (3) the genetics of pancreatic metabolism, especially the activation of putative metabolic procarcinogens or cancer causing metabolites in certain populations.
		This Program Announcement, Early Detection Research on Carcinoma of the Pancreas, is related to the priority area of cancer prevention and control.
		This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
	grants.nih.gov /grants/guide/pa-files/PA-95-031.html (1197 words)

	[No title] (Site not responding. Last check: 2007-10-18)
		Cancer of the endocrine pancreas includes a highly treatable and often curable collection of tumors.
		However, one large retrospective series has suggested that extensive preoperative radiologic studies are neither clinically effective nor cost-effective, since intraoperative ultrasound and visual inspection of the pancreas at surgery localize most occult insulinomas.
		Prospective study of the clinical course, prognostic factors, causes of death, and survival in patients with long-standing Zollinger-Ellison syndrome.
	www.acor.org /cnet/62794.content (2282 words)

	MIR Teaching file case ot007
		CT: Atrophic pancreas with a dilated pancreatic duct.
		The pancreas was also noted to be atrophic with a markedly dilated pancreatic duct(12mm).
		Surgical pathology revealed a well-differentiated neuroendocrine carcinoma with peripancreatic soft tissue, lymphovascular, and perineural invasion.
	gamma.wustl.edu /ot007te173.html (497 words)

	Health Library -
		Since the clinical manifestations in functional tumors may result from the metabolic effects of polypeptide(s) secreted by the cancer cells rather than from tumor bulk or metastatic disease, each tumor type must be considered separately, both diagnostically and therapeutically.[1,2,3] Functional tumors may be too small in size to be detected by conventional imaging techniques.
		These are usually slow-growing tumors and, when localized to the pancreas or regional lymph nodes, can be cured with pancreatic resection.
		Only 15% are found within the substance of the pancreas.
	myhealth.ucsd.edu /library/healthguide/en-us/illnessconditions/topic.asp?hwid=ncicdr0000062794 (2410 words)

	Medical Dictionary: Carcinoma of the pancreas - CureResearch.com
		Medical Dictionary: Carcinoma of the pancreas - CureResearch.com
		Carcinoma of the pancreas: Another name for Pancreatic cancer.
		Carcinoma of the pancreas (condition): Cancer of the pancreas (usually digestive area).
	www.cureresearch.com /medical/carcinoma_of_the_pancreas.htm (220 words)

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