Cardiac marker - Factbites

Cardiac marker - Factbites
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Topic: Cardiac marker

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	Cardiac Enzymes
		A specific, sensitive marker that is present in 1-2 hours after the cardiac muscle injury continues to be sought.
		Damage to skeletal or cardiac muscle releases myoglobin into circulation.
		The cardiac isoforms are very specific for cardiac injury and are not present in serum from healthy people.
	classes.kumc.edu /son/nurs420/unit5/cardiac_enzymes.htm

	Cardiac Enzymes
		A specific, sensitive marker that is present in 1-2 hours after the cardiac muscle injury continues to be sought.
		The cardiac isoforms are very specific for cardiac injury and are not present in serum from healthy people.
		Damage to skeletal or cardiac muscle releases myoglobin into circulation.
	classes.kumc.edu /son/nurs420/unit5/cardiac_enzymes.htm (227 words)

	Acute yellow oleander (Thevetia peruviana) poisoning: cardiac arrhythmias, electrolyte disturbances, and serum cardiac glycoside concentrations on presentation to hospital -- Eddleston et al. 83 (3): 301 -- Heart
		Hyperkalaemia exacerbates cardiac glycoside induced cardiac arrhythmias and is a marker of a poor outcome in cardiac glycoside
		The cardiac rhythms of these patients on admission are given in table 1.
		Acute yellow oleander (Thevetia peruviana) poisoning: cardiac arrhythmias, electrolyte disturbances, and serum cardiac glycoside concentrations on presentation to hospital -- Eddleston et al.
	www.heartjnl.com /cgi/content/full/83/3/301 (2721 words)

	JEFF MANN�S EM GUIDELINES � CARDIAC ENZYMES
		- cardiac markers that may detect cardiac ischemia before infarction develops (glycogen phosphorylase-BB isoenzyme, glutathione peroxidase activity), or which detect platelet activation and thrombus formation (P selectin, thrombus precursor protein) are being evaluated, but none of these cardiac marker tests have entered mainstream clinical practice
		Unstable angina is a clinical diagnosis and negative cardiac markers should not influence medical decision-making re: admission of chest pain patients with suspected cardiac ischemia events to a CCU
		(* none of the cardiac markers are sensitive/specific enough to definitely exclude an AMI before ~ 8 - 10 hours, and frequent serial sampling during the first 8 hours has no real clinical utility if the patient is going to be admitted to the CCU and treated aggressively for cardiac ischemia)
	www.homestead.com /emguidemaps/files/enzymes.htm (2721 words)

	Anger Can Provoke Sudden Cardiac Death
		In recent years, however, doctors have been able to more clearly identify people who are at risk for these arrhythmias -- as well as the activities that can trigger sudden cardiac death.
		For example, researchers have identified an abnormal heart rate pattern called T-wave alternans (TWA) that are proving to be a new marker of heart rhythm instability that precedes potentially dangerous arrhythmias.
		The unpredictable nature of these arrhythmias has posed a major challenge in preventing sudden cardiac death, writes researcher Willem J. Kop, PhD, with the Uniformed Services University of the Health Sciences in Bethesda, Md.
	www.webmd.com /content/article/84/98077.htm (530 words)

	ScienceDaily Third Party New : Shockingly Close to the Truth : Confessions of a Grave-Robbing Ufologist
		Blood Test Can Accurately Diagnose Heart Failure In Emergency Patients (June 23, 2005) — A new blood test that measures a particular marker of cardiac distress can markedly improve the ability to diagnose or exclude congestive heart failure in patients with shortness of breath who come to hospital emergency departments.
		"Pick Me" and receive a "FREE BOOK MARKER" and "Five Star Service!"
		L.B. Freund, a professor of engineering at Brown University, and colleagues at the Max Planck Institute for Metals Research have published a model showing an optimal size for cell entry -- an idea that can be exploited in drug design -- in the Proceedings of the National Academy of Sciences.
	www.sciencedaily.com /cgi-bin/apf4/amazon_products_feed.cgi?myOperation=New&ItemId=1573929913 (530 words)

	Myoglobin protein (ab9926) datasheet
		Myoglobin is known as a marker of myocardial damage and it has been used for more than three decades.
		Only one form of myoglobin is expressed in cardiac and skeletal muscles.
		Nowadays it still is very commonly used in clinical practice as an early marker of AMI.
	www.abcam.com /?datasheet=9926 (335 words)

	CHEST: Evaluation of intravascular hemolysis with erythrocyte creatine in patients with cardiac valve prostheses
		In this study, we measured erythrocyte creatine by means of the enzymatic method with other hemolytic markers to compare their characteristics in patients with cardiac valve prostheses, and examined the relation between intravascular hemolysis and hemodynamic parameters in these patients.
		However, erythrocyte creatine is regarded as a sensitive and quantitative marker of mean age of the erythrocyte population, because young erythrocytes contain considerably higher creatine levels than older erythrocytes, (8) and creatine contents in erythrocytes decrease gradually with advancing cell age.
		Erythrocyte creatine, a marker of erythrocyte age that increases with shortening erythrocyte survival, was evaluated with other hemolytic markers and hemodynamic parameters.
	www.findarticles.com /p/articles/mi_m0984/is_6_125/ai_n6151133 (1088 words)

	Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major -- Davis et al. 104 (1): 263 -- Blood
		Mariotti E, Agostini A, Angelucci E, Lucarelli G, Sgarbi E, Picano E. Reduced left ventricular contractile reserve identified by low dose dobutamine echocardiography as an early marker of cardiac involvement in asymptomatic patients with thalassemia major.
		Detection of early cardiac dysfunction in patients with severe beta-thalassemia and chronic iron overload.
		Longitudinal study of cardiac function in thalassemia major.
	www.bloodjournal.org /cgi/content/full/104/1/263 (1088 words)

	Book Text
		Adams JE, Bodor GS, Davila-Roman VG, et al: Cardiac troponin I: A marker with high specificity for cardiac injury.
		Stubbs P, Collinson P, Moseley D, et al: Prospective study of the role of cardiac troponin T in patients admitted with unstable angina.
		Williams MJ, Morison IM, Parker JH, Stewart RA: Progression of the culprit lesion in unstable coronary artery disease with warfarin and aspirin versus aspirin alone: Preliminary study.
	www.gsf002.hpg.ig.com.br /106.html (1088 words)

	Acute yellow oleander (Thevetia peruviana) poisoning: cardiac arrhythmias, electrolyte disturbances, and serum cardiac glycoside concentrations on presentation to hospital -- Eddleston et al. 83 (3): 301 -- Heart
		Hyperkalaemia exacerbates cardiac glycoside induced cardiac arrhythmias and is a marker of a poor outcome in cardiac glycoside
		Figure 3 Relation between serum cardiac glycoside concentration and (A) potassium concentration and (B) magnesium concentration in relation to cardiac abnormality on presentation to Colombo coronary care unit.
		Figure 1 Serum concentrations of cardiac glycosides, potassium, and magnesium in patients admitted to Anuradhapura General Hospital who were then either transferred to Colombo or discharged without specific treatment.
	www.heartjnl.com /cgi/content/full/83/3/301 (2721 words)

	Sodium Channel Blockers Identify Risk for Sudden Death in Patients With ST-Segment Elevation and Right Bundle Branch Block but Structurally Normal Hearts -- Brugada et al. 101 (5): 510 -- Circulation
		Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome.
		Brugada J, Brugada R, Brugada P. Right bundle branch block and ST segment elevation in leads V1 through V3: a marker for sudden death in patients without demonstrable structural heart disease.
		Brugada J, Brugada P. Further characterization of the syndrome of right bundle branch block, ST segment elevation and sudden cardiac death.
	circ.ahajournals.org /cgi/content/full/101/5/510 (2721 words)

	HyTest Ltd. is a supplier of cardiac markers, human proteins, neuroscience, autoimmune and infectious disease reagents.
		Myeloperoxidase is thought to be a very promising cardiac marker at the moment.
		Today we can proudly say that HyTest is one of the leading producers and suppliers to IVD industry of reagents for cardiac diagnostics.
		A recent study shows that also PAPP-A may be a new candidate marker of Acute Coronary Syndromes.
	www.hytest.fi (2721 words)

	Sarnoff Endowment Fellows: Anna Lisa Chamis
		These vectors are designed to contain a selectable marker gene- Green Fluorescent Protein (GFP); a promoter gene whose expression is tightly associated with skeletal muscle phenotype - myogenin; or a promoter whose expression is restricted to cardiac myocytes - cardiac troponin T (cTNT); and a reporter gene - human Growth Hormone (hGH).
		Cloning of the new vectors uses an LNCX 6 base retroviral vector, with the neomycin and CMV genes replaced by a multiple cloning site into which our genes of interest can be inserted.
		We are cloning new retroviral vectors to monitor differentiation patterns of transplanted myoblasts.
	www.sarnoffendowment.org /fellows/chamis.shtml (2721 words)

	Serum cardiac troponin T and plasma brain natriuretic peptide in patients with cardiac decompensation -- Sato et al. 88 (6): 647 -- Heart
		Serum cardiac troponin T and plasma brain natriuretic peptide in patients with cardiac decompensation -- Sato et al.
		an increase in TnT is not a marker of decompensated CHF.
		of cardiac decompensation, 7 of whom ultimately died.
	heart.bmjjournals.com /cgi/content/full/88/6/647 (934 words)

	Different effects on human skeletal myosin heavy chain isoform expression: strength vs. combination training -- Liu et al. 94 (6): 2282 -- Journal of Applied Physiology
		Lanes 1 and 2: samples before and after training of one subject in Max group (traditional strength training with maximum contractions); lane 3: protein marker (A) or DNA size marker (B); lanes 4 and 5: samples before and after training of one subject in the Combi group (strength training combined with ballistic and stretch-shortening contractions).
		Rabbit masseter expresses the cardiac-myosin heavy chain gene-evidence from messenger RNA sequence analysis.
		Strength training is frequently used to improve the development of force and velocity.
	jap.physiology.org /cgi/content/full/94/6/2282 (3529 words)

	Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes -- Park et al. 95 (16): 9366 -- Proceedings of the National Academy of Sciences
		Visceral mesoderm marker is also restored in heat-shocked embryos of this genotype (data not shown).
		Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes -- Park et al.
		Without heat shock (A and C) no visceral mesoderm (A, asterisks) nor cardiac progenitors (C, asterisks) form, which is typical of tin mutants.
	www.pnas.org /cgi/content/full/95/16/9366 (3529 words)

	QRS Widening as a Marker of Dys-synchrony IHJ May- June 2003 Vol 55 No. 3
		Wide QRS duration has been considered a key criteria for selecting patients with congestive heart failure (CHF) for cardiac resynchronization therapy (CRT), as it has been suggested to be associated with marked RV-to-LV and intra-LV dys-synchrony.
		Most studies in cardiac resynchronization have focused on conduction system disease involving left bundle branch block.
		Hopefully, future studies, including the one mentioned by the authors, will concentrate on other conduction system abnormalities and on studying patients with congestive heart failure without bundle branch block.
	indianheartjournal.com /MayJune2003/Letter-to-Editors/qrs_widening_as_a_marker_of_dys.htm (3529 words)

	PR Newswire : Abbott and Axis-Shield Announce US 510(K) Submission and Non-US Launch Of AxSYM(R) BNP Test for Heart Failure. @ HighBeam Research
		BNP is a cardiac marker used in the diagnosis of heart failure.
		ABBOTT PARK, Illinois, December 8 /PRNewswire/ -- - Elevated Levels of B-type Natriuretic Peptide (BNP) are Associated with Cardiac Dysfunction or the Severity of Heart Failure
		Abbott Laboratories today announced that its manufacturing partner, Axis-Shield, has submitted a Premarket Notification 510(k) Application with the U.S. Food and Drug Administration (FDA) seeking clearance of a B-type Natriuretic Peptide (BNP) test for use on Abbott's widely used AxSYM(R) automated immunoassay instrument system.
	static.elibrary.com /p/prnewswire/december082003/abbottandaxisshieldannounceus510ksubmissionandnonu/index.html (264 words)

	BioMed Central Full text Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism
		It has been reported before that an increased excretion of orotate in sick children may not be uncommon and that a positive allopurinol load test may indicate unrecognized mitochondrial disease, making orotic acid as a potential marker of mitochondrial dysfunction [35].
		Clinical manifestations of cardiac disease occur in 57% of patients with Kearns-Sayre syndrome [17].
		Mitochondrial cytopathies are a group of disorders that are clinically heterogeneous with variable forms of presentation.
	www.biomedcentral.com /1471-2431/2/12 (264 words)

	Legal Medicine.
		Maeda, M.Q. Fujita, B.-L. Zhu, K. Ishida, L. Quan, S. Oritani, M. Taniguchi, Pulmonary surfactant-associated protein A as a marker of respiratory distress in forensic pathology: assessment of the immunohistochemical and biochemical findings, Legal Medicine 5 (0) (2003) pp.
		Bao-Li Zhu, Masaki Q. Fujita, Li Quan, Kaori Ishida, Shigeki Oritani, Kazunori Fukita, Yasunobu Kamikodai, Hitoshi Maeda, A sudden death due to cardiac conduction system injury from a blunt chest impact, Legal Medicine 1 (4) (1999) pp.
		Masaki Q. Fujita, Bao-Li Zhu, Li Quan, Kaori Ishida, Shigeki Oritani, Hitoshi Maeda, Pulmonary embolism: a case of sudden unexpected death in a psychiatric hospital, Legal Medicine 1 (3) (1999) pp.
	www.elsevier.com /cdweb/journals/13446223/viewer.htt?viewtype=authors&rangeselected=27 (264 words)

	Dr. David D. Frisbie - Equine Sciences Colorado State University
		Frisbie, D., Billinghurst, R., McIlwraith, C. "Changes in synovial fluid and serum markers associated with osteochondral fragmentation." Proc Molecular Marker of Cartilage and Bone Metabolism in the Horse.
		Frye, M., Bright, J., Fettman, M., Frisbie, D., Dargatz, D., Traub-Dargatz, J. "The use of dobutamine as a pharmacologic cardiac stressor in the equid." Proc Phi Zeta Res Day.
		Frisbie, D., Sandler, E., Trotter, G., McIlwraith, C. "Dose response study of insulin-like growth factor-1 modulating the metabolic and mitogenic activities in interleukin-1 conditioned equine cartilage." Am J Vet Res.
	equinescience.colostate.edu /facu/frpub.html (778 words)

	THIRD GENERATION
		On October 17, 1982, a marker was erected on the grounds located in front of the building.
		This document indicates her cause of death as "cerebral hemorrhage, complicated by senility, arteriosclerosis, cardiac renal disease, hip injury and hypo static pneumonia." The document was signed by Robert G. Wagner, M.D. Children were:
		On the 1920 census in Tarrant County, Texas, where her daughter, Frances Hester Morrow is shown as the wife of William A. Northcutt, Frances' mother is shown to have been born in Tennessee.
	members.aol.com /mbrewer233/winkie/d98.htm (3601 words)

	Effects of carvedilol on left ventricular remodelling in chronic stable heart failure: a cardiovascular magnetic resonance study -- Bellenger et al. 90 (7): 760 -- Heart
		Abbreviations: CHRISTMAS, carvedilol hibernation reversible ischaemia trial, marker of success; CMR, cardiovascular magnetic resonance; COI, cardiac output index; COMET, carvedilol or metoprolol European trial; EDV
	www.heartjnl.com /cgi/content/abstract/90/7/760 (3601 words)

	Increased expression of alternatively spliced dominant-negative isoform of SRF in human failing hearts -- Davis et al. 282 (4): 1521 -- AJP - Heart and Circulatory Physiology
		Expression of SRF isoforms in primary cultures of cardiac myocytes and fibroblasts.
		5 was used as a marker to determine electrophoretic mobility of different SRF isoforms.
		SRF with an alkaline phosphatase that nonspecifically dephosphorylates
	ajpheart.physiology.org /cgi/content/full/282/4/H1521 (6843 words)

	MDA Research Rehabilitation Management in Neuromuscular Disease
		The use of fluorescent dextrans as a marker of sarcolemmal injury.
		Kawashima S, Ueno M, Kondo T, Yamamoto J, Iwasaki T. Marked cardiac involvement in limb-girdle muscular dystrophy.
		Kurz LT, Mubarak SJ, Schultz P, Min Park S, Leach J. Correlation of scoliosis and pulmonary function in Duchenne muscular dystrophy.
	www.mdausa.org /research/carter.html (7051 words)

	Dr. Susan Smith
		Smith, S.M. The retinoic acid receptor isoform ß-2 is a early marker for alimentary tract and central nervous system positional specification in the chicken.
		Smith, and M. Walker Insulin Regulation in AhR-null Mice: Embryonic Cardiac Enlargement, Neonatal Macrosomia, and Altered Insulin Regulation and Response in Pregnant and Aging AhR-null Females.
		Induction of proline-rich glycoprotein synthesis in mouse salivary glands by isoproterenol and by tannins.
	www.erp.wisc.edu /faculty/smith.html (598 words)

	Use of Measurements of Myoglobin and Cardiac Troponins in the Diagnosis of Acute Myocardial Infarction
		Although myoglobin is not the perfect cardiac marker for diagnosing AMI, it is the earliest significant indicator of breakdown of myocardial cells.
		Myoglobin may be most helpful when used in conjunction with other cardiac markers in the rapid determination of AMI, especially in patients with atypical chest pain or nonspecific ECG changes.
		Myoglobin is a heme protein that is found in all striated muscle fibers, which account for about 2% of both skeletal and cardiac tissue mass.
	www.aacn.org /aacn/jrnlccn.nsf/c54ad59fdf5d6228882565a0006a1369/5a2783b7a758d435882567300061f9f2?OpenDocument (4384 words)

	Myoglobin Test AHealthyMe.com
		Myoglobin levels and levels of other cardiac markers are usually considered before finally confirming a diagnosis of heart attack.
		It is the first marker to rise after chest pain begins.
		Myoglobin is one of the first tests done to determine if a person with chest pain is having a heart attack, as it may be one of the first blood tests to become abnormal.
	www.ahealthyme.com /topic/topic100587189 (688 words)

	Role of myocardial perfusion imaging for risk stratification in suspected or known coronary artery disease -- Sabharwal and Lahiri 89 (11): 1291 -- Heart
		Abbreviations: ASNC, American Society of Nuclear Cardiology; CHRISTMAS, carvedilol hibernation reversible ischaemia trial: marker of success; EMPIRE, economics of myocardial perfusion imaging in Europe; END, economics of noninvasive diagnosis; FDG, fluorodeoxyglucose; MPI, myocardial perfusion imaging; PET, positron emission tomography; SPECT, single photon emission computed tomography; SSS, summed stress score
		Department of Cardiac Research, Northwick Park Hospital, Harrow, Middlesex, UK
		Keywords: myocardial perfusion imaging; SPECT; gated SPECT; coronary artery disease
	heart.bmjjournals.com /cgi/content/abstract/89/11/1291 (688 words)

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In the News (Fri 25 Dec 09)