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Topic: Cardiotoxic

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	Resident Report Volume 3, Number 11; September 10, 2004
		To assess whether this estimate is reflective of the incidence in the broader clinical oncology setting, the authors evaluated data from three prospective studies to determine both the incidence of doxorubicin-related CHF and the accumulated dose of doxorubicin at which CHF occurs.
		We examined echocardiograms from 120 children and adults who had received cumulative doses of 244 to 550 mg of doxorubicin per square meter of body-surface area for the treatment of acute lymphoblastic leukemia or osteogenic sarcoma in childhood, a mean of 8.1 years earlier.
		Cardiotoxicity is a recognized complication of doxorubicin therapy, but the long-term effects of doxorubicin are not well documented.
	www.emory.edu /WHSCL/grady/amreport/litsrch04/p040915ap.html (1579 words)

	Cardiotoxic effects of arsenic trioxide/imatinib mesilate combination in rats
		Cardiotoxicity is an important consideration in the evaluation of cancer chemotherapy, because chemotherapy-induced myocardial damage might be irreversible and lethal.
		Cardiotoxicity was evaluated by biochemical and histopathological examination 48 h after the last dose.
		In conclusion, both arsenic trioxide and imatinib mesilate might have significant cardiotoxicity and cardiac function should be monitored during treatment with them alone or in combination, as well as in the presence of pre-existing cardiac dysfunction.
	www.aapspharmaceutica.com /search/view.asp?ID=76227 (395 words)

	Chloroquine (PIM 123)
		The cardiotoxicity of chloroquine is related to it quinidine-like (membrane/stabilizing) effects.
		If cardiotoxic symptoms are present or if the dose ingested is higher than 3 g in adult or 30 mg/kg in child, a continuous infusion of diazepam may be given at a dose of 5 to 10 mg/hour in adults or 0.25 to 0.4 mg/kg/hour in children over a period of 24/48 hours.
		Given that chloroquine cardiotoxicity is rarely observed later than 48 hours after ingestion, diazepam administration after the 48th hour appears not to be justified.
	www.inchem.org /documents/pims/pharm/chloroqu.htm (5450 words)

	Cardiotoxic Potential of Anti-Emetics (5-HT3)
		Nonetheless, the development of significant electrocardiograph changes with some agents may indicate a potential for significant cardiac effects in patients, particularly those who may be predisposed to cardiac complication.
		Because two of the most common major comorbidities are cardiovascular related, we need to be acutely aware of the toxic effects of chemotherapy, as well as the possible cardiac interaction of supportive agents, specifically the 5-HT3 antiemetics.
		Until more data are made available, the best antiemetic option for patients receiving emetogenic and cardiotoxic chemotherapy may be the agent with the fewest apparent cardiac effects.
	www.annieappleseedproject.org /carpotofan5h.html (320 words)

	Batrachotoxin - Wikipedia, the free encyclopedia
		Batrachotoxins are extremely potent cardiotoxic and neurotoxic steroidal alkaloids found in certain species of frogs (poison dart frog), Melyridae beetles and birds (Pitohui, Ifrita kowaldi).
		These effects are similar to the cardiotoxic effects of digitalis (digoxin), a poison found in the foxglove plant.
		While it is not an antidote, the membrane depolarization can be prevented or reversed by either tetrodotoxin (from puffer fish), which is a noncompetitive inhibitor, or saxitoxin ("red tide").
	en.wikipedia.org /wiki/Batrachotoxin (1126 words)

	Reduced cardiotoxicity of DOXIL (pegylated liposomal doxorubicin) in AIDS Kaposi's sarcoma patients compared to a ...
		Reduced cardiotoxicity of DOXIL (pegylated liposomal doxorubicin) in AIDS Kaposi's sarcoma patients compared to a matched control group of cancer patients given doxorubicin (Meeting abstract).
		Doxorubicin (DOX)-induced cardiotoxicity can limit the duration of therapy with this agent and may be exacerbated by combination with newer agents such as taxanes.
		DOXIL, a pegylated liposome formulation of doxorubicin, is less cardiotoxic than DOX in rats, dogs and rabbits.
	www.aegis.com /aidsline/1997/feb/M9721709.html (596 words)

	EMedHome.com
		That may not always be the case in the intubated patient or the patient with a cardiotoxic overdose.) The expertise of the ED physician must overcome this thought process (or lack thereof).
		Sodium channel blockade is the most important factor in toxicity, resulting in slowing of the maximum upstroke slope (Vmax) of phase zero depolarization of the action potential, decreasing conduction velocity in the Purkinje fibers and increasing QRS duration, and decreasing automaticity.
		In summary, cardiotoxicity results from multiple effects on the cardiac cell action potential, direct effects on vascular tone and indirect effects mediated by the ANS.
	www.emedhome.com /features_printfriendly.cfm?FID=38 (1830 words)

	HFSA: Heart Failure Resulting From Trastuzumab (Herceptin) Use Largely Reversible
		TORONTO, ON -- September 15, 2004 -- Cardiotoxic events that occur as a result of treatment with the human monoclonal antibody trastuzumab (Herceptin) are largely reversible, according to a study from the MD Anderson Cancer Center, in Houston, Texas.
		To determine the true risk of cardiotoxicity associated with trastuzumab, researchers reviewed the charts of 35 patients who were receiving trastuzumab and were referred for evaluation of possible left ventricular (LV) dysfunction.
		All had received prior anthracycline-based chemotherapy and were from a much larger population of patients with breast cancer that were treated with trastuzumab at MD Anderson Cancer Center.
	www.docguide.com /dg.nsf/PrintPrint/30EB96891955B6EE85256F10006575F7 (541 words)

	The Cardiotoxic Potential of the 5-HT3 Receptor Antagonist Antiemetics: Is There Cause for Concern? -- Keefe 7 (1): 65 ...
		Epidemiology of anthracycline cardiotoxicity in children and adults.
		Epirubicin cardiotoxicity: an analysis of 469 patients with metastatic breast cancer.
		Cyclophosphamide cardiotoxicity in bone marrow transplantation: a prospective evaluation of new dosing regimens.
	theoncologist.alphamedpress.org /cgi/content/full/7/1/65 (3662 words)

	Drug-induced heart failure -- Feenstra et al. 33 (5): 1152 -- Journal of the American College of Cardiology
		Cardiotoxicity of mitozantrone assessed by stress and resting nuclear ventriculography.
		Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer.
		Assessment of interferon cardiotoxicity with quantitative radionuclide angiocardiography.
	content.onlinejacc.org /cgi/content/full/33/5/1152 (5863 words)

	The Technician's Guide to Euthanizing Small Animals
		Dibucaine in itself is a highly toxic, local anesthetic with a marked cardiotoxic effect in addition to the ability to cause paralysis of the respiratory center.2
		Dibucaine is twice as potent as tetracaine, which is fatal to dogs when given intravenously at a rate of 4.3mg/kg.
		When the technician is to perform euthanasia, he or she must choose the most efficient route that is available to them.
	www.vettech.com /articles/Euthansia.htm (2047 words)

	[No title]
		Excessive blood levels can be caused by a rapid intravascular injection of a therapeutic dose of drug, but serious toxicity is most often the result of a frank local anesthetic overdose.
		The typical patient who succumbs in the dental setting is not an adult administered one of the supposedly more cardiotoxic anesthetics or those implicated in methemoglobinemia.
		It is important to realize that narcotic sedative regimens lower the convulsive threshold of local anesthetics and increase the likelihood of respiratory depression and precipitous falls in cardiac output.
	www.columbia.edu /ccnmtl/draft/abena/aegd/to-do/V-2.txt (704 words)

	Clinical Trial: Epidemiology of Cardiotoxicity in Children With Cancer (Site not responding. Last check: 2007-10-08)
		To provide a comprehensive analysis of risk factors for the development of clinical cardiotoxicities in over 6,000 children with cancer who had been treated on standardized protocols involving the use of anthracyclines alone or in combination with other potentially cardiotoxic therapies or with no use of anthracycline therapy.
		The data were analyzed to estimate the incidence of clinical cardiotoxicity as measured by sudden death, congestive heart failure, or discontinuation of therapy based on cardiac function.
		The incidence of clinical cardiotoxicity was calculated using Kaplan- Meier estimates as a function of total cumulative anthracycline dose and also as a function of the time since the end of treatment stratified by dose levels.
	clinicaltrials.gov /ct/show/NCT00005418 (351 words)

	IBC and Chemotherapy
		Dear oceanblue: Obviously, without knowing the whole story, it is difficult to speculate on your mother's physician's rationale for all treatment decisions.
		It is true that epirubicin can be cardiotoxic - there is a lifetime maximum for these types of drugs.
		The maximum of epirubicin may be lower if she has had doxorubicin or another cardiotoxic drug in the past.
	www.medhelp.org /forums/BreastCancer/messages/582.html (420 words)

	Novantrone Online, Description, Chemistry, Ingredients - Mitoxantrone - RxList Monographs
		In order to monitor the occurrence of bone marrow suppression, primarily neutropenia, which may be severe and result in infection, it is recommended that frequent peripheral blood cell counts be performed on all patients receiving NOVANTRONE
		In cancer patients, the risk of symptomatic congestive heart failure (CHF) was estimated to be 2.6% for patients receiving up to a cumulative dose of 140 mg/m
		Presence or history of cardiovascular disease, prior or concomitant radiotherapy to the mediastinal/pericardial area, previous therapy with other anthracyclines or anthracenediones, or concomitant use of other cardiotoxic drugs may increase the risk of cardiac toxicity.
	www.rxlist.com /cgi/generic2/mitoxantrone.htm (641 words)

	Zoloft
		Of the 1 million Americans hospitalized each year for a heart attack, about 20 percent will also suffer from depression that puts them at triple the risk of dying.
		Yet most of these patients are not treated with antidepressants because older antidepressants were known to be cardiotoxic and the effects of the new antidepressants were unknown.
		In the first study of an SSRI (selective serotonin reuptake inhibitor) antidepressant in 369 depressed patients recently hospitalized for heart attack, the drug sertraline (Zoloft) has been found to be safe and effective.
	cpmcnet.columbia.edu /news/in-vivo/Vol1_Iss14_sept11_02/zoloft.html (637 words)

	TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin -- ...
		Cardiotoxic damage is more likely if multiple doses and an increased accumulated dose of DXR are received (31, 52).
		Evaluation of anthracycline cardiotoxicity: predictive ability and functional correlation of endomyocardial biopsy.
		Suppression of doxorubicin cardiotoxicity by overexpression of catalase in the heart of transgenic mice.
	ajpheart.physiology.org /cgi/content/full/276/3/H803 (6513 words)

	Diagnosis of Heart Failure in Adults - December 1, 2004 - American Family Physician
		Patients with coronary artery disease, hypertension, diabetes mellitus, exposure to cardiotoxic drugs, alcohol abuse, or a family history of cardiomyopathy are at high risk for heart failure and may benefit from routine screening.
		The evaluation of symptomatic patients with suspected heart failure is directed at confirming the presence of heart failure, determining the cause, identifying comorbid illnesses, establishing the severity of heart failure, and guiding therapy.
		Alcohol use, anemia, cardiotoxic medications, chest irradiation, connective tissue disease, exposure to cardiotoxic medications, exposure to sexually transmitted disease (e.g., human immunodeficiency virus infection), hemochromatosis, hyperthyroidism, hypothyroidism, infectious diseases, pheochromocytoma
	www.aafp.org /afp/20041201/2145.html (3648 words)

	Anthracycline-Induced Cardiotoxicity -- Shan et al. 125 (1): 47 -- Annals of Internal Medicine
		Prospective evaluation of cardiotoxicity during a six-hour doxorubicin infusion regimen in women with adenocarcinoma of the breast.
		Mediation of subacute anthracycline cardiotoxicity in rabbits by cardiac histamine release.
		Early detection of doxorubicin and daunorubicin cardiotoxicity by echocardiography: diastolic versus systolic parameters.
	www.annals.org /cgi/content/full/125/1/47 (6786 words)

	Functional monitoring of anthracycline cardiotoxicity: a prospective, blinded, long-term observational study of outcome ...
		Functional monitoring of anthracycline cardiotoxicity: a prospective, blinded, long-term observational study of outcome in 120 patients -- Jensen et al.
		the degree of cardiotoxicity and the cumulative dose.
		cardiotoxicity resembles the cardiotoxicity caused by the burst
	annonc.oxfordjournals.org /cgi/content/full/13/5/699 (4528 words)

	NCI Cancer Bulletin for August 1, 2006 (HTML) - National Cancer Institute
		To further evaluate whether imatinib may have cardiotoxic effects, the research team treated healthy mice with the drug for 3 or 6 weeks using a range of doses.
		In addition to detecting mitochondrial abnormalities that are indicative of cardiotoxic effects, they found that mice treated for 3 to 4 weeks with a 200 mg dose also developed left ventricular contractile dysfunction and dilation.
		In 1994, when the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study showed that beta-carotene was associated with lung cancer, many questioned earlier dietary epidemiology studies demonstrating its protective effects.
	www.cancer.gov /ncicancerbulletin/NCI_Cancer_Bulletin_080106/page5 (1263 words)

	Leslie C. Sharkey - College of Veterinary Medicine - University of Minnesota
		I have previously studied the impact of reproductive senescence on the progression of genetically-programmed hypertension and congestive heart failure and have developed rat models for the study of hypertensive disorders of pregnancy.
		Current projects focus on the study of gender susceptibility to the cardiotoxic chemotherapy drug doxorubicin and the interaction of toxic and genetically programmed cardiovascular disease.
		My main clinical interests are improving the diagnostic accuracy of cytology and optimization of the use of clinical chemistry testing as a diagnostic tool.
	www.cvm.umn.edu /facultystaff/vpm/sharkey.html (404 words)

	Phase I/II Study of the Rituximab-EPOCT Regimen in Combination with Granulocyte Colony-Stimulating Factor in Patients ...
		Phase I/II Study of the Rituximab-EPOCT Regimen in Combination with Granulocyte Colony-Stimulating Factor in Patients with Relapsed or Refractory Follicular Lymphoma Including Evaluation of Its Cardiotoxicity Using B-Type Natriuretic Peptide and Troponin T Levels -- Niitsu et al.
		cardiotoxic and highly effective antineoplastic drug (3, 4).
		Prolonged monitoring of troponin T for the detection of anthracycline cardiotoxicity in adults with hematological malignancies.
	clincancerres.aacrjournals.org /cgi/content/full/11/2/697 (3540 words)

	ARK Online - Student Work
		-Lily of the valley, rhododendron, azalea, yew and foxglove are cardiotoxic and affect the heart and circulatory system.
		-Oleander is also a cardiotoxic, and can spell death within minutes for many animals.
		It is widespread and many animals (mostly horses) are killed each year from a simple nibble.
	www.arkonline.com /stu_life_02.html (331 words)

	Barrier Word Algorithm and Approximate Matching
		A potential nominal phrase is computed as a sequence of words occurring between barrier words, which are derived from a set of stopwords including articles, prepositions, and verbs.
		The set of barrier words might be used to identify local anesthetic bupivacaine, cardiotoxic, and circulation as nominal phrases.
		While this method has been used for some time, the use of a very long list of barrier words (approximately 24,000) was found to be much more effective in identifying nominal phrases in text than the traditional shorter lists.
	ii.nlm.nih.gov /MTI/barrier.shtml (453 words)

	Abstract for Jessica Nielson (Site not responding. Last check: 2007-10-08)
		Anticancer and Cardiotoxic Effects of the Anthracycline Antibiotic Doxorubicin
		This deadly side effect of Doxorubicin treatment limits the maximum lifetime dose of the drug.
		Mechanisms for the anticancer behavior and the cardiotoxic behavior of Doxorubicin will be discussed.
	www.humboldt.edu /~chem_dpt/events/nielson.html (66 words)

	Recent studies on ECG changes, antipsychotic use and sudden death in psychiatric patients -- Reilly et al. 26 (3): 110 ...
		in accumulation of metabolites that may be cardiotoxic.
		and sudden death are rare, thioridazine's cardiotoxicity is
		BUCKLEY, N. and DAWSON, A. (1995) Cardiotoxicity more common in thioridazine overdose than with other neuroleptics.
	pb.rcpsych.org /cgi/content/full/26/3/110 (1578 words)

	Early Detection of Cardiotoxic Side Effects in the Drug Development Process - 050302140402 (Site not responding. Last check: 2007-10-08)
		The early detection of cardiotoxic side effects in the drug development process requires reliable high throughput assays to detect evidence of arrythmogenic properties.
		With the QT-Screen system it is possible to record from primary cardiac myocyte cultures, or from the mammalian cardiomyocyte cell line HL-1.
		We pharmacologically analyzed the various components of the field potential and correlate this components with the respective action potential data.
	www.sbsonline.org /sbscon/2005/posters/050302140402.php (192 words)

	Comparative Study on Cardiotoxic Effect of Tinuvin 770: A Light Stabilizer of Medical Plastics in Rat Model -- ...
		Comparative Study on Cardiotoxic Effect of Tinuvin 770: A Light Stabilizer of Medical Plastics in Rat Model -- Sótonyi et al.
		Comparative Study on Cardiotoxic Effect of Tinuvin 770: A Light Stabilizer of Medical Plastics in Rat Model
		Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues.
	toxsci.oxfordjournals.org /cgi/content/abstract/77/2/368 (343 words)

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